Obiettivo Autism spectrum disorders (ASD) affect 1-2% of the population and are a major public health issue. Heterogeneity between affected ASD individuals is substantial both at clinical and etiological levels, thus warranting the idea that we should begin characterizing the ASD population as multiple kinds of ‘autisms’. Without an advanced understanding of how heterogeneity manifests in ASD, it is likely that we will not make pronounced progress towards translational research goals that can have real impact on patient’s lives. This research program is focused on decomposing heterogeneity in ASD at multiple levels of analysis. Using multiple ‘big data’ resources that are both ‘broad’ (large sample size) and ‘deep’ (multiple levels of analysis measured within each individual), I will examine how known variables such as sex, early language development, early social preferences, and early intervention treatment response may be important stratification variables that differentiate ASD subgroups at phenotypic, neural systems/circuits, and genomic levels of analysis. In addition to examining known stratification variables, this research program will engage in data-driven discovery via application of advanced unsupervised computational techniques that can highlight novel multivariate distinctions in the data that signal important ASD subgroups. These data-driven approaches may hold promise for discovering novel ASD subgroups at biological and phenotypic levels of analysis that may be valuable for prioritization in future work developing personalized assessment, monitoring, and treatment strategies for subsets of the ASD population. By enhancing the precision of our understanding about multiple subtypes of ASD this work will help accelerate progress towards the ideals of personalized medicine and help to reduce the burden of ASD on individuals, families, and society. Campo scientifico scienze mediche e della salutescienze della salutesalute pubblicascienze naturaliinformatica e scienze dell'informazionescienza dei datimegadatiscienze mediche e della salutescienze della salutemedicina personalizzata Parole chiave autism precision medicine heterogeneity subtypes stratification development toddler connectome phenome big data brain gene expression fMRI clustering biomarker Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-2017-STG - ERC Starting Grant Invito a presentare proposte ERC-2017-STG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-STG - Starting Grant Coordinatore FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Contribution nette de l'UE € 1 122 969,85 Indirizzo Via morego 30 16163 Genova Italia Mostra sulla mappa Regione Nord-Ovest Liguria Genova Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00 Beneficiari (3) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italia Contribution nette de l'UE € 1 122 969,85 Indirizzo Via morego 30 16163 Genova Mostra sulla mappa Regione Nord-Ovest Liguria Genova Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Stati Uniti Contribution nette de l'UE € 281 250,00 Indirizzo Franklin street 1111 12 floor 94607 Oakland ca Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00 UNIVERSITY OF CYPRUS Partecipazione conclusa Cipro Contribution nette de l'UE € 95 224,15 Indirizzo Avenue panepistimiou 2109 aglantzi 1678 Nicosia Mostra sulla mappa Regione Κύπρος Κύπρος Κύπρος Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Altri finanziamenti € 0,00
