Deliverables
R-packages for patient specific stratificationMotivation for change:There has been delay in the development of R tools to be used for patient specific stratification as their application and hence development to data in retrospective cohort data has been delayed.
Software for stratification and clinical decision support systemSoftware for stratification and clinical decision support system. combination of previous D6.3 and D6.4.Motivation for change:After evaluating the market needs and existing software, we plan to combine software for stratification with that for clinical stratification into one product and hence would like to combine D6.3 and 6.4. Depending on intended users, we will make some features unavailable. The software is developed, and the core is ready. However, it is missing a few critical services to be genuinely market-ready which we estimate would require additional time.
Data availability and knowledge discovery tool to monitor for the availability of the different data typesValidation and formulation of candidate MS guidelines to be implemented into clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed
Report on novel biomarkers and suggestions for their application in clinical practiceReport on novel biomarkers and suggestions for their application in clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed
Development of guidelines for reporting biomarker results and their classification into different levels of evidencePublications
Author(s):
Russell Ouellette, Constantina A Treaba, Tobias Granberg, Elena Herranz, Valeria Barletta, Ambica Mehndiratta, Benjamin De Leener, Shahamat Tauhid, Fawad Yousuf, Sarah M Dupont, Eric C Klawiter, Jacob A Sloane, Rohit Bakshi, Julien Cohen-Adad, Caterina Mainero
Published in:
Brain, Issue 143/10, 2020, Page(s) 2973-2987, ISSN 0006-8950
Publisher:
Oxford University Press
DOI:
10.1093/brain/awaa249
Author(s):
Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
Published in:
Epigenetics, Issue 15/6-7, 2020, Page(s) 646-663, ISSN 1559-2294
Publisher:
Landes Bioscience
DOI:
10.1080/15592294.2019.1700628
Author(s):
Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, Fredrik Piehl, Tobias Granberg
Published in:
Journal of Neuroimaging, Issue 30/2, 2020, Page(s) 198-204, ISSN 1051-2284
Publisher:
Sage Science Press
DOI:
10.1111/jon.12676
Author(s):
Moridi T, Stawiarz L, McKay KA, Ineichen BV, Ouellette R, Ferreira D, Muehlboeck JS, Westman E, Kockum I, Olsson T, Piehl F, Hillert J, Manouchehrinia A, Granberg T.
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Mult Scler J Exp Transl Clin, 2022, ISSN 2055-2173
Publisher:
Sage Publications
DOI:
10.1177/20552173221144230
Author(s):
Xabier Martinez-de-Morentin , Sumeer A. Khan , Robert Lehmann , Sisi Qu , Alberto Maillo , Narsis A. Kiani , Felipe Prosper , Jesper Tegner , David Gomez-Cabrero
Published in:
Quant. Biol, 2023, ISSN 2095-4697
Publisher:
Higher Education Press
DOI:
10.15302/j-qb-022-0318
Author(s):
Stridh P, Kockum I, Huang J
Published in:
Sci Rep, Issue 2021 Oct 25;11(1):20989, 2021, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-021-00344-0
Author(s):
Vandebergh, Marijne; Degryse, Nicolas; Dubois, Benedicte; Goris, An
Published in:
JOURNAL OF NEUROLOGY, Issue J Neurol . 2022 Aug;269(8):4565-4574, 2022, ISSN 0340-5354
Publisher:
Dr. Dietrich Steinkopff Verlag
DOI:
10.1007/s00415-022-11072-4
Author(s):
Anna Karin Hedström, Jesse Huang, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Published in:
Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-020-67883-w
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Held F, Kalluri SR, Berthele A, Klein AK, Reindl M, Hemmer B
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MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Issue Mult Scler J Exp Transl Clin . 2021 Jun 25;7(2):20552173211022767, 2021, ISSN 2055-2173
Publisher:
SAGE PUBLICATIONS INC
DOI:
10.1177/20552173211022767
Author(s):
Vandebergh, Marijne; Becelaere, Sara; Dubois, Benedicte; Goris, An; CHARGE, Inflammation Working Grp
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Frontiers In Immunology, Issue 2022 Mar 21;13:834644, 2022, ISSN 1664-3224
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FRONTIERS MEDIA SA
DOI:
10.3389/fimmu.2022.834644
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Jesse Huang, Mohsen Khademi, Lars Fugger, Örjan Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, Fredrik Piehl, Tomas Olsson, Ingrid Kockum
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Proceedings of the National Academy of Sciences, Issue 117/23, 2020, Page(s) 12952-12960, ISSN 0027-8424
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National Academy of Sciences
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10.1073/pnas.1912839117
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Garth R. Ilsley, Ritsuko Suyama, Takeshi Noda, Nori Satoh, Nicholas M. Luscombe
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Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
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Nature Publishing Group
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10.1038/s41598-020-61591-1
Author(s):
Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
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Ann Clin Transl Neurol, 2023, ISSN 2328-9503
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Wiley
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Sonja Hochmeister, Shahin Aeinehband, Charles Dorris, Rasmus Berglund, Michaela T. Haindl, Vid Velikic, Sven A. Gustafsson, Tomas Olsson, Fredrik Piehl, Maja Jagodic, Manuel Zeitelhofer, Milena Z. Adzemovic
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Frontiers in Neurology, Issue 11, 2020, ISSN 1664-2295
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Frontiers Research Foundation
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10.3389/fneur.2020.600401
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Silvia Peroni, Melissa Sorosina, Sunny Malhotra, Ferdinando Clarelli, Ana Maria Osiceanu, Laura Ferrè, Tina Roostaei, Jordi Rio, Luciana Midaglia, Luisa María Villar, José Carlos Álvarez-Cermeño, Clara Guaschino, Marta Radaelli, Lorena Citterio, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Vittorio Martinelli, Xavier Montalban, Howard L Weiner, Philip de Jager, Giancarlo Comi, Feder
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Multiple Sclerosis Journal, Issue 26/9, 2020, Page(s) 1074-1082, ISSN 1352-4585
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SAGE Publications
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Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, Cuici; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid;
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Ann Neurol, 2023, ISSN 0364-5134
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John Wiley & Sons Inc.
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10.1002/ana.26807
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Thomas O G, Bronge M, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Ortlieb Guerreiro-Cacais A, Grönlund H, Olsson T, Kockum I
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Sci Adv., 2023, ISSN 2375-2548
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AAAS
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10.1126/sciadv.adg3032
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Stefanos Klironomos, Antonios Tzortzakakis, Annika Kits, Claes Öhberg, Evangelia Kollia, Amir Ahoromazdae, Håkan Almqvist, Åsa Aspelin, Heather Martin, Russell Ouellette, Jonathan Al-Saadi, Mikael Hasselberg, Mansour Haghgou, Mitra Pedersen, Sven Petersson, Johannes Finnsson, Johan Lundberg, Anna Falk Delgado, Tobias Granberg
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Radiology, Issue 297/3, 2020, Page(s) E324-E334, ISSN 0033-8419
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Radiological Society of North America
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European Journal of Human Genetics, Issue 28/7, 2020, Page(s) 849-850, ISSN 1018-4813
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Natue Publishing Group
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Vandebergh, Marijne; Andlauer, Till FM; Zhou, Yuan; Mallants, Klara; Held, Friederike; Aly, Lilian; Taylor, Bruce V; Hemmer, Bernhard; Dubois, Benedicte; Goris, An
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Annals Of Neurology, Issue 2021 May;89(5):884-894., 2021, ISSN 0364-5134
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John Wiley & Sons Inc.
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Lancet Neurology, Issue 2022 Mar;21(3):246-257., 2022, ISSN 1474-4422
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The Lancet Publishing Group
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10.1016/s1474-4422(22)00009-6
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Marijne Vandebergh, An Goris
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Journal of Neurology, Issue 267/10, 2020, Page(s) 3083-3091, ISSN 0340-5354
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Dr. Dietrich Steinkopff Verlag
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Mol Cell Proteomics., 2021, ISSN 1535-9484
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MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Issue 2021 Dec 22;7(4):20552173211065730., 2021, ISSN 2055-2173
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SAGE PUBLICATIONS I
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10.1177/20552173211065730
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Zheleznyakova GY, Piket E, Needhamsen M, Hagemann-Jensen M, Ekman D, Han Y, James T, Khademi M, Al Nimer F, Scicluna P, Huang J, Kockum I, Faridani OR, Olsson T, Piehl F, Jagodic M
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Proc Natl Acad Sci U S A. 2021 Apr 27;118(17), 2021, ISSN 0027-8424
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National Academy of Sciences
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10.1073/pnas.2011574118
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J Neurol Neurosurg Psychiatry, 2023, ISSN 1468-330X
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Nature Immunology, Issue 22, pages1479–1489 (2021), 2021, ISSN 1529-2908
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Nature Publishing Group
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Christiane Gasperi, Till F.M. Andlauer, Ana Keating, Benjamin Knier, Ana Klein, Verena Pernpeintner, Peter Lichtner, Ralf Gold, Frauke Zipp, Florian Then Bergh, Martin Stangel, Hayrettin Tumani, Brigitte Wildemann, Heinz Wiendl, Antonios Bayas, Tania Kümpfel, Uwe K. Zettl, Ralf A. Linker, Ulf Ziemann, Matthias Knop, Clemens Warnke, Manuel A. Friese, Friedemann Paul, Björn Tackenberg, Achim Berth
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Neurology - Neuroimmunology Neuroinflammation, Issue 7/5, 2020, Page(s) e827, ISSN 2332-7812
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Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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10.1212/nxi.0000000000000827
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Starvaggi Cucuzza C, Longinetti E, Ruffin N, Evertsson B, Kockum I, Jagodic M, Al Nimer F, Frisell T, Piehl F.
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Neurol Neuroimmunol Neuroinflamm., 2022, ISSN 2332-7812
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Wolters Kluwer Health/Lippincott Williams & Wilkins
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Kockum I, Huang J, Stridh P
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Curr Protoc, 2023, ISSN 2691-1299
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Wiley
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FRONTIERS IN IMMUNOLOGY, 2022, ISSN 1664-3224
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Ide Smets, An Goris, Marijne Vandebergh, Jelle Demeestere, Stefan Sunaert, Patrick Dupont, Bénédicte Dubois
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Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
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Nature Publishing Group
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Multiple Sclerosis and Related Disorders, Issue 44, 2020, Page(s) 102326, ISSN 2211-0348
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Elsevier
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PLoS Comput Biol, 2023, ISSN 1553-734X
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Public Library of Science
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European Journal of Neurology, Issue 28/2, 2021, Page(s) 579-586, ISSN 1351-5101
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Neurol Neuroimmunol Neuroinflamm, 2022, ISSN 2332-7812
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Eur J Neurol., 2021, ISSN 1351-5101
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Journal of Internal Medicine, Issue 288/1, 2020, Page(s) 82-102, ISSN 0954-6820
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Epigenomics, 2021, ISSN 1750-1911
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NEUROLOGY, Issue 2021 Apr 26;10.1212/WNL.0000000000012074., 2021, ISSN 0028-3878
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Neuroimage Clin., 2023, ISSN 2213-1582
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Elsevier BV
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Annals of Clinical and Translational Neurology, Issue 7/10, 2020, Page(s) 2057-2071, ISSN 2328-9503
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BMC Bioinformatics, Issue 21/1, 2020, ISSN 1471-2105
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Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
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BioEssays, Issue 40/2, 2018, Page(s) 1700148, ISSN 0265-9247
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Human Molecular Genetics, Issue 27/5, 2018, Page(s) 912-928, ISSN 0964-6906
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Multiple Sclerosis Journal, Issue 24/8, 2018, Page(s) 1046-1054, ISSN 1352-4585
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npj Genomic Medicine, Issue 2/1, 2017, ISSN 2056-7944
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Brain, Issue 141/3, 2018, Page(s) 786-796, ISSN 0006-8950
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Genome Medicine, Issue 10/1, 2018, ISSN 1756-994X
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Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
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Multiple Sclerosis Journal, Issue 24/10, 2018, Page(s) 1288-1300, ISSN 1352-4585
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JAMA Neurology, Issue 76/7, 2019, Page(s) 841, ISSN 2168-6149
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Genome Medicine, Issue 12/1, 2020, ISSN 1756-994X
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Annals of Neurology, 2020, ISSN 0364-5134
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Tanja Daltrozzo, Alexander Hapfelmeier, Ewan Donnachie, Antonius Schneider, Bernhard Hemmer
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Frontiers in Neurology, Issue 9, 2018, ISSN 1664-2295
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