Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions

Deliverables

Websites, patent fillings, videos etc. (1)

Website/online assets (maintained and updated during project)

Website/online assets (maintained and updated during project)

Publications

Non-peer reviewed articles (1)

Towards a European Health Research and Innovation Cloud (HRIC)

Author(s): Charles Auffray; P. Bogaert; N. P. Oxtoby; B. Claerhout; G. Bertolini; Rudi Balling; Niklas Blomberg; P. Oksvold; Lars Hjorth; G. D’Errico; C. Larue; J. Van Bussel; H. Van Oyen; C. Gans-Combe; W. J. Armitage; Gard O. S. Thomassen; C. Ohmann; Y. Ioannidis; Olaf Riess; Jan G. Bjaalie; N. Benhabiles; E. Morley-Fletcher; Josep Roca; B. De Meulder; A. E. Gray; A. Albeyatti; I. Perseil; H. Riper; A. M
Published in: Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020), Issue 6, 2020, ISSN 1756-994X
DOI: 10.1186/s13073-020-0713-z

Peer reviewed articles (16)

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Author(s): Aoife A. Nolan, Nourhan K. Aboud, Walter Kolch, David Matallanas
Published in: Genes, Issue 12/4, 2021, Page(s) 553, ISSN 2073-4425
DOI: 10.3390/genes12040553

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Author(s): Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito; Sun, Hua; Mashl, R. Jay; Davies, Sherri; Jeon, Ryan; Frech, Christian; Randjelovic, Jele
Published in: Nature Genetics, Issue 7, 2020, ISSN 1061-4036
DOI: 10.1101/861393

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

Author(s): Florent Petitprez, Sacha Levy, Cheng-Ming Sun, Maxime Meylan, Christophe Linhard, Etienne Becht, Nabila Elarouci, David Tavel, Lubka T. Roumenina, Mira Ayadi, Catherine Sautès-Fridman, Wolf H. Fridman, Aurélien de Reyniès
Published in: Genome Medicine, Issue 12/1, 2020, ISSN 1756-994X
DOI: 10.1186/s13073-020-00783-w

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Author(s): Alice C. O’Farrell and Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea Bertotti, Livio Trusolino, Annette T. Byrne and
Published in: Cancers, Issue 2020, 12(10), 2978, 2020, ISSN 2072-6694
DOI: 10.3390/cancers12102978

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author(s): Yu Bian; Monica Montone; Yonina R. Murciano-Goroff; Carlotta Cancelliere; Federica Di Nicolantonio; Efsevia Vakiani; Sheeno Thyparambil; Sandra Misale; Livio Trusolino; Pamela Arcella; Salvatore Siena; Huiyong Zhao; Alberto Bardelli; Adele Whaley; Annalisa Lorenzato; Simona Lamba; Marika Pinnelli; Benedetta Mussolin; Anuja Bhalkikar; Nicola Valeri; Nicola Valeri; Rona Yaeger; Neal Rosen; Elisa de
Published in: Cancer Discovery, Issue 5, 2020, ISSN 2159-8274
DOI: 10.1158/2159-8290.cd-20-0187

Anti-angiogenic drug scheduling optimisation with application to colorectal cancer

Author(s): M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne, J. H. Prehn
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-29318-5

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy

Author(s): Irene Catalano, Livio Trusolino
Published in: Cancer Cell, Issue 36/1, 2019, Page(s) 1-3, ISSN 1535-6108
DOI: 10.1016/j.ccell.2019.06.001

Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre‐Clinical Detection of Off‐Target Toxicities Associated with Sunitinib Malate

Author(s): Alice C. O'Farrell, Ian S. Miller, Rhys Evans, Marina Alamanou, Maurice Cary, Girish Mallya Udupi, Adam Lafferty, Naser Monsefi, Mattia Cremona, Jochen H. M. Prehn, Henk M. Verheul, William M. Gallagher, Mathias Gehrmann, Annette T. Byrne
Published in: PROTEOMICS – Clinical Applications, 2019, Page(s) 1800159, ISSN 1862-8346
DOI: 10.1002/prca.201800159

Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine

Author(s): Florent Petitprez, Cheng-Ming Sun, Laetitia Lacroix, Catherine Sautès-Fridman, Aurélien de Reyniès, Wolf H. Fridman
Published in: Frontiers in Oncology, Issue 8, 2018, ISSN 2234-943X
DOI: 10.3389/fonc.2018.00390

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Author(s): Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, Boris N. Kholodenko
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-34353-3

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A

Author(s): Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert
Published in: EBioMedicine, Issue 45, 2019, Page(s) 139-154, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2019.07.004

Adaptive mutability of colorectal cancers in response to targeted therapies

Author(s): Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, Nicole M. Reilly, Sabrina Arena, Simona Lamba, Alice Bartolini, Vito Amodio, Alessandro Magrì, Luca Novara, Ivana Sarotto, Zachary D. Nagel, Cortt G. Piett, Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Mattia Corigliano, Marco Gherardi, Marco Cosentino Lagomarsino, Federica Di Nicolantonio, Alberto
Published in: Science, Issue 366/6472, 2019, Page(s) 1473-1480, ISSN 0036-8075
DOI: 10.1126/science.aav4474

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Author(s): Irene Catalano, Elena Grassi, Andrea Bertotti, Livio Trusolino
Published in: Trends in Cancer, Issue 5/12, 2019, Page(s) 779-788, ISSN 2405-8033
DOI: 10.1016/j.trecan.2019.10.006

Therapeutic Targeting of the Colorectal Tumor Stroma

Author(s): Wolf H. Fridman, Ian Miller, Catherine Sautès-Fridman, Annette T. Byrne
Published in: Gastroenterology, Issue 158/2, 2020, Page(s) 303-321, ISSN 0016-5085
DOI: 10.1053/j.gastro.2019.09.045

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Author(s): Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Published in: Science Translational Medicine, Issue 12/555, 2020, Page(s) eaax8313, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aax8313

Precision Therapy in RAS Mutant Colorectal Cancer

Author(s): Rodrigo Dienstmann, Kate Connor, Annette T. Byrne, W.H. Fridman, D. Lambrechts, A. Sadanandam, L. Trusolino, J.H.M. Prehn, J. Tabernero, W. Kolch
Published in: Gastroenterology, Issue 158/4, 2020, Page(s) 806-811, ISSN 0016-5085
DOI: 10.1053/j.gastro.2019.12.051