Advancing a Precision Medicine Paradigm in metastatic Colorectal Cancer: Systems based patient stratification solutions

Información del proyecto

COLOSSUS

Identificador del acuerdo de subvención: 754923

DOI

10.3030/754923

Proyecto cerrado

Fecha de la firma de la CE 21 Noviembre 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Junio 2023

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 996 359,50

Aportación de la UE

€ 5 996 359,50

Coordinado por

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Website/online assets (maintained and updated during project)

Publicaciones

Peer reviewed articles (27)

Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer

Autores: Simonetta M. Leto, Martina Ferri, Francesco Sassi, Eugenia R. Zanella, Francesca Cottino, Valentina Vurchio, Irene Catalano, Alessandro Ferrero, Caterina C. Zingaretti, Caterina Marchiò, Elena Grassi, Livio Trusolino, and Andrea Bertotti,
Publicado en: Clin Cancer Res, Edición Volume 29, Edición 6, 2023, Página(s) 1102–13, ISSN 1557-3265
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-2550

Towards precision oncology with patient-derived xenografts

Autores: Eugenia R. Zanella; Elena Grassi; Livio Trusolino
Publicado en: Crossref, Edición 3, 2022, ISSN 1759-4782
Editor: Nature
DOI: 10.1038/s41571-022-00682-6

The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRASG12C Inhibitors.

Autores: Marika Pinnelli; Livio Trusolino
Publicado en: Cancer Discov. 2021;11:1874-1876, Edición 9, 2021, Página(s) 1874-1876, ISSN 2159-8290
Editor: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-21-0609

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

Autores: Aoife A. Nolan, Nourhan K. Aboud, Walter Kolch, David Matallanas
Publicado en: Genes, Edición 12/4, 2021, Página(s) 553, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12040553

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Autores: Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito; Sun, Hua; Mashl, R. Jay; Davies, Sherri; Jeon, Ryan; Frech, Christian; Randjelovic, Jele
Publicado en: Nature Genetics, Edición 7, 2020, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1101/861393

Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Autores: Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S, Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P, Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L, Cittaro D, Tonon G.
Publicado en: Nature Biotechnology, Edición 40, 2022, Página(s) 235–244, ISSN 1546-1696
Editor: Springer Nature
DOI: 10.1038/s41587-021-01031-1

Master Transcription Regulators and Transcription Factors Regulate Immune-Associated Differences Between Patients of African and European Ancestry With Colorectal Cancer

Autores: Myer PA, Kim H, Blümel AM, Finnegan E, Kel A, Thompson TV, Greally JM, Prehn JH, O’Connor DP, Friedman RA, Floratos A, Das S.
Publicado en: Gastro Hep Adv., Edición 1(3), 2022, Página(s) 328-341, ISSN 2772-5723
Editor: Elsevier
DOI: 10.1016/j.gastha.2022.01.004

Precision oncology in metastatic colorectal cancer — from biology to medicine

Autores: Di Nicolantonio F, Vitiello PP, Marsoni S, Siena S, Tabernero J, Trusolino L, Bernards R, Bardelli A.
Publicado en: Nat Rev Clin Oncol., Edición 18, 2021, Página(s) 506-525, ISSN 1759-4782
Editor: Springer Nature
DOI: 10.1038/s41571-021-00495-z

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Autores: Bas Ponsioen; Jasmin B. Post; Julian R. Buissant des Amorie; Dimitrios Laskaris; Ravian L. van Ineveld; Simone Kersten; Andrea Bertotti; Francesco Sassi; François Sipieter; François Sipieter; Benjamin Cappe; Sander Mertens; Ingrid Verlaan-Klink; Sylvia F. Boj; Rob G. J. Vries; Holger Rehmann; Peter Vandenabeele; Franck B. Riquet; Franck B. Riquet; Livio Trusolino; Johannes L. Bos; Hugo J. Snippe
Publicado en: Nature Cell Biology, Edición 10, 2021, Página(s) 377–390, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-021-00654-5

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

Autores: Florent Petitprez, Sacha Levy, Cheng-Ming Sun, Maxime Meylan, Christophe Linhard, Etienne Becht, Nabila Elarouci, David Tavel, Lubka T. Roumenina, Mira Ayadi, Catherine Sautès-Fridman, Wolf H. Fridman, Aurélien de Reyniès
Publicado en: Genome Medicine, Edición 12/1, 2020, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-020-00783-w

Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes

Autores: Marco Avolio; Livio Trusolino
Publicado en: Cancer Discov. 2021;11:1, Edición 8, 2021, Página(s) 644-1660, ISSN 2159-8290
Editor: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-20-1531

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Autores: Alice C. O’Farrell and Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea Bertotti, Livio Trusolino, Annette T. Byrne and
Publicado en: Cancers, Edición 2020, 12(10), 2978, 2020, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102978

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Autores: Yu Bian; Monica Montone; Yonina R. Murciano-Goroff; Carlotta Cancelliere; Federica Di Nicolantonio; Efsevia Vakiani; Sheeno Thyparambil; Sandra Misale; Livio Trusolino; Pamela Arcella; Salvatore Siena; Huiyong Zhao; Alberto Bardelli; Adele Whaley; Annalisa Lorenzato; Simona Lamba; Marika Pinnelli; Benedetta Mussolin; Anuja Bhalkikar; Nicola Valeri; Nicola Valeri; Rona Yaeger; Neal Rosen; Elisa de
Publicado en: Cancer Discovery, Edición 5, 2020, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0187

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system

Autores: Simone Pernice; Roberta Sirovich; Elena Grassi; Marco Viviani; Martina Ferri; Francesco Sassi; Luca Alessandrı; Dora Tortarolo; Raffaele A. Calogero; Livio Trusolino; Andrea Bertotti; Marco Beccuti; Martina Olivero; Francesca Cordero
Publicado en: Bioinformatics, Edición 19, 2023, ISSN 1367-4811
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btad201

Anti-angiogenic drug scheduling optimisation with application to colorectal cancer

Autores: M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne, J. H. Prehn
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-29318-5

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy

Autores: Irene Catalano, Livio Trusolino
Publicado en: Cancer Cell, Edición 36/1, 2019, Página(s) 1-3, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2019.06.001

Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine

Autores: Florent Petitprez, Cheng-Ming Sun, Laetitia Lacroix, Catherine Sautès-Fridman, Aurélien de Reyniès, Wolf H. Fridman
Publicado en: Frontiers in Oncology, Edición 8, 2018, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00390

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Autores: Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, Boris N. Kholodenko
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-34353-3

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A

Autores: Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert
Publicado en: EBioMedicine, Edición 45, 2019, Página(s) 139-154, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2019.07.004

Adaptive mutability of colorectal cancers in response to targeted therapies

Autores: Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, Nicole M. Reilly, Sabrina Arena, Simona Lamba, Alice Bartolini, Vito Amodio, Alessandro Magrì, Luca Novara, Ivana Sarotto, Zachary D. Nagel, Cortt G. Piett, Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Mattia Corigliano, Marco Gherardi, Marco Cosentino Lagomarsino, Federica Di Nicolantonio, Alberto
Publicado en: Science, Edición 366/6472, 2019, Página(s) 1473-1480, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aav4474

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Autores: Irene Catalano, Elena Grassi, Andrea Bertotti, Livio Trusolino
Publicado en: Trends in Cancer, Edición 5/12, 2019, Página(s) 779-788, ISSN 2405-8033
Editor: Cell Press, Trends in Cancer
DOI: 10.1016/j.trecan.2019.10.006

Therapeutic Targeting of the Colorectal Tumor Stroma

Autores: Wolf H. Fridman, Ian Miller, Catherine Sautès-Fridman, Annette T. Byrne
Publicado en: Gastroenterology, Edición 158/2, 2020, Página(s) 303-321, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.09.045

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Autores: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar
Publicado en: Science Translational Medicine, Edición 12/555, 2020, Página(s) eaax8313, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8313

Effective drug combinations in breast, colon and pancreatic cancer cells

Autores: Jaaks, P., Coker, E.A., Vis, D.J. et al.
Publicado en: NATURE, Edición 603, 2022, Página(s) 166–173, ISSN 1476-4687
Editor: Springer Nature
DOI: 10.1038/s41586-022-04437-2

Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models

Autores: Annabelle Nwaokorie and Dirk Fey
Publicado en: Int. J. Mol. Sci., Edición 9970; 2021 22(18), 2021, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189970

Precision Therapy in RAS Mutant Colorectal Cancer

Autores: Rodrigo Dienstmann, Kate Connor, Annette T. Byrne, W.H. Fridman, D. Lambrechts, A. Sadanandam, L. Trusolino, J.H.M. Prehn, J. Tabernero, W. Kolch
Publicado en: Gastroenterology, Edición 158/4, 2020, Página(s) 806-811, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2019.12.051

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer

Autores: Adam Lafferty, Alice C O’Farrell, Giorgia Migliardi, Niraj Khemka, Andreas U Lindner, Francesco Sassi, Eugenia R Zanella, Manuela Salvucci, Evy Vanderheyden, Elodie Modave, Bram Boeckx, Luise Halang, Johannes Betge, Matthias P A Ebert, Patrick Dicker, Guillem Argilés, Josep Tabernero, Rodrigo Dienstmann, Enzo Medico, Diether Lambrechts, Andrea Bertotti, Claudio Isella, Livio Trusolino, Jochen H
Publicado en: Clin Cancer Res, Edición 27 (21), 2021, Página(s) 5979–5992, ISSN 1557-3265
Editor: AACR Journals
DOI: 10.1158/1078-0432.ccr-21-0818

Non-peer reviewed articles (1)

Towards a European Health Research and Innovation Cloud (HRIC)

Autores: Charles Auffray; P. Bogaert; N. P. Oxtoby; B. Claerhout; G. Bertolini; Rudi Balling; Niklas Blomberg; P. Oksvold; Lars Hjorth; G. D’Errico; C. Larue; J. Van Bussel; H. Van Oyen; C. Gans-Combe; W. J. Armitage; Gard O. S. Thomassen; C. Ohmann; Y. Ioannidis; Olaf Riess; Jan G. Bjaalie; N. Benhabiles; E. Morley-Fletcher; Josep Roca; B. De Meulder; A. E. Gray; A. Albeyatti; I. Perseil; H. Riper; A. M
Publicado en: Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020), Edición 6, 2020, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-020-0713-z