Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Risultati finali

R-packages for patient specific stratification

R-packages for patient specific stratificationMotivation for change:There has been delay in the development of R tools to be used for patient specific stratification as their application and hence development to data in retrospective cohort data has been delayed.

Software for stratification and clinical decision support system

Software for stratification and clinical decision support system. combination of previous D6.3 and D6.4.Motivation for change:After evaluating the market needs and existing software, we plan to combine software for stratification with that for clinical stratification into one product and hence would like to combine D6.3 and 6.4. Depending on intended users, we will make some features unavailable. The software is developed, and the core is ready. However, it is missing a few critical services to be genuinely market-ready which we estimate would require additional time.

Data availability and knowledge discovery tool to monitor for the availability of the different data types

Validation and formulation of candidate MS guidelines to be implemented into clinical practice

Validation and formulation of candidate MS guidelines to be implemented into clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Report on novel biomarkers and suggestions for their application in clinical practice

Report on novel biomarkers and suggestions for their application in clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Development of guidelines for reporting biomarker results and their classification into different levels of evidence

Project website

Pubblicazioni

7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis

Autori: Russell Ouellette, Constantina A Treaba, Tobias Granberg, Elena Herranz, Valeria Barletta, Ambica Mehndiratta, Benjamin De Leener, Shahamat Tauhid, Fawad Yousuf, Sarah M Dupont, Eric C Klawiter, Jacob A Sloane, Rohit Bakshi, Julien Cohen-Adad, Caterina Mainero
Pubblicato in: Brain, Numero 143/10, 2020, Pagina/e 2973-2987, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaa249

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression

Autori: Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
Pubblicato in: Epigenetics, Numero 15/6-7, 2020, Pagina/e 646-663, ISSN 1559-2294
Editore: Landes Bioscience
DOI: 10.1080/15592294.2019.1700628

MRI‐Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis

Autori: Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, Fredrik Piehl, Tobias Granberg
Pubblicato in: Journal of Neuroimaging, Numero 30/2, 2020, Pagina/e 198-204, ISSN 1051-2284
Editore: Sage Science Press
DOI: 10.1111/jon.12676

Association between brain volume and disability over time in multiple sclerosis

Autori: Moridi T, Stawiarz L, McKay KA, Ineichen BV, Ouellette R, Ferreira D, Muehlboeck JS, Westman E, Kockum I, Olsson T, Piehl F, Hillert J, Manouchehrinia A, Granberg T.
Pubblicato in: Mult Scler J Exp Transl Clin, 2022, ISSN 2055-2173
Editore: Sage Publications
DOI: 10.1177/20552173221144230

LIBRA: an adaptative integrative tool for paired single-cell multi-omics data

Autori: Xabier Martinez-de-Morentin , Sumeer A. Khan , Robert Lehmann , Sisi Qu , Alberto Maillo , Narsis A. Kiani , Felipe Prosper , Jesper Tegner , David Gomez-Cabrero
Pubblicato in: Quant. Biol, 2023, ISSN 2095-4697
Editore: Higher Education Press
DOI: 10.15302/j-qb-022-0318

Seasonal variability of serum 25-hydroxyvitamin D on multiple sclerosis onset.

Autori: Stridh P, Kockum I, Huang J
Pubblicato in: Sci Rep, Numero 2021 Oct 25;11(1):20989, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-00344-0

Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.

Autori: Vandebergh, Marijne; Degryse, Nicolas; Dubois, Benedicte; Goris, An
Pubblicato in: JOURNAL OF NEUROLOGY, Numero J Neurol . 2022 Aug;269(8):4565-4574, 2022, ISSN 0340-5354
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-022-11072-4

Smoking and Epstein–Barr virus infection in multiple sclerosis development

Autori: Anna Karin Hedström, Jesse Huang, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-67883-w

Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients

Autori: Held F, Kalluri SR, Berthele A, Klein AK, Reindl M, Hemmer B
Pubblicato in: MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Numero Mult Scler J Exp Transl Clin . 2021 Jun 25;7(2):20552173211022767, 2021, ISSN 2055-2173
Editore: SAGE PUBLICATIONS INC
DOI: 10.1177/20552173211022767

Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study.

Autori: Vandebergh, Marijne; Becelaere, Sara; Dubois, Benedicte; Goris, An; CHARGE, Inflammation Working Grp
Pubblicato in: Frontiers In Immunology, Numero 2022 Mar 21;13:834644, 2022, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.834644

Inflammation-related plasma and CSF biomarkers for multiple sclerosis

Autori: Jesse Huang, Mohsen Khademi, Lars Fugger, Örjan Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, Fredrik Piehl, Tomas Olsson, Ingrid Kockum
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/23, 2020, Pagina/e 12952-12960, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1912839117

Finding cell-specific expression patterns in the early Ciona embryo with single-cell RNA-seq

Autori: Garth R. Ilsley, Ritsuko Suyama, Takeshi Noda, Nori Satoh, Nicholas M. Luscombe
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-61591-1

Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Autori: Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Pubblicato in: Ann Clin Transl Neurol, 2023, ISSN 2328-9503
Editore: Wiley

Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

Autori: Sonja Hochmeister, Shahin Aeinehband, Charles Dorris, Rasmus Berglund, Michaela T. Haindl, Vid Velikic, Sven A. Gustafsson, Tomas Olsson, Fredrik Piehl, Maja Jagodic, Manuel Zeitelhofer, Milena Z. Adzemovic
Pubblicato in: Frontiers in Neurology, Numero 11, 2020, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.600401

A pharmacogenetic study implicates NINJ2 in the response to Interferon-β in multiple sclerosis

Autori: Silvia Peroni, Melissa Sorosina, Sunny Malhotra, Ferdinando Clarelli, Ana Maria Osiceanu, Laura Ferrè, Tina Roostaei, Jordi Rio, Luciana Midaglia, Luisa María Villar, José Carlos Álvarez-Cermeño, Clara Guaschino, Marta Radaelli, Lorena Citterio, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Vittorio Martinelli, Xavier Montalban, Howard L Weiner, Philip de Jager, Giancarlo Comi, Feder
Pubblicato in: Multiple Sclerosis Journal, Numero 26/9, 2020, Pagina/e 1074-1082, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/1352458519851428

A genetic risk variant for multiple sclerosis severity is associated with brain atrophy

Autori: Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, Cuici; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid;
Pubblicato in: Ann Neurol, 2023, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.26807

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis

Autori: Thomas O G, Bronge M, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Ortlieb Guerreiro-Cacais A, Grönlund H, Olsson T, Kockum I
Pubblicato in: Sci Adv., 2023, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.adg3032

Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort

Autori: Stefanos Klironomos, Antonios Tzortzakakis, Annika Kits, Claes Öhberg, Evangelia Kollia, Amir Ahoromazdae, Håkan Almqvist, Åsa Aspelin, Heather Martin, Russell Ouellette, Jonathan Al-Saadi, Mikael Hasselberg, Mansour Haghgou, Mitra Pedersen, Sven Petersson, Johannes Finnsson, Johan Lundberg, Anna Falk Delgado, Tobias Granberg
Pubblicato in: Radiology, Numero 297/3, 2020, Pagina/e E324-E334, ISSN 0033-8419
Editore: Radiological Society of North America
DOI: 10.1148/radiol.2020202791

Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

Autori: Lies Van Horebeek, An Goris
Pubblicato in: European Journal of Human Genetics, Numero 28/7, 2020, Pagina/e 849-850, ISSN 1018-4813
Editore: Natue Publishing Group
DOI: 10.1038/s41431-020-0615-y

Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis.

Autori: Vandebergh, Marijne; Andlauer, Till FM; Zhou, Yuan; Mallants, Klara; Held, Friederike; Aly, Lilian; Taylor, Bruce V; Hemmer, Bernhard; Dubois, Benedicte; Goris, An
Pubblicato in: Annals Of Neurology, Numero 2021 May;89(5):884-894., 2021, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.26061

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

Autori: Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive P H, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg Z, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle Jfor the RDB in the Swiss Multiple Sclerosis Cohort Study Grou
Pubblicato in: Lancet Neurology, Numero 2022 Mar;21(3):246-257., 2022, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(22)00009-6

Smoking and multiple sclerosis risk: a Mendelian randomization study

Autori: Marijne Vandebergh, An Goris
Pubblicato in: Journal of Neurology, Numero 267/10, 2020, Pagina/e 3083-3091, ISSN 0340-5354
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09980-4

Assessing the preanalytical variability of plasma and cerebrospinal fluid processing and its effects on inflammation-related protein biomarkers.

Autori: Huang J, Khademi M, Lindhe Ö, Jönsson G, Piehl F, Olsson T, Kockum I
Pubblicato in: Mol Cell Proteomics., 2021, ISSN 1535-9484
Editore: ELSEVIER

Season of birth is associated with multiple sclerosis and disease severity

Autori: Stridh P, Huang J, Hedström AK, Alfredsson L, Olsson T, Hillert J, Manouchehrinia A, Kockum I
Pubblicato in: MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Numero 2021 Dec 22;7(4):20552173211065730., 2021, ISSN 2055-2173
Editore: SAGE PUBLICATIONS I
DOI: 10.1177/20552173211065730

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology

Autori: Zheleznyakova GY, Piket E, Needhamsen M, Hagemann-Jensen M, Ekman D, Han Y, James T, Khademi M, Al Nimer F, Scicluna P, Huang J, Kockum I, Faridani OR, Olsson T, Piehl F, Jagodic M
Pubblicato in: Proc Natl Acad Sci U S A. 2021 Apr 27;118(17), 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2011574118

Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.

Autori: Lauerer M, McGinnis J, Bussas M, El Husseini M, Pongratz V, Engl C, Wuschek A, Berthele A, Riederer I, Kirschke JS, Zimmer C, Hemmer B, Mühlau M.
Pubblicato in: J Neurol Neurosurg Psychiatry, 2023, ISSN 1468-330X
Editore: BMJ

Human immune diversity: from evolution to modernity.

Autori: Liston, Adrian; Humblet-Baron, Stephanie; Duffy, Darragh; Goris, An
Pubblicato in: Nature Immunology, Numero 22, pages1479–1489 (2021), 2021, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-021-01058-1

Genetic determinants of the humoral immune response in MS

Autori: Christiane Gasperi, Till F.M. Andlauer, Ana Keating, Benjamin Knier, Ana Klein, Verena Pernpeintner, Peter Lichtner, Ralf Gold, Frauke Zipp, Florian Then Bergh, Martin Stangel, Hayrettin Tumani, Brigitte Wildemann, Heinz Wiendl, Antonios Bayas, Tania Kümpfel, Uwe K. Zettl, Ralf A. Linker, Ulf Ziemann, Matthias Knop, Clemens Warnke, Manuel A. Friese, Friedemann Paul, Björn Tackenberg, Achim Berth
Pubblicato in: Neurology - Neuroimmunology Neuroinflammation, Numero 7/5, 2020, Pagina/e e827, ISSN 2332-7812
Editore: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DOI: 10.1212/nxi.0000000000000827

Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis.

Autori: Starvaggi Cucuzza C, Longinetti E, Ruffin N, Evertsson B, Kockum I, Jagodic M, Al Nimer F, Frisell T, Piehl F.
Pubblicato in: Neurol Neuroimmunol Neuroinflamm., 2022, ISSN 2332-7812
Editore: Wolters Kluwer Health/Lippincott Williams & Wilkins

Overview of genotyping technologies and methods

Autori: Kockum I, Huang J, Stridh P
Pubblicato in: Curr Protoc, 2023, ISSN 2691-1299
Editore: Wiley
DOI: 10.1002/cpz1.727

Natural Killer Cells in Multiple Sclerosis: Entering the Stage

Autori: Beliën, Jarne; Goris, An; Matthys, Patrick
Pubblicato in: FRONTIERS IN IMMUNOLOGY, 2022, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.869447

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Autori: Ide Smets, An Goris, Marijne Vandebergh, Jelle Demeestere, Stefan Sunaert, Patrick Dupont, Bénédicte Dubois
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-81035-8

Impact of multiple sclerosis risk loci in postinfectious neurological syndromes

Autori: Filippo Martinelli-Boneschi, Riccardo Currò, Silvia Santoro, Giulia Berzero, Melissa Sorosina, Laura Ferrè, Elisabetta Mascia, Silvia Peroni, Giancarlo Comi, Angelo Gugliemi, Elisa Vegezzi, Ilaria Callegari, Massimo Filippi, Andrea Cortese, Federica Esposito, Ferdinando Clarelli, Enrico Marchioni
Pubblicato in: Multiple Sclerosis and Related Disorders, Numero 44, 2020, Pagina/e 102326, ISSN 2211-0348
Editore: Elsevier
DOI: 10.1016/j.msard.2020.102326

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

Autori: Giulio Ruffini ,Giada Damiani,Diego Lozano-Soldevilla,Nikolas Deco,Fernando E. Rosas,Narsis A. Kiani,Adrián Ponce-Alvarez,Morten L. Kringelbach,Robin Carhart-Harris,Gustavo Deco
Pubblicato in: PLoS Comput Biol, 2023, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1010811

Epstein–Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis

Autori: M. Biström, D. Jons, E. Engdahl, R. Gustafsson, J. Huang, N. Brenner, J. Butt, L. Alonso‐Magdalena, M. Gunnarsson, M. Vrethem, N. Bender, T. Waterboer, G. Granåsen, T. Olsson, I. Kockum, O. Andersen, A. Fogdell‐Hahn, Peter Sundström
Pubblicato in: European Journal of Neurology, Numero 28/2, 2021, Pagina/e 579-586, ISSN 1351-5101
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ene.14597

The Aryl Hydrocarbon Receptor-Dependent TGF-alpha/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis

Autori: Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V
Pubblicato in: Neurol Neuroimmunol Neuroinflamm, 2022, ISSN 2332-7812
Editore: LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/nxi.0000000000001043

Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis - a presymptomatic case-control study.

Autori: Grut V, Biström M, Salzer J, Stridh P, Jons D, Gustafsson R, Fogdell-Hahn A, Huang J, Brenner N, Butt J, Bender N, Lindam A, Alonso-Magdalena L, Gunnarsson M, Vrethem M, Bergström T, Andersen O, Kockum I, Waterboer T, Olsson T, Sundström P
Pubblicato in: Eur J Neurol., 2021, ISSN 1351-5101
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ene.14961

Epigenetic insights into multiple sclerosis disease progression

Autori: L. Kular, M. Jagodic
Pubblicato in: Journal of Internal Medicine, Numero 288/1, 2020, Pagina/e 82-102, ISSN 0954-6820
Editore: Blackwell Publishing Inc.
DOI: 10.1111/joim.13045

Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients. . 2021 Oct;13(20):1607-1618. doi: /

Autori: Fernandes SJ, Ericsson M, Khademi M, Jagodic M, Olsson T, Gomez-Cabrero D, Kockum I, Tegnér J.
Pubblicato in: Epigenomics, 2021, ISSN 1750-1911
Editore: Future Medicine Ltd.
DOI: 10.2217/epi-2021-0205

Systematic Assessment of Medical Diagnoses Preceding the First Diagnosis of Multiple Sclerosis

Autori: Gasperi C, Hapfelmeier A, Daltrozzo T, Schneider A, Donnachie E, Hemmer B.
Pubblicato in: NEUROLOGY, Numero 2021 Apr 26;10.1212/WNL.0000000000012074., 2021, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000012074

Lesion location across diagnostic regions in multiple sclerosis

Autori: Viola Pongratz, Matthias Bussas, Paul Schmidt, Sophia Grahl, Christiane Gasperi, Malek El Husseini, Laura Harabacz, Viktor Pineker, Dominik Sepp, Lioba Grundl, Benedikt Wiestler, Jan Kirschke, Claus Zimmer, Achim Berthele, Bernhard Hemmer, Mark Mühlau
Pubblicato in: Neuroimage Clin., 2023, ISSN 2213-1582
Editore: Elsevier BV

Neurological manifestations of coronavirus infections – a systematic review

Autori: Jesper Almqvist, Tobias Granberg, Antonios Tzortzakakis, Stefanos Klironomos, Evangelia Kollia, Claes Öhberg, Roland Martin, Fredrik Piehl, Russell Ouellette, Benjamin V. Ineichen
Pubblicato in: Annals of Clinical and Translational Neurology, Numero 7/10, 2020, Pagina/e 2057-2071, ISSN 2328-9503
Editore: Wiley Periodicals LLC on behalf of American Neurological Association.
DOI: 10.1002/acn3.51166

GeneSetCluster: a tool for summarizing and integrating gene-set analysis results

Autori: Ewoud Ewing, Nuria Planell-Picola, Maja Jagodic, David Gomez-Cabrero
Pubblicato in: BMC Bioinformatics, Numero 21/1, 2020, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-020-03784-z

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Autori: Lara Kular, Yun Liu, Sabrina Ruhrmann, Galina Zheleznyakova, Francesco Marabita, David Gomez-Cabrero, Tojo James, Ewoud Ewing, Magdalena Lindén, Bartosz Górnikiewicz, Shahin Aeinehband, Pernilla Stridh, Jenny Link, Till F. M. Andlauer, Christiane Gasperi, Heinz Wiendl, Frauke Zipp, Ralf Gold, Björn Tackenberg, Frank Weber, Bernhard Hemmer, Konstantin Strauch, Stefanie Heilmann-Heimbach, Rajesh
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04732-5

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity

Autori: Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck, Dirk S. Paul
Pubblicato in: BioEssays, Numero 40/2, 2018, Pagina/e 1700148, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.1002/bies.201700148

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients

Autori: Tojo James, Magdalena Lindén, Hiromasa Morikawa, Sunjay Jude Fernandes, Sabrina Ruhrmann, Mikael Huss, Maya Brandi, Fredrik Piehl, Maja Jagodic, Jesper Tegnér, Mohsen Khademi, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum
Pubblicato in: Human Molecular Genetics, Numero 27/5, 2018, Pagina/e 912-928, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddy001

Epigenetic variation taking center stage in immunological research

Autori: Simone Ecker, Stephan Beck
Pubblicato in: Epigenomics, Numero 9/4, 2017, Pagina/e 375-378, ISSN 1750-1911
Editore: Future Medicine Ltd.
DOI: 10.2217/epi-2017-0006

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

Autori: Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson
Pubblicato in: Multiple Sclerosis Journal, Numero 24/8, 2018, Pagina/e 1046-1054, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/1352458517715132

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

Autori: Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Th
Pubblicato in: npj Genomic Medicine, Numero 2/1, 2017, ISSN 2056-7944
Editore: NPJ Genom Med
DOI: 10.1038/s41525-017-0027-2

Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis

Autori: Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Pubblicato in: Multiple Sclerosis Journal - Experimental, Translational and Clinical, Numero 4/2, 2018, Pagina/e 205521731876719, ISSN 2055-2173
Editore: Mult Scler J Exp Transl Clin.
DOI: 10.1177/2055217318767192

Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells

Autori: Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
Pubblicato in: Brain, Numero 141/3, 2018, Pagina/e 786-796, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awx372

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Autori: Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Pubblicato in: Genome Medicine, Numero 10/1, 2018, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-018-0575-9

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship

Autori: Francesco Marabita, Malin Almgren, Louise K. Sjöholm, Lara Kular, Yun Liu, Tojo James, Nimrod B. Kiss, Andrew P. Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J. Ekström, Maja Jagodic
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-14788-w

Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

Autori: Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M Absher, Donna K Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic
Pubblicato in: Multiple Sclerosis Journal, Numero 24/10, 2018, Pagina/e 1288-1300, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/1352458517721356

Ensembl 2018

Autori: Daniel R Zerbino, Premanand Achuthan, Wasiu Akanni, M Ridwan Amode, Daniel Barrell, Jyothish Bhai, Konstantinos Billis, Carla Cummins, Astrid Gall, Carlos García Girón, Laurent Gil, Leo Gordon, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Jimmy Kiang To, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, Thomas Maurel, Willia
Pubblicato in: Nucleic Acids Research, Numero 46/D1, 2017, Pagina/e D754-D761, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkx1098

Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis

Autori: Christiane Gasperi, Anke Salmen, Gisela Antony, Antonios Bayas, Christoph Heesen, Tania Kümpfel, Ralf A. Linker, Friedemann Paul, Martin Stangel, Björn Tackenberg, Florian Then Bergh, Clemens Warnke, Frank Weber, Heinz Wiendl, Brigitte Wildemann, Uwe K. Zettl, Ulf Ziemann, Frauke Zipp, Hayrettin Tumani, Ralf Gold, Bernhard Hemmer
Pubblicato in: JAMA Neurology, Numero 76/7, 2019, Pagina/e 841, ISSN 2168-6149
Editore: American Medical Association
DOI: 10.1001/jamaneurol.2019.0905

Towards a European health research and innovation cloud (HRIC)

Autori: F. M. Aarestrup, A. Albeyatti, W. J. Armitage, C. Auffray, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie, M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. L
Pubblicato in: Genome Medicine, Numero 12/1, 2020, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-020-0713-z

CHIT1 at Diagnosis Reflects Long‐Term Multiple Sclerosis Disease Activity

Autori: Emanuela Oldoni, Ide Smets, Klara Mallants, Marijne Vandebergh, Lies Van Horebeek, Koen Poesen, Patrick Dupont, Bénédicte Dubois, An Goris
Pubblicato in: Annals of Neurology, 2020, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25691

A Systematic Assessment of Prevalence, Incidence and Regional Distribution of Multiple Sclerosis in Bavaria From 2006 to 2015

Autori: Tanja Daltrozzo, Alexander Hapfelmeier, Ewan Donnachie, Antonius Schneider, Bernhard Hemmer
Pubblicato in: Frontiers in Neurology, Numero 9, 2018, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00871

CSF parameters associated with early MRI activity in patients with MS

Autori: Ana Klein, Rebecca C. Selter, Alexander Hapfelmeier, Achim Berthele, Bertram Müller-Myhsok, Viola Pongratz, Christiane Gasperi, Claus Zimmer, Mark Mühlau, Bernhard Hemmer
Pubblicato in: Neurology - Neuroimmunology Neuroinflammation, Numero 6/4, 2019, Pagina/e e573, ISSN 2332-7812
Editore: A. Neurol Neuroimmunol Neuroinflamm.
DOI: 10.1212/nxi.0000000000000573

Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis

Autori: Elin Engdahl, Rasmus Gustafsson, Jesse Huang, Martin Biström, Izaura Lima Bomfim, Pernilla Stridh, Mohsen Khademi, Nicole Brenner, Julia Butt, Angelika Michel, Daniel Jons, Maria Hortlund, Lucia Alonso-Magdalena, Anna Karin Hedström, Louis Flamand, Masaru Ihira, Tetsushi Yoshikawa, Oluf Andersen, Jan Hillert, Lars Alfredsson, Tim Waterboer, Peter Sundström, Tomas Olsson, Ingrid Kockum, Anna Fog
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Front immunol
DOI: 10.3389/fimmu.2019.02715

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Autori: Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A. De Riz, Marina Arcaro, Marianna D'Anca, Anna M. Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo Comi, Roberto Cantello, Elio Scarpini, Daniela Galimberti
Pubblicato in: Journal of Neuroimmunology, Numero 324, 2018, Pagina/e 129-135, ISSN 0165-5728
Editore: Elsevier BV
DOI: 10.1016/j.jneuroim.2018.08.008

The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status

Autori: Anna Karin Hedström, Ola Hössjer, Jan Hillert, Pernilla Stridh, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Pubblicato in: Multiple Sclerosis Journal, 2019, Pagina/e 135245851987768, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/1352458519877685

Low sun exposure increases multiple sclerosis risk both directly and indirectly

Autori: Anna Karin Hedström, Tomas Olsson, Ingrid Kockum, Jan Hillert, Lars Alfredsson
Pubblicato in: Journal of Neurology, 2019, ISSN 0340-5354
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-019-09677-3

A large case-control study on vaccination as risk factor for multiple sclerosis

Autori: Alexander Hapfelmeier, Christiane Gasperi, Ewan Donnachie, Bernhard Hemmer
Pubblicato in: Neurology, Numero 93/9, 2019, Pagina/e e908-e916, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000008012

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators

Autori: Vasiliki Lagou, Josselyn E. Garcia-Perez, Ide Smets, Lies Van Horebeek, Marijne Vandebergh, Liye Chen, Klara Mallants, Teresa Prezzemolo, Kelly Hilven, Stephanie Humblet-Baron, Matthieu Moisse, Philip Van Damme, Guy Boeckxstaens, Paul Bowness, Bénédicte Dubois, James Dooley, Adrian Liston, An Goris
Pubblicato in: Cell Reports, Numero 25/3, 2018, Pagina/e 798-810.e6, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.09.048

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Autori: Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R. van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-From, Sonia Moreno-Grau, Mich
Pubblicato in: Acta Neuropathologica, Numero 138/2, 2019, Pagina/e 237-250, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-019-02026-8

Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients

Autori: Sunjay Jude Fernandes, Hiromasa Morikawa, Ewoud Ewing, Sabrina Ruhrmann, Rubin Narayan Joshi, Vincenzo Lagani, Nestoras Karathanasis, Mohsen Khademi, Nuria Planell, Angelika Schmidt, Ioannis Tsamardinos, Tomas Olsson, Fredrik Piehl, Ingrid Kockum, Maja Jagodic, Jesper Tegnér, David Gomez-Cabrero
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-48493-7

Leveraging human genetics to inform intervention strategies for multiple sclerosis

Autori: An Goris, Bénédicte Dubois
Pubblicato in: Neurology, Numero 92/16, 2019, Pagina/e 735-736, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000007298

Validation of rapid magnetic resonance myelin imaging in multiple sclerosis

Autori: Russell Ouellette, Gabriel Mangeat, Ildiko Polyak, Marcel Warntjes, Yngve Forslin, åsa Bergendal, Michael Plattén, Martin Uppman, Constantina Andrada Treaba, Julien Cohen‐Adad, Fredrik Piehl, Maria Kristoffersen Wiberg, Sten Fredrikson, Caterina Mainero, Tobias Granberg
Pubblicato in: Annals of Neurology, 2020, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.25705

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

Autori: Janine Arloth, Gökcen Eraslan, Till F. M. Andlauer, Jade Martins, Stella Iurato, Brigitte Kühnel, Melanie Waldenberger, Josef Frank, Ralf Gold, Bernhard Hemmer, Felix Luessi, Sandra Nischwitz, Friedemann Paul, Heinz Wiendl, Christian Gieger, Stefanie Heilmann-Heimbach, Tim Kacprowski, Matthias Laudes, Thomas Meitinger, Annette Peters, Rajesh Rawal, Konstantin Strauch, Susanne Lucae, Bertram Mül
Pubblicato in: PLOS Computational Biology, Numero 16/2, 2020, Pagina/e e1007616, ISSN 1553-7358
Editore: PLoS Comput Biol
DOI: 10.1371/journal.pcbi.1007616

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Autori: Mitja Mitrovič, Nikolaos A. Patsopoulos, Ashley H. Beecham, Theresa Dankowski, An Goris, Bénédicte Dubois, Marie B. D’hooghe, Robin Lemmens, Philip Van Damme, Helle Bach Søndergaard, Finn Sellebjerg, Per Soelberg Sorensen, Henrik Ullum, Lise W. Thørner, Thomas Werge, Janna Saarela, Isabelle Cournu-Rebeix, Vincent Damotte, Bertrand Fontaine, Lena Guillot-Noel, Mark Lathrop, Sandra Vukusik, P
Pubblicato in: Cell, Numero 175/6, 2018, Pagina/e 1679-1687.e7, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2018.09.049

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Autori: Patsopoulos, N.A., Baranzini, S.E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A.H., James, T., Replogle, J., Vlachos, I.S., McCabe, C., Pers, T.H., Brandes, A., White, C., Keenan, B., Cimpean, M., Winn, P., Panteliadis, I-P., Robbins, A., Andlauer, T.F M., Zarzycki, O., Dubois, B., Goris, A., Sondergaard, H.B., Sellebjerg, F., Sorensen, P.S., Ullum, H., Thorner, L.W., Saarel
Pubblicato in: Science, Numero 365/6460, 2019, Pagina/e eaav7188, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aav7188

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk

Autori: Katarina Tengvall, Jesse Huang, Cecilia Hellström, Patrick Kammer, Martin Biström, Burcu Ayoglu, Izaura Lima Bomfim, Pernilla Stridh, Julia Butt, Nicole Brenner, Angelika Michel, Karin Lundberg, Leonid Padyukov, Ingrid E. Lundberg, Elisabet Svenungsson, Ingemar Ernberg, Sigurgeir Olafsson, Alexander T. Dilthey, Jan Hillert, Lars Alfredsson, Peter Sundström, Peter Nilsson, Tim Waterboer, Tomas O
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 116/34, 2019, Pagina/e 16955-16960, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1902623116

Prognostic value of white matter lesion shrinking in early multiple sclerosis: An intuitive or naïve notion?

Autori: Viola Pongratz, Paul Schmidt, Matthias Bussas, Sophia Grahl, Christian Gaser, Achim Berthele, Muna‐Miriam Hoshi, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Pubblicato in: Brain and Behavior, Numero 9/12, 2019, ISSN 2162-3279
Editore: Brain Behav
DOI: 10.1002/brb3.1417

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

Autori: Ali Manouchehrinia, Fredrik Piehl, Jan Hillert, Jens Kuhle, Lars Alfredsson, Tomas Olsson, Ingrid Kockum
Pubblicato in: Annals of Clinical and Translational Neurology, Numero 7/1, 2019, Pagina/e 139-143, ISSN 2328-9503
Editore: Ann Clin Transl Neurol.
DOI: 10.1002/acn3.50972

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

Autori: Lies Van Horebeek, Kelly Hilven, Klara Mallants, Annemarie Van Nieuwenhuijze, Tiina Kelkka, Paula Savola, Satu Mustjoki, Susan M Schlenner, Adrian Liston, Bénédicte Dubois, An Goris
Pubblicato in: Human Molecular Genetics, Numero 28/8, 2018, Pagina/e 1369-1380, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddy425

Somatic Variants: New Kids on the Block in Human Immunogenetics

Autori: L. Van Horebeek, B. Dubois, A. Goris
Pubblicato in: Trends in Genetics, Numero 35/12, 2019, Pagina/e 935-947, ISSN 0168-9525
Editore: Elsevier BV
DOI: 10.1016/j.tig.2019.09.005

Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases

Autori: Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger, Martijn Van Griensven, Verena Grummel, Markus Krumbholz, Achim Berthele, Bernhard Hemmer, Markus C. Kowarik
Pubblicato in: Journal of Neuroinflammation, Numero 16/1, 2019, ISSN 1742-2094
Editore: BioMed Central
DOI: 10.1186/s12974-019-1601-6

Blood neurofilament light levels segregate treatment effects in multiple sclerosis

Autori: Bénédicte Delcoigne, Ali Manouchehrinia, Christian Barro, Pascal Benkert, Zuzanna Michalak, Ludwig Kappos, David Leppert, Jon A. Tsai, Tatiana Plavina, Bernd C. Kieseier, Jan Lycke, Lars Alfredsson, Ingrid Kockum, Jens Kuhle, Tomas Olsson, Fredrik Piehl
Pubblicato in: Neurology, 2020, Pagina/e 10.1212/WNL.0000000000009097, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009097

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Autori: Madireddy, L., Patsopoulos, N.A., Cotsapas, C., Bos, S.D., Beecham, A., McCauley, J., Kim, K., Jia, X., Santaniello, A., Caillier, S.J., Andlauer, T.F M., Barcellos, L.F., Berge, T., Bernardinelli, L., Martinelli-Boneschi, F., Booth, D.R., Briggs, F., Celius, E.G., Comabella, M., Comi, G., Cree, B.A C., D'Alfonso, S., Dedham, K., Duquette, P., Efthimios, D., Esposito, F., Fontaine, B., Gasperi, C.
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09773-y

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Autori: Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17871-5

C-type lectin receptors Mcl and Mincle control development of multiple sclerosis–like neuroinflammation

Autori: Marie N’diaye, Susanna Brauner, Sevasti Flytzani, Lara Kular, Andreas Warnecke, Milena Z. Adzemovic, Eliane Piket, Jin-Hong Min, Will Edwards, Filia Mela, Hoi Ying Choi, Vera Magg, Tojo James, Magdalena Linden, Holger M. Reichardt, Michael R. Daws, Jack van Horssen, Ingrid Kockum, Robert A. Harris, Tomas Olsson, Andre O. Guerreiro-Cacais, Maja Jagodic
Pubblicato in: Journal of Clinical Investigation, Numero 130/2, 2019, Pagina/e 838-852, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci125857

Trends in the environmental risk assessment for the early onset of multiple sclerosis

Autori: Huang J, Kockum I, Stridh P
Pubblicato in: Mult Scler Relat Disord., 2021, ISSN 2211-0356
Editore: Elsevier
DOI: 10.1016/j.msard.2022.104250

Locus for severity implicates CNS resilience in progression of multiple sclerosis

Autori: International Multiple Sclerosis Genetics Consortium, MultipleMS Consortium, , Adil Harroud, Pernilla Stridh, Jacob L. McCauley, Janna Saarela, Ingileif Jónsdóttir, Aletta M. R. van den Bosch, Hendrik J. Engelenburg, Ashley H. Beecham, Lars Alfredsson, Katayoun Alikhani, Lilyana Amezcua, Till F. M. Andlauer, Maria Ban, Lisa F. Barcellos, Nadia Barizzone, Tone Berge, Achim Berthele, Stefan Bittne
Pubblicato in: Nature, Numero 619, 2023, Pagina/e 323–331, ISSN 1476-4687
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-06250-x

Association between exposure to combustion-related air pollution and multiple sclerosis risk

Autori: Hedström AK, Segersson D, Hillert J, Stridh P, Kockum I, Olsson T, Bellander T, Alfredsson L.
Pubblicato in: Int J Epidemiol, 2023, ISSN 1464-3685
Editore: Oxford University Press
DOI: 10.1212/nxi.0000000000200056

A topological data analysis based classification method for multiple measurements.

Autori: Henri Riihimäki, Wojciech Chachólski, Jakob Theorell, Jan Hillert, Ryan Ramanujam
Pubblicato in: BMC Bioinformatics, 2020, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-020-03659-3

Pregnancy does not modify the risk of MS in genetically susceptible women

Autori: Cameron J. Adams, Sean L. Wu, Xiaorong Shao, Patrick T. Bradshaw, Edlin Gonzales, Jessica B. Smith, Anny H. Xiang, Kalliope H. Bellesis, Terrence Chinn, Steffan D. Bos, Marte Wendel-Haga, Tomas Olsson, Ingrid Kockum, Annette M. Langer-Gould, Catherine Schaefer, Lars Alfredsson, Lisa F. Barcellos
Pubblicato in: Neurology - Neuroimmunology Neuroinflammation, Numero 7/6, 2020, Pagina/e e898, ISSN 2332-7812
Editore: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DOI: 10.1212/nxi.0000000000000898

A Scoping Review on Body Fluid Biomarkers for Prognosis and Disease Activity in Patients with Multiple Sclerosis.

Autori: Barizzone N, Leone M, Pizzino A, Kockum I; MultipleMS Consortium; Martinelli-Boneschi F, D'Alfonso S.
Pubblicato in: J Pers Med., 2022, ISSN 2075-4426
Editore: MDPI
DOI: 10.3390/jpm12091430

Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking

Autori: Mikael V Ringh, Michael Hagemann-Jensen, Maria Needhamsen, Susanna Kullberg, Jan Wahlström, Johan Grunewald, Boel Brynedal, Maja Jagodic, Tomas J Ekström, Johan Öckinger, Lara Kular
Pubblicato in: Multiple Sclerosis Journal, 2020, Pagina/e 135245852094376, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/1352458520943768

Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability

Autori: Anne Kerbrat, Charley Gros, Atef Badji, Elise Bannier, Francesca Galassi, Benoit Combès, Raphaël Chouteau, Pierre Labauge, Xavier Ayrignac, Clarisse Carra-Dalliere, Josefina Maranzano, Tobias Granberg, Russell Ouellette, Leszek Stawiarz, Jan Hillert, Jason Talbott, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya, Lydia Chougar, Jennifer Lefeuvre, Daniel S Reich, Govind Nair, Paola Valsasina, Mar
Pubblicato in: Brain, Numero 143/7, 2020, Pagina/e 2089-2105, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaa162

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.

Autori: Patsopoulos, Nikolas A; Baranzini, Sergio E; Santaniello, Adams; Shoostari, Parisa; Cotsapas, Chris; Wong, Garrett; Beecham, Ashley H; James, Tojo; Replogle, Joseph; Vlachos, Ioannis S; McCabe, Cristin; Pers, Tune H; Brandes, Aaron; White, Charles; Keenan, Brendan; Cimpean, Maria; Winn, Phoebe; Panteliadis, Ioannis-Pavlos; Robbins, Allison; Andlauer, Till FM; Zarzycki, Onigiusz; Dubois, Benedicte;
Pubblicato in: Science, Numero 2019 Sep 27;365(6460):eaav7188., 2019, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aav7188

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis

Autori: Tobias Granberg, Thomas Moridi, Judith S. Brand, Susanne Neumann, Martin Hlavica, Fredrik Piehl, Benjamin V. Ineichen
Pubblicato in: Journal of Neurology, Numero 267/11, 2020, Pagina/e 3199-3212, ISSN 0340-5354
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09971-5

Ensembl 2021

Autori: Kevin L Howe, Premanand Achuthan, James Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Andrey G Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla Cummins, Luca Da Rin Fioretto, Claire Davidson, Kamalkumar Dodiya, Bilal El Houdaigui, Reham Fatima, Astrid Gall, Carlos Garcia Giron, Tiago Grego, Cristina Guijarro-Clarke, Lea
Pubblicato in: Nucleic Acids Research, Numero 49/D1, 2020, Pagina/e D884-D891, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa942

Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis

Autori: Gabriel Mangeat, Russell Ouellette, Maxime Wabartha, Benjamin De Leener, Michael Plattén, Virginija Danylaité Karrenbauer, Marcel Warntjes, Nikola Stikov, Caterina Mainero, Julien Cohen‐Adad, Tobias Granberg
Pubblicato in: Journal of Neuroimaging, Numero 30/5, 2020, Pagina/e 674-682, ISSN 1051-2284
Editore: Sage Science Press
DOI: 10.1111/jon.12725

Decomposing filtered chain complexes: Geometry behind barcoding algorithms

Autori: Wojciech Chachólski, Barbara Giunti, Alvin Jin, Claudia Landi
Pubblicato in: Computational Geometry, 2023, ISSN 0925-7721
Editore: Elsevier BV
DOI: 10.1016/j.comgeo.2022.101938

Supervised Learning Using Homology Stable Rank Kernels

Autori: Jens Agerberg, Ryan Ramanujam, Martina Scolamiero, Wojciech Chachólski
Pubblicato in: Front. Appl. Math. Stat. Sec. Mathematics of Computation and Data Science, 2021, ISSN 2297-4687
Editore: Frontiers Media SA
DOI: 10.3389/fams.2021.668046

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