Dissection of Glycan Function by Engineered Tissue Models

Información del proyecto

GlycoSkin

Identificador del acuerdo de subvención: 772735

DOI

10.3030/772735

Proyecto cerrado

Fecha de la firma de la CE 7 Febrero 2018

Fecha de inicio 1 Marzo 2018

Fecha de finalización 30 Noviembre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 995 199,00

Aportación de la UE

€ 1 995 199,00

Coordinado por

KOBENHAVNS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (20)

CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation

Autores: Troels Boldt Rømer; Fawzi Khoder-Agha; Mikkel Koed Møller Aasted; Noortje de Haan; Sabrina Horn; August Dylander; Tao Zhang; Emil Marek Heymans Pallesen; Sally Dabelsteen; Manfred Wuhrer; Christine Flodgaard Høgsbro; Emil Aagaard Thomsen; Jacob Giehm Mikkelsen; Hans H Wandall
Publicado en: Glycobiology, Edición 2, 2023, ISSN 1460-2423
Editor: Oxford Journals
DOI: 10.1093/glycob/cwad003

O‐glycan initiation directs distinct biological pathways and controls epithelial differentiation

Autores: Ieva Bagdonaite, Emil MH Pallesen, Zilu Ye, Sergey Y Vakhrushev, Irina N Marinova, Mathias I Nielsen, Signe H Kramer, Stine F Pedersen, Hiren J Joshi, Eric P Bennett, Sally Dabelsteen, Hans H Wandall
Publicado en: EMBO reports, Edición 21/6, 2020, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201948885

Global aspects of viral glycosylation

Autores: Ieva Bagdonaite, Hans H Wandall
Publicado en: Glycobiology, Edición 28/7, 2018, Página(s) 443-467, ISSN 1460-2423
Editor: Oxford Academic
DOI: 10.1093/glycob/cwy021

Reading and Writing the Human Glycocode

Autores: Noortje de Haan, Mathias I. Nielsen, Hans H. Wandall
Publicado en: Annual Review of Biochemistry, Edición 93, 2024, Página(s) 529-564, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030122-044347

Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples

Autores: Noortje de Haan, Maja Pučić-Baković, Mislav Novokmet, David Falck, Guinevere Lageveen-Kammeijer, Genadij Razdorov, Frano Vučković, Irena Trbojević-Akmačić, Olga Gornik, Maja Hanić, Manfred Wuhrer, Gordan Lauc, null null, Andras Guttman, Richard Cummings, Samia Mora, Yoann Rombouts, Andad Mehta
Publicado en: Glycobiology, Edición 32, 2022, Página(s) 651-663, ISSN 1460-2423
Editor: Oxford University Press
DOI: 10.1093/glycob/cwac026

Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line

Autores: Mathias I. Nielsen, Noortje de Haan, Weston Kightlinger, Zilu Ye, Sally Dabelsteen, Minyan Li, Michael C. Jewett, Ieva Bagdonaite, Sergey Y. Vakhrushev, Hans H. Wandall
Publicado en: Nature Communications, Edición 13, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-33806-8

Binding of Akkermansia muciniphila to mucin is O-glycan specific

Autores: Janneke Elzinga, Yoshiki Narimatsu, Noortje de Haan, Henrik Clausen, Willem M. de Vos, Hanne L. P. Tytgat
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-48770-8

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

Autores: Sofie H. Møller, Maiken Mellergaard, Mikkel Madsen, Amaia V. Bermejo, Stine D. Jepsen, Marie H. Hansen, Rikke I. Høgh, Blanca I. Aldana, Claus Desler, Lene Juel Rasmussen, Elahu G. Sustarsic, Zachary Gerhart-Hines, Evangelia Daskalaki, Craig E. Wheelock, Thomas K. Hiron, Da Lin, Christopher A. O’Callaghan, Hans H. Wandall, Lars Andresen, Søren Skov
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2020.01968

Role of N-Glycosylation in FcγRIIIa interaction with IgG

Autores: Julie Van Coillie, Morten A. Schulz, Arthur E. H. Bentlage, Noortje de Haan, Zilu Ye, Dionne M. Geerdes, Wim J. E. van Esch, Lise Hafkenscheid, Rebecca L. Miller, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Zhang Yang, Gestur Vidarsson, Henrik Clausen
Publicado en: Frontiers in Immunology, Edición 13, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.987151

Glycoproteomics

Autores: Ieva Bagdonaite, Stacy A. Malaker, Daniel A. Polasky, Nicholas M. Riley, Katrine Schjoldager, Sergey Y. Vakhrushev, Adnan Halim, Kiyoko F. Aoki-Kinoshita, Alexey I. Nesvizhskii, Carolyn R. Bertozzi, Hans H. Wandall, Benjamin L. Parker, Morten Thaysen-Andersen, Nichollas E. Scott
Publicado en: Nature Reviews Methods Primers, Edición 2, 2024, ISSN 2662-8449
Editor: Nature
DOI: 10.1038/s43586-022-00128-4

Sensitive and Specific Global Cell Surface <i>N</i>-Glycoproteomics Shows Profound Differences Between Glycosylation Sites and Subcellular Components

Autores: Noortje de Haan; Ming Song; Oliver C. Grant; Zilu Ye; Fawzi Khoder Agha; Mikkel Koed Møller Aasted; Robert J. Woods; Sergey Y. Vakhrushev; Hans H. Wandall
Publicado en: Analytical Chemistry, Edición 3, 2023, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.3c03626

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Autores: Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall, Morten Frödin
Publicado en: Nucleic Acids Research, Edición 48/21, 2020, Página(s) 11958-11981, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa975

Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells

Autores: Ieva Bagdonaite, Andrew J. Thompson, Xiaoning Wang, Max Søgaard, Cyrielle Fougeroux, Martin Frank, Jolene K. Diedrich, John R. Yates, Ali Salanti, Sergey Y. Vakhrushev, James C. Paulson, Hans H. Wandall
Publicado en: Viruses, Edición 13/4, 2021, Página(s) 551, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13040551

Genetic glycoengineering in mammalian cells

Autores: Yoshiki Narimatsu, Christian Büll, Yen-Hsi Chen, Hans H. Wandall, Zhang Yang, Henrik Clausen
Publicado en: Journal of Biological Chemistry, Edición 296, 2021, Página(s) 100448, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100448

Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context

Autores: Mathias Ingemann Nielsen, John Stegmayr, Oliver C. Grant, Zhang Yang, Ulf J. Nilsson, Irene Boos, Michael C. Carlsson, Robert J. Woods, Carlo Unverzagt, Hakon Leffler, Hans H. Wandall
Publicado en: Journal of Biological Chemistry, Edición 293/52, 2018, Página(s) 20249-20262, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.004636

Quantitative characterization of O-GalNAc glycosylation

Autores: Tomislav Čaval, Noortje de Haan, Andriana Konstantinidi, Sergey Y Vakhrushev
Publicado en: Current Opinion in Structural Biology, Edición 68, 2023, Página(s) 135-141, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2020.12.010

Twin Prime Editing Mediated Exon Skipping/Reinsertion for Restored Collagen VII Expression in Recessive Dystrophic Epidermolysis Bullosa

Autores: Benjamin J. Steinbeck, Xin D. Gao, Amber N. McElroy, Smriti Pandey, Jordan L. Doman, Megan J. Riddle, Lily Xia, Weili Chen, Cindy R. Eide, Andre H. Lengert, Sang Won Han, Bruce R. Blazar, Hans H. Wandall, Sally Dabelsteen, David R. Liu, Jakub Tolar, Mark J. Osborn
Publicado en: Journal of Investigative Dermatology, Edición 144, 2024, Página(s) 2764-2777.e9, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.04.013

Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

Autores: Sally Dabelsteen, Emil M.H. Pallesen, Irina N. Marinova, Mathias I. Nielsen, Maria Adamopoulou, Troels B. Rømer, Asha Levann, Mikkel M. Andersen, Zilu Ye, David Thein, Eric P. Bennett, Christian Büll, Sam J. Moons, Thomas Boltje, Henrik Clausen, Sergey Y. Vakhrushev, Ieva Bagdonaite, Hans H. Wandall
Publicado en: Developmental Cell, Edición 54/5, 2020, Página(s) 669-684.e7, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2020.06.039

In-Depth Profiling of <i>O</i>-Glycan Isomers in Human Cells Using C18 Nanoliquid Chromatography–Mass Spectrometry and Glycogenomics

Autores: Noortje de Haan; Yoshiki Narimatsu; Mikkel Koed Møller Aasted; Ida S. B. Larsen; Irina N. Marinova; Sally Dabelsteen; Sergey Y. Vakhrushev; Hans H. Wandall
Publicado en: Analytical Chemistry, Edición 2, 2022, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.1c05068

Golgi fragmentation – One of the earliest organelle phenotypes in Alzheimer’s disease neurons

Autores: Henriette Haukedal, Giulia I. Corsi, Veerendra P. Gadekar, Nadezhda T. Doncheva, Shekhar Kedia, Noortje de Haan, Abinaya Chandrasekaran, Pia Jensen, Pernille Schiønning, Sarah Vallin, Frederik Ravnkilde Marlet, Anna Poon, Carlota Pires, Fawzi Khoder Agha, Hans H. Wandall, Susanna Cirera, Anja Hviid Simonsen, Troels Tolstrup Nielsen, Jørgen Erik Nielsen, Poul Hyttel, Ravi Muddashetty, Blanca I. A
Publicado en: Frontiers in Neuroscience, Edición 17, 2024, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2023.1120086