Single-cell temporal tracking of epigenetic DNA marks

Informazioni relative al progetto

EpiTrack

ID dell’accordo di sovvenzione: 742654

DOI

10.3030/742654

Progetto chiuso

Data della firma CE 21 Aprile 2017

Data di avvio 1 Settembre 2017

Data di completamento 28 Febbraio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 875,00

Contributo UE

€ 2 499 875,00

Coordinato da

VILNIAUS UNIVERSITETAS
Lithuania

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (13)

Methyltransferase-directed orthogonal tagging and sequencing of miRNAs and bacterial small RNAs

Autori: Milda Mickutė, Kotryna Kvederavičiūtė, Aleksandr Osipenko, Raminta Mineikaitė, Saulius Klimašauskas, Giedrius Vilkaitis
Pubblicato in: BMC Biology, Numero 19/1, 2021, Pagina/e 129, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-021-01053-w

Enzymatic hydroxylation and excision of extended 5-methylcytosine analogues

Autori: Miglė Tomkuvienė, Diana Ikasalaitė, Anton Slyvka, Audronė Rukšėnaitė, Mirunalini Ravichandran, Tomasz P. Jurkowski, Matthias Bochtler, Saulius Klimašauskas
Pubblicato in: Journal of Molecular Biology, Numero 423, 2020, Pagina/e 6157-6167, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2020.10.011

Engineered Methionine Adenosyltransferase Cascades for Metabolic Labeling of Individual DNA Methylomes in Live Cells

Autori: Liepa Gasiulė, Vaidotas Stankevičius, Kotryna Kvederavičiu̅tė, Jonas Mindaugas Rimšelis, Vaidas Klimkevičius, Gražina Petraitytė, Audronė Rukšėnaitė, Viktoras Masevičius, Saulius Klimašauskas
Pubblicato in: Journal of the American Chemical Society, Numero 146, 2024, Pagina/e 18722-18729, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c06529

Selective chemical tracking of Dnmt1 catalytic activity in live cells.

Autori: V. Stankevičius, P. Gibas, B. Masiulionytė, L. Gasiulė, V. Masevičius, S. Klimašauskas, G. Vilkaitis
Pubblicato in: Molecular Cell, Numero 82/5, 2022, Pagina/e 1053-1065.e8, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2022.02.008

Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein

Autori: Almaz Nigatu Tesfahun, Marina Alexeeva, Miglė Tomkuvienė, Aysha Arshad, Prashanna Guragain, Arne Klungland, Saulius Klimašauskas, Peter Ruoff, Svein Bjelland
Pubblicato in: Frontiers in Microbiology, Numero 12, 2021, Pagina/e 608839, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2021.608839

Distribution and regulatory roles of oxidized 5-methylcytosines in DNA and RNA of the Basidiomycete fungi Laccaria bicolor and Coprinopsis cinerea.

Autori: J. Ličytė, K. Kvederavičiūtė, A. Rukšėnaitė, E. Godliauskaitė, P. Gibas, V. Tomkutė, G. Petraitytė, V. Masevičius, S. Klimašauskas, E. Kriukienė
Pubblicato in: Open Biology, Numero 12/3, 2022, Pagina/e 210302, ISSN 2046-2441
Editore: Royal Society Publishing
DOI: 10.1098/rsob.210302

Repurposing enzymatic transferase reactions for targeted labeling and analysis of DNA and RNA

Autori: Miglė Tomkuvienė, Milda Mickutė, Giedrius Vilkaitis, Saulius Klimašauskas
Pubblicato in: Current Opinion in Biotechnology, Numero 55, 2019, Pagina/e 114-123, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2018.09.008

Animal Hen1 2′-O-methyltransferases as tools for 3′-terminal functionalization and labelling of single-stranded RNAs

Autori: Milda Mickutė, Milda Nainytė, Lina Vasiliauskaitė, Alexandra Plotnikova, Viktoras Masevičius, Saulius Klimašauskas, Giedrius Vilkaitis
Pubblicato in: Nucleic Acids Research, Numero 46/17, 2018, Pagina/e e104-e104, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky514

An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing

Autori: Soo-Mi Kweon, Yibu Chen, Eugene Moon, Kotryna Kvederaviciutė, Saulius Klimasauskas, Douglas E. Feldman
Pubblicato in: Molecular Cell, Numero 74, 2019, Pagina/e 1138-1147.e6, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.03.018

Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing

Autori: Povilas Gibas, Milda Narmontė, Zdislav Staševskij, Juozas Gordevičius, Saulius Klimašauskas, Edita Kriukienė
Pubblicato in: PLOS Biology, Numero 18, 2020, Pagina/e e3000684, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3000684

Enhanced nucleosome assembly at CpG sites containing an extended 5-methylcytosine analogue

Autori: Miglė Tomkuvienė, Markus Meier, Diana Ikasalaitė, Julia Wildenauer, Visvaldas Kairys, Saulius Klimašauskas, Laura Manelytė
Pubblicato in: Nucleic Acids Research, Numero 50/11, 2022, Pagina/e 6549–6561, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkac444

FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine.

Autori: María José Peña-Gómez, Paula Moreno-Gordillo, Milda Narmontė, Clara B. García-Calderón, Audronė Rukšėnaitė, Saulius Klimašauskas, Iván V. Rosado
Pubblicato in: Cell Death & Disease, Numero 13/5, 2022, Pagina/e 503, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-022-04952-0

One-pot trimodal mapping of unmethylated, hydroxymethylated and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci.

Autori: K. Skardžiūtė, K. Kvederavičiūtė, I. Pečiulienė, M. Narmontė, P. Gibas, J. Ličytė, S. Klimašauskas, E. Kriukienė
Pubblicato in: Cell Chemical Biology, 2024, Pagina/e in press, ISSN 2451-9456
Editore: Cell Press
DOI: 10.1016/j.chembiol.2023.12.003

Non-peer reviewed articles (1)

Meet the author: Vaidotas Stankevičius, Giedrius Vilkaitis, and Saulius Klimašauskas

Autori: Vaidotas Stankevičius, Giedrius Vilkaitis, and Saulius Klimašauskas
Pubblicato in: Molecular Cell, Numero 82/5, 2022, Pagina/e 879-881, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2022.02.019

Book chapters (1)

DNA Labeling Using DNA Methyltransferases

Autori: Miglė Tomkuvienė, Edita Kriukienė, Saulius Klimašauskas
Pubblicato in: Advances in Experimental Medicine and Biology, Numero 1389, 2022, Pagina/e 535–562, ISBN 978-3-031-11454-0
Editore: Springer
DOI: 10.1007/978-3-031-11454-0_19