Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions

Informacje na temat projektu

COLOSSUS

Identyfikator umowy o grant: 754923

DOI

10.3030/754923

Projekt został zamknięty

Data podpisania przez KE 21 Listopada 2017

Data rozpoczęcia 1 Stycznia 2018

Data zakończenia 30 Czerwca 2023

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 5 996 359,50

Wkład UE

€ 5 996 359,50

Koordynowany przez

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

Website/online assets (maintained and updated during project)

Publikacje

Peer reviewed articles (27)

Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer

Autorzy: Simonetta M. Leto, Martina Ferri, Francesco Sassi, Eugenia R. Zanella, Francesca Cottino, Valentina Vurchio, Irene Catalano, Alessandro Ferrero, Caterina C. Zingaretti, Caterina Marchiò, Elena Grassi, Livio Trusolino, and Andrea Bertotti,
Opublikowane w: Clin Cancer Res, Numer Volume 29, Numer 6, 2023, Strona(/y) 1102–13, ISSN 1557-3265
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-2550

Towards precision oncology with patient-derived xenografts

Autorzy: Eugenia R. Zanella; Elena Grassi; Livio Trusolino
Opublikowane w: Crossref, Numer 3, 2022, ISSN 1759-4782
Wydawca: Nature
DOI: 10.1038/s41571-022-00682-6

The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRASG12C Inhibitors.

Autorzy: Marika Pinnelli; Livio Trusolino
Opublikowane w: Cancer Discov. 2021;11:1874-1876, Numer 9, 2021, Strona(/y) 1874-1876, ISSN 2159-8290
Wydawca: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-21-0609

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Autorzy: Aoife A. Nolan, Nourhan K. Aboud, Walter Kolch, David Matallanas
Opublikowane w: Genes, Numer 12/4, 2021, Strona(/y) 553, ISSN 2073-4425
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12040553

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Autorzy: Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito; Sun, Hua; Mashl, R. Jay; Davies, Sherri; Jeon, Ryan; Frech, Christian; Randjelovic, Jele
Opublikowane w: Nature Genetics, Numer 7, 2020, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1101/861393

Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Autorzy: Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S, Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P, Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L, Cittaro D, Tonon G.
Opublikowane w: Nature Biotechnology, Numer 40, 2022, Strona(/y) 235–244, ISSN 1546-1696
Wydawca: Springer Nature
DOI: 10.1038/s41587-021-01031-1

Master Transcription Regulators and Transcription Factors Regulate Immune-Associated Differences Between Patients of African and European Ancestry With Colorectal Cancer

Autorzy: Myer PA, Kim H, Blümel AM, Finnegan E, Kel A, Thompson TV, Greally JM, Prehn JH, O’Connor DP, Friedman RA, Floratos A, Das S.
Opublikowane w: Gastro Hep Adv., Numer 1(3), 2022, Strona(/y) 328-341, ISSN 2772-5723
Wydawca: Elsevier
DOI: 10.1016/j.gastha.2022.01.004

Precision oncology in metastatic colorectal cancer — from biology to medicine

Autorzy: Di Nicolantonio F, Vitiello PP, Marsoni S, Siena S, Tabernero J, Trusolino L, Bernards R, Bardelli A.
Opublikowane w: Nat Rev Clin Oncol., Numer 18, 2021, Strona(/y) 506-525, ISSN 1759-4782
Wydawca: Springer Nature
DOI: 10.1038/s41571-021-00495-z

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Autorzy: Bas Ponsioen; Jasmin B. Post; Julian R. Buissant des Amorie; Dimitrios Laskaris; Ravian L. van Ineveld; Simone Kersten; Andrea Bertotti; Francesco Sassi; François Sipieter; François Sipieter; Benjamin Cappe; Sander Mertens; Ingrid Verlaan-Klink; Sylvia F. Boj; Rob G. J. Vries; Holger Rehmann; Peter Vandenabeele; Franck B. Riquet; Franck B. Riquet; Livio Trusolino; Johannes L. Bos; Hugo J. Snippe
Opublikowane w: Nature Cell Biology, Numer 10, 2021, Strona(/y) 377–390, ISSN 1465-7392
Wydawca: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

Autorzy: Florent Petitprez, Sacha Levy, Cheng-Ming Sun, Maxime Meylan, Christophe Linhard, Etienne Becht, Nabila Elarouci, David Tavel, Lubka T. Roumenina, Mira Ayadi, Catherine Sautès-Fridman, Wolf H. Fridman, Aurélien de Reyniès
Opublikowane w: Genome Medicine, Numer 12/1, 2020, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-020-00783-w

Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes

Autorzy: Marco Avolio; Livio Trusolino
Opublikowane w: Cancer Discov. 2021;11:1, Numer 8, 2021, Strona(/y) 644-1660, ISSN 2159-8290
Wydawca: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-20-1531

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Autorzy: Alice C. O’Farrell and Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea Bertotti, Livio Trusolino, Annette T. Byrne and
Opublikowane w: Cancers, Numer 2020, 12(10), 2978, 2020, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102978

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Autorzy: Yu Bian; Monica Montone; Yonina R. Murciano-Goroff; Carlotta Cancelliere; Federica Di Nicolantonio; Efsevia Vakiani; Sheeno Thyparambil; Sandra Misale; Livio Trusolino; Pamela Arcella; Salvatore Siena; Huiyong Zhao; Alberto Bardelli; Adele Whaley; Annalisa Lorenzato; Simona Lamba; Marika Pinnelli; Benedetta Mussolin; Anuja Bhalkikar; Nicola Valeri; Nicola Valeri; Rona Yaeger; Neal Rosen; Elisa de
Opublikowane w: Cancer Discovery, Numer 5, 2020, ISSN 2159-8274
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system

Autorzy: Simone Pernice; Roberta Sirovich; Elena Grassi; Marco Viviani; Martina Ferri; Francesco Sassi; Luca Alessandrı; Dora Tortarolo; Raffaele A. Calogero; Livio Trusolino; Andrea Bertotti; Marco Beccuti; Martina Olivero; Francesca Cordero
Opublikowane w: Bioinformatics, Numer 19, 2023, ISSN 1367-4811
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btad201

Anti-angiogenic drug scheduling optimisation with application to colorectal cancer

Autorzy: M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne, J. H. Prehn
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-29318-5

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy

Autorzy: Irene Catalano, Livio Trusolino
Opublikowane w: Cancer Cell, Numer 36/1, 2019, Strona(/y) 1-3, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2019.06.001

Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine

Autorzy: Florent Petitprez, Cheng-Ming Sun, Laetitia Lacroix, Catherine Sautès-Fridman, Aurélien de Reyniès, Wolf H. Fridman
Opublikowane w: Frontiers in Oncology, Numer 8, 2018, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00390

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Autorzy: Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, Boris N. Kholodenko
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-34353-3

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A

Autorzy: Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert
Opublikowane w: EBioMedicine, Numer 45, 2019, Strona(/y) 139-154, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.004

Adaptive mutability of colorectal cancers in response to targeted therapies

Autorzy: Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, Nicole M. Reilly, Sabrina Arena, Simona Lamba, Alice Bartolini, Vito Amodio, Alessandro Magrì, Luca Novara, Ivana Sarotto, Zachary D. Nagel, Cortt G. Piett, Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Mattia Corigliano, Marco Gherardi, Marco Cosentino Lagomarsino, Federica Di Nicolantonio, Alberto
Opublikowane w: Science, Numer 366/6472, 2019, Strona(/y) 1473-1480, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.aav4474

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Autorzy: Irene Catalano, Elena Grassi, Andrea Bertotti, Livio Trusolino
Opublikowane w: Trends in Cancer, Numer 5/12, 2019, Strona(/y) 779-788, ISSN 2405-8033
Wydawca: Cell Press, Trends in Cancer
DOI: 10.1016/j.trecan.2019.10.006

Therapeutic Targeting of the Colorectal Tumor Stroma

Autorzy: Wolf H. Fridman, Ian Miller, Catherine Sautès-Fridman, Annette T. Byrne
Opublikowane w: Gastroenterology, Numer 158/2, 2020, Strona(/y) 303-321, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.09.045

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Autorzy: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Opublikowane w: Science Translational Medicine, Numer 12/555, 2020, Strona(/y) eaax8313, ISSN 1946-6234
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

Effective drug combinations in breast, colon and pancreatic cancer cells

Autorzy: Jaaks, P., Coker, E.A., Vis, D.J. et al.
Opublikowane w: NATURE, Numer 603, 2022, Strona(/y) 166–173, ISSN 1476-4687
Wydawca: Springer Nature
DOI: 10.1038/s41586-022-04437-2

Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models

Autorzy: Annabelle Nwaokorie and Dirk Fey
Opublikowane w: Int. J. Mol. Sci., Numer 9970; 2021 22(18), 2021, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189970

Precision Therapy in RAS Mutant Colorectal Cancer

Autorzy: Rodrigo Dienstmann, Kate Connor, Annette T. Byrne, W.H. Fridman, D. Lambrechts, A. Sadanandam, L. Trusolino, J.H.M. Prehn, J. Tabernero, W. Kolch
Opublikowane w: Gastroenterology, Numer 158/4, 2020, Strona(/y) 806-811, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.12.051

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer

Autorzy: Adam Lafferty, Alice C O’Farrell, Giorgia Migliardi, Niraj Khemka, Andreas U Lindner, Francesco Sassi, Eugenia R Zanella, Manuela Salvucci, Evy Vanderheyden, Elodie Modave, Bram Boeckx, Luise Halang, Johannes Betge, Matthias P A Ebert, Patrick Dicker, Guillem Argilés, Josep Tabernero, Rodrigo Dienstmann, Enzo Medico, Diether Lambrechts, Andrea Bertotti, Claudio Isella, Livio Trusolino, Jochen H
Opublikowane w: Clin Cancer Res, Numer 27 (21), 2021, Strona(/y) 5979–5992, ISSN 1557-3265
Wydawca: AACR Journals
DOI: 10.1158/1078-0432.ccr-21-0818

Non-peer reviewed articles (1)

Towards a European Health Research and Innovation Cloud (HRIC)

Autorzy: Charles Auffray; P. Bogaert; N. P. Oxtoby; B. Claerhout; G. Bertolini; Rudi Balling; Niklas Blomberg; P. Oksvold; Lars Hjorth; G. D’Errico; C. Larue; J. Van Bussel; H. Van Oyen; C. Gans-Combe; W. J. Armitage; Gard O. S. Thomassen; C. Ohmann; Y. Ioannidis; Olaf Riess; Jan G. Bjaalie; N. Benhabiles; E. Morley-Fletcher; Josep Roca; B. De Meulder; A. E. Gray; A. Albeyatti; I. Perseil; H. Riper; A. M
Opublikowane w: Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020), Numer 6, 2020, ISSN 1756-994X
Wydawca: BioMed Central
DOI: 10.1186/s13073-020-0713-z