Educating the next generation of scientists in translational medicine: Focus on eye diseases

Livrables

Communication and dissemination III

Communication and dissemination of project activities to different audiences

Dissemination material

Design & distribution of dissemination material

Communication and dissemination I

Communication and dissemination of project activities to different audiences

Communication and dissemination II

Communication and dissemination of project activities to different audiences

Project website

Establishment and launch of the transMed website, having two levels of accessibility (public + password protected internal side)

Publications

Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations

Auteurs: Manisha Prajapati; Gustav Christensen; François Paquet-Durand; Thorsteinn Loftsson
Publié dans: Molecules, Numéro 26 / 5, 2021, Page(s) 1492, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26051492

Visualizing Cell Death in Live Retina: Using Calpain Activity Detection as a Biomarker for Retinal Degeneration

Auteurs: Belhadj, Soumaya; Hermann, Nina Sofia; Zhu, Yu; Christensen, Gustav; Strasser, Torsten; Paquet-Durand, François
Publié dans: International Journal of Molecular Sciences, Numéro 23(7), 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073892

Fluorescent detection of PARP activity in unfixed tissue

Auteurs: Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Publié dans: PLOS ONE, Numéro 16/1, 2021, Page(s) e0245369, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0245369

Targeting molecular pathways for the treatment of inherited retinal degeneration

Auteurs: Valeria Marigo, Meltem Kutluer, Li Huang
Publié dans: Neural Regeneration Research, Numéro 15/10, 2020, Page(s) 1784, ISSN 1673-5374
Éditeur: Neural Regeneration Research
DOI: 10.4103/1673-5374.280303

cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology

Auteurs: Jiaming Zhou, Michel Rasmussen, Per Ekström
Publié dans: Experimental Eye Research, Numéro 212, 2021, Page(s) 108752, ISSN 0014-4835
Éditeur: Academic Press
DOI: 10.1016/j.exer.2021.108752

Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery

Auteurs: Dileep Urimi, Ronja Widenbring, Raúl Oswaldo Pérez García, Lars Gedda, Katarina Edwards, Thorsteinn Loftsson, Nicolaas Schipper
Publié dans: International Journal of Pharmaceutics, Numéro 602, 2021, Page(s) 120640, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120640

Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure

Auteurs: Laura Lorenzo‐Soler, Olof Birna Olafsdottir, Gerhard Garhöfer, Phatsawee Jansook, Iris Myrdal Kristinsdottir, Aimin Tan, Thorsteinn Loftsson, Einar Stefansson
Publié dans: Acta Ophthalmologica, 2020, ISSN 1755-375X
Éditeur: Wiley-Blackwell
DOI: 10.1111/aos.14639

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration

Auteurs: Akanksha Roy, John Groten, Valeria Marigo, Tushar Tomar, Riet Hilhorst
Publié dans: International Journal of Molecular Sciences, Numéro 22/3, 2021, Page(s) 1180, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031180

Drug delivery to retinal photoreceptors

Auteurs: Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorsteinn Loftsson, François Paquet-Durand
Publié dans: Drug Discovery Today, Numéro 24/8, 2019, Page(s) 1637-1643, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.1016/j.drudis.2019.03.004

The cGMP Pathway and Inherited Photoreceptor Degeneration: Targets, Compounds, and Biomarkers

Auteurs: Arianna Tolone, Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Publié dans: Genes, Numéro 10/6, 2019, Page(s) 453, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10060453

Preparative Synthesis of an R P -Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations

Auteurs: Oswaldo Pérez, Nicolaas Schipper, Martin Bollmark
Publié dans: Organic Process Research & Development, Numéro 25/11, 2021, Page(s) 2453-2460, ISSN 1083-6160
Éditeur: American Chemical Society
DOI: 10.1021/acs.oprd.1c00230

New In Vitro Cellular Model for Molecular Studies of Retinitis Pigmentosa

Auteurs: Li Huang, Meltem Kutluer, Elisa Adani, Antonella Comitato, Valeria Marigo
Publié dans: International Journal of Molecular Sciences, Numéro 22/12, 2021, Page(s) 6440, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126440

The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach

Auteurs: Michel Rasmussen, Charlotte Welinder, Frank Schwede, Per Ekström
Publié dans: Journal of Neurochemistry, 2020, ISSN 0022-3042
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15251

The stereospecific interaction sites and target specificity of cGMP analogs in mouse cortex

Auteurs: Michel Rasmussen; Charlotte Welinder; Frank Schwede; Per Ekström
Publié dans: Chemical Biology and Drug Design, 2021, ISSN 1747-0285
Éditeur: Wiley-Blackwell
DOI: 10.1111/cbdd.13976

Efficient Delivery of Hydrophilic Small Molecules to Retinal Cell Lines Using Gel Core-Containing Solid Lipid Nanoparticles

Auteurs: Li Huang, Erico Himawan, Soumaya Belhadj, Raúl Oswaldo Pérez García, François Paquet Durand, Nicolaas Schipper, Matej Buzgo, Aiva Simaite and Valeria Marigo
Publié dans: Pharmaceutics, Numéro 14(1), 2022, Page(s) 74, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010074

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