Implications of Medical Low Dose Radiation Exposure

Livrables

Report on optimisation of multi-modality imaging

Report on optimisation of multimodality imaging

Midterm recruitment report. Recruitment applies only to the nested case control study
Report on estimated doses for the case-control study subjects
Report on status of posting results in the study registry(s) for WP5

Report on status of posting results in the study registrys for WP5

Report on the current use of multi-modality systems in nuclear medicine
Update of administered activity-to-organ-dose conversion factors for two commonly used radiopharmaceuticals

Update of administered activitytoorgandose conversion factors for two commonly used radiopharmaceuticals

Report on results of the analysis miRNA and lncRNA
MEDIRAD Second Recommendations
Guidelines and recommendations for quantitative I-131 imaging and dosimetry
Midterm recruitment report for radiopharmaceutical dosimetry study
MEDIRAD Third Recommendations
Comprehensive Reporting Templates and Pilot system for SR-Reporting
Report on a) the organ dose data representation and b) collected organ doses
Report on results of dose-response analyses from case-control study

Report on results of doseresponse analyses from casecontrol study

Report on status of posting results in the study registry(s) for WP3

Report on status of posting results in the study registrys for WP3

MEDIRAD First Reommendations

MEDIRAD First Recommendations

Correlation analysis between objective and subjective image quality in chest CT patient parameter and indication dependent
Second Stakeholder Board annual report
Report on the organization and findings of the two seminars organized within Task 6.4

Report on the organization and findings of the two seminars organized within Task 64

Report on the Stakeholder Forum: composition, content of the web-consultation, guidelines for the use of the stakeholder infrastructure
Report on the use of the DNA damage assay to determine radiosensitivity in patients
Third Stakeholder Board annual report
Report on status of posting results in the study registry(s) for WP2
Report on system integration and publication of the basic user guidelines
Imaging and data collection study protocols
Report on results of the analyses of factors – environmental, genetic and epigenetic – that can modify risk of cancer following low doses of radiation from CT scanning in childhood and adolescence

Report on results of the analyses of factors environmental genetic and epigenetic that can modify risk of cancer following low doses of radiation from CT scanning in childhood and adolescence

European DRLs for specific applications of CT in multi-modality systems
Organ dose conversion coefficients for the estimation of patient doses from CT for attenuation correction and anatomic localization in multi-modality imaging
Report on results of the analysis of exomes and methylation
Report on validation of centres for imaging network
Protocol for a large scale epidemiological study
Report on effectiveness of protective devices for staff in interventional procedures
Report on results of extended follow-up of cohorts

Report on results of extended followup of cohorts

MEDIRAD Fourth Recommendations
Midterm recruitment report for WP3
Project website and visual identity

Project website and visual identity established and completed

First Stakeholder Board annual report

Dosimetry protocol and software
Implementation of the prototype of the central DICOM repository
Implementation and testing of the RDF repository
Biokinetic model for treatment planning
Accelerated Monte Carlo code for an on-line patient monitoring system in interventional cardiology procedures
Software tool (CT-IQURAD) module on image quality
Software tool (CT-IQURAD) module on radiation dose
Catalogue with Codes relevant for MEDIRAD project
Six segmented thorax phantoms

Publications

Efficacy of MAVIG X-Ray Protective Drapes in Reducing CTO Operator Radiation

Auteurs: Keir McCutcheon, Maarten Vanhaverbeke, Jérémie Dabin, Ruben Pauwels, Werner Schoonjans, Walter Desmet, Johan Bennett
Publié dans: Journal of Interventional Cardiology, Numéro 2021, 2021, ISSN 0896-4327
Éditeur: Blackwell Publishing Inc.
DOI: 10.1155/2021/3146104

Validation of organ dose calculations with PyMCGPU-IR in realistic interventional set-ups

Auteurs: David Fernández-Bosman, Ariel von Barnekow, Jérémie Dabin, Françoise Malchair, Filip Vanhavere, Maria Amor Duch, Mercè Ginjaume
Publié dans: Physica Medica, Numéro 93, 2021, Page(s) 29-37, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2021.12.004

MEDIRAD formulation of science-based recommendations for medical radiation protection: a stakeholder forum survey

Auteurs: M. Benderitter, E. Herrera Reyes, M.A. Benadjaoud, F. Vanhavere, N. Impens, U. Mayerhofer-Sebera, M. Hierath, J.R. Jourdain, G. Frija, J. Repussard
Publié dans: Radioprotection, Numéro 56 / 4, 2021, Page(s) 275 - 285, ISSN 0033-8451
Éditeur: EDP Sciences
DOI: 10.1051/radiopro/2021030

Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

Auteurs: Magy Sallam, Mohammed Abderrafi Benotmane, Sarah Baatout, Pieter-Jan Guns, An Aerts
Publié dans: Epigenetics, Numéro 17 / 1, 2021, Page(s) 59-80, ISSN 1559-2308
Éditeur: Taylor & Francis
DOI: 10.1080/15592294.2021.1873628

Penalized estimation of the Gaussian graphical model from data with replicates

Auteurs: Wessel N. van Wieringen,Yao Chen
Publié dans: Statistics in Medicine, Numéro 40 / 19, 2021, Page(s) 4279-4293, ISSN 1097-0258
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/sim.9028

Evaluation of a suspended radiation protection system to reduce operator exposure in cardiology interventional procedures

Auteurs: Federica Zanca PhD, Jérémie Dabin IR, Celine Collard DNP, Nicolas Alexandre IR, Alicia De Groote IR, Jean Paul Salembier MD, Michel Henry MD, Emmanuel Rombaut MD, Sonia Sghaier MD, Pierre-Emmanuel Massart MD
Publié dans: Catheterization and Cardiovascular Interventions, Numéro 98 / 5, 2021, Page(s) E687-E694, ISSN 1522-726X
Éditeur: John Wiley & Sons, Ltd.
DOI: 10.1002/ccd.29894

The effect of lead free cap on the doses of ionizing radiation to the head of interventional cardiologists working in haemodynamic room

Auteurs: Włodzimierz Grabowicz, Konrad Masiarek, Tomasz Górnik, Tomasz Grycewicz, Marcin Brodecki, Jérémie Dabin, Christelle Huet, Filip Vanhavere, Joanna K. Domienik-Andrzejewska
Publié dans: International Journal of occupational medicine and environmental health, Numéro 2022, 2022, ISSN 1232-1087
Éditeur: Instytut Medycyny Pracy im. Jerzego Nofera/Nofer Institute of Occupational Medicine
DOI: 10.13075/ijomeh.1896.01958

VIEWDEX 3.0 - recent development of a software application facilitating assessment of image quality and observer performance

Auteurs: Angelica Svalkvist, Sune Svensson, Tommy Hagberg, Magnus Båth
Publié dans: Radiation Protection Dosimetry, Numéro 195 / 3-4, 2021, Page(s) 372–377, ISSN 1742-3406
Éditeur: Oxford University Press
DOI: 10.1093/rpd/ncab014

Simulating the dynamics of atherosclerosis to the incidence of myocardial infarction, applied to the KORA population

Auteurs: Cristoforo Simonetto, Susanne Rospleszcz, Margit Heier, Christa Meisinger, Annette Peters, Jan Christian Kaiser
Publié dans: Statistics in Medicine, Numéro 40 / 14, 2021, Page(s) 3299-3312, ISSN 1097-0258
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/sim.8951

Does deep inspiration breath-hold prolong life? Individual risk estimates of ischaemic heart disease after breast cancer radiotherapy

Auteurs: Cristoforo Simonetto, Markus Eidemüller, Aurélie Gaasch, Montserrat Pazos, Stephan Schönecker, Daniel Reitz, Stefan Kääb, Michael Braun, Nadia Harbeck, Maximilian Niyazi, Claus Belka, Stefanie Corradini
Publié dans: Radiotherapy and Oncology, Numéro 7 Aug 2018 (on-line publication), 2018, Page(s) Print not yet available, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2018.07.024

Automatic Tube Current Modulation and Tube Voltage Selection in Pediatric Computed Tomography

Auteurs: Antonios E. Papadakis, John Damilakis
Publié dans: Investigative Radiology, Numéro December 17, 2018 - Volume Publish Ahead of Print - Numéro - p, 2019, Page(s) 1, ISSN 0020-9996
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rli.0000000000000537

Early Detection of Cardiovascular Changes After Radiotherapy for Breast Cancer: Protocol for a European Multicenter Prospective Cohort Study (MEDIRAD EARLY HEART Study)

Auteurs: Valentin Walker, Anne Crijns, Johannes Langendijk, Daan Spoor, Rozemarijn Vliegenthart, Stephanie E Combs, Michael Mayinger, Arantxa Eraso, Ferran Guedea, Manuela Fiuza, Susana Constantino, Radia Tamarat, Dominique Laurier, Jean Ferrières, Elie Mousseaux, Elisabeth Cardis, Sophie Jacob
Publié dans: JMIR Research Protocols, Numéro 7/10, 2018, Page(s) e178, ISSN 1929-0748
Éditeur: Journal of Medical Internet Research (JMIR) Publications
DOI: 10.2196/resprot.9906

Conference Program

Auteurs: J. Damilakis
Publié dans: Medical Physics, Numéro 45/6, 2018, Page(s) 2691-2794, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.12968

Clinical Trials in Radiology

Auteurs: M.-O. Bernier, S. Jacob, A.P.G. Crijns, J.A. Langendijk, R. Vliegenhart, S.E. Combs, M. Mayinger, A. Eraso, F. Guedea, M. Fiuza, S. Constantino Rosa Santos, E. Mousseaux, E. Cardis, G. Frija
Publié dans: Insights into Imaging, Numéro 9/S1, 2018, Page(s) 643-649, ISSN 1869-4101
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s13244-018-0625-2

342. “MEDIRAD – Implications of Medical Low Dose Radiation Exposure”: A European-funded project aims to enhance the protection of patients and health professionals from exposure to low dose medical radiation

Auteurs: A. Palma, E. Cisbani, C. De Angelis, S. Della Monaca, V. Dini, S. Grande, A. Rosi
Publié dans: Physica Medica, Numéro 56, 2018, Page(s) 268-269, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2018.04.351

Risk for cardiovascular events responds nonlinearly to carotid intima-media thickness in the KORA F4 study

Auteurs: Cristoforo Simonetto, Margit Heier, Susanne Rospleszcz, Christa Meisinger, Cornelia Then, Jochen Seißler, Annette Peters, Jan Christian Kaiser
Publié dans: Atherosclerosis, Numéro 296, 2020, Page(s) 32-39, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2020.01.013

OpenDose: open access resources for nuclear medicine dosimetry

Auteurs: Maxime Chauvin, Damian Borys, Francesca Botta, Pawel Bzowski, Jérémie Dabin, Ana M Denis-Bacelar, Aurélie Desbrée, Nadia Falzone, Boon Quand Lee, Andrea Mairiani, Alessandra Malaroda, Gilles Mathieu, Erin McKay, Erick Mora-Ramirez, Andrew P Robinson, David Sarrut, Lara Struelens, Alex Vergara Gil, Manuel Bardiès
Publié dans: Journal of Nuclear Medicine, 2020, Page(s) jnumed.119.240366, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.240366

Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study

Auteurs: Helmut Schöllnberger, Jan Christian Kaiser, Markus Eidemüller, Lydia B. Zablotska
Publié dans: Radiation and Environmental Biophysics, Numéro 59/1, 2020, Page(s) 63-78, ISSN 0301-634X
Éditeur: Springer Verlag
DOI: 10.1007/s00411-019-00819-9

Standardised quantitative radioiodine SPECT/CT Imaging for multicentre dosimetry trials in molecular radiotherapy

Auteurs: Rebecca A Gregory, Iain Murray, Jonathan Gear, Francesca Leek, Sarah Chittenden, Andrew Fenwick, Jill Wevrett, James Scuffham, Jill Tipping, Brian Murby, Steve Jeans, Martha Stuffins, Sofia Michopoulou, Matthew Guy, Darren Morgan, Aida Hallam, David Hall, Heather Polydor, Colin Brown, Gerry Gillen, Nathan Dickinson, Sarah Brown, Jonathan Wadsley, Glenn Flux
Publié dans: Physics in Medicine & Biology, Numéro 64/24, 2019, Page(s) 245013, ISSN 1361-6560
Éditeur: IOP Publishing on behalf of the Institute of Physics and Engineering in Medicine
DOI: 10.1088/1361-6560/ab5b6c

A multicentric IT platform for storage and sharing of imaging-based radiation dosimetric data

Auteurs: Joël Spaltenstein, Nicolas van Dooren, Gérôme Pasquier, Nicolas Roduit, Marine Brenet, Guillaume Pasquier, Bernard Gibaud, Peter Mildenberger, Osman Ratib
Publié dans: International Journal of Computer Assisted Radiology and Surgery, 2020, ISSN 1861-6410
Éditeur: Springer Verlag
DOI: 10.1007/s11548-020-02179-y

A Hybrid Reporting Platform for Extended RadLex Coding Combining Structured Reporting Templates and Natural Language Processing

Auteurs: Florian Jungmann, G. Arnhold, B. Kämpgen, T. Jorg, C. Düber, P. Mildenberger, R. Kloeckner
Publié dans: Journal of Digital Imaging, 2020, ISSN 0897-1889
Éditeur: Springer Verlag
DOI: 10.1007/s10278-020-00342-0

When Stiffness Matters: Mechanosensing in Heart Development and Disease

Auteurs: Roberto Gaetani, Eric Adriano Zizzi, Marco Agostino Deriu, Umberto Morbiducci, Maurizio Pesce, Elisa Messina
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 8, 2020, Page(s) Article 334, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.00334

Evaluation of an organ-based tube current modulation tool in pediatric CT examinations

Auteurs: Antonios E. Papadakis, John Damilakis
Publié dans: European Radiology, 2020, ISSN 0938-7994
Éditeur: Springer Verlag
DOI: 10.1007/s00330-020-06888-5

Longitudinal atherosclerotic changes after radio(chemo)therapy of hypopharyngeal carcinoma

Auteurs: Cristoforo Simonetto, Michael Mayinger, Thamer Ahmed, Kai Borm, Pavel Kundrát, Steffi Pigorsch, Jan Christian Kaiser, Stephanie E. Combs
Publié dans: Radiation Oncology, Numéro 15/1, 2020, ISSN 1748-717X
Éditeur: BioMed Central
DOI: 10.1186/s13014-020-01541-3

Compartmental Model for 223Ra-Dichloride in Patients With Metastatic Bone Disease From Castration-Resistant Prostate Cancer

Auteurs: Jan Taprogge, Iain Murray, Jonathan Gear, Sarah J. Chittenden, Christopher C. Parker, Glenn D. Flux
Publié dans: International Journal of Radiation Oncology*Biology*Physics, Numéro 105/4, 2019, Page(s) 884-892, ISSN 0360-3016
Éditeur: Elsevier BV
DOI: 10.1016/j.ijrobp.2019.07.022

DNA damage and repair in peripheral blood mononuclear cells after internal ex vivo irradiation of patient blood with 131I

Auteurs: S. Schumann, H. Scherthan, K. Pfestroff, S. Schoof, A. Pfestroff, P. Hartrampf, N. Hasenauer, A. K. Buck, M. Luster, M. Port, M. Lassmann & U. Eberlein
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, Numéro 49, 2022, Page(s) 1447-1455, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-021-05605-8

Occupational exposure to physicians working with a Zero-Gravity™ protection system in haemodynamic and electrophysiology labs and the assessment of its performance against a standard ceiling suspended shield

Auteurs: Joanna Domienik-Andrzejewska, Mateusz Mirowski, Marek Jastrzębski, Tomasz Górnik, Konrad Masiarek, Izabela Warchoł & Włodzimierz Grabowicz
Publié dans: Radiation and Environmental Biophysics, Numéro 61, 2022, Page(s) 293-300, ISSN 0301-634X
Éditeur: Springer Verlag
DOI: 10.1007/s00411-022-00968-4

Setting up a quantitative SPECT imaging network for a European multi-centre dosimetry study of radioiodine treatment for thyroid cancer as part of the MEDIRAD project

Auteurs: Jan Taprogge, Francesca Leek, Tino Schurrat, Johannes Tran-Gia, Delphine Vallot, Manuel Bardiès, Uta Eberlein, Michael Lassmann, Susanne Schlögl, Alex Vergara Gil, the MEDIRAD WP3 Investigator Team & Glenn D. Flux
Publié dans: EJNMMI Physics, Numéro 7 / 61, 2020, ISSN 2197-7364
Éditeur: Springer
DOI: 10.1186/s40658-020-00332-9

From atherosclerosis to myocardial infarction – a process-oriented model investigating the role of risk factors

Auteurs: Cristoforo Simonetto, Margit Heier, Annette Peters, Jan Christian Kaiser, Susanne Rospleszcz Author Notes
Publié dans: American Journal of Epidemiology, Numéro 2022, 2022, ISSN 0002-9262
Éditeur: Oxford University Press
DOI: 10.1093/aje/kwac038

Generation of clinical 177Lu SPECT/CT images based on Monte Carlo simulation with GATE

Auteurs: Gunjan Kayal, Maxime Chauvin, Alex Vergara-Gil, Naomi Clayton, Ludovic Ferrer, Tumelo Moalosi, Peter Knoll, Lara Struelens, Manuel Bardiès
Publié dans: Physica Medica, Numéro 85, 2021, Page(s) 24-31, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2021.04.002

Modelling SPECT auto-contouring acquisitions for 177Lu & 131I molecular radiotherapy using new developments in Geant4/GATE

Auteurs: Gunjan Kayal, Maxime Chauvin, Erick Mora-Ramirez, Naomi Clayton, Alex Vergara-Gil, Johannes Tran-Gia, Michael Lassmann, Nicholas Calvert, Jill Tipping, Lara Struelens, Manuel Bardiès
Publié dans: Physica Medica, Numéro 96, 2022, Page(s) 101-113, ISSN 1120-1797
Éditeur: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2022.03.003

Adjustment of the iodine ICRP population pharmacokinetic model for the use in thyroid cancer patients after thyroidectomy

Auteurs: Jan Taprogge, Lily Carnegie-Peake, Iain Murray, Jonathan I Gear, Glenn D Flux
Publié dans: Journal of Radiological Protection, Numéro 41 / 4, 2021, ISSN 0952-4746
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6498/ac149a

Building an Artificial Cardiac Microenvironment: A Focus on the Extracellular Matrix.

Auteurs: Olivia Pagliarosi; Vittorio Picchio; Isotta Chimenti; Isotta Chimenti; Elisa Messina; Roberto Gaetani; Roberto Gaetani
Publié dans: Frontiers in Cell and Development Biology, Numéro 12, 2020, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.559032

Efficacy of MAVIG X-Ray Protective Drapes in Reducing Operator Radiation Dose in the Cardiac Catheterization Laboratory

Auteurs: Keir McCutcheon, Maarten Vanhaverbeke, Ruben Pauwels, Jérémie Dabin, Werner Schoonjans, Johan Bennett, Tom Adriaenssens, Christophe Dubois, Peter Sinnaeve and Walter Desmet
Publié dans: Circulation: Cardiovascular Interventions, Numéro 13 / 11, 2020, ISSN 1941-7632
Éditeur: American Heart Association
DOI: 10.1161/circinterventions.120.009627

Implications of Medical Low Dose Radiation Exposure (MEDIRAD)

Auteurs: E. Cardis, G. Frija, EIBIR
Publié dans: European Congress of Radiology 2018 (EuroSafe Imaging poster exhibition), 2018
Éditeur: European Society of Radiology
DOI: 10.1594/esi2018/esi-0080

MEDIRAD project “implications of medical low dose radiation exposure”: Enhancing the protection of patients and health professionals from exposure to low dose medical radiation

Auteurs: S. Grande, A.Palma, E. Cisbani, C. De Angelis, S. Della Monaca, V. Dini, A. Rosi, on behalf of the MEDIRAD Consortium
Publié dans: "Il Nuovo Cimento (proceedings of ""XVIII Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni"")", Numéro IL NUOVO CIMENTO41 C(2018) 214, 2019
Éditeur: Società Italiana di Fisica
DOI: 10.1393/ncc/i2018-18214-5

Image quality assessment of real patient thorax CT images using modulation transfer function and noise power spectrum

Auteurs: Zahra Passand, Christoph Hoeschen
Publié dans: Medical Imaging 2020: Physics of Medical Imaging, 2020, Page(s) 94, ISBN 9781-510633926
Éditeur: SPIE
DOI: 10.1117/12.2550073

Radiotherapy-induced cardiotoxicity in breast cancer patients: New approaches of early detection and prediction based on cardiac imaging and circulating biomarkers (European MEDIRAD EARLY-HEART study)

Auteurs: V. Walker, S. Jacob, A. Crijns, J. Langendijk, D. Spoor, R. Vliegenthart, S. Combs, M. Mayinger, K. Borm, A. Eraso, F. Guedea, M. Fiuza, S. Constantino Rosa Santos, R. Tamarat, D. Laurier, J. Ferrières, E. Cardis, E. Mousseaux
Publié dans: Archives of Cardiovascular Diseases Supplements, Numéro 11/1, 2019, Page(s) 124-125, ISSN 1878-6480
Éditeur: Elsevier Masson
DOI: 10.1016/j.acvdsp.2018.10.275

Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain

Auteurs: F Leek, J Taprogge R Gregory, K Newbold, F Verburg, M Luster, T Schurrat, J Trans-Gia, U Eberlein, C Lapa, AK Buck, M Lassmann, E Mora-Ramirez, A Vergara-Gil, M Bardies, D Vallot, F Courbon, L Vija, G Flux
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, Numéro 46/S1, 2019, Page(s) 1-952, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-019-04486-2

British Nuclear Medicine Society 47th Annual Spring Meeting, Oxford 1st–3rd April 2019

Auteurs: J Taprogge et al: A population pharmacokinetic model for 131I-NaI therapy after thyroidectomy in thyroid cancer patients F Leek et al: The MEDIRAD multinational I-131 dosimetry study for thyroid ablation and adjuvant therapy
Publié dans: Nuclear Medicine Communications, Numéro 40/4, 2019, Page(s) 393-453, ISSN 0143-3636
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mnm.0000000000000998

Biological effects of thoracic irradiation with low to moderate daily doses on rat lung

Auteurs: Rocha, Filipe Nunes
Publié dans: Numéro 2, 2019
Éditeur: Universidade de Lisboa

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