Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Rezultaty

R-packages for patient specific stratification

R-packages for patient specific stratificationMotivation for change:There has been delay in the development of R tools to be used for patient specific stratification as their application and hence development to data in retrospective cohort data has been delayed.

Software for stratification and clinical decision support system

Software for stratification and clinical decision support system. combination of previous D6.3 and D6.4.Motivation for change:After evaluating the market needs and existing software, we plan to combine software for stratification with that for clinical stratification into one product and hence would like to combine D6.3 and 6.4. Depending on intended users, we will make some features unavailable. The software is developed, and the core is ready. However, it is missing a few critical services to be genuinely market-ready which we estimate would require additional time.

Data availability and knowledge discovery tool to monitor for the availability of the different data types

Validation and formulation of candidate MS guidelines to be implemented into clinical practice

Validation and formulation of candidate MS guidelines to be implemented into clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Report on novel biomarkers and suggestions for their application in clinical practice

Report on novel biomarkers and suggestions for their application in clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Development of guidelines for reporting biomarker results and their classification into different levels of evidence

Project website

Publikacje

7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis

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Opublikowane w: Brain, Numer 143/10, 2020, Strona(/y) 2973-2987, ISSN 0006-8950
Wydawca: Oxford University Press
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Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression

Autorzy: Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
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Wydawca: Landes Bioscience
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MRI‐Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis

Autorzy: Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, Fredrik Piehl, Tobias Granberg
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Wydawca: Sage Science Press
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Association between brain volume and disability over time in multiple sclerosis

Autorzy: Moridi T, Stawiarz L, McKay KA, Ineichen BV, Ouellette R, Ferreira D, Muehlboeck JS, Westman E, Kockum I, Olsson T, Piehl F, Hillert J, Manouchehrinia A, Granberg T.
Opublikowane w: Mult Scler J Exp Transl Clin, 2022, ISSN 2055-2173
Wydawca: Sage Publications
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LIBRA: an adaptative integrative tool for paired single-cell multi-omics data

Autorzy: Xabier Martinez-de-Morentin , Sumeer A. Khan , Robert Lehmann , Sisi Qu , Alberto Maillo , Narsis A. Kiani , Felipe Prosper , Jesper Tegner , David Gomez-Cabrero
Opublikowane w: Quant. Biol, 2023, ISSN 2095-4697
Wydawca: Higher Education Press
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Seasonal variability of serum 25-hydroxyvitamin D on multiple sclerosis onset.

Autorzy: Stridh P, Kockum I, Huang J
Opublikowane w: Sci Rep, Numer 2021 Oct 25;11(1):20989, 2021, ISSN 2045-2322
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Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.

Autorzy: Vandebergh, Marijne; Degryse, Nicolas; Dubois, Benedicte; Goris, An
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Smoking and Epstein–Barr virus infection in multiple sclerosis development

Autorzy: Anna Karin Hedström, Jesse Huang, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
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Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients

Autorzy: Held F, Kalluri SR, Berthele A, Klein AK, Reindl M, Hemmer B
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Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study.

Autorzy: Vandebergh, Marijne; Becelaere, Sara; Dubois, Benedicte; Goris, An; CHARGE, Inflammation Working Grp
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Wydawca: FRONTIERS MEDIA SA
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Inflammation-related plasma and CSF biomarkers for multiple sclerosis

Autorzy: Jesse Huang, Mohsen Khademi, Lars Fugger, Örjan Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, Fredrik Piehl, Tomas Olsson, Ingrid Kockum
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Finding cell-specific expression patterns in the early Ciona embryo with single-cell RNA-seq

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Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Autorzy: Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
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Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

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A pharmacogenetic study implicates NINJ2 in the response to Interferon-β in multiple sclerosis

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A genetic risk variant for multiple sclerosis severity is associated with brain atrophy

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Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort

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Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

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Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis.

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Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

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Opublikowane w: Lancet Neurology, Numer 2022 Mar;21(3):246-257., 2022, ISSN 1474-4422
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Assessing the preanalytical variability of plasma and cerebrospinal fluid processing and its effects on inflammation-related protein biomarkers.

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Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology

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Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.

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Human immune diversity: from evolution to modernity.

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Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis.

Autorzy: Starvaggi Cucuzza C, Longinetti E, Ruffin N, Evertsson B, Kockum I, Jagodic M, Al Nimer F, Frisell T, Piehl F.
Opublikowane w: Neurol Neuroimmunol Neuroinflamm., 2022, ISSN 2332-7812
Wydawca: Wolters Kluwer Health/Lippincott Williams & Wilkins

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Autorzy: Kockum I, Huang J, Stridh P
Opublikowane w: Curr Protoc, 2023, ISSN 2691-1299
Wydawca: Wiley
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Natural Killer Cells in Multiple Sclerosis: Entering the Stage

Autorzy: Beliën, Jarne; Goris, An; Matthys, Patrick
Opublikowane w: FRONTIERS IN IMMUNOLOGY, 2022, ISSN 1664-3224
Wydawca: FRONTIERS MEDIA SA
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Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Autorzy: Ide Smets, An Goris, Marijne Vandebergh, Jelle Demeestere, Stefan Sunaert, Patrick Dupont, Bénédicte Dubois
Opublikowane w: Scientific Reports, Numer 11/1, 2021, ISSN 2045-2322
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Impact of multiple sclerosis risk loci in postinfectious neurological syndromes

Autorzy: Filippo Martinelli-Boneschi, Riccardo Currò, Silvia Santoro, Giulia Berzero, Melissa Sorosina, Laura Ferrè, Elisabetta Mascia, Silvia Peroni, Giancarlo Comi, Angelo Gugliemi, Elisa Vegezzi, Ilaria Callegari, Massimo Filippi, Andrea Cortese, Federica Esposito, Ferdinando Clarelli, Enrico Marchioni
Opublikowane w: Multiple Sclerosis and Related Disorders, Numer 44, 2020, Strona(/y) 102326, ISSN 2211-0348
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LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

Autorzy: Giulio Ruffini ,Giada Damiani,Diego Lozano-Soldevilla,Nikolas Deco,Fernando E. Rosas,Narsis A. Kiani,Adrián Ponce-Alvarez,Morten L. Kringelbach,Robin Carhart-Harris,Gustavo Deco
Opublikowane w: PLoS Comput Biol, 2023, ISSN 1553-734X
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Epstein–Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis

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The Aryl Hydrocarbon Receptor-Dependent TGF-alpha/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis

Autorzy: Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V
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Wydawca: LIPPINCOTT WILLIAMS & WILKINS
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Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis - a presymptomatic case-control study.

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Epigenetic insights into multiple sclerosis disease progression

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Autorzy: Fernandes SJ, Ericsson M, Khademi M, Jagodic M, Olsson T, Gomez-Cabrero D, Kockum I, Tegnér J.
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GeneSetCluster: a tool for summarizing and integrating gene-set analysis results

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DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

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Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity

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Epigenetic variation taking center stage in immunological research

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Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

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Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

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Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis

Autorzy: Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
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Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells

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Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

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Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship

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