Protein nano-patterning using DNA nanotechnology; control of surface-based immune system activation

Publikacje

Selecting optimal support grids for super-resolution cryogenic correlated light and electron microscopy

Autorzy: Mart G. F. Last, Maarten W. Tuijtel, Lenard M. Voortman, Thomas H. Sharp
Opublikowane w: Scientific Reports, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-35590-x

Alternative Polyadenylation Utilization Results in Ribosome Assembly and mRNA Translation Deficiencies in a Model for Muscle Aging

Autorzy: Hailiang Mei, PhD, Jasper Boom, BSc, Salma el Abdellaoui, BSc, Kotb Abdelmohsen, PhD, Rachel Munk, MSc, Jennifer L Martindale, MSc, Susan Kloet, PhD, Szymone M Kielbasa, PhD, Thomas H Sharp, PhD, Myriam Gorospe, PhD, Vered Raz, PhD
Opublikowane w: The Journals of Gerontology: Series A, 2022, ISSN 1079-5006
Wydawca: Gerontological Society of America
DOI: 10.1093/gerona/glac058

Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein

Autorzy: Dylan P. Noone, Tijn T. van der Velden and Thomas H. Sharp
Opublikowane w: Frontiers in Immunology, 2021, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2021.757633

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

Autorzy: Douwe J Dijkstra, Fleur S van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia SM Kramer, Linda M Slot, Jan W Drijfhout, Lisanne de Vor, Kyra A Gelderman, Suzan HM Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H Sharp, Paul WHI Parren, Leendert A Trouw
Opublikowane w: PNAS, 2024, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2310666120

PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation

Autorzy: Dylan P. Noone, Douwe J. Dijkstra, Teun T. van der Klugt https, Peter A. van Veelen, Arnoud H. de Ru, Paul J. Hensbergen, Leendert A. Trouw, and Thomas H. Sharp
Opublikowane w: Proceedings of the National Academy of Sciences, USA, 2022, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.220814411

Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM

Autorzy: Mart G.F. Last; Willem E.M. Noteborn; Lenard M. Voortman; Thomas H. Sharp
Opublikowane w: Journal of Structural Biology, Numer 2, 2023, ISSN 1047-8477
Wydawca: Academic Press
DOI: 10.1016/j.jsb.2023.108040

Efficient mRNA delivery using lipid nanoparticles modified with fusogenic coiled-coil peptides

Autorzy: Ye Zeng, Mengjie Shen, Roy Pattipeiluhu, Xuequan Zhou, Yun Zhang, Thomas Bakkum, Thomas H Sharp, Aimee L Boyle, Alexander Kros
Opublikowane w: Nanoscale, 2023, ISSN 2040-3372
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3nr02175k

Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins

Autorzy: Maarten W. Tuijtel, Abraham J. Koster, Stefan Jakobs, Frank G. A. Faas, Thomas H. Sharp
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-37728-8

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Autorzy: R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. Ru, G. M. C. Janssen, P. A. Veelen, E. T. J. den Bremer, B. Bleijlevens, B.‐J. Kreuk, F. J. Beurskens, L. A. Trouw
Opublikowane w: Clinical & Experimental Immunology, Numer 200/1, 2020, Strona(/y) 1-11, ISSN 0009-9104
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/cei.13411

scNodes: a correlation and processing toolkit for super-resolution fluorescence and electron microscopy

Autorzy: Mart G. F. Last; Lenard M. Voortman; Thomas H. Sharp
Opublikowane w: Nature Methods, 2023, ISSN 1548-7091
Wydawca: Nature Publishing Group
DOI: 10.1038/s41592-023-01991-z

Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

Autorzy: Thomas H. Sharp, Aimee L. Boyle, Christoph A. Diebolder, Alexander Kros, Abraham J. Koster, Piet Gros
Opublikowane w: Proceedings of the National Academy of Sciences, 2019, Strona(/y) 201901841, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1901841116

Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

Autorzy: Roy Pattipeiluhu, Ye Zeng, Marco M.R.M. Hendrix, Ilja K. Voets, Alexander Kros, Thomas H. Sharp
Opublikowane w: Nature Communications, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-45666-5

One-Pot Synthesis of Defined-Length ssDNA for Multiscaffold DNA Origami

Autorzy: Willem E. M. Noteborn, Leoni Abendstein, Thomas H. Sharp
Opublikowane w: Bioconjugate Chemistry, Numer 32/1, 2021, Strona(/y) 94-98, ISSN 1043-1802
Wydawca: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00644

Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System

Autorzy: Roy Pattipeiluhu,Gabriela Arias-Alpizar,Genc Basha,Karen Y. T. Chan,Jeroen Bussmann,Thomas H. Sharp,Mohammad-Amin Moradi,Nico Sommerdijk,Edward N. Harris,Pieter R. Cullis,Alexander Kros,Dominik Witzigmann,Frederick Campbell
Opublikowane w: Advanced Materials, 2022, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202201095

Measuring cryo-TEM sample thickness using reflected light microscopy and machine learning

Autorzy: Mart G F, Last; Lenard M, Voortman; Thomas H, Sharp
Opublikowane w: Journal of Structural Biology, 2023, ISSN 1047-8477
Wydawca: Academic Press
DOI: 10.1016/j.jsb.2023.107965

Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

Autorzy: Chenggong Ji, Hao Shen, Chen Su, Yaxin Li, Shihua Chen, Thomas H. Sharp, Junyu Xiao
Opublikowane w: Nature Communications, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-38320-z

Autorzy: Maarten W. Tuijtel, Abraham J. Koster, Frank G. A. Faas, Thomas H. Sharp
Opublikowane w: Small Methods, Numer 3/12, 2019, Strona(/y) 1900425, ISSN 2366-9608
Wydawca: Wiley
DOI: 10.1002/smtd.201900425

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

Autorzy: Leoni Abendstein; Douwe J. Dijkstra; Rayman T. N. Tjokrodirijo; Peter A. van Veelen; Leendert A. Trouw; Paul J. Hensbergen; Thomas H. Sharp
Opublikowane w: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023), 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-39788-5

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