Safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS)

Projektinformationen

TUDCA-ALS

ID Finanzhilfevereinbarung: 755094

DOI

10.3030/755094

Projekt abgeschlossen

EK-Unterschriftsdatum 15 November 2017

Startdatum 1 Januar 2018

Enddatum 31 Dezember 2023

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 5 596 928,00

EU-Beitrag

€ 5 596 928,00

Koordiniert durch

HUMANITAS MIRASOLE SPA
Italy

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Open Research Data Pilot (1)

Report on status of posting results in the study registry

Report on status of posting results in the study registry. The report will include the status of the result posting as well as the timelines when final posting of results is scheduled at end of funding period (Month 72)

Documents, reports (4)

Dissemination and exploitation plan

Dissemination and Exploitation Plan. The document will describe the dissemination and exploitation strategies and action plan (Month 3

Statistical analysis of primary and secondary outcome variables

Statistical analysis of primary and secondary outcome variables. (Month 72) This report will include the statistical analysis on primary and secondaty outcome variables

Demographic and clinical description of the study population

This report will include study population data on demographic and clinical aspects

Statistical analysis of biomarker and correlation with clinical outcomes

Statistical analysis of biomarker and correlation with clinical outcomes. (Month 66) This report will include data on statistical analysis of biomarkers and related correlation to clinical outcomes.

Websites, patent fillings, videos etc. (1)

Project website

Project website. The report will include the characteristics of the website, the activities involved for its creation and print screens of the website pages (Month 6

Veröffentlichungen

Peer reviewed articles (6)

Review of disease-modifying drug trials in amyotrophic lateral sclerosis

Autoren: Paolo Tornese; Stefania Lalli; Antoniangela Cocco; Alberto Albanese
Veröffentlicht in: Journal of Neurology Neurosurgery and Psychiatry, Ausgabe 3, 2022, Seite(n) 521-529, ISSN 0022-3050
Herausgeber: BMJ Publishing Group
DOI: 10.1136/jnnp-2021-328470

Tauro-Urso-Deoxycholic Acid Trials in Amyotrophic Lateral Sclerosis: What is Achieved and What to Expect

Autoren: Maria Lo Giudice, Antoniangela Cocco, Giorgio Reggiardo, Stefania Lalli, Alberto Albanese
Veröffentlicht in: Clinical Drug Investigation, 2023, ISSN 1179-1918
Herausgeber: Springer
DOI: 10.1007/s40261-023-01324-0

Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases

Autoren: Kareem Khalaf; Paolo Tornese; Antoniangela Cocco; Alberto Albanese
Veröffentlicht in: Translational Neurodegeneration, Ausgabe 3, 2022, Seite(n) 33, ISSN 2047-9158
Herausgeber: Springer Nature
DOI: 10.1186/s40035-022-00307-z

A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial

Autoren: Flavia L Lombardo, Stefania Spila Alegiani, Flavia Mayer, Marta Cipriani, Maria Lo Giudice, Albert Christian Ludolph, Christopher J McDermott, Philippe Corcia, Philip Van Damme, Leonard H Van den Berg, Orla Hardiman, Gabriele Nicolini, Nicola Vanacore, Brian Dickie, Alberto Albanese, Maria Puopolo; TUDCA-ALS Study Group (Paolo Tornese, Antoniangela Cocco, Michela Matteoli, Eliana Lauranzano, Maria
Veröffentlicht in: Trials, 2023, ISSN 1745-6215
Herausgeber: BioMed Central
DOI: 10.1186/s13063-023-07638-w

Cox regression and survival analysis from the tauro-urso-deoxycholic trial in amyotrophic lateral sclerosis

Autoren: Giorgio Reggiardo; Maria Lo Giudice; Stefania Lalli; Gilberto Rinaldi; Alberto Albanese
Veröffentlicht in: Frontiers in Neurology, Ausgabe 5, 2023, ISSN 1664-2295
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fneur.2023.1163855

Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol

Autoren: Alberto Albanese, Albert Christian Ludolph, Christopher J McDermott, Philippe Corcia, Philip Van Damme, Leonard H Van den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dickie, TUDCA-ALS Study Group (Tornese Paolo, Cocco Antoniangela, Lo Giudice Maria, Matteoli Michela, Lauranzano Eliana, Malosio Maria Luisa, Adriana Elia Chiara, Lombardo Flavia, Mayer Flavia, Puopolo Maria, Alegian
Veröffentlicht in: Frontiers in Neurology, Ausgabe 16642295, 2022, ISSN 1664-2295
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.1009113