Spectroscopy in cells with tailored in-vivo labelling strategies and multiply addressable nano-structural probes

Informazioni relative al progetto

SPICE

ID dell’accordo di sovvenzione: 772027

DOI

10.3030/772027

Progetto chiuso

Data della firma CE 18 Aprile 2018

Data di avvio 1 Giugno 2018

Data di completamento 30 Novembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 988 697,50

Contributo UE

€ 1 988 697,50

Coordinato da

UNIVERSITAT KONSTANZ
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (22)

Magnesium induced structural reorganization in the active site of adenylate kinase

Autori: Kwangho Nam, Abdul Raafik Arattu Thodika, Sonja Tischlik, Chanrith Phoeurk, Tamás Milán Nagy, Léon Schierholz, Jörgen Ådén, Per Rogne, Malte Drescher, A. Elisabeth Sauer-Eriksson, Magnus Wolf-Watz
Pubblicato in: Science Advances, Numero 10, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.ado5504

Intracellular Protein–Lipid Interactions Studied by Rapid-Scan Electron Paramagnetic Resonance Spectroscopy

Autori: Theresa S. Braun, Juliane Stehle, Sylwia Kacprzak, Patrick Carl, Peter Höfer, Vinod Subramaniam, Malte Drescher
Pubblicato in: The Journal of Physical Chemistry Letters, Numero 12, 2023, Pagina/e 2471-2475, ISSN 1948-7185
Editore: American Chemical Society
DOI: 10.1021/acs.jpclett.0c03583

Dance with spins: site-directed spin labeling coupled to electron paramagnetic resonance spectroscopy directly inside cells

Autori: Annalisa Pierro, Malte Drescher
Pubblicato in: Chemical Communications, Numero 59, 2024, Pagina/e 1274-1284, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cc05907j

Insights into Enzymatic Catalysis from Binding and Hydrolysis of Diadenosine Tetraphosphate by <i>E</i>. <i>coli</i> Adenylate Kinase

Autori: Sonja Tischlik, Melanie Oelker, Per Rogne, A. Elisabeth Sauer-Eriksson, Malte Drescher, Magnus Wolf-Watz
Pubblicato in: Biochemistry, Numero 62, 2023, Pagina/e 2238-2243, ISSN 0006-2960
Editore: American Chemical Society
DOI: 10.1021/acs.biochem.3c00189

Increasing the Modulation Depth of Gd^III-Based Pulsed Dipolar EPR Spectroscopy (PDS) with Porphyrin–Gd^III Laser-Induced Magnetic Dipole Spectroscopy

Autori: Andreas Scherer, Xuemei Yao, Mian Qi, Max Wiedmaier, Adelheid Godt, Malte Drescher
Pubblicato in: The Journal of Physical Chemistry Letters, Numero 13, 2023, Pagina/e 10958-10964, ISSN 1948-7185
Editore: American Chemical Society
DOI: 10.1021/acs.jpclett.2c02138

Combining Site-Directed Spin Labeling in Vivo and In-Cell EPR Distance Determination

Autori: Pia Widder, Julian Schuck, Daniel Summerer, Malte Drescher
Pubblicato in: PCCP, 2021, ISSN 1463-9076
Editore: Royal Society of Chemistry
DOI: 10.26434/chemrxiv.9746222.v1

Background removal from rapid-scan EPR spectra of nitroxide-based spin labels by minimizing non-quadratic cost functions

Autori: Florian Johannsen, Malte Drescher
Pubblicato in: Journal of Magnetic Resonance Open, Numero 16-17, 2023, Pagina/e 100121, ISSN 2666-4410
Editore: Elsevier BV
DOI: 10.1016/j.jmro.2023.100121

Optimising broadband pulses for DEER depends on concentration and distance range of interest

Autori: Andreas Scherer, Sonja Tischlik, Sabrina Weickert, Valentin Wittmann, Malte Drescher
Pubblicato in: Magnetic Resonance, Numero 1, 2025, Pagina/e 59-74, ISSN 2699-0016
Editore: Copernicus GmbH
DOI: 10.5194/mr-1-59-2020

Isoindoline‐Based Nitroxides as Bioresistant Spin Labels for Protein Labeling through Cysteines and Alkyne‐Bearing Noncanonical Amino Acids

Autori: Theresa Sophie Braun, Pia Widder, Uwe Osswald, Lina Groß, Lara Williams, Moritz Schmidt, Irina Helmle, Daniel Summerer, Malte Drescher
Pubblicato in: ChemBioChem, Numero 21, 2023, Pagina/e 958-962, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900537

The molecular mechanism of Hsp90-induced oligomerization of Tau

Autori: Sabrina Weickert, Magdalena Wawrzyniuk, Laura John, Stefan G. D. Rüdiger, Malte Drescher
Pubblicato in: Science Advances, 2019, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1101/614289

Double Nitroxide Labeling by Copper-Catalyzed Azide–Alkyne Cycloadditions with Noncanonical Amino Acids for Electron Paramagnetic Resonance Spectroscopy

Autori: Pia Widder, Frederic Berner, Daniel Summerer, Malte Drescher
Pubblicato in: ACS Chemical Biology, Numero 14/5, 2019, Pagina/e 839-844, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.8b01111

Gd(III)–Gd(III) Relaxation-Induced Dipolar Modulation Enhancement for In-Cell Electron Paramagnetic Resonance Distance Determination

Autori: Mykhailo Azarkh, Anna Bieber, Mian Qi, Jörg W. A. Fischer, Maxim Yulikov, Adelheid Godt, Malte Drescher
Pubblicato in: The Journal of Physical Chemistry Letters, Numero 10/7, 2019, Pagina/e 1477-1481, ISSN 1948-7185
Editore: American Chemical Society
DOI: 10.1021/acs.jpclett.9b00340

Protein Spin Labeling with a Photocaged Nitroxide Using Diels–Alder Chemistry

Autori: Anandi Kugele, Bjarne Silkenath, Jakob Langer, Valentin Wittmann, Malte Drescher
Pubblicato in: ChemBioChem, 2019, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900318

Site-directed spin labelling of proteins by Suzuki–Miyaura coupling via a genetically encoded aryliodide amino acid

Autori: Anandi Kugele, Theresa Sophie Braun, Pia Widder, Lara Williams, Moritz Johannes Schmidt, Daniel Summerer, Malte Drescher
Pubblicato in: Chemical Communications, Numero 55/13, 2019, Pagina/e 1923-1926, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c8cc09325c

Expanding the Genetic Code for Site-Directed Spin-Labeling

Autori: Theresa Braun, Malte Drescher, Daniel Summerer
Pubblicato in: International Journal of Molecular Sciences, Numero 20/2, 2019, Pagina/e 373, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20020373

Light-induced dipolar spectroscopy – A quantitative comparison between LiDEER and LaserIMD

Autori: Anna Bieber, Dennis Bücker, Malte Drescher
Pubblicato in: Journal of Magnetic Resonance, Numero 296, 2018, Pagina/e 29-35, ISSN 1090-7807
Editore: Academic Press
DOI: 10.1016/j.jmr.2018.08.006

Site-directed attachment of photoexcitable spin labels for light-induced pulsed dipolar spectroscopy

Autori: Lara Williams, Sonja Tischlik, Andreas Scherer, Jörg Wolfram Anselm Fischer, Malte Drescher
Pubblicato in: Chemical Communications, Numero 56, 2024, Pagina/e 14669-14672, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc03101a

Rapid Scan Electron Paramagnetic Resonance Spectroscopy Is a Suitable Tool to Study Intermolecular Interactions of Intrinsically Disordered Protein

Autori: Jessica Dröden, Malte Drescher
Pubblicato in: Biology, Numero 12, 2024, Pagina/e 79, ISSN 2079-7737
Editore: MDPI AG
DOI: 10.3390/biology12010079

<i>In situ</i> EPR spectroscopy of a bacterial membrane transporter using an expanded genetic code

Autori: Anandi Kugele, Sophie Ketter, Bjarne Silkenath, Valentin Wittmann, Benesh Joseph, Malte Drescher
Pubblicato in: Chemical Communications, Numero 57, 2024, Pagina/e 12980-12983, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cc04612h

Arabidopsis CaLB1 undergoes phase separation with the ESCRT protein ALIX and modulates autophagosome maturation

Autori: Niccolò Mosesso, Niharika Savant Lerner, Tobias Bläske, Felix Groh, Shane Maguire, Marie Laura Niedermeier, Eliane Landwehr, Karin Vogel, Konstanze Meergans, Marie-Kristin Nagel, Malte Drescher, Florian Stengel, Karin Hauser, Erika Isono
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-49485-6

The effect of the zero-field splitting in light-induced pulsed dipolar electron paramagnetic resonance (EPR) spectroscopy

Autori: Andreas Scherer, Berk Yildirim, Malte Drescher
Pubblicato in: Magnetic Resonance, Numero 4, 2025, Pagina/e 27-46, ISSN 2699-0016
Editore: Copernicus GmbH
DOI: 10.5194/mr-4-27-2023

Real-time Monitoring of Photoinduced pH-jumps by In Situ Rapid-scan EPR Spectroscopy

Autori: Florian Johannsen, Lara Williams, Man Him Chak, Malte Drescher
Pubblicato in: Journal of Physical Chemistry Letters, 2023, ISSN 1948-7185
Editore: American Chemical Society
DOI: 10.26434/chemrxiv-2023-x6d2t

Other (1)

Spin labelling via metabolic glycoengineering for studying post-translational protein modification by electron paramagnetic resonance spectroscopy

Autori: Anna Rubailo, Valentin Wittmann, Malte Drescher
Pubblicato in: Chemrxiv, 2022
Editore: chemrxiv
DOI: 10.26434/chemrxiv-2022-j2mc1-v2