Investigation of adaptive design and rewiring of Survival-Apoptosis-Mitogenic (SAM) signalling transduction network

Project Information

SAMNets

Grant agreement ID: 750688

DOI 10.3030/750688

Project closed

EC signature date 14 March 2017

Start date 1 May 2017

End date 30 April 2019

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 187 866,00

EU contribution € 187 866,00

Coordinated by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

Publications

Peer reviewed articles (6)

Mapping connections in signaling networks with ambiguous modularity

Author(s): Daniel Lill, Oleksii S. Rukhlenko, Anthony James Mc Elwee, Eugene Kashdan, Jens Timmer, Boris N. Kholodenko
Published in: npj Systems Biology and Applications, Issue 5/1, 2019, ISSN 2056-7189
Publisher: Springer Nature
DOI: 10.1038/s41540-019-0096-1

Reconstructing static and dynamic models of signaling pathways using Modular Response Analysis

Author(s): Tapesh Santra, Oleksii Rukhlenko, Vadim Zhernovkov, Boris N. Kholodenko
Published in: Current Opinion in Systems Biology, Issue 9, 2018, Page(s) 11-21, ISSN 2452-3100
Publisher: Elsevier
DOI: 10.1016/j.coisb.2018.02.003

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling

Author(s): Keesha E. Erickson, Oleksii S. Rukhlenko, Richard G. Posner, William S. Hlavacek, Boris N. Kholodenko
Published in: Seminars in Cancer Biology, Issue 54, 2019, Page(s) 162-173, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2018.02.008

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

Author(s): Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia Gómez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko
Published in: Cell Systems, Issue 7/2, 2018, Page(s) 161-179.e14, ISSN 2405-4712
Publisher: Cell Press
DOI: 10.1016/j.cels.2018.06.002

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Author(s): Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, Boris N. Kholodenko
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34353-3

Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Author(s): Keesha E. Erickson, Oleksii S. Rukhlenko, Md Shahinuzzaman, Kalina P. Slavkova, Yen Ting Lin, Ryan Suderman, Edward C. Stites, Marian Anghel, Richard G. Posner, Dipak Barua, Boris N. Kholodenko, William S. Hlavacek
Published in: PLOS Computational Biology, Issue 15/1, 2019, Page(s) e1006706, ISSN 1553-7358
Publisher: Public Library of Science (United States)
DOI: 10.1371/journal.pcbi.1006706

Intellectual Property Rights

Patent (1)

Compositions and Uses Thereof

Application/Publication number: UK 1808321.2
Date: 2018-05-21
Applicant(s): UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN