Dissection of Glycan Function by Engineered Tissue Models

Project Information

GlycoSkin

Grant agreement ID: 772735

DOI 10.3030/772735

Project closed

EC signature date 7 February 2018

Start date 1 March 2018

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 995 199,00

EU contribution € 1 995 199,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

Publications

Peer reviewed articles (11)

CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation

Author(s): Troels Boldt Rømer; Fawzi Khoder-Agha; Mikkel Koed Møller Aasted; Noortje de Haan; Sabrina Horn; August Dylander; Tao Zhang; Emil Marek Heymans Pallesen; Sally Dabelsteen; Manfred Wuhrer; Christine Flodgaard Høgsbro; Emil Aagaard Thomsen; Jacob Giehm Mikkelsen; Hans H Wandall
Published in: Glycobiology, Issue 2, 2023, ISSN 1460-2423
Publisher: Oxford Journals
DOI: 10.1093/glycob/cwad003

O‐glycan initiation directs distinct biological pathways and controls epithelial differentiation

Author(s): Ieva Bagdonaite, Emil MH Pallesen, Zilu Ye, Sergey Y Vakhrushev, Irina N Marinova, Mathias I Nielsen, Signe H Kramer, Stine F Pedersen, Hiren J Joshi, Eric P Bennett, Sally Dabelsteen, Hans H Wandall
Published in: EMBO reports, Issue 21/6, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201948885

Global aspects of viral glycosylation

Author(s): Ieva Bagdonaite, Hans H Wandall
Published in: Glycobiology, Issue 28/7, 2018, Page(s) 443-467, ISSN 1460-2423
Publisher: Oxford Academic
DOI: 10.1093/glycob/cwy021

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

Author(s): Sofie H. Møller, Maiken Mellergaard, Mikkel Madsen, Amaia V. Bermejo, Stine D. Jepsen, Marie H. Hansen, Rikke I. Høgh, Blanca I. Aldana, Claus Desler, Lene Juel Rasmussen, Elahu G. Sustarsic, Zachary Gerhart-Hines, Evangelia Daskalaki, Craig E. Wheelock, Thomas K. Hiron, Da Lin, Christopher A. O’Callaghan, Hans H. Wandall, Lars Andresen, Søren Skov
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.01968

Sensitive and Specific Global Cell Surface <i>N</i>-Glycoproteomics Shows Profound Differences Between Glycosylation Sites and Subcellular Components

Author(s): Noortje de Haan; Ming Song; Oliver C. Grant; Zilu Ye; Fawzi Khoder Agha; Mikkel Koed Møller Aasted; Robert J. Woods; Sergey Y. Vakhrushev; Hans H. Wandall
Published in: Analytical Chemistry, Issue 3, 2023, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.3c03626

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Author(s): Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall, Morten Frödin
Published in: Nucleic Acids Research, Issue 48/21, 2020, Page(s) 11958-11981, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa975

Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells

Author(s): Ieva Bagdonaite, Andrew J. Thompson, Xiaoning Wang, Max Søgaard, Cyrielle Fougeroux, Martin Frank, Jolene K. Diedrich, John R. Yates, Ali Salanti, Sergey Y. Vakhrushev, James C. Paulson, Hans H. Wandall
Published in: Viruses, Issue 13/4, 2021, Page(s) 551, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13040551

Genetic glycoengineering in mammalian cells

Author(s): Yoshiki Narimatsu, Christian Büll, Yen-Hsi Chen, Hans H. Wandall, Zhang Yang, Henrik Clausen
Published in: Journal of Biological Chemistry, Issue 296, 2021, Page(s) 100448, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100448

Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context

Author(s): Mathias Ingemann Nielsen, John Stegmayr, Oliver C. Grant, Zhang Yang, Ulf J. Nilsson, Irene Boos, Michael C. Carlsson, Robert J. Woods, Carlo Unverzagt, Hakon Leffler, Hans H. Wandall
Published in: Journal of Biological Chemistry, Issue 293/52, 2018, Page(s) 20249-20262, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.004636

Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

Author(s): Sally Dabelsteen, Emil M.H. Pallesen, Irina N. Marinova, Mathias I. Nielsen, Maria Adamopoulou, Troels B. Rømer, Asha Levann, Mikkel M. Andersen, Zilu Ye, David Thein, Eric P. Bennett, Christian Büll, Sam J. Moons, Thomas Boltje, Henrik Clausen, Sergey Y. Vakhrushev, Ieva Bagdonaite, Hans H. Wandall
Published in: Developmental Cell, Issue 54/5, 2020, Page(s) 669-684.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.06.039

In-Depth Profiling of <i>O</i>-Glycan Isomers in Human Cells Using C18 Nanoliquid Chromatography–Mass Spectrometry and Glycogenomics

Author(s): Noortje de Haan; Yoshiki Narimatsu; Mikkel Koed Møller Aasted; Ida S. B. Larsen; Irina N. Marinova; Sally Dabelsteen; Sergey Y. Vakhrushev; Hans H. Wandall
Published in: Analytical Chemistry, Issue 2, 2022, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.1c05068