Protein nano-patterning using DNA nanotechnology; control of surface-based immune system activation

Publicaciones

Selecting optimal support grids for super-resolution cryogenic correlated light and electron microscopy

Autores: Mart G. F. Last, Maarten W. Tuijtel, Lenard M. Voortman, Thomas H. Sharp
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-35590-x

Alternative Polyadenylation Utilization Results in Ribosome Assembly and mRNA Translation Deficiencies in a Model for Muscle Aging

Autores: Hailiang Mei, PhD, Jasper Boom, BSc, Salma el Abdellaoui, BSc, Kotb Abdelmohsen, PhD, Rachel Munk, MSc, Jennifer L Martindale, MSc, Susan Kloet, PhD, Szymone M Kielbasa, PhD, Thomas H Sharp, PhD, Myriam Gorospe, PhD, Vered Raz, PhD
Publicado en: The Journals of Gerontology: Series A, 2022, ISSN 1079-5006
Editor: Gerontological Society of America
DOI: 10.1093/gerona/glac058

Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein

Autores: Dylan P. Noone, Tijn T. van der Velden and Thomas H. Sharp
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.757633

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

Autores: Douwe J Dijkstra, Fleur S van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia SM Kramer, Linda M Slot, Jan W Drijfhout, Lisanne de Vor, Kyra A Gelderman, Suzan HM Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H Sharp, Paul WHI Parren, Leendert A Trouw
Publicado en: PNAS, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2310666120

PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation

Autores: Dylan P. Noone, Douwe J. Dijkstra, Teun T. van der Klugt https, Peter A. van Veelen, Arnoud H. de Ru, Paul J. Hensbergen, Leendert A. Trouw, and Thomas H. Sharp
Publicado en: Proceedings of the National Academy of Sciences, USA, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.220814411

Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM

Autores: Mart G.F. Last; Willem E.M. Noteborn; Lenard M. Voortman; Thomas H. Sharp
Publicado en: Journal of Structural Biology, Edición 2, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.108040

Efficient mRNA delivery using lipid nanoparticles modified with fusogenic coiled-coil peptides

Autores: Ye Zeng, Mengjie Shen, Roy Pattipeiluhu, Xuequan Zhou, Yun Zhang, Thomas Bakkum, Thomas H Sharp, Aimee L Boyle, Alexander Kros
Publicado en: Nanoscale, 2023, ISSN 2040-3372
Editor: Royal Society of Chemistry
DOI: 10.1039/d3nr02175k

Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins

Autores: Maarten W. Tuijtel, Abraham J. Koster, Stefan Jakobs, Frank G. A. Faas, Thomas H. Sharp
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-37728-8

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Autores: R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. Ru, G. M. C. Janssen, P. A. Veelen, E. T. J. den Bremer, B. Bleijlevens, B.‐J. Kreuk, F. J. Beurskens, L. A. Trouw
Publicado en: Clinical & Experimental Immunology, Edición 200/1, 2020, Página(s) 1-11, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cei.13411

scNodes: a correlation and processing toolkit for super-resolution fluorescence and electron microscopy

Autores: Mart G. F. Last; Lenard M. Voortman; Thomas H. Sharp
Publicado en: Nature Methods, 2023, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-023-01991-z

Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

Autores: Thomas H. Sharp, Aimee L. Boyle, Christoph A. Diebolder, Alexander Kros, Abraham J. Koster, Piet Gros
Publicado en: Proceedings of the National Academy of Sciences, 2019, Página(s) 201901841, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1901841116

Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

Autores: Roy Pattipeiluhu, Ye Zeng, Marco M.R.M. Hendrix, Ilja K. Voets, Alexander Kros, Thomas H. Sharp
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-45666-5

One-Pot Synthesis of Defined-Length ssDNA for Multiscaffold DNA Origami

Autores: Willem E. M. Noteborn, Leoni Abendstein, Thomas H. Sharp
Publicado en: Bioconjugate Chemistry, Edición 32/1, 2021, Página(s) 94-98, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00644

Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System

Autores: Roy Pattipeiluhu,Gabriela Arias-Alpizar,Genc Basha,Karen Y. T. Chan,Jeroen Bussmann,Thomas H. Sharp,Mohammad-Amin Moradi,Nico Sommerdijk,Edward N. Harris,Pieter R. Cullis,Alexander Kros,Dominik Witzigmann,Frederick Campbell
Publicado en: Advanced Materials, 2022, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202201095

Measuring cryo-TEM sample thickness using reflected light microscopy and machine learning

Autores: Mart G F, Last; Lenard M, Voortman; Thomas H, Sharp
Publicado en: Journal of Structural Biology, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.107965

Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

Autores: Chenggong Ji, Hao Shen, Chen Su, Yaxin Li, Shihua Chen, Thomas H. Sharp, Junyu Xiao
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38320-z

Autores: Maarten W. Tuijtel, Abraham J. Koster, Frank G. A. Faas, Thomas H. Sharp
Publicado en: Small Methods, Edición 3/12, 2019, Página(s) 1900425, ISSN 2366-9608
Editor: Wiley
DOI: 10.1002/smtd.201900425

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

Autores: Leoni Abendstein; Douwe J. Dijkstra; Rayman T. N. Tjokrodirijo; Peter A. van Veelen; Leendert A. Trouw; Paul J. Hensbergen; Thomas H. Sharp
Publicado en: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023), 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-39788-5

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