Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Livrables

R-packages for patient specific stratification

R-packages for patient specific stratificationMotivation for change:There has been delay in the development of R tools to be used for patient specific stratification as their application and hence development to data in retrospective cohort data has been delayed.

Software for stratification and clinical decision support system

Software for stratification and clinical decision support system. combination of previous D6.3 and D6.4.Motivation for change:After evaluating the market needs and existing software, we plan to combine software for stratification with that for clinical stratification into one product and hence would like to combine D6.3 and 6.4. Depending on intended users, we will make some features unavailable. The software is developed, and the core is ready. However, it is missing a few critical services to be genuinely market-ready which we estimate would require additional time.

Data availability and knowledge discovery tool to monitor for the availability of the different data types

Validation and formulation of candidate MS guidelines to be implemented into clinical practice

Validation and formulation of candidate MS guidelines to be implemented into clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Report on novel biomarkers and suggestions for their application in clinical practice

Report on novel biomarkers and suggestions for their application in clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Development of guidelines for reporting biomarker results and their classification into different levels of evidence

Project website

Publications

7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis

Auteurs: Russell Ouellette, Constantina A Treaba, Tobias Granberg, Elena Herranz, Valeria Barletta, Ambica Mehndiratta, Benjamin De Leener, Shahamat Tauhid, Fawad Yousuf, Sarah M Dupont, Eric C Klawiter, Jacob A Sloane, Rohit Bakshi, Julien Cohen-Adad, Caterina Mainero
Publié dans: Brain, Numéro 143/10, 2020, Page(s) 2973-2987, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awaa249

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression

Auteurs: Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
Publié dans: Epigenetics, Numéro 15/6-7, 2020, Page(s) 646-663, ISSN 1559-2294
Éditeur: Landes Bioscience
DOI: 10.1080/15592294.2019.1700628

MRI‐Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis

Auteurs: Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, Fredrik Piehl, Tobias Granberg
Publié dans: Journal of Neuroimaging, Numéro 30/2, 2020, Page(s) 198-204, ISSN 1051-2284
Éditeur: Sage Science Press
DOI: 10.1111/jon.12676

Association between brain volume and disability over time in multiple sclerosis

Auteurs: Moridi T, Stawiarz L, McKay KA, Ineichen BV, Ouellette R, Ferreira D, Muehlboeck JS, Westman E, Kockum I, Olsson T, Piehl F, Hillert J, Manouchehrinia A, Granberg T.
Publié dans: Mult Scler J Exp Transl Clin, 2022, ISSN 2055-2173
Éditeur: Sage Publications
DOI: 10.1177/20552173221144230

LIBRA: an adaptative integrative tool for paired single-cell multi-omics data

Auteurs: Xabier Martinez-de-Morentin , Sumeer A. Khan , Robert Lehmann , Sisi Qu , Alberto Maillo , Narsis A. Kiani , Felipe Prosper , Jesper Tegner , David Gomez-Cabrero
Publié dans: Quant. Biol, 2023, ISSN 2095-4697
Éditeur: Higher Education Press
DOI: 10.15302/j-qb-022-0318

Seasonal variability of serum 25-hydroxyvitamin D on multiple sclerosis onset.

Auteurs: Stridh P, Kockum I, Huang J
Publié dans: Sci Rep, Numéro 2021 Oct 25;11(1):20989, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-00344-0

Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.

Auteurs: Vandebergh, Marijne; Degryse, Nicolas; Dubois, Benedicte; Goris, An
Publié dans: JOURNAL OF NEUROLOGY, Numéro J Neurol . 2022 Aug;269(8):4565-4574, 2022, ISSN 0340-5354
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-022-11072-4

Smoking and Epstein–Barr virus infection in multiple sclerosis development

Auteurs: Anna Karin Hedström, Jesse Huang, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-67883-w

Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients

Auteurs: Held F, Kalluri SR, Berthele A, Klein AK, Reindl M, Hemmer B
Publié dans: MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Numéro Mult Scler J Exp Transl Clin . 2021 Jun 25;7(2):20552173211022767, 2021, ISSN 2055-2173
Éditeur: SAGE PUBLICATIONS INC
DOI: 10.1177/20552173211022767

Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study.

Auteurs: Vandebergh, Marijne; Becelaere, Sara; Dubois, Benedicte; Goris, An; CHARGE, Inflammation Working Grp
Publié dans: Frontiers In Immunology, Numéro 2022 Mar 21;13:834644, 2022, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.834644

Inflammation-related plasma and CSF biomarkers for multiple sclerosis

Auteurs: Jesse Huang, Mohsen Khademi, Lars Fugger, Örjan Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, Fredrik Piehl, Tomas Olsson, Ingrid Kockum
Publié dans: Proceedings of the National Academy of Sciences, Numéro 117/23, 2020, Page(s) 12952-12960, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1912839117

Finding cell-specific expression patterns in the early Ciona embryo with single-cell RNA-seq

Auteurs: Garth R. Ilsley, Ritsuko Suyama, Takeshi Noda, Nori Satoh, Nicholas M. Luscombe
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-61591-1

Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Auteurs: Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Publié dans: Ann Clin Transl Neurol, 2023, ISSN 2328-9503
Éditeur: Wiley

Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

Auteurs: Sonja Hochmeister, Shahin Aeinehband, Charles Dorris, Rasmus Berglund, Michaela T. Haindl, Vid Velikic, Sven A. Gustafsson, Tomas Olsson, Fredrik Piehl, Maja Jagodic, Manuel Zeitelhofer, Milena Z. Adzemovic
Publié dans: Frontiers in Neurology, Numéro 11, 2020, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.600401

A pharmacogenetic study implicates NINJ2 in the response to Interferon-β in multiple sclerosis

Auteurs: Silvia Peroni, Melissa Sorosina, Sunny Malhotra, Ferdinando Clarelli, Ana Maria Osiceanu, Laura Ferrè, Tina Roostaei, Jordi Rio, Luciana Midaglia, Luisa María Villar, José Carlos Álvarez-Cermeño, Clara Guaschino, Marta Radaelli, Lorena Citterio, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Vittorio Martinelli, Xavier Montalban, Howard L Weiner, Philip de Jager, Giancarlo Comi, Feder
Publié dans: Multiple Sclerosis Journal, Numéro 26/9, 2020, Page(s) 1074-1082, ISSN 1352-4585
Éditeur: SAGE Publications
DOI: 10.1177/1352458519851428

A genetic risk variant for multiple sclerosis severity is associated with brain atrophy

Auteurs: Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, Cuici; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid;
Publié dans: Ann Neurol, 2023, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.26807

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis

Auteurs: Thomas O G, Bronge M, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Ortlieb Guerreiro-Cacais A, Grönlund H, Olsson T, Kockum I
Publié dans: Sci Adv., 2023, ISSN 2375-2548
Éditeur: AAAS
DOI: 10.1126/sciadv.adg3032

Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort

Auteurs: Stefanos Klironomos, Antonios Tzortzakakis, Annika Kits, Claes Öhberg, Evangelia Kollia, Amir Ahoromazdae, Håkan Almqvist, Åsa Aspelin, Heather Martin, Russell Ouellette, Jonathan Al-Saadi, Mikael Hasselberg, Mansour Haghgou, Mitra Pedersen, Sven Petersson, Johannes Finnsson, Johan Lundberg, Anna Falk Delgado, Tobias Granberg
Publié dans: Radiology, Numéro 297/3, 2020, Page(s) E324-E334, ISSN 0033-8419
Éditeur: Radiological Society of North America
DOI: 10.1148/radiol.2020202791

Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

Auteurs: Lies Van Horebeek, An Goris
Publié dans: European Journal of Human Genetics, Numéro 28/7, 2020, Page(s) 849-850, ISSN 1018-4813
Éditeur: Natue Publishing Group
DOI: 10.1038/s41431-020-0615-y

Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis.

Auteurs: Vandebergh, Marijne; Andlauer, Till FM; Zhou, Yuan; Mallants, Klara; Held, Friederike; Aly, Lilian; Taylor, Bruce V; Hemmer, Bernhard; Dubois, Benedicte; Goris, An
Publié dans: Annals Of Neurology, Numéro 2021 May;89(5):884-894., 2021, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.26061

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

Auteurs: Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive P H, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg Z, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle Jfor the RDB in the Swiss Multiple Sclerosis Cohort Study Grou
Publié dans: Lancet Neurology, Numéro 2022 Mar;21(3):246-257., 2022, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(22)00009-6

Smoking and multiple sclerosis risk: a Mendelian randomization study

Auteurs: Marijne Vandebergh, An Goris
Publié dans: Journal of Neurology, Numéro 267/10, 2020, Page(s) 3083-3091, ISSN 0340-5354
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09980-4

Assessing the preanalytical variability of plasma and cerebrospinal fluid processing and its effects on inflammation-related protein biomarkers.

Auteurs: Huang J, Khademi M, Lindhe Ö, Jönsson G, Piehl F, Olsson T, Kockum I
Publié dans: Mol Cell Proteomics., 2021, ISSN 1535-9484
Éditeur: ELSEVIER

Season of birth is associated with multiple sclerosis and disease severity

Auteurs: Stridh P, Huang J, Hedström AK, Alfredsson L, Olsson T, Hillert J, Manouchehrinia A, Kockum I
Publié dans: MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Numéro 2021 Dec 22;7(4):20552173211065730., 2021, ISSN 2055-2173
Éditeur: SAGE PUBLICATIONS I
DOI: 10.1177/20552173211065730

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology

Auteurs: Zheleznyakova GY, Piket E, Needhamsen M, Hagemann-Jensen M, Ekman D, Han Y, James T, Khademi M, Al Nimer F, Scicluna P, Huang J, Kockum I, Faridani OR, Olsson T, Piehl F, Jagodic M
Publié dans: Proc Natl Acad Sci U S A. 2021 Apr 27;118(17), 2021, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2011574118

Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.

Auteurs: Lauerer M, McGinnis J, Bussas M, El Husseini M, Pongratz V, Engl C, Wuschek A, Berthele A, Riederer I, Kirschke JS, Zimmer C, Hemmer B, Mühlau M.
Publié dans: J Neurol Neurosurg Psychiatry, 2023, ISSN 1468-330X
Éditeur: BMJ

Human immune diversity: from evolution to modernity.

Auteurs: Liston, Adrian; Humblet-Baron, Stephanie; Duffy, Darragh; Goris, An
Publié dans: Nature Immunology, Numéro 22, pages1479–1489 (2021), 2021, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-021-01058-1

Genetic determinants of the humoral immune response in MS

Auteurs: Christiane Gasperi, Till F.M. Andlauer, Ana Keating, Benjamin Knier, Ana Klein, Verena Pernpeintner, Peter Lichtner, Ralf Gold, Frauke Zipp, Florian Then Bergh, Martin Stangel, Hayrettin Tumani, Brigitte Wildemann, Heinz Wiendl, Antonios Bayas, Tania Kümpfel, Uwe K. Zettl, Ralf A. Linker, Ulf Ziemann, Matthias Knop, Clemens Warnke, Manuel A. Friese, Friedemann Paul, Björn Tackenberg, Achim Berth
Publié dans: Neurology - Neuroimmunology Neuroinflammation, Numéro 7/5, 2020, Page(s) e827, ISSN 2332-7812
Éditeur: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DOI: 10.1212/nxi.0000000000000827

Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis.

Auteurs: Starvaggi Cucuzza C, Longinetti E, Ruffin N, Evertsson B, Kockum I, Jagodic M, Al Nimer F, Frisell T, Piehl F.
Publié dans: Neurol Neuroimmunol Neuroinflamm., 2022, ISSN 2332-7812
Éditeur: Wolters Kluwer Health/Lippincott Williams & Wilkins

Overview of genotyping technologies and methods

Auteurs: Kockum I, Huang J, Stridh P
Publié dans: Curr Protoc, 2023, ISSN 2691-1299
Éditeur: Wiley
DOI: 10.1002/cpz1.727

Natural Killer Cells in Multiple Sclerosis: Entering the Stage

Auteurs: Beliën, Jarne; Goris, An; Matthys, Patrick
Publié dans: FRONTIERS IN IMMUNOLOGY, 2022, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.869447

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Auteurs: Ide Smets, An Goris, Marijne Vandebergh, Jelle Demeestere, Stefan Sunaert, Patrick Dupont, Bénédicte Dubois
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-81035-8

Impact of multiple sclerosis risk loci in postinfectious neurological syndromes

Auteurs: Filippo Martinelli-Boneschi, Riccardo Currò, Silvia Santoro, Giulia Berzero, Melissa Sorosina, Laura Ferrè, Elisabetta Mascia, Silvia Peroni, Giancarlo Comi, Angelo Gugliemi, Elisa Vegezzi, Ilaria Callegari, Massimo Filippi, Andrea Cortese, Federica Esposito, Ferdinando Clarelli, Enrico Marchioni
Publié dans: Multiple Sclerosis and Related Disorders, Numéro 44, 2020, Page(s) 102326, ISSN 2211-0348
Éditeur: Elsevier
DOI: 10.1016/j.msard.2020.102326

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

Auteurs: Giulio Ruffini ,Giada Damiani,Diego Lozano-Soldevilla,Nikolas Deco,Fernando E. Rosas,Narsis A. Kiani,Adrián Ponce-Alvarez,Morten L. Kringelbach,Robin Carhart-Harris,Gustavo Deco
Publié dans: PLoS Comput Biol, 2023, ISSN 1553-734X
Éditeur: Public Library of Science
DOI: 10.1371/journal.pcbi.1010811

Epstein–Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis

Auteurs: M. Biström, D. Jons, E. Engdahl, R. Gustafsson, J. Huang, N. Brenner, J. Butt, L. Alonso‐Magdalena, M. Gunnarsson, M. Vrethem, N. Bender, T. Waterboer, G. Granåsen, T. Olsson, I. Kockum, O. Andersen, A. Fogdell‐Hahn, Peter Sundström
Publié dans: European Journal of Neurology, Numéro 28/2, 2021, Page(s) 579-586, ISSN 1351-5101
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ene.14597

The Aryl Hydrocarbon Receptor-Dependent TGF-alpha/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis

Auteurs: Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V
Publié dans: Neurol Neuroimmunol Neuroinflamm, 2022, ISSN 2332-7812
Éditeur: LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/nxi.0000000000001043

Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis - a presymptomatic case-control study.

Auteurs: Grut V, Biström M, Salzer J, Stridh P, Jons D, Gustafsson R, Fogdell-Hahn A, Huang J, Brenner N, Butt J, Bender N, Lindam A, Alonso-Magdalena L, Gunnarsson M, Vrethem M, Bergström T, Andersen O, Kockum I, Waterboer T, Olsson T, Sundström P
Publié dans: Eur J Neurol., 2021, ISSN 1351-5101
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ene.14961

Epigenetic insights into multiple sclerosis disease progression

Auteurs: L. Kular, M. Jagodic
Publié dans: Journal of Internal Medicine, Numéro 288/1, 2020, Page(s) 82-102, ISSN 0954-6820
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/joim.13045

Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients. . 2021 Oct;13(20):1607-1618. doi: /

Auteurs: Fernandes SJ, Ericsson M, Khademi M, Jagodic M, Olsson T, Gomez-Cabrero D, Kockum I, Tegnér J.
Publié dans: Epigenomics, 2021, ISSN 1750-1911
Éditeur: Future Medicine Ltd.
DOI: 10.2217/epi-2021-0205

Systematic Assessment of Medical Diagnoses Preceding the First Diagnosis of Multiple Sclerosis

Auteurs: Gasperi C, Hapfelmeier A, Daltrozzo T, Schneider A, Donnachie E, Hemmer B.
Publié dans: NEUROLOGY, Numéro 2021 Apr 26;10.1212/WNL.0000000000012074., 2021, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000012074

Lesion location across diagnostic regions in multiple sclerosis

Auteurs: Viola Pongratz, Matthias Bussas, Paul Schmidt, Sophia Grahl, Christiane Gasperi, Malek El Husseini, Laura Harabacz, Viktor Pineker, Dominik Sepp, Lioba Grundl, Benedikt Wiestler, Jan Kirschke, Claus Zimmer, Achim Berthele, Bernhard Hemmer, Mark Mühlau
Publié dans: Neuroimage Clin., 2023, ISSN 2213-1582
Éditeur: Elsevier BV

Neurological manifestations of coronavirus infections – a systematic review

Auteurs: Jesper Almqvist, Tobias Granberg, Antonios Tzortzakakis, Stefanos Klironomos, Evangelia Kollia, Claes Öhberg, Roland Martin, Fredrik Piehl, Russell Ouellette, Benjamin V. Ineichen
Publié dans: Annals of Clinical and Translational Neurology, Numéro 7/10, 2020, Page(s) 2057-2071, ISSN 2328-9503
Éditeur: Wiley Periodicals LLC on behalf of American Neurological Association.
DOI: 10.1002/acn3.51166

GeneSetCluster: a tool for summarizing and integrating gene-set analysis results

Auteurs: Ewoud Ewing, Nuria Planell-Picola, Maja Jagodic, David Gomez-Cabrero
Publié dans: BMC Bioinformatics, Numéro 21/1, 2020, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-020-03784-z

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Auteurs: Lara Kular, Yun Liu, Sabrina Ruhrmann, Galina Zheleznyakova, Francesco Marabita, David Gomez-Cabrero, Tojo James, Ewoud Ewing, Magdalena Lindén, Bartosz Górnikiewicz, Shahin Aeinehband, Pernilla Stridh, Jenny Link, Till F. M. Andlauer, Christiane Gasperi, Heinz Wiendl, Frauke Zipp, Ralf Gold, Björn Tackenberg, Frank Weber, Bernhard Hemmer, Konstantin Strauch, Stefanie Heilmann-Heimbach, Rajesh
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-04732-5

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity

Auteurs: Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck, Dirk S. Paul
Publié dans: BioEssays, Numéro 40/2, 2018, Page(s) 1700148, ISSN 0265-9247
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/bies.201700148

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients

Auteurs: Tojo James, Magdalena Lindén, Hiromasa Morikawa, Sunjay Jude Fernandes, Sabrina Ruhrmann, Mikael Huss, Maya Brandi, Fredrik Piehl, Maja Jagodic, Jesper Tegnér, Mohsen Khademi, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum
Publié dans: Human Molecular Genetics, Numéro 27/5, 2018, Page(s) 912-928, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddy001

Epigenetic variation taking center stage in immunological research

Auteurs: Simone Ecker, Stephan Beck
Publié dans: Epigenomics, Numéro 9/4, 2017, Page(s) 375-378, ISSN 1750-1911
Éditeur: Future Medicine Ltd.
DOI: 10.2217/epi-2017-0006

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

Auteurs: Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson
Publié dans: Multiple Sclerosis Journal, Numéro 24/8, 2018, Page(s) 1046-1054, ISSN 1352-4585
Éditeur: SAGE Publications
DOI: 10.1177/1352458517715132

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

Auteurs: Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Th
Publié dans: npj Genomic Medicine, Numéro 2/1, 2017, ISSN 2056-7944
Éditeur: NPJ Genom Med
DOI: 10.1038/s41525-017-0027-2

Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis

Auteurs: Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Publié dans: Multiple Sclerosis Journal - Experimental, Translational and Clinical, Numéro 4/2, 2018, Page(s) 205521731876719, ISSN 2055-2173
Éditeur: Mult Scler J Exp Transl Clin.
DOI: 10.1177/2055217318767192

Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells

Auteurs: Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
Publié dans: Brain, Numéro 141/3, 2018, Page(s) 786-796, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awx372

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Auteurs: Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Publié dans: Genome Medicine, Numéro 10/1, 2018, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-018-0575-9

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship

Auteurs: Francesco Marabita, Malin Almgren, Louise K. Sjöholm, Lara Kular, Yun Liu, Tojo James, Nimrod B. Kiss, Andrew P. Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J. Ekström, Maja Jagodic
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-14788-w

Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

Auteurs: Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M Absher, Donna K Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic
Publié dans: Multiple Sclerosis Journal, Numéro 24/10, 2018, Page(s) 1288-1300, ISSN 1352-4585
Éditeur: SAGE Publications
DOI: 10.1177/1352458517721356

Ensembl 2018

Auteurs: Daniel R Zerbino, Premanand Achuthan, Wasiu Akanni, M Ridwan Amode, Daniel Barrell, Jyothish Bhai, Konstantinos Billis, Carla Cummins, Astrid Gall, Carlos García Girón, Laurent Gil, Leo Gordon, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Jimmy Kiang To, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, Thomas Maurel, Willia
Publié dans: Nucleic Acids Research, Numéro 46/D1, 2017, Page(s) D754-D761, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkx1098

Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis

Auteurs: Christiane Gasperi, Anke Salmen, Gisela Antony, Antonios Bayas, Christoph Heesen, Tania Kümpfel, Ralf A. Linker, Friedemann Paul, Martin Stangel, Björn Tackenberg, Florian Then Bergh, Clemens Warnke, Frank Weber, Heinz Wiendl, Brigitte Wildemann, Uwe K. Zettl, Ulf Ziemann, Frauke Zipp, Hayrettin Tumani, Ralf Gold, Bernhard Hemmer
Publié dans: JAMA Neurology, Numéro 76/7, 2019, Page(s) 841, ISSN 2168-6149
Éditeur: American Medical Association
DOI: 10.1001/jamaneurol.2019.0905

Towards a European health research and innovation cloud (HRIC)

Auteurs: F. M. Aarestrup, A. Albeyatti, W. J. Armitage, C. Auffray, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie, M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. L
Publié dans: Genome Medicine, Numéro 12/1, 2020, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-020-0713-z

CHIT1 at Diagnosis Reflects Long‐Term Multiple Sclerosis Disease Activity

Auteurs: Emanuela Oldoni, Ide Smets, Klara Mallants, Marijne Vandebergh, Lies Van Horebeek, Koen Poesen, Patrick Dupont, Bénédicte Dubois, An Goris
Publié dans: Annals of Neurology, 2020, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.25691

A Systematic Assessment of Prevalence, Incidence and Regional Distribution of Multiple Sclerosis in Bavaria From 2006 to 2015

Auteurs: Tanja Daltrozzo, Alexander Hapfelmeier, Ewan Donnachie, Antonius Schneider, Bernhard Hemmer
Publié dans: Frontiers in Neurology, Numéro 9, 2018, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00871

CSF parameters associated with early MRI activity in patients with MS

Auteurs: Ana Klein, Rebecca C. Selter, Alexander Hapfelmeier, Achim Berthele, Bertram Müller-Myhsok, Viola Pongratz, Christiane Gasperi, Claus Zimmer, Mark Mühlau, Bernhard Hemmer
Publié dans: Neurology - Neuroimmunology Neuroinflammation, Numéro 6/4, 2019, Page(s) e573, ISSN 2332-7812
Éditeur: A. Neurol Neuroimmunol Neuroinflamm.
DOI: 10.1212/nxi.0000000000000573

Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis

Auteurs: Elin Engdahl, Rasmus Gustafsson, Jesse Huang, Martin Biström, Izaura Lima Bomfim, Pernilla Stridh, Mohsen Khademi, Nicole Brenner, Julia Butt, Angelika Michel, Daniel Jons, Maria Hortlund, Lucia Alonso-Magdalena, Anna Karin Hedström, Louis Flamand, Masaru Ihira, Tetsushi Yoshikawa, Oluf Andersen, Jan Hillert, Lars Alfredsson, Tim Waterboer, Peter Sundström, Tomas Olsson, Ingrid Kockum, Anna Fog
Publié dans: Frontiers in Immunology, Numéro 10, 2019, ISSN 1664-3224
Éditeur: Front immunol
DOI: 10.3389/fimmu.2019.02715

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Auteurs: Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A. De Riz, Marina Arcaro, Marianna D'Anca, Anna M. Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo Comi, Roberto Cantello, Elio Scarpini, Daniela Galimberti
Publié dans: Journal of Neuroimmunology, Numéro 324, 2018, Page(s) 129-135, ISSN 0165-5728
Éditeur: Elsevier BV
DOI: 10.1016/j.jneuroim.2018.08.008

The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status

Auteurs: Anna Karin Hedström, Ola Hössjer, Jan Hillert, Pernilla Stridh, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Publié dans: Multiple Sclerosis Journal, 2019, Page(s) 135245851987768, ISSN 1352-4585
Éditeur: SAGE Publications
DOI: 10.1177/1352458519877685

Low sun exposure increases multiple sclerosis risk both directly and indirectly

Auteurs: Anna Karin Hedström, Tomas Olsson, Ingrid Kockum, Jan Hillert, Lars Alfredsson
Publié dans: Journal of Neurology, 2019, ISSN 0340-5354
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-019-09677-3

A large case-control study on vaccination as risk factor for multiple sclerosis

Auteurs: Alexander Hapfelmeier, Christiane Gasperi, Ewan Donnachie, Bernhard Hemmer
Publié dans: Neurology, Numéro 93/9, 2019, Page(s) e908-e916, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000008012

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators

Auteurs: Vasiliki Lagou, Josselyn E. Garcia-Perez, Ide Smets, Lies Van Horebeek, Marijne Vandebergh, Liye Chen, Klara Mallants, Teresa Prezzemolo, Kelly Hilven, Stephanie Humblet-Baron, Matthieu Moisse, Philip Van Damme, Guy Boeckxstaens, Paul Bowness, Bénédicte Dubois, James Dooley, Adrian Liston, An Goris
Publié dans: Cell Reports, Numéro 25/3, 2018, Page(s) 798-810.e6, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.09.048

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Auteurs: Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R. van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-From, Sonia Moreno-Grau, Mich
Publié dans: Acta Neuropathologica, Numéro 138/2, 2019, Page(s) 237-250, ISSN 0001-6322
Éditeur: Springer Verlag
DOI: 10.1007/s00401-019-02026-8

Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients

Auteurs: Sunjay Jude Fernandes, Hiromasa Morikawa, Ewoud Ewing, Sabrina Ruhrmann, Rubin Narayan Joshi, Vincenzo Lagani, Nestoras Karathanasis, Mohsen Khademi, Nuria Planell, Angelika Schmidt, Ioannis Tsamardinos, Tomas Olsson, Fredrik Piehl, Ingrid Kockum, Maja Jagodic, Jesper Tegnér, David Gomez-Cabrero
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-48493-7

Leveraging human genetics to inform intervention strategies for multiple sclerosis

Auteurs: An Goris, Bénédicte Dubois
Publié dans: Neurology, Numéro 92/16, 2019, Page(s) 735-736, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007298

Validation of rapid magnetic resonance myelin imaging in multiple sclerosis

Auteurs: Russell Ouellette, Gabriel Mangeat, Ildiko Polyak, Marcel Warntjes, Yngve Forslin, åsa Bergendal, Michael Plattén, Martin Uppman, Constantina Andrada Treaba, Julien Cohen‐Adad, Fredrik Piehl, Maria Kristoffersen Wiberg, Sten Fredrikson, Caterina Mainero, Tobias Granberg
Publié dans: Annals of Neurology, 2020, ISSN 0364-5134
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ana.25705

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

Auteurs: Janine Arloth, Gökcen Eraslan, Till F. M. Andlauer, Jade Martins, Stella Iurato, Brigitte Kühnel, Melanie Waldenberger, Josef Frank, Ralf Gold, Bernhard Hemmer, Felix Luessi, Sandra Nischwitz, Friedemann Paul, Heinz Wiendl, Christian Gieger, Stefanie Heilmann-Heimbach, Tim Kacprowski, Matthias Laudes, Thomas Meitinger, Annette Peters, Rajesh Rawal, Konstantin Strauch, Susanne Lucae, Bertram Mül
Publié dans: PLOS Computational Biology, Numéro 16/2, 2020, Page(s) e1007616, ISSN 1553-7358
Éditeur: PLoS Comput Biol
DOI: 10.1371/journal.pcbi.1007616

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Auteurs: Mitja Mitrovič, Nikolaos A. Patsopoulos, Ashley H. Beecham, Theresa Dankowski, An Goris, Bénédicte Dubois, Marie B. D’hooghe, Robin Lemmens, Philip Van Damme, Helle Bach Søndergaard, Finn Sellebjerg, Per Soelberg Sorensen, Henrik Ullum, Lise W. Thørner, Thomas Werge, Janna Saarela, Isabelle Cournu-Rebeix, Vincent Damotte, Bertrand Fontaine, Lena Guillot-Noel, Mark Lathrop, Sandra Vukusik, P
Publié dans: Cell, Numéro 175/6, 2018, Page(s) 1679-1687.e7, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2018.09.049

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Auteurs: Patsopoulos, N.A., Baranzini, S.E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A.H., James, T., Replogle, J., Vlachos, I.S., McCabe, C., Pers, T.H., Brandes, A., White, C., Keenan, B., Cimpean, M., Winn, P., Panteliadis, I-P., Robbins, A., Andlauer, T.F M., Zarzycki, O., Dubois, B., Goris, A., Sondergaard, H.B., Sellebjerg, F., Sorensen, P.S., Ullum, H., Thorner, L.W., Saarel
Publié dans: Science, Numéro 365/6460, 2019, Page(s) eaav7188, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aav7188

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk

Auteurs: Katarina Tengvall, Jesse Huang, Cecilia Hellström, Patrick Kammer, Martin Biström, Burcu Ayoglu, Izaura Lima Bomfim, Pernilla Stridh, Julia Butt, Nicole Brenner, Angelika Michel, Karin Lundberg, Leonid Padyukov, Ingrid E. Lundberg, Elisabet Svenungsson, Ingemar Ernberg, Sigurgeir Olafsson, Alexander T. Dilthey, Jan Hillert, Lars Alfredsson, Peter Sundström, Peter Nilsson, Tim Waterboer, Tomas O
Publié dans: Proceedings of the National Academy of Sciences, Numéro 116/34, 2019, Page(s) 16955-16960, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1902623116

Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or naïve notion?

Auteurs: Viola Pongratz, Paul Schmidt, Matthias Bussas, Sophia Grahl, Christian Gaser, Achim Berthele, Muna‐Miriam Hoshi, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Publié dans: Brain and Behavior, Numéro 9/12, 2019, ISSN 2162-3279
Éditeur: Brain Behav
DOI: 10.1002/brb3.1417

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

Auteurs: Ali Manouchehrinia, Fredrik Piehl, Jan Hillert, Jens Kuhle, Lars Alfredsson, Tomas Olsson, Ingrid Kockum
Publié dans: Annals of Clinical and Translational Neurology, Numéro 7/1, 2019, Page(s) 139-143, ISSN 2328-9503
Éditeur: Ann Clin Transl Neurol.
DOI: 10.1002/acn3.50972

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

Auteurs: Lies Van Horebeek, Kelly Hilven, Klara Mallants, Annemarie Van Nieuwenhuijze, Tiina Kelkka, Paula Savola, Satu Mustjoki, Susan M Schlenner, Adrian Liston, Bénédicte Dubois, An Goris
Publié dans: Human Molecular Genetics, Numéro 28/8, 2018, Page(s) 1369-1380, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddy425

Somatic Variants: New Kids on the Block in Human Immunogenetics

Auteurs: L. Van Horebeek, B. Dubois, A. Goris
Publié dans: Trends in Genetics, Numéro 35/12, 2019, Page(s) 935-947, ISSN 0168-9525
Éditeur: Elsevier BV
DOI: 10.1016/j.tig.2019.09.005

Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases

Auteurs: Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger, Martijn Van Griensven, Verena Grummel, Markus Krumbholz, Achim Berthele, Bernhard Hemmer, Markus C. Kowarik
Publié dans: Journal of Neuroinflammation, Numéro 16/1, 2019, ISSN 1742-2094
Éditeur: BioMed Central
DOI: 10.1186/s12974-019-1601-6

Blood neurofilament light levels segregate treatment effects in multiple sclerosis

Auteurs: Bénédicte Delcoigne, Ali Manouchehrinia, Christian Barro, Pascal Benkert, Zuzanna Michalak, Ludwig Kappos, David Leppert, Jon A. Tsai, Tatiana Plavina, Bernd C. Kieseier, Jan Lycke, Lars Alfredsson, Ingrid Kockum, Jens Kuhle, Tomas Olsson, Fredrik Piehl
Publié dans: Neurology, 2020, Page(s) 10.1212/WNL.0000000000009097, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009097

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Auteurs: Madireddy, L., Patsopoulos, N.A., Cotsapas, C., Bos, S.D., Beecham, A., McCauley, J., Kim, K., Jia, X., Santaniello, A., Caillier, S.J., Andlauer, T.F M., Barcellos, L.F., Berge, T., Bernardinelli, L., Martinelli-Boneschi, F., Booth, D.R., Briggs, F., Celius, E.G., Comabella, M., Comi, G., Cree, B.A C., D'Alfonso, S., Dedham, K., Duquette, P., Efthimios, D., Esposito, F., Fontaine, B., Gasperi, C.
Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-09773-y

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Auteurs: Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-17871-5

C-type lectin receptors Mcl and Mincle control development of multiple sclerosis–like neuroinflammation

Auteurs: Marie N’diaye, Susanna Brauner, Sevasti Flytzani, Lara Kular, Andreas Warnecke, Milena Z. Adzemovic, Eliane Piket, Jin-Hong Min, Will Edwards, Filia Mela, Hoi Ying Choi, Vera Magg, Tojo James, Magdalena Linden, Holger M. Reichardt, Michael R. Daws, Jack van Horssen, Ingrid Kockum, Robert A. Harris, Tomas Olsson, Andre O. Guerreiro-Cacais, Maja Jagodic
Publié dans: Journal of Clinical Investigation, Numéro 130/2, 2019, Page(s) 838-852, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci125857

Trends in the environmental risk assessment for the early onset of multiple sclerosis

Auteurs: Huang J, Kockum I, Stridh P
Publié dans: Mult Scler Relat Disord., 2021, ISSN 2211-0356
Éditeur: Elsevier
DOI: 10.1016/j.msard.2022.104250

Locus for severity implicates CNS resilience in progression of multiple sclerosis

Auteurs: International Multiple Sclerosis Genetics Consortium, MultipleMS Consortium, , Adil Harroud, Pernilla Stridh, Jacob L. McCauley, Janna Saarela, Ingileif Jónsdóttir, Aletta M. R. van den Bosch, Hendrik J. Engelenburg, Ashley H. Beecham, Lars Alfredsson, Katayoun Alikhani, Lilyana Amezcua, Till F. M. Andlauer, Maria Ban, Lisa F. Barcellos, Nadia Barizzone, Tone Berge, Achim Berthele, Stefan Bittne
Publié dans: Nature, Numéro 619, 2023, Page(s) 323–331, ISSN 1476-4687
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-023-06250-x

Association between exposure to combustion-related air pollution and multiple sclerosis risk

Auteurs: Hedström AK, Segersson D, Hillert J, Stridh P, Kockum I, Olsson T, Bellander T, Alfredsson L.
Publié dans: Int J Epidemiol, 2023, ISSN 1464-3685
Éditeur: Oxford University Press
DOI: 10.1212/nxi.0000000000200056

A topological data analysis based classification method for multiple measurements.

Auteurs: Henri Riihimäki, Wojciech Chachólski, Jakob Theorell, Jan Hillert, Ryan Ramanujam
Publié dans: BMC Bioinformatics, 2020, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-020-03659-3

Pregnancy does not modify the risk of MS in genetically susceptible women

Auteurs: Cameron J. Adams, Sean L. Wu, Xiaorong Shao, Patrick T. Bradshaw, Edlin Gonzales, Jessica B. Smith, Anny H. Xiang, Kalliope H. Bellesis, Terrence Chinn, Steffan D. Bos, Marte Wendel-Haga, Tomas Olsson, Ingrid Kockum, Annette M. Langer-Gould, Catherine Schaefer, Lars Alfredsson, Lisa F. Barcellos
Publié dans: Neurology - Neuroimmunology Neuroinflammation, Numéro 7/6, 2020, Page(s) e898, ISSN 2332-7812
Éditeur: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DOI: 10.1212/nxi.0000000000000898

A Scoping Review on Body Fluid Biomarkers for Prognosis and Disease Activity in Patients with Multiple Sclerosis.

Auteurs: Barizzone N, Leone M, Pizzino A, Kockum I; MultipleMS Consortium; Martinelli-Boneschi F, D'Alfonso S.
Publié dans: J Pers Med., 2022, ISSN 2075-4426
Éditeur: MDPI
DOI: 10.3390/jpm12091430

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking

Auteurs: Mikael V Ringh, Michael Hagemann-Jensen, Maria Needhamsen, Susanna Kullberg, Jan Wahlström, Johan Grunewald, Boel Brynedal, Maja Jagodic, Tomas J Ekström, Johan Öckinger, Lara Kular
Publié dans: Multiple Sclerosis Journal, 2020, Page(s) 135245852094376, ISSN 1352-4585
Éditeur: SAGE Publications
DOI: 10.1177/1352458520943768

Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability

Auteurs: Anne Kerbrat, Charley Gros, Atef Badji, Elise Bannier, Francesca Galassi, Benoit Combès, Raphaël Chouteau, Pierre Labauge, Xavier Ayrignac, Clarisse Carra-Dalliere, Josefina Maranzano, Tobias Granberg, Russell Ouellette, Leszek Stawiarz, Jan Hillert, Jason Talbott, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya, Lydia Chougar, Jennifer Lefeuvre, Daniel S Reich, Govind Nair, Paola Valsasina, Mar
Publié dans: Brain, Numéro 143/7, 2020, Page(s) 2089-2105, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/brain/awaa162

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.

Auteurs: Patsopoulos, Nikolas A; Baranzini, Sergio E; Santaniello, Adams; Shoostari, Parisa; Cotsapas, Chris; Wong, Garrett; Beecham, Ashley H; James, Tojo; Replogle, Joseph; Vlachos, Ioannis S; McCabe, Cristin; Pers, Tune H; Brandes, Aaron; White, Charles; Keenan, Brendan; Cimpean, Maria; Winn, Phoebe; Panteliadis, Ioannis-Pavlos; Robbins, Allison; Andlauer, Till FM; Zarzycki, Onigiusz; Dubois, Benedicte;
Publié dans: Science, Numéro 2019 Sep 27;365(6460):eaav7188., 2019, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aav7188

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis

Auteurs: Tobias Granberg, Thomas Moridi, Judith S. Brand, Susanne Neumann, Martin Hlavica, Fredrik Piehl, Benjamin V. Ineichen
Publié dans: Journal of Neurology, Numéro 267/11, 2020, Page(s) 3199-3212, ISSN 0340-5354
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09971-5

Ensembl 2021

Auteurs: Kevin L Howe, Premanand Achuthan, James Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Andrey G Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla Cummins, Luca Da Rin Fioretto, Claire Davidson, Kamalkumar Dodiya, Bilal El Houdaigui, Reham Fatima, Astrid Gall, Carlos Garcia Giron, Tiago Grego, Cristina Guijarro-Clarke, Lea
Publié dans: Nucleic Acids Research, Numéro 49/D1, 2020, Page(s) D884-D891, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkaa942

Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis

Auteurs: Gabriel Mangeat, Russell Ouellette, Maxime Wabartha, Benjamin De Leener, Michael Plattén, Virginija Danylaité Karrenbauer, Marcel Warntjes, Nikola Stikov, Caterina Mainero, Julien Cohen‐Adad, Tobias Granberg
Publié dans: Journal of Neuroimaging, Numéro 30/5, 2020, Page(s) 674-682, ISSN 1051-2284
Éditeur: Sage Science Press
DOI: 10.1111/jon.12725

Decomposing filtered chain complexes: Geometry behind barcoding algorithms

Auteurs: Wojciech Chachólski, Barbara Giunti, Alvin Jin, Claudia Landi
Publié dans: Computational Geometry, 2023, ISSN 0925-7721
Éditeur: Elsevier BV
DOI: 10.1016/j.comgeo.2022.101938

Supervised Learning Using Homology Stable Rank Kernels

Auteurs: Jens Agerberg, Ryan Ramanujam, Martina Scolamiero, Wojciech Chachólski
Publié dans: Front. Appl. Math. Stat. Sec. Mathematics of Computation and Data Science, 2021, ISSN 2297-4687
Éditeur: Frontiers Media SA
DOI: 10.3389/fams.2021.668046

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