Educating the next generation of scientists in translational medicine: Focus on eye diseases

Rezultaty

Communication and dissemination III

Communication and dissemination of project activities to different audiences

Dissemination material

Design & distribution of dissemination material

Communication and dissemination I

Communication and dissemination of project activities to different audiences

Communication and dissemination II

Communication and dissemination of project activities to different audiences

Project website

Establishment and launch of the transMed website, having two levels of accessibility (public + password protected internal side)

Publikacje

Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations

Autorzy: Manisha Prajapati; Gustav Christensen; François Paquet-Durand; Thorsteinn Loftsson
Opublikowane w: Molecules, Numer 26 / 5, 2021, Strona(/y) 1492, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26051492

Visualizing Cell Death in Live Retina: Using Calpain Activity Detection as a Biomarker for Retinal Degeneration

Autorzy: Belhadj, Soumaya; Hermann, Nina Sofia; Zhu, Yu; Christensen, Gustav; Strasser, Torsten; Paquet-Durand, François
Opublikowane w: International Journal of Molecular Sciences, Numer 23(7), 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073892

Fluorescent detection of PARP activity in unfixed tissue

Autorzy: Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Opublikowane w: PLOS ONE, Numer 16/1, 2021, Strona(/y) e0245369, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0245369

Targeting molecular pathways for the treatment of inherited retinal degeneration

Autorzy: Valeria Marigo, Meltem Kutluer, Li Huang
Opublikowane w: Neural Regeneration Research, Numer 15/10, 2020, Strona(/y) 1784, ISSN 1673-5374
Wydawca: Neural Regeneration Research
DOI: 10.4103/1673-5374.280303

cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology

Autorzy: Jiaming Zhou, Michel Rasmussen, Per Ekström
Opublikowane w: Experimental Eye Research, Numer 212, 2021, Strona(/y) 108752, ISSN 0014-4835
Wydawca: Academic Press
DOI: 10.1016/j.exer.2021.108752

Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery

Autorzy: Dileep Urimi, Ronja Widenbring, Raúl Oswaldo Pérez García, Lars Gedda, Katarina Edwards, Thorsteinn Loftsson, Nicolaas Schipper
Opublikowane w: International Journal of Pharmaceutics, Numer 602, 2021, Strona(/y) 120640, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120640

Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure

Autorzy: Laura Lorenzo‐Soler, Olof Birna Olafsdottir, Gerhard Garhöfer, Phatsawee Jansook, Iris Myrdal Kristinsdottir, Aimin Tan, Thorsteinn Loftsson, Einar Stefansson
Opublikowane w: Acta Ophthalmologica, 2020, ISSN 1755-375X
Wydawca: Wiley-Blackwell
DOI: 10.1111/aos.14639

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration

Autorzy: Akanksha Roy, John Groten, Valeria Marigo, Tushar Tomar, Riet Hilhorst
Opublikowane w: International Journal of Molecular Sciences, Numer 22/3, 2021, Strona(/y) 1180, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031180

Drug delivery to retinal photoreceptors

Autorzy: Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorsteinn Loftsson, François Paquet-Durand
Opublikowane w: Drug Discovery Today, Numer 24/8, 2019, Strona(/y) 1637-1643, ISSN 1359-6446
Wydawca: Elsevier BV
DOI: 10.1016/j.drudis.2019.03.004

The cGMP Pathway and Inherited Photoreceptor Degeneration: Targets, Compounds, and Biomarkers

Autorzy: Arianna Tolone, Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Opublikowane w: Genes, Numer 10/6, 2019, Strona(/y) 453, ISSN 2073-4425
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10060453

Preparative Synthesis of an R P -Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations

Autorzy: Oswaldo Pérez, Nicolaas Schipper, Martin Bollmark
Opublikowane w: Organic Process Research & Development, Numer 25/11, 2021, Strona(/y) 2453-2460, ISSN 1083-6160
Wydawca: American Chemical Society
DOI: 10.1021/acs.oprd.1c00230

New In Vitro Cellular Model for Molecular Studies of Retinitis Pigmentosa

Autorzy: Li Huang, Meltem Kutluer, Elisa Adani, Antonella Comitato, Valeria Marigo
Opublikowane w: International Journal of Molecular Sciences, Numer 22/12, 2021, Strona(/y) 6440, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126440

The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach

Autorzy: Michel Rasmussen, Charlotte Welinder, Frank Schwede, Per Ekström
Opublikowane w: Journal of Neurochemistry, 2020, ISSN 0022-3042
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15251

The stereospecific interaction sites and target specificity of cGMP analogs in mouse cortex

Autorzy: Michel Rasmussen; Charlotte Welinder; Frank Schwede; Per Ekström
Opublikowane w: Chemical Biology and Drug Design, 2021, ISSN 1747-0285
Wydawca: Wiley-Blackwell
DOI: 10.1111/cbdd.13976

Efficient Delivery of Hydrophilic Small Molecules to Retinal Cell Lines Using Gel Core-Containing Solid Lipid Nanoparticles

Autorzy: Li Huang, Erico Himawan, Soumaya Belhadj, Raúl Oswaldo Pérez García, François Paquet Durand, Nicolaas Schipper, Matej Buzgo, Aiva Simaite and Valeria Marigo
Opublikowane w: Pharmaceutics, Numer 14(1), 2022, Strona(/y) 74, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010074

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