Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions

Risultati finali

Website/online assets (maintained and updated during project)

Pubblicazioni

Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer

Autori: Simonetta M. Leto, Martina Ferri, Francesco Sassi, Eugenia R. Zanella, Francesca Cottino, Valentina Vurchio, Irene Catalano, Alessandro Ferrero, Caterina C. Zingaretti, Caterina Marchiò, Elena Grassi, Livio Trusolino, and Andrea Bertotti,
Pubblicato in: Clin Cancer Res, Numero Volume 29, Numero 6, 2023, Pagina/e 1102–13, ISSN 1557-3265
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-2550

Towards precision oncology with patient-derived xenografts

Autori: Eugenia R. Zanella; Elena Grassi; Livio Trusolino
Pubblicato in: Crossref, Numero 3, 2022, ISSN 1759-4782
Editore: Nature
DOI: 10.1038/s41571-022-00682-6

The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRASG12C Inhibitors.

Autori: Marika Pinnelli; Livio Trusolino
Pubblicato in: Cancer Discov. 2021;11:1874-1876, Numero 9, 2021, Pagina/e 1874-1876, ISSN 2159-8290
Editore: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-21-0609

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Autori: Aoife A. Nolan, Nourhan K. Aboud, Walter Kolch, David Matallanas
Pubblicato in: Genes, Numero 12/4, 2021, Pagina/e 553, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12040553

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Autori: Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito; Sun, Hua; Mashl, R. Jay; Davies, Sherri; Jeon, Ryan; Frech, Christian; Randjelovic, Jele
Pubblicato in: Nature Genetics, Numero 7, 2020, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1101/861393

Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Autori: Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S, Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P, Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L, Cittaro D, Tonon G.
Pubblicato in: Nature Biotechnology, Numero 40, 2022, Pagina/e 235–244, ISSN 1546-1696
Editore: Springer Nature
DOI: 10.1038/s41587-021-01031-1

Master Transcription Regulators and Transcription Factors Regulate Immune-Associated Differences Between Patients of African and European Ancestry With Colorectal Cancer

Autori: Myer PA, Kim H, Blümel AM, Finnegan E, Kel A, Thompson TV, Greally JM, Prehn JH, O’Connor DP, Friedman RA, Floratos A, Das S.
Pubblicato in: Gastro Hep Adv., Numero 1(3), 2022, Pagina/e 328-341, ISSN 2772-5723
Editore: Elsevier
DOI: 10.1016/j.gastha.2022.01.004

Precision oncology in metastatic colorectal cancer — from biology to medicine

Autori: Di Nicolantonio F, Vitiello PP, Marsoni S, Siena S, Tabernero J, Trusolino L, Bernards R, Bardelli A.
Pubblicato in: Nat Rev Clin Oncol., Numero 18, 2021, Pagina/e 506-525, ISSN 1759-4782
Editore: Springer Nature
DOI: 10.1038/s41571-021-00495-z

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Autori: Bas Ponsioen; Jasmin B. Post; Julian R. Buissant des Amorie; Dimitrios Laskaris; Ravian L. van Ineveld; Simone Kersten; Andrea Bertotti; Francesco Sassi; François Sipieter; François Sipieter; Benjamin Cappe; Sander Mertens; Ingrid Verlaan-Klink; Sylvia F. Boj; Rob G. J. Vries; Holger Rehmann; Peter Vandenabeele; Franck B. Riquet; Franck B. Riquet; Livio Trusolino; Johannes L. Bos; Hugo J. Snippe
Pubblicato in: Nature Cell Biology, Numero 10, 2021, Pagina/e 377–390, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

Autori: Florent Petitprez, Sacha Levy, Cheng-Ming Sun, Maxime Meylan, Christophe Linhard, Etienne Becht, Nabila Elarouci, David Tavel, Lubka T. Roumenina, Mira Ayadi, Catherine Sautès-Fridman, Wolf H. Fridman, Aurélien de Reyniès
Pubblicato in: Genome Medicine, Numero 12/1, 2020, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-020-00783-w

Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes

Autori: Marco Avolio; Livio Trusolino
Pubblicato in: Cancer Discov. 2021;11:1, Numero 8, 2021, Pagina/e 644-1660, ISSN 2159-8290
Editore: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-20-1531

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Autori: Alice C. O’Farrell and Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea Bertotti, Livio Trusolino, Annette T. Byrne and
Pubblicato in: Cancers, Numero 2020, 12(10), 2978, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102978

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Autori: Yu Bian; Monica Montone; Yonina R. Murciano-Goroff; Carlotta Cancelliere; Federica Di Nicolantonio; Efsevia Vakiani; Sheeno Thyparambil; Sandra Misale; Livio Trusolino; Pamela Arcella; Salvatore Siena; Huiyong Zhao; Alberto Bardelli; Adele Whaley; Annalisa Lorenzato; Simona Lamba; Marika Pinnelli; Benedetta Mussolin; Anuja Bhalkikar; Nicola Valeri; Nicola Valeri; Rona Yaeger; Neal Rosen; Elisa de
Pubblicato in: Cancer Discovery, Numero 5, 2020, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system

Autori: Simone Pernice; Roberta Sirovich; Elena Grassi; Marco Viviani; Martina Ferri; Francesco Sassi; Luca Alessandrı; Dora Tortarolo; Raffaele A. Calogero; Livio Trusolino; Andrea Bertotti; Marco Beccuti; Martina Olivero; Francesca Cordero
Pubblicato in: Bioinformatics, Numero 19, 2023, ISSN 1367-4811
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btad201

Anti-angiogenic drug scheduling optimisation with application to colorectal cancer

Autori: M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne, J. H. Prehn
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-29318-5

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy

Autori: Irene Catalano, Livio Trusolino
Pubblicato in: Cancer Cell, Numero 36/1, 2019, Pagina/e 1-3, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2019.06.001

Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine

Autori: Florent Petitprez, Cheng-Ming Sun, Laetitia Lacroix, Catherine Sautès-Fridman, Aurélien de Reyniès, Wolf H. Fridman
Pubblicato in: Frontiers in Oncology, Numero 8, 2018, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00390

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Autori: Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, Boris N. Kholodenko
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-34353-3

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A

Autori: Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert
Pubblicato in: EBioMedicine, Numero 45, 2019, Pagina/e 139-154, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.004

Adaptive mutability of colorectal cancers in response to targeted therapies

Autori: Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, Nicole M. Reilly, Sabrina Arena, Simona Lamba, Alice Bartolini, Vito Amodio, Alessandro Magrì, Luca Novara, Ivana Sarotto, Zachary D. Nagel, Cortt G. Piett, Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Mattia Corigliano, Marco Gherardi, Marco Cosentino Lagomarsino, Federica Di Nicolantonio, Alberto
Pubblicato in: Science, Numero 366/6472, 2019, Pagina/e 1473-1480, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aav4474

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Autori: Irene Catalano, Elena Grassi, Andrea Bertotti, Livio Trusolino
Pubblicato in: Trends in Cancer, Numero 5/12, 2019, Pagina/e 779-788, ISSN 2405-8033
Editore: Cell Press, Trends in Cancer
DOI: 10.1016/j.trecan.2019.10.006

Therapeutic Targeting of the Colorectal Tumor Stroma

Autori: Wolf H. Fridman, Ian Miller, Catherine Sautès-Fridman, Annette T. Byrne
Pubblicato in: Gastroenterology, Numero 158/2, 2020, Pagina/e 303-321, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.09.045

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Autori: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Pubblicato in: Science Translational Medicine, Numero 12/555, 2020, Pagina/e eaax8313, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

Effective drug combinations in breast, colon and pancreatic cancer cells

Autori: Jaaks, P., Coker, E.A., Vis, D.J. et al.
Pubblicato in: NATURE, Numero 603, 2022, Pagina/e 166–173, ISSN 1476-4687
Editore: Springer Nature
DOI: 10.1038/s41586-022-04437-2

Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models

Autori: Annabelle Nwaokorie and Dirk Fey
Pubblicato in: Int. J. Mol. Sci., Numero 9970; 2021 22(18), 2021, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189970

Precision Therapy in RAS Mutant Colorectal Cancer

Autori: Rodrigo Dienstmann, Kate Connor, Annette T. Byrne, W.H. Fridman, D. Lambrechts, A. Sadanandam, L. Trusolino, J.H.M. Prehn, J. Tabernero, W. Kolch
Pubblicato in: Gastroenterology, Numero 158/4, 2020, Pagina/e 806-811, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.12.051

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer

Autori: Adam Lafferty, Alice C O’Farrell, Giorgia Migliardi, Niraj Khemka, Andreas U Lindner, Francesco Sassi, Eugenia R Zanella, Manuela Salvucci, Evy Vanderheyden, Elodie Modave, Bram Boeckx, Luise Halang, Johannes Betge, Matthias P A Ebert, Patrick Dicker, Guillem Argilés, Josep Tabernero, Rodrigo Dienstmann, Enzo Medico, Diether Lambrechts, Andrea Bertotti, Claudio Isella, Livio Trusolino, Jochen H
Pubblicato in: Clin Cancer Res, Numero 27 (21), 2021, Pagina/e 5979–5992, ISSN 1557-3265
Editore: AACR Journals
DOI: 10.1158/1078-0432.ccr-21-0818

Towards a European Health Research and Innovation Cloud (HRIC)

Autori: Charles Auffray; P. Bogaert; N. P. Oxtoby; B. Claerhout; G. Bertolini; Rudi Balling; Niklas Blomberg; P. Oksvold; Lars Hjorth; G. D’Errico; C. Larue; J. Van Bussel; H. Van Oyen; C. Gans-Combe; W. J. Armitage; Gard O. S. Thomassen; C. Ohmann; Y. Ioannidis; Olaf Riess; Jan G. Bjaalie; N. Benhabiles; E. Morley-Fletcher; Josep Roca; B. De Meulder; A. E. Gray; A. Albeyatti; I. Perseil; H. Riper; A. M
Pubblicato in: Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020), Numero 6, 2020, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-020-0713-z

Risultati finali

Pubblicazioni

Condividi questa pagina

Scarica