Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions

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Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer

Auteurs: Simonetta M. Leto, Martina Ferri, Francesco Sassi, Eugenia R. Zanella, Francesca Cottino, Valentina Vurchio, Irene Catalano, Alessandro Ferrero, Caterina C. Zingaretti, Caterina Marchiò, Elena Grassi, Livio Trusolino, and Andrea Bertotti,
Publié dans: Clin Cancer Res, Numéro Volume 29, Numéro 6, 2023, Page(s) 1102–13, ISSN 1557-3265
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-2550

Towards precision oncology with patient-derived xenografts

Auteurs: Eugenia R. Zanella; Elena Grassi; Livio Trusolino
Publié dans: Crossref, Numéro 3, 2022, ISSN 1759-4782
Éditeur: Nature
DOI: 10.1038/s41571-022-00682-6

The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRASG12C Inhibitors.

Auteurs: Marika Pinnelli; Livio Trusolino
Publié dans: Cancer Discov. 2021;11:1874-1876, Numéro 9, 2021, Page(s) 1874-1876, ISSN 2159-8290
Éditeur: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-21-0609

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Auteurs: Aoife A. Nolan, Nourhan K. Aboud, Walter Kolch, David Matallanas
Publié dans: Genes, Numéro 12/4, 2021, Page(s) 553, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12040553

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Auteurs: Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito; Sun, Hua; Mashl, R. Jay; Davies, Sherri; Jeon, Ryan; Frech, Christian; Randjelovic, Jele
Publié dans: Nature Genetics, Numéro 7, 2020, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1101/861393

Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Auteurs: Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S, Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P, Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L, Cittaro D, Tonon G.
Publié dans: Nature Biotechnology, Numéro 40, 2022, Page(s) 235–244, ISSN 1546-1696
Éditeur: Springer Nature
DOI: 10.1038/s41587-021-01031-1

Master Transcription Regulators and Transcription Factors Regulate Immune-Associated Differences Between Patients of African and European Ancestry With Colorectal Cancer

Auteurs: Myer PA, Kim H, Blümel AM, Finnegan E, Kel A, Thompson TV, Greally JM, Prehn JH, O’Connor DP, Friedman RA, Floratos A, Das S.
Publié dans: Gastro Hep Adv., Numéro 1(3), 2022, Page(s) 328-341, ISSN 2772-5723
Éditeur: Elsevier
DOI: 10.1016/j.gastha.2022.01.004

Precision oncology in metastatic colorectal cancer — from biology to medicine

Auteurs: Di Nicolantonio F, Vitiello PP, Marsoni S, Siena S, Tabernero J, Trusolino L, Bernards R, Bardelli A.
Publié dans: Nat Rev Clin Oncol., Numéro 18, 2021, Page(s) 506-525, ISSN 1759-4782
Éditeur: Springer Nature
DOI: 10.1038/s41571-021-00495-z

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Auteurs: Bas Ponsioen; Jasmin B. Post; Julian R. Buissant des Amorie; Dimitrios Laskaris; Ravian L. van Ineveld; Simone Kersten; Andrea Bertotti; Francesco Sassi; François Sipieter; François Sipieter; Benjamin Cappe; Sander Mertens; Ingrid Verlaan-Klink; Sylvia F. Boj; Rob G. J. Vries; Holger Rehmann; Peter Vandenabeele; Franck B. Riquet; Franck B. Riquet; Livio Trusolino; Johannes L. Bos; Hugo J. Snippe
Publié dans: Nature Cell Biology, Numéro 10, 2021, Page(s) 377–390, ISSN 1465-7392
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

Auteurs: Florent Petitprez, Sacha Levy, Cheng-Ming Sun, Maxime Meylan, Christophe Linhard, Etienne Becht, Nabila Elarouci, David Tavel, Lubka T. Roumenina, Mira Ayadi, Catherine Sautès-Fridman, Wolf H. Fridman, Aurélien de Reyniès
Publié dans: Genome Medicine, Numéro 12/1, 2020, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-020-00783-w

Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes

Auteurs: Marco Avolio; Livio Trusolino
Publié dans: Cancer Discov. 2021;11:1, Numéro 8, 2021, Page(s) 644-1660, ISSN 2159-8290
Éditeur: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-20-1531

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Auteurs: Alice C. O’Farrell and Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea Bertotti, Livio Trusolino, Annette T. Byrne and
Publié dans: Cancers, Numéro 2020, 12(10), 2978, 2020, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102978

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Auteurs: Yu Bian; Monica Montone; Yonina R. Murciano-Goroff; Carlotta Cancelliere; Federica Di Nicolantonio; Efsevia Vakiani; Sheeno Thyparambil; Sandra Misale; Livio Trusolino; Pamela Arcella; Salvatore Siena; Huiyong Zhao; Alberto Bardelli; Adele Whaley; Annalisa Lorenzato; Simona Lamba; Marika Pinnelli; Benedetta Mussolin; Anuja Bhalkikar; Nicola Valeri; Nicola Valeri; Rona Yaeger; Neal Rosen; Elisa de
Publié dans: Cancer Discovery, Numéro 5, 2020, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system

Auteurs: Simone Pernice; Roberta Sirovich; Elena Grassi; Marco Viviani; Martina Ferri; Francesco Sassi; Luca Alessandrı; Dora Tortarolo; Raffaele A. Calogero; Livio Trusolino; Andrea Bertotti; Marco Beccuti; Martina Olivero; Francesca Cordero
Publié dans: Bioinformatics, Numéro 19, 2023, ISSN 1367-4811
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btad201

Anti-angiogenic drug scheduling optimisation with application to colorectal cancer

Auteurs: M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne, J. H. Prehn
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-29318-5

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy

Auteurs: Irene Catalano, Livio Trusolino
Publié dans: Cancer Cell, Numéro 36/1, 2019, Page(s) 1-3, ISSN 1535-6108
Éditeur: Cell Press
DOI: 10.1016/j.ccell.2019.06.001

Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine

Auteurs: Florent Petitprez, Cheng-Ming Sun, Laetitia Lacroix, Catherine Sautès-Fridman, Aurélien de Reyniès, Wolf H. Fridman
Publié dans: Frontiers in Oncology, Numéro 8, 2018, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00390

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Auteurs: Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, Boris N. Kholodenko
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-34353-3

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A

Auteurs: Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert
Publié dans: EBioMedicine, Numéro 45, 2019, Page(s) 139-154, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.004

Adaptive mutability of colorectal cancers in response to targeted therapies

Auteurs: Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, Nicole M. Reilly, Sabrina Arena, Simona Lamba, Alice Bartolini, Vito Amodio, Alessandro Magrì, Luca Novara, Ivana Sarotto, Zachary D. Nagel, Cortt G. Piett, Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Mattia Corigliano, Marco Gherardi, Marco Cosentino Lagomarsino, Federica Di Nicolantonio, Alberto
Publié dans: Science, Numéro 366/6472, 2019, Page(s) 1473-1480, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aav4474

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Auteurs: Irene Catalano, Elena Grassi, Andrea Bertotti, Livio Trusolino
Publié dans: Trends in Cancer, Numéro 5/12, 2019, Page(s) 779-788, ISSN 2405-8033
Éditeur: Cell Press, Trends in Cancer
DOI: 10.1016/j.trecan.2019.10.006

Therapeutic Targeting of the Colorectal Tumor Stroma

Auteurs: Wolf H. Fridman, Ian Miller, Catherine Sautès-Fridman, Annette T. Byrne
Publié dans: Gastroenterology, Numéro 158/2, 2020, Page(s) 303-321, ISSN 0016-5085
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.09.045

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Auteurs: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Publié dans: Science Translational Medicine, Numéro 12/555, 2020, Page(s) eaax8313, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

Effective drug combinations in breast, colon and pancreatic cancer cells

Auteurs: Jaaks, P., Coker, E.A., Vis, D.J. et al.
Publié dans: NATURE, Numéro 603, 2022, Page(s) 166–173, ISSN 1476-4687
Éditeur: Springer Nature
DOI: 10.1038/s41586-022-04437-2

Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models

Auteurs: Annabelle Nwaokorie and Dirk Fey
Publié dans: Int. J. Mol. Sci., Numéro 9970; 2021 22(18), 2021, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189970

Precision Therapy in RAS Mutant Colorectal Cancer

Auteurs: Rodrigo Dienstmann, Kate Connor, Annette T. Byrne, W.H. Fridman, D. Lambrechts, A. Sadanandam, L. Trusolino, J.H.M. Prehn, J. Tabernero, W. Kolch
Publié dans: Gastroenterology, Numéro 158/4, 2020, Page(s) 806-811, ISSN 0016-5085
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.12.051

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer

Auteurs: Adam Lafferty, Alice C O’Farrell, Giorgia Migliardi, Niraj Khemka, Andreas U Lindner, Francesco Sassi, Eugenia R Zanella, Manuela Salvucci, Evy Vanderheyden, Elodie Modave, Bram Boeckx, Luise Halang, Johannes Betge, Matthias P A Ebert, Patrick Dicker, Guillem Argilés, Josep Tabernero, Rodrigo Dienstmann, Enzo Medico, Diether Lambrechts, Andrea Bertotti, Claudio Isella, Livio Trusolino, Jochen H
Publié dans: Clin Cancer Res, Numéro 27 (21), 2021, Page(s) 5979–5992, ISSN 1557-3265
Éditeur: AACR Journals
DOI: 10.1158/1078-0432.ccr-21-0818

Towards a European Health Research and Innovation Cloud (HRIC)

Auteurs: Charles Auffray; P. Bogaert; N. P. Oxtoby; B. Claerhout; G. Bertolini; Rudi Balling; Niklas Blomberg; P. Oksvold; Lars Hjorth; G. D’Errico; C. Larue; J. Van Bussel; H. Van Oyen; C. Gans-Combe; W. J. Armitage; Gard O. S. Thomassen; C. Ohmann; Y. Ioannidis; Olaf Riess; Jan G. Bjaalie; N. Benhabiles; E. Morley-Fletcher; Josep Roca; B. De Meulder; A. E. Gray; A. Albeyatti; I. Perseil; H. Riper; A. M
Publié dans: Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020), Numéro 6, 2020, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-020-0713-z

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