Dissection of Glycan Function by Engineered Tissue Models

Project Information

GlycoSkin

Grant agreement ID: 772735

DOI

10.3030/772735

Project closed

EC signature date 7 February 2018

Start date 1 March 2018

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 995 199,00

EU contribution

€ 1 995 199,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation

Author(s): Troels Boldt Rømer; Fawzi Khoder-Agha; Mikkel Koed Møller Aasted; Noortje de Haan; Sabrina Horn; August Dylander; Tao Zhang; Emil Marek Heymans Pallesen; Sally Dabelsteen; Manfred Wuhrer; Christine Flodgaard Høgsbro; Emil Aagaard Thomsen; Jacob Giehm Mikkelsen; Hans H Wandall
Published in: Glycobiology, Issue 2, 2023, ISSN 1460-2423
Publisher: Oxford Journals
DOI: 10.1093/glycob/cwad003

O‐glycan initiation directs distinct biological pathways and controls epithelial differentiation

Author(s): Ieva Bagdonaite, Emil MH Pallesen, Zilu Ye, Sergey Y Vakhrushev, Irina N Marinova, Mathias I Nielsen, Signe H Kramer, Stine F Pedersen, Hiren J Joshi, Eric P Bennett, Sally Dabelsteen, Hans H Wandall
Published in: EMBO reports, Issue 21/6, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201948885

Global aspects of viral glycosylation

Author(s): Ieva Bagdonaite, Hans H Wandall
Published in: Glycobiology, Issue 28/7, 2018, Page(s) 443-467, ISSN 1460-2423
Publisher: Oxford Academic
DOI: 10.1093/glycob/cwy021

Reading and Writing the Human Glycocode

Author(s): Noortje de Haan, Mathias I. Nielsen, Hans H. Wandall
Published in: Annual Review of Biochemistry, Issue 93, 2024, Page(s) 529-564, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030122-044347

Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples

Author(s): Noortje de Haan, Maja Pučić-Baković, Mislav Novokmet, David Falck, Guinevere Lageveen-Kammeijer, Genadij Razdorov, Frano Vučković, Irena Trbojević-Akmačić, Olga Gornik, Maja Hanić, Manfred Wuhrer, Gordan Lauc, null null, Andras Guttman, Richard Cummings, Samia Mora, Yoann Rombouts, Andad Mehta
Published in: Glycobiology, Issue 32, 2022, Page(s) 651-663, ISSN 1460-2423
Publisher: Oxford University Press
DOI: 10.1093/glycob/cwac026

Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line

Author(s): Mathias I. Nielsen, Noortje de Haan, Weston Kightlinger, Zilu Ye, Sally Dabelsteen, Minyan Li, Michael C. Jewett, Ieva Bagdonaite, Sergey Y. Vakhrushev, Hans H. Wandall
Published in: Nature Communications, Issue 13, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33806-8

Binding of Akkermansia muciniphila to mucin is O-glycan specific

Author(s): Janneke Elzinga, Yoshiki Narimatsu, Noortje de Haan, Henrik Clausen, Willem M. de Vos, Hanne L. P. Tytgat
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-48770-8

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

Author(s): Sofie H. Møller, Maiken Mellergaard, Mikkel Madsen, Amaia V. Bermejo, Stine D. Jepsen, Marie H. Hansen, Rikke I. Høgh, Blanca I. Aldana, Claus Desler, Lene Juel Rasmussen, Elahu G. Sustarsic, Zachary Gerhart-Hines, Evangelia Daskalaki, Craig E. Wheelock, Thomas K. Hiron, Da Lin, Christopher A. O’Callaghan, Hans H. Wandall, Lars Andresen, Søren Skov
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.01968

Role of N-Glycosylation in FcγRIIIa interaction with IgG

Author(s): Julie Van Coillie, Morten A. Schulz, Arthur E. H. Bentlage, Noortje de Haan, Zilu Ye, Dionne M. Geerdes, Wim J. E. van Esch, Lise Hafkenscheid, Rebecca L. Miller, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Zhang Yang, Gestur Vidarsson, Henrik Clausen
Published in: Frontiers in Immunology, Issue 13, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.987151

Glycoproteomics

Author(s): Ieva Bagdonaite, Stacy A. Malaker, Daniel A. Polasky, Nicholas M. Riley, Katrine Schjoldager, Sergey Y. Vakhrushev, Adnan Halim, Kiyoko F. Aoki-Kinoshita, Alexey I. Nesvizhskii, Carolyn R. Bertozzi, Hans H. Wandall, Benjamin L. Parker, Morten Thaysen-Andersen, Nichollas E. Scott
Published in: Nature Reviews Methods Primers, Issue 2, 2024, ISSN 2662-8449
Publisher: Nature
DOI: 10.1038/s43586-022-00128-4

Sensitive and Specific Global Cell Surface <i>N</i>-Glycoproteomics Shows Profound Differences Between Glycosylation Sites and Subcellular Components

Author(s): Noortje de Haan; Ming Song; Oliver C. Grant; Zilu Ye; Fawzi Khoder Agha; Mikkel Koed Møller Aasted; Robert J. Woods; Sergey Y. Vakhrushev; Hans H. Wandall
Published in: Analytical Chemistry, Issue 3, 2023, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.3c03626

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Author(s): Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall, Morten Frödin
Published in: Nucleic Acids Research, Issue 48/21, 2020, Page(s) 11958-11981, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa975

Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells

Author(s): Ieva Bagdonaite, Andrew J. Thompson, Xiaoning Wang, Max Søgaard, Cyrielle Fougeroux, Martin Frank, Jolene K. Diedrich, John R. Yates, Ali Salanti, Sergey Y. Vakhrushev, James C. Paulson, Hans H. Wandall
Published in: Viruses, Issue 13/4, 2021, Page(s) 551, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13040551

Genetic glycoengineering in mammalian cells

Author(s): Yoshiki Narimatsu, Christian Büll, Yen-Hsi Chen, Hans H. Wandall, Zhang Yang, Henrik Clausen
Published in: Journal of Biological Chemistry, Issue 296, 2021, Page(s) 100448, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100448

Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context

Author(s): Mathias Ingemann Nielsen, John Stegmayr, Oliver C. Grant, Zhang Yang, Ulf J. Nilsson, Irene Boos, Michael C. Carlsson, Robert J. Woods, Carlo Unverzagt, Hakon Leffler, Hans H. Wandall
Published in: Journal of Biological Chemistry, Issue 293/52, 2018, Page(s) 20249-20262, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.004636

Quantitative characterization of O-GalNAc glycosylation

Author(s): Tomislav Čaval, Noortje de Haan, Andriana Konstantinidi, Sergey Y Vakhrushev
Published in: Current Opinion in Structural Biology, Issue 68, 2023, Page(s) 135-141, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.12.010

Twin Prime Editing Mediated Exon Skipping/Reinsertion for Restored Collagen VII Expression in Recessive Dystrophic Epidermolysis Bullosa

Author(s): Benjamin J. Steinbeck, Xin D. Gao, Amber N. McElroy, Smriti Pandey, Jordan L. Doman, Megan J. Riddle, Lily Xia, Weili Chen, Cindy R. Eide, Andre H. Lengert, Sang Won Han, Bruce R. Blazar, Hans H. Wandall, Sally Dabelsteen, David R. Liu, Jakub Tolar, Mark J. Osborn
Published in: Journal of Investigative Dermatology, Issue 144, 2024, Page(s) 2764-2777.e9, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.04.013

Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

Author(s): Sally Dabelsteen, Emil M.H. Pallesen, Irina N. Marinova, Mathias I. Nielsen, Maria Adamopoulou, Troels B. Rømer, Asha Levann, Mikkel M. Andersen, Zilu Ye, David Thein, Eric P. Bennett, Christian Büll, Sam J. Moons, Thomas Boltje, Henrik Clausen, Sergey Y. Vakhrushev, Ieva Bagdonaite, Hans H. Wandall
Published in: Developmental Cell, Issue 54/5, 2020, Page(s) 669-684.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.06.039

In-Depth Profiling of <i>O</i>-Glycan Isomers in Human Cells Using C18 Nanoliquid Chromatography–Mass Spectrometry and Glycogenomics

Author(s): Noortje de Haan; Yoshiki Narimatsu; Mikkel Koed Møller Aasted; Ida S. B. Larsen; Irina N. Marinova; Sally Dabelsteen; Sergey Y. Vakhrushev; Hans H. Wandall
Published in: Analytical Chemistry, Issue 2, 2022, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c05068

Golgi fragmentation – One of the earliest organelle phenotypes in Alzheimer’s disease neurons

Author(s): Henriette Haukedal, Giulia I. Corsi, Veerendra P. Gadekar, Nadezhda T. Doncheva, Shekhar Kedia, Noortje de Haan, Abinaya Chandrasekaran, Pia Jensen, Pernille Schiønning, Sarah Vallin, Frederik Ravnkilde Marlet, Anna Poon, Carlota Pires, Fawzi Khoder Agha, Hans H. Wandall, Susanna Cirera, Anja Hviid Simonsen, Troels Tolstrup Nielsen, Jørgen Erik Nielsen, Poul Hyttel, Ravi Muddashetty, Blanca I. A
Published in: Frontiers in Neuroscience, Issue 17, 2024, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2023.1120086