Crimean-Congo Haemorrhagic Fever Vaccine

Informazioni relative al progetto

CCHFVaccine

ID dell’accordo di sovvenzione: 732732

DOI

10.3030/732732

Progetto chiuso

Data della firma CE 9 Dicembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 30 Settembre 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 255 909,80

Contributo UE

€ 5 979 607,30

Coordinato da

FOLKHALSOMYNDIGHETEN
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Demonstrators, pilots, prototypes (3)

DIVA

DIVA vaccine.

RVF-VLPs

RVFV-VLPs expressing CCHFV proteins.

RNA

RNA vaccine.

Pubblicazioni

Peer reviewed articles (24)

A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model

Autori: David W. Hawman, Gustaf Ahlén, K. Sofia Appelberg, Kimberly Meade-White, Patrick W. Hanley, Dana Scott, Vanessa Monteil, Stephanie Devignot, Atsushi Okumura, Friedemann Weber, Heinz Feldmann, Matti Sällberg, Ali Mirazimi
Pubblicato in: Nature Microbiology, Numero 6, 2024, Pagina/e 187-195, ISSN 2058-5276
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41564-020-00815-6

Diagnosis and Pathogenesis of Nairobi Sheep Disease Orthonairovirus Infections in Sheep and Cattle

Autori: Julia Hartlaub, Benjamin Gutjahr, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Pubblicato in: Viruses, Numero 13/7, 2021, Pagina/e 1250, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071250

The interplays between Crimean-Congo hemorrhagic fever virus (CCHFV) M segment-encoded accessory proteins and structural proteins promote virus assembly and infectivity

Autori: Natalia Freitas; Margot Enguehard; Solène Denolly; Camille Levy; Gregory Neveu; Solène Lerolle; Stephanie Devignot; Friedemann Weber; Eric Bergeron; Vincent Legros; François-Loïc Cosset
Pubblicato in: PLOS Pathogens, Numero 16, 2020, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1008850

Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa

Autori: Médiha Khamassi Khbou, Rihab Romdhane, Faten Bouaicha Zaafouri, Mohsen Bouajila, Limam Sassi, Sofia K. Appelberg, Ansgar Schulz, Ali Mirazimi, Martin H. Groschup, Mourad Rekik, M'hammed Benzarti, Mohamed Gharbi
Pubblicato in: Veterinary Medicine and Science, Numero 7, 2023, Pagina/e 2323-2329, ISSN 2053-1095
Editore: Wiley
DOI: 10.1002/vms3.597

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

Autori: David W Hawman, Kimberly Meade-White, Shanna Leventhal, Friederike Feldmann, Atsushi Okumura, Brian Smith, Dana Scott, Heinz Feldmann
Pubblicato in: eLife, Numero 10, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.63906

Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

Autori: Sarah Kempster, Mark Hassall, Victoria Graham, Emma Kennedy, Stephen Findlay-Wilson, Francisco J. Salguero, Binnur Bagci, Nazif Elaldi, Murtaza Oz, Tuba Tasseten, Frank W. Charlton, John N. Barr, Juan Fontana, Chinwe Duru, Ernest Ezeajughi, Paul Matejtschuk, Ulrike Arnold, Yemisi Adedeji, Ali Mirazimi, Roger Hewson, Stuart Dowall, Neil Almond
Pubblicato in: Virus Research, Numero 346, 2024, Pagina/e 199409, ISSN 0168-1702
Editore: Elsevier BV
DOI: 10.1016/j.virusres.2024.199409

Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection

Autori: Anoop T. Ambikana, Nazif Elaldib, Sara Svensson- Akusjärvia, Binnur Bagcic, Ayse Nur Pektasd, Roger Hewsone,f, Gokhan Bagcig, Mehmet Araslih, Sofia Appelbergi, Adil Mardinogluj,k, Vikas Sooda,l, Ákos Végvárim, Rui Benfeitasa, Soham Guptaa, Ilhan Cetinn, Ali Mirazimii,o,p, and Ujjwal Neogia,
Pubblicato in: Proceedings of the National Academy of Sciences (PNAS), Numero September 5, 2023, 120 (37), 2023, Pagina/e e2304722120, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2304722120

Nucleoside-Modified mRNA Vaccines Protect IFNAR–/– Mice against Crimean-Congo Hemorrhagic Fever Virus Infection

Autori: Sofia Appelberg; Lijo John; Norbert Pardi; Ákos Végvári; Sándor Bereczky; Gustaf Ahlén; Vanessa Monteil; Samir Abdurahman; Flora Mikaeloff; Mitchell Beattie; Ying Tam ; Matti Sällberg; Ujjwal Neogi; Drew Weissman; Ali Mirazimi
Pubblicato in: Journal of Virology, Numero 96, 2022, Pagina/e e01568-21, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.01568-21

Deciphering Antibody Responses to Orthonairoviruses in Ruminants

Autori: Julia Hartlaub, Markus Keller, Martin H. Groschup
Pubblicato in: Microorganisms, Numero 9/7, 2021, Pagina/e 1493, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms9071493

Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge

Autori: Sandra Moreno; Eva Calvo-Pinilla; Stephanie Devignot; Friedemann Weber; Javier Ortego; Alejandro Brun
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 14, 2020, ISSN 1935-2727
Editore: Public Library of Science
DOI: 10.1371/journal.pntd.0008942

Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

Autori: David W. Hawman; Kimberly Meade-White; Shanna Leventhal; Sofia Appelberg; Gustaf Ahlén; Negin Nikouyan; Chad Clancy; Brian Smith; Patrick Hanley; Jamie Lovaglio; Ali Mirazimi; Matti Sällberg; Heinz Feldmann
Pubblicato in: Molecular Therapy, Numero 31, 2022, Pagina/e VOLUME 31, ISSUE 2, P387-397, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.09.016

Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Autori: Marko Zivcec, David Safronetz, Dana P. Scott, Shelly Robertson, Heinz Feldmann
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 12, 2022, Pagina/e e0006628, ISSN 1935-2735
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0006628

Experimental Challenge of Sheep and Cattle with Dugbe Orthonairovirus, a Neglected African Arbovirus Distantly Related to CCHFV

Autori: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Pubblicato in: Viruses, Numero 13/3, 2021, Pagina/e 372, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030372

Comparison of Crimean-Congo Hemorrhagic Fever Virus and Aigai Virus in Life Cycle Modeling Systems Reveals a Difference in L Protein Activity

Autori: Matthew J. Pickin; Stéphanie Devignot; Friedemann Weber; Martin H. Groschup
Pubblicato in: Journal of Virology, Numero 96, 2022, Pagina/e e00599-22, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.00599-22

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Autori: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Maryna Somova, Ali Mirazimi, Martin H. Groschup, Markus Keller
Pubblicato in: Microorganisms, Numero 8/12, 2020, Pagina/e 1927, ISSN 2076-2607
Editore: US National Library of Medicine National Institutes of Health
DOI: 10.3390/microorganisms8121927

Epitope-mapping of the glycoprotein from Crimean-Congo hemorrhagic fever virus using a microarray approach

Autori: Amanda Fritzen, Christian Risinger, Gulay Korukluoglu, Iva Christova, Arina Corli Hitzeroth, Natalie Viljoen, Felicity Jane Burt, Ali Mirazimi, Ola Blixt
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 12/7, 2018, Pagina/e e0006598, ISSN 1935-2735
Editore: NIAID
DOI: 10.1371/journal.pntd.0006598

Second International Conference on Crimean-Congo Hemorrhagic Fever

Autori: Jessica R. Spengler, Dennis A. Bente, Mike Bray, Felicity Burt, Roger Hewson, Gülay Korukluoglu, Ali Mirazimi, Friedemann Weber, Anna Papa
Pubblicato in: Antiviral Research, Numero 150, 2018, Pagina/e 137-147, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/j.antiviral.2017.11.019

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Autori: Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Pubblicato in: Journal of Virology, Numero 91/10, 2017, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.02076-16

Structure and function of the Toscana virus cap-snatching endonuclease

Autori: Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera
Pubblicato in: Nucleic Acids Research, Numero 47, 2021, Pagina/e 10914-10930, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkz838

Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle

Autori: Julia Hartlaub, Oluwafemi B. Daodu, Balal Sadeghi, Markus Keller, James Olopade, Daniel Oluwayelu, Martin H. Groschup
Pubblicato in: Viruses, Numero 13/7, 2021, Pagina/e 1398, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071398

Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks

Autori: Barbara Bartolini, Cesare EM Gruber, Marion Koopmans, Tatjana Avšič, Sylvia Bino, Iva Christova, Roland Grunow, Roger Hewson, Gulay Korukluoglu, Cinthia Menel Lemos, Ali Mirazimi, Anna Papa, Maria Paz Sanchez-Seco, Aisha V. Sauer, Hervè Zeller, Carla Nisii, Maria Rosaria Capobianchi, Giuseppe Ippolito, Chantal B. Reusken, Antonino Di Caro
Pubblicato in: Eurosurveillance, Numero 24, 2024, ISSN 1560-7917
Editore: European Centre for Disease Control and Prevention (ECDC)
DOI: 10.2807/1560-7917.es.2019.24.5.1800093

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

Autori: Ujjwal Neogi; Nazif Elaldi; Sofia Appelberg; Anoop Ambikan; Emma Kennedy; Stuart Dowall; Binnur K Bagci; Soham Gupta; Jimmy E Rodriguez; Sara Svensson-Akusjärvi; Vanessa Monteil; Akos Vegvari; Rui Benfeitas; Akhil Banerjea; Friedemann Weber; Roger Hewson; Ali Mirazimi
Pubblicato in: eLife, Numero 11, 2022, Pagina/e e76071, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.76071

ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

Autori: Stephanie Devignot; Thilo Kromer; Ali Mirazimi; Friedemann Weber
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 14, 2020, Pagina/e 1-24, ISSN 1935-2727
Editore: Public Library of Science
DOI: 10.1371/journal.pntd.0008610

Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Autori: Vanessa M. Monteil, Shane C. Wright, Matheus Dyczynski, Max J. Kellner, Sofia Appelberg, Sebastian W. Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stephanie Devignot, Elizabeth Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker M. Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Monserrat
Pubblicato in: Nature Microbiology, Numero 9, 2024, Pagina/e 1499-1512, ISSN 2058-5276
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01672-3

Thesis and dissertations (1)

Mejora y evaluación de vacunas basadas en vectores víricos frente a orbivirus y bunyavirus transmitidos por vectores

Autori: Moreno Fernández, Sandra
Pubblicato in: reponame:E-Prints Complutense. Archivo Institucional de la UCM, Numero 2, 2021
Editore: Universidad Complutense de Madrid

Book chapters (1)

Vector-Borne Infections in Bulgaria

Autori: Iva Christova
Pubblicato in: Vectors and Vector-Borne Zoonotic Diseases, 2022
Editore: IntechOpen
DOI: 10.5772/intechopen.81916