Periodic Reporting for period 1 - YEFF (Comprehensive analysis of yeast expression-fitness functions (EFFs))
Periodo di rendicontazione: 2018-05-01 al 2020-04-30
The overall objectives are:
- Quantifying how expression changes in many different genes affect organismal fitness
- Generating insights into the core mechanisms of how gene expression changes affect fitness
- Systematic classification of genes into groups with similar effect characteristics
- Gaining insights into how the regulation of gene expression evolves
- It was the first systematic analysis across many genes of how the average and time-varying aspects of gene expression interact to impact organismal fitness
- It contributed the first systematic evidence for the long-hold assumption that noisy gene expression is detrimental to organisms
- It extended models of gene expression evolution by the dimension of time-varying gene expression, showing that the interplay between average and time-varying expression create specific evolutionary scenarios for how gene expression evolution might proceed