Descripción del proyecto
Formación científica avanzada para combatir patologías complejas como el síndrome cardiorrenal
El llamado síndrome cardiorrenal (SCR o CRS, por sus siglas en inglés) designa un conjunto de trastornos asociados al corazón, los vasos sanguíneos y los riñones que incluye los casos de enfermedad cardiovascular (ECV) diagnosticados en pacientes aquejados por alguna insuficiencia renal crónica (IRC). El equipo del proyecto CaReSyAn, financiado por las Acciones Marie Skłodowska-Curie, pretende mejorar la comprensión, el diagnóstico y el tratamiento de la SCR mediante la formación de especialistas, capacitándolos para utilizar tecnologías ómicas o bioinformáticas y análisis integradores en el marco de sus investigaciones. En este sentido, en el proyecto CaReSyAn se completará la labor de otros programas europeos dedicados a la investigación de la IRC o la ECV e intentará sacar el máximo partido a las cohortes de pacientes disponibles, las tecnologías más avanzadas del momento y las formas de cooperación preexistentes. Con todo ello, se espera que el fomento de la formación ofrecida a estos científicos de tan amplia formación, capaces de tender puentes entre la investigación clínica y la investigación fundamental, contribuya significativamente a la lucha contra enfermedades tan complejas como el SCR.
Objetivo
Successfully combatting a complex disease requires multi-disciplinary and methodically well-trained scientists. CaReSyAn strives to accomplish exactly this: we will train scientists to successfully integrate proteomics, clinical, experimental and bioinformatical analyses to enhance the understanding, diagnosis and therapy of the cardiorenal syndrome (CRS). CRS comprises disorders of the heart, vessels and kidneys, including the increased development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). With ~45% of all deaths in CKD patients caused by CVD, the socio-economic burden of CRS is extremely high.
CaReSyAn will train scientists in a close cooperation between academia, SME and industry partners. Key objectives are to provide: 1) Excellent scientific training on CRS pathology, integrating clinical/mechanistic knowledge with technological skills (animals and in vitro, molecular and functional studies, proteomics and bioinformatics) to generate innovative insights triggering the understanding, diagnosis and treatment of the CRS; 2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research; and 3) Exposure to both academic and non-academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative products and services.
CaReSyAn builds on already available patient cohorts, advanced technologies and established cooperations. CaReSyAn is complementary to ongoing European programs focusing solely on CKD or CVD and strives to synergistically improve structural training on European level. CaReSyAn will nurture the development of young, broadly-trained scientists able to successfully bridge clinical with basic research as well as academia and industry. This is a cornerstone in effectively combatting complex diseases as CRS, a major killer of this century.
Ámbito científico
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- social scienceseconomics and businessbusiness and managemententrepreneurship
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesbasic medicinepathology
- medical and health sciencesclinical medicinenephrologykidney diseases
Programa(s)
Régimen de financiación
MSCA-ITN-ETN - European Training NetworksCoordinador
52074 Aachen
Alemania