Educating the next generation of scientists in translational medicine: Focus on eye diseases

Información del proyecto

transMed

Identificador del acuerdo de subvención: 765441

DOI

10.3030/765441

Proyecto cerrado

Fecha de la firma de la CE 29 Agosto 2017

Fecha de inicio 1 Diciembre 2017

Fecha de finalización 30 Noviembre 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 327 702,84

Aportación de la UE

€ 3 327 702,84

Coordinado por

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (4)

Communication and dissemination III

Communication and dissemination of project activities to different audiences

Dissemination material

Design & distribution of dissemination material

Communication and dissemination I

Communication and dissemination of project activities to different audiences

Communication and dissemination II

Communication and dissemination of project activities to different audiences

Websites, patent fillings, videos etc. (1)

Project website

Establishment and launch of the transMed website, having two levels of accessibility (public + password protected internal side)

Publicaciones

Peer reviewed articles (15)

Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations

Autores: Manisha Prajapati; Gustav Christensen; François Paquet-Durand; Thorsteinn Loftsson
Publicado en: Molecules, Edición 26 / 5, 2021, Página(s) 1492, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26051492

Visualizing Cell Death in Live Retina: Using Calpain Activity Detection as a Biomarker for Retinal Degeneration

Autores: Belhadj, Soumaya; Hermann, Nina Sofia; Zhu, Yu; Christensen, Gustav; Strasser, Torsten; Paquet-Durand, François
Publicado en: International Journal of Molecular Sciences, Edición 23(7), 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073892

Fluorescent detection of PARP activity in unfixed tissue

Autores: Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Publicado en: PLOS ONE, Edición 16/1, 2021, Página(s) e0245369, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0245369

Targeting molecular pathways for the treatment of inherited retinal degeneration

Autores: Valeria Marigo, Meltem Kutluer, Li Huang
Publicado en: Neural Regeneration Research, Edición 15/10, 2020, Página(s) 1784, ISSN 1673-5374
Editor: Neural Regeneration Research
DOI: 10.4103/1673-5374.280303

cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology

Autores: Jiaming Zhou, Michel Rasmussen, Per Ekström
Publicado en: Experimental Eye Research, Edición 212, 2021, Página(s) 108752, ISSN 0014-4835
Editor: Academic Press
DOI: 10.1016/j.exer.2021.108752

Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery

Autores: Dileep Urimi, Ronja Widenbring, Raúl Oswaldo Pérez García, Lars Gedda, Katarina Edwards, Thorsteinn Loftsson, Nicolaas Schipper
Publicado en: International Journal of Pharmaceutics, Edición 602, 2021, Página(s) 120640, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120640

Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure

Autores: Laura Lorenzo‐Soler, Olof Birna Olafsdottir, Gerhard Garhöfer, Phatsawee Jansook, Iris Myrdal Kristinsdottir, Aimin Tan, Thorsteinn Loftsson, Einar Stefansson
Publicado en: Acta Ophthalmologica, 2020, ISSN 1755-375X
Editor: Wiley-Blackwell
DOI: 10.1111/aos.14639

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration

Autores: Akanksha Roy, John Groten, Valeria Marigo, Tushar Tomar, Riet Hilhorst
Publicado en: International Journal of Molecular Sciences, Edición 22/3, 2021, Página(s) 1180, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031180

Drug delivery to retinal photoreceptors

Autores: Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorsteinn Loftsson, François Paquet-Durand
Publicado en: Drug Discovery Today, Edición 24/8, 2019, Página(s) 1637-1643, ISSN 1359-6446
Editor: Elsevier BV
DOI: 10.1016/j.drudis.2019.03.004

The cGMP Pathway and Inherited Photoreceptor Degeneration: Targets, Compounds, and Biomarkers

Autores: Arianna Tolone, Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Publicado en: Genes, Edición 10/6, 2019, Página(s) 453, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10060453

Preparative Synthesis of an R P -Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations

Autores: Oswaldo Pérez, Nicolaas Schipper, Martin Bollmark
Publicado en: Organic Process Research & Development, Edición 25/11, 2021, Página(s) 2453-2460, ISSN 1083-6160
Editor: American Chemical Society
DOI: 10.1021/acs.oprd.1c00230

New In Vitro Cellular Model for Molecular Studies of Retinitis Pigmentosa

Autores: Li Huang, Meltem Kutluer, Elisa Adani, Antonella Comitato, Valeria Marigo
Publicado en: International Journal of Molecular Sciences, Edición 22/12, 2021, Página(s) 6440, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126440

The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach

Autores: Michel Rasmussen, Charlotte Welinder, Frank Schwede, Per Ekström
Publicado en: Journal of Neurochemistry, 2020, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15251

The stereospecific interaction sites and target specificity of cGMP analogs in mouse cortex

Autores: Michel Rasmussen; Charlotte Welinder; Frank Schwede; Per Ekström
Publicado en: Chemical Biology and Drug Design, 2021, ISSN 1747-0285
Editor: Wiley-Blackwell
DOI: 10.1111/cbdd.13976

Efficient Delivery of Hydrophilic Small Molecules to Retinal Cell Lines Using Gel Core-Containing Solid Lipid Nanoparticles

Autores: Li Huang, Erico Himawan, Soumaya Belhadj, Raúl Oswaldo Pérez García, François Paquet Durand, Nicolaas Schipper, Matej Buzgo, Aiva Simaite and Valeria Marigo
Publicado en: Pharmaceutics, Edición 14(1), 2022, Página(s) 74, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010074