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Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Objective

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.

MultipleMS will therefore develop, validate, and exploit methods for patient stratification in Multiple Sclerosis, a chronic inflammatory disease and a leading causes of non-traumatic disability in young adults, with an estimated cost of €37 000 per patient per year over a duration of 30 years. Here we benefit from several large clinical cohorts with multiple data types, including genetic and lifestyle information. This in combination with publically available multi-omics maps enables us to identify biomarkers of the clinical course and the response to existing therapies in a real-world setting, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions.

To create strategic global synergies, MultipleMS includes 21 partners and covers not only the necessary clinical, biological, and computational expertise, but also includes six industry partners ensuring dissemination and exploitation of the methods and clinical decision support system. Moreover, the pharmaceutical industry partners provide expertise to ensure optimal selection and validation of clinically relevant biomarkers and new targets. Our conceptual personalized approach can readily be adapted to other immune-mediated diseases with a complex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response.

MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.

Call for proposal

H2020-SC1-2016-RTD
See other projects for this call

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 179 831,50

Participants (22)

MABTECH AB
Sweden
EU contribution
€ 58 530
Address
Augustendalsv 19
13128 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
YH YOUHEALTH AB
Sweden
EU contribution
€ 1 253 298,75
Address
Fogdevreten 2 Karolinska Science
171 77 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 1 687 827,50
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
BIOCOMPUTING PLATFORMS LTD OY
Finland
EU contribution
€ 257 936,50
Address
Innopoli 3 Vaisalantie 6
02130 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 562 978,25
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 337 285,75
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 1 717 550,25
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 519 953,25
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 260 656,75
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
MEDIMMUNE LIMITED
United Kingdom
EU contribution
€ 3 375
Address
Milstein Building Granta Park
CB21 6GH Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 213 166
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 99 943,50
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
NEURIX SA
Switzerland
EU contribution
€ 0
Address
Avenue De La Roseraie 64
1205 Geneve
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 289 832,75
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 409 913,99
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
EU contribution
€ 702 104
Address
Duomo 6
13100 Vercelli
Activity type
Higher or Secondary Education Establishments
ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES
United States
EU contribution
€ 1 321 504
Address
2211 Elliott Avenue Suite 200
98121 Seattle
Activity type
Research Organisations
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 336 412,75
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 7 125
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 1 268 275,50
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
POLICLINICO SAN DONATO SPA

Participation ended

Italy
EU contribution
€ 64 158,51
Address
Via Rodolfo Morandi 30
20097 San Donato Mi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 169 793,50
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments