Protein nano-patterning using DNA nanotechnology; control of surface-based immune system activation

Publications

Selecting optimal support grids for super-resolution cryogenic correlated light and electron microscopy

Auteurs: Mart G. F. Last, Maarten W. Tuijtel, Lenard M. Voortman, Thomas H. Sharp
Publié dans: Scientific Reports, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-35590-x

Alternative Polyadenylation Utilization Results in Ribosome Assembly and mRNA Translation Deficiencies in a Model for Muscle Aging

Auteurs: Hailiang Mei, PhD, Jasper Boom, BSc, Salma el Abdellaoui, BSc, Kotb Abdelmohsen, PhD, Rachel Munk, MSc, Jennifer L Martindale, MSc, Susan Kloet, PhD, Szymone M Kielbasa, PhD, Thomas H Sharp, PhD, Myriam Gorospe, PhD, Vered Raz, PhD
Publié dans: The Journals of Gerontology: Series A, 2022, ISSN 1079-5006
Éditeur: Gerontological Society of America
DOI: 10.1093/gerona/glac058

Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein

Auteurs: Dylan P. Noone, Tijn T. van der Velden and Thomas H. Sharp
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.757633

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

Auteurs: Douwe J Dijkstra, Fleur S van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia SM Kramer, Linda M Slot, Jan W Drijfhout, Lisanne de Vor, Kyra A Gelderman, Suzan HM Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H Sharp, Paul WHI Parren, Leendert A Trouw
Publié dans: PNAS, 2024, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2310666120

PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation

Auteurs: Dylan P. Noone, Douwe J. Dijkstra, Teun T. van der Klugt https, Peter A. van Veelen, Arnoud H. de Ru, Paul J. Hensbergen, Leendert A. Trouw, and Thomas H. Sharp
Publié dans: Proceedings of the National Academy of Sciences, USA, 2022, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.220814411

Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM

Auteurs: Mart G.F. Last; Willem E.M. Noteborn; Lenard M. Voortman; Thomas H. Sharp
Publié dans: Journal of Structural Biology, Numéro 2, 2023, ISSN 1047-8477
Éditeur: Academic Press
DOI: 10.1016/j.jsb.2023.108040

Efficient mRNA delivery using lipid nanoparticles modified with fusogenic coiled-coil peptides

Auteurs: Ye Zeng, Mengjie Shen, Roy Pattipeiluhu, Xuequan Zhou, Yun Zhang, Thomas Bakkum, Thomas H Sharp, Aimee L Boyle, Alexander Kros
Publié dans: Nanoscale, 2023, ISSN 2040-3372
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3nr02175k

Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins

Auteurs: Maarten W. Tuijtel, Abraham J. Koster, Stefan Jakobs, Frank G. A. Faas, Thomas H. Sharp
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-37728-8

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Auteurs: R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. Ru, G. M. C. Janssen, P. A. Veelen, E. T. J. den Bremer, B. Bleijlevens, B.‐J. Kreuk, F. J. Beurskens, L. A. Trouw
Publié dans: Clinical & Experimental Immunology, Numéro 200/1, 2020, Page(s) 1-11, ISSN 0009-9104
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cei.13411

scNodes: a correlation and processing toolkit for super-resolution fluorescence and electron microscopy

Auteurs: Mart G. F. Last; Lenard M. Voortman; Thomas H. Sharp
Publié dans: Nature Methods, 2023, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/s41592-023-01991-z

Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

Auteurs: Thomas H. Sharp, Aimee L. Boyle, Christoph A. Diebolder, Alexander Kros, Abraham J. Koster, Piet Gros
Publié dans: Proceedings of the National Academy of Sciences, 2019, Page(s) 201901841, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1901841116

Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

Auteurs: Roy Pattipeiluhu, Ye Zeng, Marco M.R.M. Hendrix, Ilja K. Voets, Alexander Kros, Thomas H. Sharp
Publié dans: Nature Communications, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-45666-5

One-Pot Synthesis of Defined-Length ssDNA for Multiscaffold DNA Origami

Auteurs: Willem E. M. Noteborn, Leoni Abendstein, Thomas H. Sharp
Publié dans: Bioconjugate Chemistry, Numéro 32/1, 2021, Page(s) 94-98, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00644

Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System

Auteurs: Roy Pattipeiluhu,Gabriela Arias-Alpizar,Genc Basha,Karen Y. T. Chan,Jeroen Bussmann,Thomas H. Sharp,Mohammad-Amin Moradi,Nico Sommerdijk,Edward N. Harris,Pieter R. Cullis,Alexander Kros,Dominik Witzigmann,Frederick Campbell
Publié dans: Advanced Materials, 2022, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202201095

Measuring cryo-TEM sample thickness using reflected light microscopy and machine learning

Auteurs: Mart G F, Last; Lenard M, Voortman; Thomas H, Sharp
Publié dans: Journal of Structural Biology, 2023, ISSN 1047-8477
Éditeur: Academic Press
DOI: 10.1016/j.jsb.2023.107965

Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

Auteurs: Chenggong Ji, Hao Shen, Chen Su, Yaxin Li, Shihua Chen, Thomas H. Sharp, Junyu Xiao
Publié dans: Nature Communications, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-38320-z

Auteurs: Maarten W. Tuijtel, Abraham J. Koster, Frank G. A. Faas, Thomas H. Sharp
Publié dans: Small Methods, Numéro 3/12, 2019, Page(s) 1900425, ISSN 2366-9608
Éditeur: Wiley
DOI: 10.1002/smtd.201900425

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

Auteurs: Leoni Abendstein; Douwe J. Dijkstra; Rayman T. N. Tjokrodirijo; Peter A. van Veelen; Leendert A. Trouw; Paul J. Hensbergen; Thomas H. Sharp
Publié dans: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023), 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-39788-5

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