Educating the next generation of scientists in translational medicine: Focus on eye diseases

Risultati finali

Communication and dissemination III

Communication and dissemination of project activities to different audiences

Dissemination material

Design & distribution of dissemination material

Communication and dissemination I

Communication and dissemination of project activities to different audiences

Communication and dissemination II

Communication and dissemination of project activities to different audiences

Project website

Establishment and launch of the transMed website, having two levels of accessibility (public + password protected internal side)

Pubblicazioni

Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations

Autori: Manisha Prajapati; Gustav Christensen; François Paquet-Durand; Thorsteinn Loftsson
Pubblicato in: Molecules, Numero 26 / 5, 2021, Pagina/e 1492, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26051492

Visualizing Cell Death in Live Retina: Using Calpain Activity Detection as a Biomarker for Retinal Degeneration

Autori: Belhadj, Soumaya; Hermann, Nina Sofia; Zhu, Yu; Christensen, Gustav; Strasser, Torsten; Paquet-Durand, François
Pubblicato in: International Journal of Molecular Sciences, Numero 23(7), 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073892

Fluorescent detection of PARP activity in unfixed tissue

Autori: Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Pubblicato in: PLOS ONE, Numero 16/1, 2021, Pagina/e e0245369, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0245369

Targeting molecular pathways for the treatment of inherited retinal degeneration

Autori: Valeria Marigo, Meltem Kutluer, Li Huang
Pubblicato in: Neural Regeneration Research, Numero 15/10, 2020, Pagina/e 1784, ISSN 1673-5374
Editore: Neural Regeneration Research
DOI: 10.4103/1673-5374.280303

cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology

Autori: Jiaming Zhou, Michel Rasmussen, Per Ekström
Pubblicato in: Experimental Eye Research, Numero 212, 2021, Pagina/e 108752, ISSN 0014-4835
Editore: Academic Press
DOI: 10.1016/j.exer.2021.108752

Formulation development and upscaling of lipid nanocapsules as a drug delivery system for a novel cyclic GMP analogue intended for retinal drug delivery

Autori: Dileep Urimi, Ronja Widenbring, Raúl Oswaldo Pérez García, Lars Gedda, Katarina Edwards, Thorsteinn Loftsson, Nicolaas Schipper
Pubblicato in: International Journal of Pharmaceutics, Numero 602, 2021, Pagina/e 120640, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120640

Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure

Autori: Laura Lorenzo‐Soler, Olof Birna Olafsdottir, Gerhard Garhöfer, Phatsawee Jansook, Iris Myrdal Kristinsdottir, Aimin Tan, Thorsteinn Loftsson, Einar Stefansson
Pubblicato in: Acta Ophthalmologica, 2020, ISSN 1755-375X
Editore: Wiley-Blackwell
DOI: 10.1111/aos.14639

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration

Autori: Akanksha Roy, John Groten, Valeria Marigo, Tushar Tomar, Riet Hilhorst
Pubblicato in: International Journal of Molecular Sciences, Numero 22/3, 2021, Pagina/e 1180, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22031180

Drug delivery to retinal photoreceptors

Autori: Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorsteinn Loftsson, François Paquet-Durand
Pubblicato in: Drug Discovery Today, Numero 24/8, 2019, Pagina/e 1637-1643, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2019.03.004

The cGMP Pathway and Inherited Photoreceptor Degeneration: Targets, Compounds, and Biomarkers

Autori: Arianna Tolone, Soumaya Belhadj, Andreas Rentsch, Frank Schwede, François Paquet-Durand
Pubblicato in: Genes, Numero 10/6, 2019, Pagina/e 453, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10060453

Preparative Synthesis of an R P -Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations

Autori: Oswaldo Pérez, Nicolaas Schipper, Martin Bollmark
Pubblicato in: Organic Process Research & Development, Numero 25/11, 2021, Pagina/e 2453-2460, ISSN 1083-6160
Editore: American Chemical Society
DOI: 10.1021/acs.oprd.1c00230

New In Vitro Cellular Model for Molecular Studies of Retinitis Pigmentosa

Autori: Li Huang, Meltem Kutluer, Elisa Adani, Antonella Comitato, Valeria Marigo
Pubblicato in: International Journal of Molecular Sciences, Numero 22/12, 2021, Pagina/e 6440, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126440

The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach

Autori: Michel Rasmussen, Charlotte Welinder, Frank Schwede, Per Ekström
Pubblicato in: Journal of Neurochemistry, 2020, ISSN 0022-3042
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15251

The stereospecific interaction sites and target specificity of cGMP analogs in mouse cortex

Autori: Michel Rasmussen; Charlotte Welinder; Frank Schwede; Per Ekström
Pubblicato in: Chemical Biology and Drug Design, 2021, ISSN 1747-0285
Editore: Wiley-Blackwell
DOI: 10.1111/cbdd.13976

Efficient Delivery of Hydrophilic Small Molecules to Retinal Cell Lines Using Gel Core-Containing Solid Lipid Nanoparticles

Autori: Li Huang, Erico Himawan, Soumaya Belhadj, Raúl Oswaldo Pérez García, François Paquet Durand, Nicolaas Schipper, Matej Buzgo, Aiva Simaite and Valeria Marigo
Pubblicato in: Pharmaceutics, Numero 14(1), 2022, Pagina/e 74, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14010074

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