Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

R-packages for patient specific stratification

R-packages for patient specific stratificationMotivation for change:There has been delay in the development of R tools to be used for patient specific stratification as their application and hence development to data in retrospective cohort data has been delayed.

Software for stratification and clinical decision support system

Software for stratification and clinical decision support system. combination of previous D6.3 and D6.4.Motivation for change:After evaluating the market needs and existing software, we plan to combine software for stratification with that for clinical stratification into one product and hence would like to combine D6.3 and 6.4. Depending on intended users, we will make some features unavailable. The software is developed, and the core is ready. However, it is missing a few critical services to be genuinely market-ready which we estimate would require additional time.

Data availability and knowledge discovery tool to monitor for the availability of the different data types

Validation and formulation of candidate MS guidelines to be implemented into clinical practice

Validation and formulation of candidate MS guidelines to be implemented into clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Report on novel biomarkers and suggestions for their application in clinical practice

Report on novel biomarkers and suggestions for their application in clinical practiceMotivation for changeBuilds on results from D7376 and hare hence delayed

Development of guidelines for reporting biomarker results and their classification into different levels of evidence

Project website

Publikacje

7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis

Autorzy: Russell Ouellette, Constantina A Treaba, Tobias Granberg, Elena Herranz, Valeria Barletta, Ambica Mehndiratta, Benjamin De Leener, Shahamat Tauhid, Fawad Yousuf, Sarah M Dupont, Eric C Klawiter, Jacob A Sloane, Rohit Bakshi, Julien Cohen-Adad, Caterina Mainero
Opublikowane w: Brain, Numer 143/10, 2020, Strona(/y) 2973-2987, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awaa249

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression

Autorzy: Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
Opublikowane w: Epigenetics, Numer 15/6-7, 2020, Strona(/y) 646-663, ISSN 1559-2294
Wydawca: Landes Bioscience
DOI: 10.1080/15592294.2019.1700628

MRI‐Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis

Autorzy: Michael Platten, Juha Martola, Katharina Fink, Russell Ouellette, Fredrik Piehl, Tobias Granberg
Opublikowane w: Journal of Neuroimaging, Numer 30/2, 2020, Strona(/y) 198-204, ISSN 1051-2284
Wydawca: Sage Science Press
DOI: 10.1111/jon.12676

Association between brain volume and disability over time in multiple sclerosis

Autorzy: Moridi T, Stawiarz L, McKay KA, Ineichen BV, Ouellette R, Ferreira D, Muehlboeck JS, Westman E, Kockum I, Olsson T, Piehl F, Hillert J, Manouchehrinia A, Granberg T.
Opublikowane w: Mult Scler J Exp Transl Clin, 2022, ISSN 2055-2173
Wydawca: Sage Publications
DOI: 10.1177/20552173221144230

LIBRA: an adaptative integrative tool for paired single-cell multi-omics data

Autorzy: Xabier Martinez-de-Morentin , Sumeer A. Khan , Robert Lehmann , Sisi Qu , Alberto Maillo , Narsis A. Kiani , Felipe Prosper , Jesper Tegner , David Gomez-Cabrero
Opublikowane w: Quant. Biol, 2023, ISSN 2095-4697
Wydawca: Higher Education Press
DOI: 10.15302/j-qb-022-0318

Seasonal variability of serum 25-hydroxyvitamin D on multiple sclerosis onset.

Autorzy: Stridh P, Kockum I, Huang J
Opublikowane w: Sci Rep, Numer 2021 Oct 25;11(1):20989, 2021, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-021-00344-0

Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.

Autorzy: Vandebergh, Marijne; Degryse, Nicolas; Dubois, Benedicte; Goris, An
Opublikowane w: JOURNAL OF NEUROLOGY, Numer J Neurol . 2022 Aug;269(8):4565-4574, 2022, ISSN 0340-5354
Wydawca: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-022-11072-4

Smoking and Epstein–Barr virus infection in multiple sclerosis development

Autorzy: Anna Karin Hedström, Jesse Huang, Nicole Brenner, Julia Butt, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-67883-w

Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients

Autorzy: Held F, Kalluri SR, Berthele A, Klein AK, Reindl M, Hemmer B
Opublikowane w: MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Numer Mult Scler J Exp Transl Clin . 2021 Jun 25;7(2):20552173211022767, 2021, ISSN 2055-2173
Wydawca: SAGE PUBLICATIONS INC
DOI: 10.1177/20552173211022767

Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study.

Autorzy: Vandebergh, Marijne; Becelaere, Sara; Dubois, Benedicte; Goris, An; CHARGE, Inflammation Working Grp
Opublikowane w: Frontiers In Immunology, Numer 2022 Mar 21;13:834644, 2022, ISSN 1664-3224
Wydawca: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.834644

Autorzy: Jesse Huang, Mohsen Khademi, Lars Fugger, Örjan Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, Fredrik Piehl, Tomas Olsson, Ingrid Kockum
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 117/23, 2020, Strona(/y) 12952-12960, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1912839117

Finding cell-specific expression patterns in the early Ciona embryo with single-cell RNA-seq

Autorzy: Garth R. Ilsley, Ritsuko Suyama, Takeshi Noda, Nori Satoh, Nicholas M. Luscombe
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-61591-1

Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Autorzy: Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
Opublikowane w: Ann Clin Transl Neurol, 2023, ISSN 2328-9503
Wydawca: Wiley

Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

Autorzy: Sonja Hochmeister, Shahin Aeinehband, Charles Dorris, Rasmus Berglund, Michaela T. Haindl, Vid Velikic, Sven A. Gustafsson, Tomas Olsson, Fredrik Piehl, Maja Jagodic, Manuel Zeitelhofer, Milena Z. Adzemovic
Opublikowane w: Frontiers in Neurology, Numer 11, 2020, ISSN 1664-2295
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.600401

A pharmacogenetic study implicates NINJ2 in the response to Interferon-β in multiple sclerosis

Autorzy: Silvia Peroni, Melissa Sorosina, Sunny Malhotra, Ferdinando Clarelli, Ana Maria Osiceanu, Laura Ferrè, Tina Roostaei, Jordi Rio, Luciana Midaglia, Luisa María Villar, José Carlos Álvarez-Cermeño, Clara Guaschino, Marta Radaelli, Lorena Citterio, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Vittorio Martinelli, Xavier Montalban, Howard L Weiner, Philip de Jager, Giancarlo Comi, Feder
Opublikowane w: Multiple Sclerosis Journal, Numer 26/9, 2020, Strona(/y) 1074-1082, ISSN 1352-4585
Wydawca: SAGE Publications
DOI: 10.1177/1352458519851428

A genetic risk variant for multiple sclerosis severity is associated with brain atrophy

Autorzy: Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, Cuici; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid;
Opublikowane w: Ann Neurol, 2023, ISSN 0364-5134
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ana.26807

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis

Autorzy: Thomas O G, Bronge M, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Ortlieb Guerreiro-Cacais A, Grönlund H, Olsson T, Kockum I
Opublikowane w: Sci Adv., 2023, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.adg3032

Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort

Autorzy: Stefanos Klironomos, Antonios Tzortzakakis, Annika Kits, Claes Öhberg, Evangelia Kollia, Amir Ahoromazdae, Håkan Almqvist, Åsa Aspelin, Heather Martin, Russell Ouellette, Jonathan Al-Saadi, Mikael Hasselberg, Mansour Haghgou, Mitra Pedersen, Sven Petersson, Johannes Finnsson, Johan Lundberg, Anna Falk Delgado, Tobias Granberg
Opublikowane w: Radiology, Numer 297/3, 2020, Strona(/y) E324-E334, ISSN 0033-8419
Wydawca: Radiological Society of North America
DOI: 10.1148/radiol.2020202791

Transcript-specific regulation in T-cells in multiple sclerosis susceptibility

Autorzy: Lies Van Horebeek, An Goris
Opublikowane w: European Journal of Human Genetics, Numer 28/7, 2020, Strona(/y) 849-850, ISSN 1018-4813
Wydawca: Natue Publishing Group
DOI: 10.1038/s41431-020-0615-y

Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis.

Autorzy: Vandebergh, Marijne; Andlauer, Till FM; Zhou, Yuan; Mallants, Klara; Held, Friederike; Aly, Lilian; Taylor, Bruce V; Hemmer, Bernhard; Dubois, Benedicte; Goris, An
Opublikowane w: Annals Of Neurology, Numer 2021 May;89(5):884-894., 2021, ISSN 0364-5134
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ana.26061

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

Autorzy: Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive P H, Mueller C, Müller S, Naegelin Y, Oksenberg JR, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg Z, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani MP, Granziera C, Piehl F, Leppert D, Kuhle Jfor the RDB in the Swiss Multiple Sclerosis Cohort Study Grou
Opublikowane w: Lancet Neurology, Numer 2022 Mar;21(3):246-257., 2022, ISSN 1474-4422
Wydawca: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(22)00009-6

Smoking and multiple sclerosis risk: a Mendelian randomization study

Autorzy: Marijne Vandebergh, An Goris
Opublikowane w: Journal of Neurology, Numer 267/10, 2020, Strona(/y) 3083-3091, ISSN 0340-5354
Wydawca: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09980-4

Assessing the preanalytical variability of plasma and cerebrospinal fluid processing and its effects on inflammation-related protein biomarkers.

Autorzy: Huang J, Khademi M, Lindhe Ö, Jönsson G, Piehl F, Olsson T, Kockum I
Opublikowane w: Mol Cell Proteomics., 2021, ISSN 1535-9484
Wydawca: ELSEVIER

Season of birth is associated with multiple sclerosis and disease severity

Autorzy: Stridh P, Huang J, Hedström AK, Alfredsson L, Olsson T, Hillert J, Manouchehrinia A, Kockum I
Opublikowane w: MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL, Numer 2021 Dec 22;7(4):20552173211065730., 2021, ISSN 2055-2173
Wydawca: SAGE PUBLICATIONS I
DOI: 10.1177/20552173211065730

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology

Autorzy: Zheleznyakova GY, Piket E, Needhamsen M, Hagemann-Jensen M, Ekman D, Han Y, James T, Khademi M, Al Nimer F, Scicluna P, Huang J, Kockum I, Faridani OR, Olsson T, Piehl F, Jagodic M
Opublikowane w: Proc Natl Acad Sci U S A. 2021 Apr 27;118(17), 2021, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2011574118

Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.

Autorzy: Lauerer M, McGinnis J, Bussas M, El Husseini M, Pongratz V, Engl C, Wuschek A, Berthele A, Riederer I, Kirschke JS, Zimmer C, Hemmer B, Mühlau M.
Opublikowane w: J Neurol Neurosurg Psychiatry, 2023, ISSN 1468-330X
Wydawca: BMJ

Human immune diversity: from evolution to modernity.

Autorzy: Liston, Adrian; Humblet-Baron, Stephanie; Duffy, Darragh; Goris, An
Opublikowane w: Nature Immunology, Numer 22, pages1479–1489 (2021), 2021, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-021-01058-1

Genetic determinants of the humoral immune response in MS

Autorzy: Christiane Gasperi, Till F.M. Andlauer, Ana Keating, Benjamin Knier, Ana Klein, Verena Pernpeintner, Peter Lichtner, Ralf Gold, Frauke Zipp, Florian Then Bergh, Martin Stangel, Hayrettin Tumani, Brigitte Wildemann, Heinz Wiendl, Antonios Bayas, Tania Kümpfel, Uwe K. Zettl, Ralf A. Linker, Ulf Ziemann, Matthias Knop, Clemens Warnke, Manuel A. Friese, Friedemann Paul, Björn Tackenberg, Achim Berth
Opublikowane w: Neurology - Neuroimmunology Neuroinflammation, Numer 7/5, 2020, Strona(/y) e827, ISSN 2332-7812
Wydawca: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DOI: 10.1212/nxi.0000000000000827

Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis.

Autorzy: Starvaggi Cucuzza C, Longinetti E, Ruffin N, Evertsson B, Kockum I, Jagodic M, Al Nimer F, Frisell T, Piehl F.
Opublikowane w: Neurol Neuroimmunol Neuroinflamm., 2022, ISSN 2332-7812
Wydawca: Wolters Kluwer Health/Lippincott Williams & Wilkins

Overview of genotyping technologies and methods

Autorzy: Kockum I, Huang J, Stridh P
Opublikowane w: Curr Protoc, 2023, ISSN 2691-1299
Wydawca: Wiley
DOI: 10.1002/cpz1.727

Natural Killer Cells in Multiple Sclerosis: Entering the Stage

Autorzy: Beliën, Jarne; Goris, An; Matthys, Patrick
Opublikowane w: FRONTIERS IN IMMUNOLOGY, 2022, ISSN 1664-3224
Wydawca: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.869447

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Autorzy: Ide Smets, An Goris, Marijne Vandebergh, Jelle Demeestere, Stefan Sunaert, Patrick Dupont, Bénédicte Dubois
Opublikowane w: Scientific Reports, Numer 11/1, 2021, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-021-81035-8

Impact of multiple sclerosis risk loci in postinfectious neurological syndromes

Autorzy: Filippo Martinelli-Boneschi, Riccardo Currò, Silvia Santoro, Giulia Berzero, Melissa Sorosina, Laura Ferrè, Elisabetta Mascia, Silvia Peroni, Giancarlo Comi, Angelo Gugliemi, Elisa Vegezzi, Ilaria Callegari, Massimo Filippi, Andrea Cortese, Federica Esposito, Ferdinando Clarelli, Enrico Marchioni
Opublikowane w: Multiple Sclerosis and Related Disorders, Numer 44, 2020, Strona(/y) 102326, ISSN 2211-0348
Wydawca: Elsevier
DOI: 10.1016/j.msard.2020.102326

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

Autorzy: Giulio Ruffini ,Giada Damiani,Diego Lozano-Soldevilla,Nikolas Deco,Fernando E. Rosas,Narsis A. Kiani,Adrián Ponce-Alvarez,Morten L. Kringelbach,Robin Carhart-Harris,Gustavo Deco
Opublikowane w: PLoS Comput Biol, 2023, ISSN 1553-734X
Wydawca: Public Library of Science
DOI: 10.1371/journal.pcbi.1010811

Epstein–Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis

Autorzy: M. Biström, D. Jons, E. Engdahl, R. Gustafsson, J. Huang, N. Brenner, J. Butt, L. Alonso‐Magdalena, M. Gunnarsson, M. Vrethem, N. Bender, T. Waterboer, G. Granåsen, T. Olsson, I. Kockum, O. Andersen, A. Fogdell‐Hahn, Peter Sundström
Opublikowane w: European Journal of Neurology, Numer 28/2, 2021, Strona(/y) 579-586, ISSN 1351-5101
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/ene.14597

The Aryl Hydrocarbon Receptor-Dependent TGF-alpha/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis

Autorzy: Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V
Opublikowane w: Neurol Neuroimmunol Neuroinflamm, 2022, ISSN 2332-7812
Wydawca: LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/nxi.0000000000001043

Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis - a presymptomatic case-control study.

Autorzy: Grut V, Biström M, Salzer J, Stridh P, Jons D, Gustafsson R, Fogdell-Hahn A, Huang J, Brenner N, Butt J, Bender N, Lindam A, Alonso-Magdalena L, Gunnarsson M, Vrethem M, Bergström T, Andersen O, Kockum I, Waterboer T, Olsson T, Sundström P
Opublikowane w: Eur J Neurol., 2021, ISSN 1351-5101
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/ene.14961

Epigenetic insights into multiple sclerosis disease progression

Autorzy: L. Kular, M. Jagodic
Opublikowane w: Journal of Internal Medicine, Numer 288/1, 2020, Strona(/y) 82-102, ISSN 0954-6820
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/joim.13045

Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients. . 2021 Oct;13(20):1607-1618. doi: /

Autorzy: Fernandes SJ, Ericsson M, Khademi M, Jagodic M, Olsson T, Gomez-Cabrero D, Kockum I, Tegnér J.
Opublikowane w: Epigenomics, 2021, ISSN 1750-1911
Wydawca: Future Medicine Ltd.
DOI: 10.2217/epi-2021-0205

Systematic Assessment of Medical Diagnoses Preceding the First Diagnosis of Multiple Sclerosis

Autorzy: Gasperi C, Hapfelmeier A, Daltrozzo T, Schneider A, Donnachie E, Hemmer B.
Opublikowane w: NEUROLOGY, Numer 2021 Apr 26;10.1212/WNL.0000000000012074., 2021, ISSN 0028-3878
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000012074

Lesion location across diagnostic regions in multiple sclerosis

Autorzy: Viola Pongratz, Matthias Bussas, Paul Schmidt, Sophia Grahl, Christiane Gasperi, Malek El Husseini, Laura Harabacz, Viktor Pineker, Dominik Sepp, Lioba Grundl, Benedikt Wiestler, Jan Kirschke, Claus Zimmer, Achim Berthele, Bernhard Hemmer, Mark Mühlau
Opublikowane w: Neuroimage Clin., 2023, ISSN 2213-1582
Wydawca: Elsevier BV

Neurological manifestations of coronavirus infections – a systematic review

Autorzy: Jesper Almqvist, Tobias Granberg, Antonios Tzortzakakis, Stefanos Klironomos, Evangelia Kollia, Claes Öhberg, Roland Martin, Fredrik Piehl, Russell Ouellette, Benjamin V. Ineichen
Opublikowane w: Annals of Clinical and Translational Neurology, Numer 7/10, 2020, Strona(/y) 2057-2071, ISSN 2328-9503
Wydawca: Wiley Periodicals LLC on behalf of American Neurological Association.
DOI: 10.1002/acn3.51166

GeneSetCluster: a tool for summarizing and integrating gene-set analysis results

Autorzy: Ewoud Ewing, Nuria Planell-Picola, Maja Jagodic, David Gomez-Cabrero
Opublikowane w: BMC Bioinformatics, Numer 21/1, 2020, ISSN 1471-2105
Wydawca: BioMed Central
DOI: 10.1186/s12859-020-03784-z

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Autorzy: Lara Kular, Yun Liu, Sabrina Ruhrmann, Galina Zheleznyakova, Francesco Marabita, David Gomez-Cabrero, Tojo James, Ewoud Ewing, Magdalena Lindén, Bartosz Górnikiewicz, Shahin Aeinehband, Pernilla Stridh, Jenny Link, Till F. M. Andlauer, Christiane Gasperi, Heinz Wiendl, Frauke Zipp, Ralf Gold, Björn Tackenberg, Frank Weber, Bernhard Hemmer, Konstantin Strauch, Stefanie Heilmann-Heimbach, Rajesh
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-04732-5

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity

Autorzy: Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck, Dirk S. Paul
Opublikowane w: BioEssays, Numer 40/2, 2018, Strona(/y) 1700148, ISSN 0265-9247
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/bies.201700148

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients

Autorzy: Tojo James, Magdalena Lindén, Hiromasa Morikawa, Sunjay Jude Fernandes, Sabrina Ruhrmann, Mikael Huss, Maya Brandi, Fredrik Piehl, Maja Jagodic, Jesper Tegnér, Mohsen Khademi, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum
Opublikowane w: Human Molecular Genetics, Numer 27/5, 2018, Strona(/y) 912-928, ISSN 0964-6906
Wydawca: Oxford University Press
DOI: 10.1093/hmg/ddy001

Epigenetic variation taking center stage in immunological research

Autorzy: Simone Ecker, Stephan Beck
Opublikowane w: Epigenomics, Numer 9/4, 2017, Strona(/y) 375-378, ISSN 1750-1911
Wydawca: Future Medicine Ltd.
DOI: 10.2217/epi-2017-0006

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

Autorzy: Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson
Opublikowane w: Multiple Sclerosis Journal, Numer 24/8, 2018, Strona(/y) 1046-1054, ISSN 1352-4585
Wydawca: SAGE Publications
DOI: 10.1177/1352458517715132

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

Autorzy: Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Th
Opublikowane w: npj Genomic Medicine, Numer 2/1, 2017, ISSN 2056-7944
Wydawca: NPJ Genom Med
DOI: 10.1038/s41525-017-0027-2

Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis

Autorzy: Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Opublikowane w: Multiple Sclerosis Journal - Experimental, Translational and Clinical, Numer 4/2, 2018, Strona(/y) 205521731876719, ISSN 2055-2173
Wydawca: Mult Scler J Exp Transl Clin.
DOI: 10.1177/2055217318767192

Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells

Autorzy: Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
Opublikowane w: Brain, Numer 141/3, 2018, Strona(/y) 786-796, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awx372

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Autorzy: Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
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