Educating the next generation of scientists in translational medicine: Focus on eye diseases

Project Information

transMed

Grant agreement ID: 765441

DOI 10.3030/765441

Project closed

EC signature date 29 August 2017

Start date 1 December 2017

End date 30 November 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 327 702,84

EU contribution € 3 327 702,84

Coordinated by

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Deliverables

Documents, reports (4)

Communication and dissemination III

Communication and dissemination of project activities to different audiences

Dissemination material

Design & distribution of dissemination material

Communication and dissemination I

Communication and dissemination of project activities to different audiences

Communication and dissemination II

Communication and dissemination of project activities to different audiences

Websites, patent fillings, videos etc. (1)

Project website

Establishment and launch of the transMed website, having two levels of accessibility (public + password protected internal side)

Publications

Peer reviewed articles (15)

Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations

Author(s): Manisha Prajapati; Gustav Christensen; François Paquet-Durand; Thorsteinn Loftsson
Published in: Molecules, Issue 26 / 5, 2021, Page(s) 1492, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26051492

Visualizing Cell Death in Live Retina: Using Calpain Activity Detection as a Biomarker for Retinal Degeneration

Author(s): Belhadj, Soumaya; Hermann, Nina Sofia; Zhu, Yu; Christensen, Gustav; Strasser, Torsten; Paquet-Durand, François
Published in: International Journal of Molecular Sciences, Issue 23(7), 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073892

Fluorescent detection of PARP activity in unfixed tissue

Author(s): Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Published in: PLOS ONE, Issue 16/1, 2021, Page(s) e0245369, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0245369

Targeting molecular pathways for the treatment of inherited retinal degeneration

Author(s): Valeria Marigo, Meltem Kutluer, Li Huang
Published in: Neural Regeneration Research, Issue 15/10, 2020, Page(s) 1784, ISSN 1673-5374
Publisher: Neural Regeneration Research
DOI: 10.4103/1673-5374.280303

cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology

Author(s): Jiaming Zhou, Michel Rasmussen, Per Ekström
Published in: Experimental Eye Research, Issue 212, 2021, Page(s) 108752, ISSN 0014-4835
Publisher: Academic Press
DOI: 10.1016/j.exer.2021.108752

Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery

Author(s): Dileep Urimi, Ronja Widenbring, Raúl Oswaldo Pérez García, Lars Gedda, Katarina Edwards, Thorsteinn Loftsson, Nicolaas Schipper
Published in: International Journal of Pharmaceutics, Issue 602, 2021, Page(s) 120640, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120640

Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure

Author(s): Laura Lorenzo‐Soler, Olof Birna Olafsdottir, Gerhard Garhöfer, Phatsawee Jansook, Iris Myrdal Kristinsdottir, Aimin Tan, Thorsteinn Loftsson, Einar Stefansson
Published in: Acta Ophthalmologica, 2020, ISSN 1755-375X
Publisher: Wiley-Blackwell
DOI: 10.1111/aos.14639

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration

Author(s): Akanksha Roy, John Groten, Valeria Marigo, Tushar Tomar, Riet Hilhorst
Published in: International Journal of Molecular Sciences, Issue 22/3, 2021, Page(s) 1180, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031180

Drug delivery to retinal photoreceptors

Author(s): Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorsteinn Loftsson, François Paquet-Durand
Published in: Drug Discovery Today, Issue 24/8, 2019, Page(s) 1637-1643, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2019.03.004

The cGMP Pathway and Inherited Photoreceptor Degeneration: Targets, Compounds, and Biomarkers

Author(s): Arianna Tolone, Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Published in: Genes, Issue 10/6, 2019, Page(s) 453, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10060453

Preparative Synthesis of an R P -Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations

Author(s): Oswaldo Pérez, Nicolaas Schipper, Martin Bollmark
Published in: Organic Process Research & Development, Issue 25/11, 2021, Page(s) 2453-2460, ISSN 1083-6160
Publisher: American Chemical Society
DOI: 10.1021/acs.oprd.1c00230

New In Vitro Cellular Model for Molecular Studies of Retinitis Pigmentosa

Author(s): Li Huang, Meltem Kutluer, Elisa Adani, Antonella Comitato, Valeria Marigo
Published in: International Journal of Molecular Sciences, Issue 22/12, 2021, Page(s) 6440, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126440

The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach

Author(s): Michel Rasmussen, Charlotte Welinder, Frank Schwede, Per Ekström
Published in: Journal of Neurochemistry, 2020, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15251

The stereospecific interaction sites and target specificity of cGMP analogs in mouse cortex

Author(s): Michel Rasmussen; Charlotte Welinder; Frank Schwede; Per Ekström
Published in: Chemical Biology and Drug Design, 2021, ISSN 1747-0285
Publisher: Wiley-Blackwell
DOI: 10.1111/cbdd.13976

Efficient Delivery of Hydrophilic Small Molecules to Retinal Cell Lines Using Gel Core-Containing Solid Lipid Nanoparticles

Author(s): Li Huang, Erico Himawan, Soumaya Belhadj, Raúl Oswaldo Pérez García, François Paquet Durand, Nicolaas Schipper, Matej Buzgo, Aiva Simaite and Valeria Marigo
Published in: Pharmaceutics, Issue 14(1), 2022, Page(s) 74, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010074