Periodic Reporting for period 4 - HIV ECLIPSE (HIV-1 acquisition and the future of prevention strategies: deciphering the eclipse phase through modelling and phylogenetics)
Berichtszeitraum: 2021-08-01 bis 2023-01-31
This work will likely lead to new insights about how HIV infection becomes established, why vaccine candidates have failed, and advance the use of quantitative methodology in this understudied but important area.
Our work has found that the transmitting partner during sexual exposure determines both the number of virus particles and the number of founding variants that establishes infection in the recipient partner. That is, during early infection, the transmitting partner is responsible for transmitting twice the number of founding variants as would be transmitted during the later stage of infection.