Implications of Medical Low Dose Radiation Exposure

Risultati finali

Report on optimisation of multi-modality imaging

Report on optimisation of multimodality imaging

Midterm recruitment report. Recruitment applies only to the nested case control study
Report on estimated doses for the case-control study subjects
Report on status of posting results in the study registry(s) for WP5

Report on status of posting results in the study registrys for WP5

Report on the current use of multi-modality systems in nuclear medicine
Update of administered activity-to-organ-dose conversion factors for two commonly used radiopharmaceuticals

Update of administered activitytoorgandose conversion factors for two commonly used radiopharmaceuticals

Report on results of the analysis miRNA and lncRNA
MEDIRAD Second Recommendations
Guidelines and recommendations for quantitative I-131 imaging and dosimetry
Midterm recruitment report for radiopharmaceutical dosimetry study
MEDIRAD Third Recommendations
Comprehensive Reporting Templates and Pilot system for SR-Reporting
Report on a) the organ dose data representation and b) collected organ doses
Report on results of dose-response analyses from case-control study

Report on results of doseresponse analyses from casecontrol study

Report on status of posting results in the study registry(s) for WP3

Report on status of posting results in the study registrys for WP3

MEDIRAD First Reommendations

MEDIRAD First Recommendations

Correlation analysis between objective and subjective image quality in chest CT patient parameter and indication dependent
Second Stakeholder Board annual report
Report on the organization and findings of the two seminars organized within Task 6.4

Report on the organization and findings of the two seminars organized within Task 64

Report on the Stakeholder Forum: composition, content of the web-consultation, guidelines for the use of the stakeholder infrastructure
Report on the use of the DNA damage assay to determine radiosensitivity in patients
Third Stakeholder Board annual report
Report on status of posting results in the study registry(s) for WP2
Report on system integration and publication of the basic user guidelines
Imaging and data collection study protocols
Report on results of the analyses of factors – environmental, genetic and epigenetic – that can modify risk of cancer following low doses of radiation from CT scanning in childhood and adolescence

Report on results of the analyses of factors environmental genetic and epigenetic that can modify risk of cancer following low doses of radiation from CT scanning in childhood and adolescence

European DRLs for specific applications of CT in multi-modality systems
Organ dose conversion coefficients for the estimation of patient doses from CT for attenuation correction and anatomic localization in multi-modality imaging
Report on results of the analysis of exomes and methylation
Report on validation of centres for imaging network
Protocol for a large scale epidemiological study
Report on effectiveness of protective devices for staff in interventional procedures
Report on results of extended follow-up of cohorts

Report on results of extended followup of cohorts

MEDIRAD Fourth Recommendations
Midterm recruitment report for WP3
Project website and visual identity

Project website and visual identity established and completed

First Stakeholder Board annual report

Dosimetry protocol and software
Implementation of the prototype of the central DICOM repository
Implementation and testing of the RDF repository
Biokinetic model for treatment planning
Accelerated Monte Carlo code for an on-line patient monitoring system in interventional cardiology procedures
Software tool (CT-IQURAD) module on image quality
Software tool (CT-IQURAD) module on radiation dose
Catalogue with Codes relevant for MEDIRAD project
Six segmented thorax phantoms

Pubblicazioni

Efficacy of MAVIG X-Ray Protective Drapes in Reducing CTO Operator Radiation

Autori: Keir McCutcheon, Maarten Vanhaverbeke, Jérémie Dabin, Ruben Pauwels, Werner Schoonjans, Walter Desmet, Johan Bennett
Pubblicato in: Journal of Interventional Cardiology, Numero 2021, 2021, ISSN 0896-4327
Editore: Blackwell Publishing Inc.
DOI: 10.1155/2021/3146104

Validation of organ dose calculations with PyMCGPU-IR in realistic interventional set-ups

Autori: David Fernández-Bosman, Ariel von Barnekow, Jérémie Dabin, Françoise Malchair, Filip Vanhavere, Maria Amor Duch, Mercè Ginjaume
Pubblicato in: Physica Medica, Numero 93, 2021, Pagina/e 29-37, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2021.12.004

MEDIRAD formulation of science-based recommendations for medical radiation protection: a stakeholder forum survey

Autori: M. Benderitter, E. Herrera Reyes, M.A. Benadjaoud, F. Vanhavere, N. Impens, U. Mayerhofer-Sebera, M. Hierath, J.R. Jourdain, G. Frija, J. Repussard
Pubblicato in: Radioprotection, Numero 56 / 4, 2021, Pagina/e 275 - 285, ISSN 0033-8451
Editore: EDP Sciences
DOI: 10.1051/radiopro/2021030

Radiation-induced cardiovascular disease: an overlooked role for DNA methylation?

Autori: Magy Sallam, Mohammed Abderrafi Benotmane, Sarah Baatout, Pieter-Jan Guns, An Aerts
Pubblicato in: Epigenetics, Numero 17 / 1, 2021, Pagina/e 59-80, ISSN 1559-2308
Editore: Taylor & Francis
DOI: 10.1080/15592294.2021.1873628

Penalized estimation of the Gaussian graphical model from data with replicates

Autori: Wessel N. van Wieringen,Yao Chen
Pubblicato in: Statistics in Medicine, Numero 40 / 19, 2021, Pagina/e 4279-4293, ISSN 1097-0258
Editore: John Wiley & Sons Ltd
DOI: 10.1002/sim.9028

Evaluation of a suspended radiation protection system to reduce operator exposure in cardiology interventional procedures

Autori: Federica Zanca PhD, Jérémie Dabin IR, Celine Collard DNP, Nicolas Alexandre IR, Alicia De Groote IR, Jean Paul Salembier MD, Michel Henry MD, Emmanuel Rombaut MD, Sonia Sghaier MD, Pierre-Emmanuel Massart MD
Pubblicato in: Catheterization and Cardiovascular Interventions, Numero 98 / 5, 2021, Pagina/e E687-E694, ISSN 1522-726X
Editore: John Wiley & Sons, Ltd.
DOI: 10.1002/ccd.29894

The effect of lead free cap on the doses of ionizing radiation to the head of interventional cardiologists working in haemodynamic room

Autori: Włodzimierz Grabowicz, Konrad Masiarek, Tomasz Górnik, Tomasz Grycewicz, Marcin Brodecki, Jérémie Dabin, Christelle Huet, Filip Vanhavere, Joanna K. Domienik-Andrzejewska
Pubblicato in: International Journal of occupational medicine and environmental health, Numero 2022, 2022, ISSN 1232-1087
Editore: Instytut Medycyny Pracy im. Jerzego Nofera/Nofer Institute of Occupational Medicine
DOI: 10.13075/ijomeh.1896.01958

VIEWDEX 3.0 - recent development of a software application facilitating assessment of image quality and observer performance

Autori: Angelica Svalkvist, Sune Svensson, Tommy Hagberg, Magnus Båth
Pubblicato in: Radiation Protection Dosimetry, Numero 195 / 3-4, 2021, Pagina/e 372–377, ISSN 1742-3406
Editore: Oxford University Press
DOI: 10.1093/rpd/ncab014

Simulating the dynamics of atherosclerosis to the incidence of myocardial infarction, applied to the KORA population

Autori: Cristoforo Simonetto, Susanne Rospleszcz, Margit Heier, Christa Meisinger, Annette Peters, Jan Christian Kaiser
Pubblicato in: Statistics in Medicine, Numero 40 / 14, 2021, Pagina/e 3299-3312, ISSN 1097-0258
Editore: John Wiley & Sons Ltd
DOI: 10.1002/sim.8951

Does deep inspiration breath-hold prolong life? Individual risk estimates of ischaemic heart disease after breast cancer radiotherapy

Autori: Cristoforo Simonetto, Markus Eidemüller, Aurélie Gaasch, Montserrat Pazos, Stephan Schönecker, Daniel Reitz, Stefan Kääb, Michael Braun, Nadia Harbeck, Maximilian Niyazi, Claus Belka, Stefanie Corradini
Pubblicato in: Radiotherapy and Oncology, Numero 7 Aug 2018 (on-line publication), 2018, Pagina/e Print not yet available, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2018.07.024

Automatic Tube Current Modulation and Tube Voltage Selection in Pediatric Computed Tomography

Autori: Antonios E. Papadakis, John Damilakis
Pubblicato in: Investigative Radiology, Numero December 17, 2018 - Volume Publish Ahead of Print - Numero - p, 2019, Pagina/e 1, ISSN 0020-9996
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/rli.0000000000000537

Early Detection of Cardiovascular Changes After Radiotherapy for Breast Cancer: Protocol for a European Multicenter Prospective Cohort Study (MEDIRAD EARLY HEART Study)

Autori: Valentin Walker, Anne Crijns, Johannes Langendijk, Daan Spoor, Rozemarijn Vliegenthart, Stephanie E Combs, Michael Mayinger, Arantxa Eraso, Ferran Guedea, Manuela Fiuza, Susana Constantino, Radia Tamarat, Dominique Laurier, Jean Ferrières, Elie Mousseaux, Elisabeth Cardis, Sophie Jacob
Pubblicato in: JMIR Research Protocols, Numero 7/10, 2018, Pagina/e e178, ISSN 1929-0748
Editore: Journal of Medical Internet Research (JMIR) Publications
DOI: 10.2196/resprot.9906

Conference Program

Autori: J. Damilakis
Pubblicato in: Medical Physics, Numero 45/6, 2018, Pagina/e 2691-2794, ISSN 0094-2405
Editore: American Association of Physicists in Medicine
DOI: 10.1002/mp.12968

Clinical Trials in Radiology

Autori: M.-O. Bernier, S. Jacob, A.P.G. Crijns, J.A. Langendijk, R. Vliegenhart, S.E. Combs, M. Mayinger, A. Eraso, F. Guedea, M. Fiuza, S. Constantino Rosa Santos, E. Mousseaux, E. Cardis, G. Frija
Pubblicato in: Insights into Imaging, Numero 9/S1, 2018, Pagina/e 643-649, ISSN 1869-4101
Editore: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s13244-018-0625-2

342. “MEDIRAD – Implications of Medical Low Dose Radiation Exposure”: A European-funded project aims to enhance the protection of patients and health professionals from exposure to low dose medical radiation

Autori: A. Palma, E. Cisbani, C. De Angelis, S. Della Monaca, V. Dini, S. Grande, A. Rosi
Pubblicato in: Physica Medica, Numero 56, 2018, Pagina/e 268-269, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2018.04.351

Risk for cardiovascular events responds nonlinearly to carotid intima-media thickness in the KORA F4 study

Autori: Cristoforo Simonetto, Margit Heier, Susanne Rospleszcz, Christa Meisinger, Cornelia Then, Jochen Seißler, Annette Peters, Jan Christian Kaiser
Pubblicato in: Atherosclerosis, Numero 296, 2020, Pagina/e 32-39, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2020.01.013

OpenDose: open access resources for nuclear medicine dosimetry

Autori: Maxime Chauvin, Damian Borys, Francesca Botta, Pawel Bzowski, Jérémie Dabin, Ana M Denis-Bacelar, Aurélie Desbrée, Nadia Falzone, Boon Quand Lee, Andrea Mairiani, Alessandra Malaroda, Gilles Mathieu, Erin McKay, Erick Mora-Ramirez, Andrew P Robinson, David Sarrut, Lara Struelens, Alex Vergara Gil, Manuel Bardiès
Pubblicato in: Journal of Nuclear Medicine, 2020, Pagina/e jnumed.119.240366, ISSN 0161-5505
Editore: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.240366

Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study

Autori: Helmut Schöllnberger, Jan Christian Kaiser, Markus Eidemüller, Lydia B. Zablotska
Pubblicato in: Radiation and Environmental Biophysics, Numero 59/1, 2020, Pagina/e 63-78, ISSN 0301-634X
Editore: Springer Verlag
DOI: 10.1007/s00411-019-00819-9

Standardised quantitative radioiodine SPECT/CT Imaging for multicentre dosimetry trials in molecular radiotherapy

Autori: Rebecca A Gregory, Iain Murray, Jonathan Gear, Francesca Leek, Sarah Chittenden, Andrew Fenwick, Jill Wevrett, James Scuffham, Jill Tipping, Brian Murby, Steve Jeans, Martha Stuffins, Sofia Michopoulou, Matthew Guy, Darren Morgan, Aida Hallam, David Hall, Heather Polydor, Colin Brown, Gerry Gillen, Nathan Dickinson, Sarah Brown, Jonathan Wadsley, Glenn Flux
Pubblicato in: Physics in Medicine & Biology, Numero 64/24, 2019, Pagina/e 245013, ISSN 1361-6560
Editore: IOP Publishing on behalf of the Institute of Physics and Engineering in Medicine
DOI: 10.1088/1361-6560/ab5b6c

A multicentric IT platform for storage and sharing of imaging-based radiation dosimetric data

Autori: Joël Spaltenstein, Nicolas van Dooren, Gérôme Pasquier, Nicolas Roduit, Marine Brenet, Guillaume Pasquier, Bernard Gibaud, Peter Mildenberger, Osman Ratib
Pubblicato in: International Journal of Computer Assisted Radiology and Surgery, 2020, ISSN 1861-6410
Editore: Springer Verlag
DOI: 10.1007/s11548-020-02179-y

A Hybrid Reporting Platform for Extended RadLex Coding Combining Structured Reporting Templates and Natural Language Processing

Autori: Florian Jungmann, G. Arnhold, B. Kämpgen, T. Jorg, C. Düber, P. Mildenberger, R. Kloeckner
Pubblicato in: Journal of Digital Imaging, 2020, ISSN 0897-1889
Editore: Springer Verlag
DOI: 10.1007/s10278-020-00342-0

When Stiffness Matters: Mechanosensing in Heart Development and Disease

Autori: Roberto Gaetani, Eric Adriano Zizzi, Marco Agostino Deriu, Umberto Morbiducci, Maurizio Pesce, Elisa Messina
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 8, 2020, Pagina/e Article 334, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.00334

Evaluation of an organ-based tube current modulation tool in pediatric CT examinations

Autori: Antonios E. Papadakis, John Damilakis
Pubblicato in: European Radiology, 2020, ISSN 0938-7994
Editore: Springer Verlag
DOI: 10.1007/s00330-020-06888-5

Longitudinal atherosclerotic changes after radio(chemo)therapy of hypopharyngeal carcinoma

Autori: Cristoforo Simonetto, Michael Mayinger, Thamer Ahmed, Kai Borm, Pavel Kundrát, Steffi Pigorsch, Jan Christian Kaiser, Stephanie E. Combs
Pubblicato in: Radiation Oncology, Numero 15/1, 2020, ISSN 1748-717X
Editore: BioMed Central
DOI: 10.1186/s13014-020-01541-3

Compartmental Model for 223Ra-Dichloride in Patients With Metastatic Bone Disease From Castration-Resistant Prostate Cancer

Autori: Jan Taprogge, Iain Murray, Jonathan Gear, Sarah J. Chittenden, Christopher C. Parker, Glenn D. Flux
Pubblicato in: International Journal of Radiation Oncology*Biology*Physics, Numero 105/4, 2019, Pagina/e 884-892, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2019.07.022

DNA damage and repair in peripheral blood mononuclear cells after internal ex vivo irradiation of patient blood with 131I

Autori: S. Schumann, H. Scherthan, K. Pfestroff, S. Schoof, A. Pfestroff, P. Hartrampf, N. Hasenauer, A. K. Buck, M. Luster, M. Port, M. Lassmann & U. Eberlein
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, Numero 49, 2022, Pagina/e 1447-1455, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-021-05605-8

Occupational exposure to physicians working with a Zero-Gravity™ protection system in haemodynamic and electrophysiology labs and the assessment of its performance against a standard ceiling suspended shield

Autori: Joanna Domienik-Andrzejewska, Mateusz Mirowski, Marek Jastrzębski, Tomasz Górnik, Konrad Masiarek, Izabela Warchoł & Włodzimierz Grabowicz
Pubblicato in: Radiation and Environmental Biophysics, Numero 61, 2022, Pagina/e 293-300, ISSN 0301-634X
Editore: Springer Verlag
DOI: 10.1007/s00411-022-00968-4

Setting up a quantitative SPECT imaging network for a European multi-centre dosimetry study of radioiodine treatment for thyroid cancer as part of the MEDIRAD project

Autori: Jan Taprogge, Francesca Leek, Tino Schurrat, Johannes Tran-Gia, Delphine Vallot, Manuel Bardiès, Uta Eberlein, Michael Lassmann, Susanne Schlögl, Alex Vergara Gil, the MEDIRAD WP3 Investigator Team & Glenn D. Flux
Pubblicato in: EJNMMI Physics, Numero 7 / 61, 2020, ISSN 2197-7364
Editore: Springer
DOI: 10.1186/s40658-020-00332-9

From atherosclerosis to myocardial infarction – a process-oriented model investigating the role of risk factors

Autori: Cristoforo Simonetto, Margit Heier, Annette Peters, Jan Christian Kaiser, Susanne Rospleszcz Author Notes
Pubblicato in: American Journal of Epidemiology, Numero 2022, 2022, ISSN 0002-9262
Editore: Oxford University Press
DOI: 10.1093/aje/kwac038

Generation of clinical 177Lu SPECT/CT images based on Monte Carlo simulation with GATE

Autori: Gunjan Kayal, Maxime Chauvin, Alex Vergara-Gil, Naomi Clayton, Ludovic Ferrer, Tumelo Moalosi, Peter Knoll, Lara Struelens, Manuel Bardiès
Pubblicato in: Physica Medica, Numero 85, 2021, Pagina/e 24-31, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2021.04.002

Modelling SPECT auto-contouring acquisitions for 177Lu & 131I molecular radiotherapy using new developments in Geant4/GATE

Autori: Gunjan Kayal, Maxime Chauvin, Erick Mora-Ramirez, Naomi Clayton, Alex Vergara-Gil, Johannes Tran-Gia, Michael Lassmann, Nicholas Calvert, Jill Tipping, Lara Struelens, Manuel Bardiès
Pubblicato in: Physica Medica, Numero 96, 2022, Pagina/e 101-113, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2022.03.003

Adjustment of the iodine ICRP population pharmacokinetic model for the use in thyroid cancer patients after thyroidectomy

Autori: Jan Taprogge, Lily Carnegie-Peake, Iain Murray, Jonathan I Gear, Glenn D Flux
Pubblicato in: Journal of Radiological Protection, Numero 41 / 4, 2021, ISSN 0952-4746
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6498/ac149a

Building an Artificial Cardiac Microenvironment: A Focus on the Extracellular Matrix.

Autori: Olivia Pagliarosi; Vittorio Picchio; Isotta Chimenti; Isotta Chimenti; Elisa Messina; Roberto Gaetani; Roberto Gaetani
Pubblicato in: Frontiers in Cell and Development Biology, Numero 12, 2020, ISSN 2296-634X
Editore: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.559032

Efficacy of MAVIG X-Ray Protective Drapes in Reducing Operator Radiation Dose in the Cardiac Catheterization Laboratory

Autori: Keir McCutcheon, Maarten Vanhaverbeke, Ruben Pauwels, Jérémie Dabin, Werner Schoonjans, Johan Bennett, Tom Adriaenssens, Christophe Dubois, Peter Sinnaeve and Walter Desmet
Pubblicato in: Circulation: Cardiovascular Interventions, Numero 13 / 11, 2020, ISSN 1941-7632
Editore: American Heart Association
DOI: 10.1161/circinterventions.120.009627

Implications of Medical Low Dose Radiation Exposure (MEDIRAD)

Autori: E. Cardis, G. Frija, EIBIR
Pubblicato in: European Congress of Radiology 2018 (EuroSafe Imaging poster exhibition), 2018
Editore: European Society of Radiology
DOI: 10.1594/esi2018/esi-0080

MEDIRAD project “implications of medical low dose radiation exposure”: Enhancing the protection of patients and health professionals from exposure to low dose medical radiation

Autori: S. Grande, A.Palma, E. Cisbani, C. De Angelis, S. Della Monaca, V. Dini, A. Rosi, on behalf of the MEDIRAD Consortium
Pubblicato in: "Il Nuovo Cimento (proceedings of ""XVIII Convegno Nazionale della Società Italiana per le Ricerche sulle Radiazioni"")", Numero IL NUOVO CIMENTO41 C(2018) 214, 2019
Editore: Società Italiana di Fisica
DOI: 10.1393/ncc/i2018-18214-5

Image quality assessment of real patient thorax CT images using modulation transfer function and noise power spectrum

Autori: Zahra Passand, Christoph Hoeschen
Pubblicato in: Medical Imaging 2020: Physics of Medical Imaging, 2020, Pagina/e 94, ISBN 9781-510633926
Editore: SPIE
DOI: 10.1117/12.2550073

Radiotherapy-induced cardiotoxicity in breast cancer patients: New approaches of early detection and prediction based on cardiac imaging and circulating biomarkers (European MEDIRAD EARLY-HEART study)

Autori: V. Walker, S. Jacob, A. Crijns, J. Langendijk, D. Spoor, R. Vliegenthart, S. Combs, M. Mayinger, K. Borm, A. Eraso, F. Guedea, M. Fiuza, S. Constantino Rosa Santos, R. Tamarat, D. Laurier, J. Ferrières, E. Cardis, E. Mousseaux
Pubblicato in: Archives of Cardiovascular Diseases Supplements, Numero 11/1, 2019, Pagina/e 124-125, ISSN 1878-6480
Editore: Elsevier Masson
DOI: 10.1016/j.acvdsp.2018.10.275

Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain

Autori: F Leek, J Taprogge R Gregory, K Newbold, F Verburg, M Luster, T Schurrat, J Trans-Gia, U Eberlein, C Lapa, AK Buck, M Lassmann, E Mora-Ramirez, A Vergara-Gil, M Bardies, D Vallot, F Courbon, L Vija, G Flux
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, Numero 46/S1, 2019, Pagina/e 1-952, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-019-04486-2

British Nuclear Medicine Society 47th Annual Spring Meeting, Oxford 1st–3rd April 2019

Autori: J Taprogge et al: A population pharmacokinetic model for 131I-NaI therapy after thyroidectomy in thyroid cancer patients F Leek et al: The MEDIRAD multinational I-131 dosimetry study for thyroid ablation and adjuvant therapy
Pubblicato in: Nuclear Medicine Communications, Numero 40/4, 2019, Pagina/e 393-453, ISSN 0143-3636
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mnm.0000000000000998

Biological effects of thoracic irradiation with low to moderate daily doses on rat lung

Autori: Rocha, Filipe Nunes
Pubblicato in: Numero 2, 2019
Editore: Universidade de Lisboa

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