Dissection of Glycan Function by Engineered Tissue Models

Informazioni relative al progetto

GlycoSkin

ID dell’accordo di sovvenzione: 772735

DOI

10.3030/772735

Progetto chiuso

Data della firma CE 7 Febbraio 2018

Data di avvio 1 Marzo 2018

Data di completamento 30 Novembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 995 199,00

Contributo UE

€ 1 995 199,00

Coordinato da

KOBENHAVNS UNIVERSITET
Denmark

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (20)

CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation

Autori: Troels Boldt Rømer; Fawzi Khoder-Agha; Mikkel Koed Møller Aasted; Noortje de Haan; Sabrina Horn; August Dylander; Tao Zhang; Emil Marek Heymans Pallesen; Sally Dabelsteen; Manfred Wuhrer; Christine Flodgaard Høgsbro; Emil Aagaard Thomsen; Jacob Giehm Mikkelsen; Hans H Wandall
Pubblicato in: Glycobiology, Numero 2, 2023, ISSN 1460-2423
Editore: Oxford Journals
DOI: 10.1093/glycob/cwad003

O‐glycan initiation directs distinct biological pathways and controls epithelial differentiation

Autori: Ieva Bagdonaite, Emil MH Pallesen, Zilu Ye, Sergey Y Vakhrushev, Irina N Marinova, Mathias I Nielsen, Signe H Kramer, Stine F Pedersen, Hiren J Joshi, Eric P Bennett, Sally Dabelsteen, Hans H Wandall
Pubblicato in: EMBO reports, Numero 21/6, 2020, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.201948885

Global aspects of viral glycosylation

Autori: Ieva Bagdonaite, Hans H Wandall
Pubblicato in: Glycobiology, Numero 28/7, 2018, Pagina/e 443-467, ISSN 1460-2423
Editore: Oxford Academic
DOI: 10.1093/glycob/cwy021

Reading and Writing the Human Glycocode

Autori: Noortje de Haan, Mathias I. Nielsen, Hans H. Wandall
Pubblicato in: Annual Review of Biochemistry, Numero 93, 2024, Pagina/e 529-564, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030122-044347

Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples

Autori: Noortje de Haan, Maja Pučić-Baković, Mislav Novokmet, David Falck, Guinevere Lageveen-Kammeijer, Genadij Razdorov, Frano Vučković, Irena Trbojević-Akmačić, Olga Gornik, Maja Hanić, Manfred Wuhrer, Gordan Lauc, null null, Andras Guttman, Richard Cummings, Samia Mora, Yoann Rombouts, Andad Mehta
Pubblicato in: Glycobiology, Numero 32, 2022, Pagina/e 651-663, ISSN 1460-2423
Editore: Oxford University Press
DOI: 10.1093/glycob/cwac026

Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line

Autori: Mathias I. Nielsen, Noortje de Haan, Weston Kightlinger, Zilu Ye, Sally Dabelsteen, Minyan Li, Michael C. Jewett, Ieva Bagdonaite, Sergey Y. Vakhrushev, Hans H. Wandall
Pubblicato in: Nature Communications, Numero 13, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-33806-8

Binding of Akkermansia muciniphila to mucin is O-glycan specific

Autori: Janneke Elzinga, Yoshiki Narimatsu, Noortje de Haan, Henrik Clausen, Willem M. de Vos, Hanne L. P. Tytgat
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-48770-8

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

Autori: Sofie H. Møller, Maiken Mellergaard, Mikkel Madsen, Amaia V. Bermejo, Stine D. Jepsen, Marie H. Hansen, Rikke I. Høgh, Blanca I. Aldana, Claus Desler, Lene Juel Rasmussen, Elahu G. Sustarsic, Zachary Gerhart-Hines, Evangelia Daskalaki, Craig E. Wheelock, Thomas K. Hiron, Da Lin, Christopher A. O’Callaghan, Hans H. Wandall, Lars Andresen, Søren Skov
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.01968

Role of N-Glycosylation in FcγRIIIa interaction with IgG

Autori: Julie Van Coillie, Morten A. Schulz, Arthur E. H. Bentlage, Noortje de Haan, Zilu Ye, Dionne M. Geerdes, Wim J. E. van Esch, Lise Hafkenscheid, Rebecca L. Miller, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Zhang Yang, Gestur Vidarsson, Henrik Clausen
Pubblicato in: Frontiers in Immunology, Numero 13, 2023, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.987151

Glycoproteomics

Autori: Ieva Bagdonaite, Stacy A. Malaker, Daniel A. Polasky, Nicholas M. Riley, Katrine Schjoldager, Sergey Y. Vakhrushev, Adnan Halim, Kiyoko F. Aoki-Kinoshita, Alexey I. Nesvizhskii, Carolyn R. Bertozzi, Hans H. Wandall, Benjamin L. Parker, Morten Thaysen-Andersen, Nichollas E. Scott
Pubblicato in: Nature Reviews Methods Primers, Numero 2, 2024, ISSN 2662-8449
Editore: Nature
DOI: 10.1038/s43586-022-00128-4

Sensitive and Specific Global Cell Surface <i>N</i>-Glycoproteomics Shows Profound Differences Between Glycosylation Sites and Subcellular Components

Autori: Noortje de Haan; Ming Song; Oliver C. Grant; Zilu Ye; Fawzi Khoder Agha; Mikkel Koed Møller Aasted; Robert J. Woods; Sergey Y. Vakhrushev; Hans H. Wandall
Pubblicato in: Analytical Chemistry, Numero 3, 2023, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.3c03626

INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

Autori: Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall, Morten Frödin
Pubblicato in: Nucleic Acids Research, Numero 48/21, 2020, Pagina/e 11958-11981, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa975

Site-Specific O-Glycosylation Analysis of SARS-CoV-2 Spike Protein Produced in Insect and Human Cells

Autori: Ieva Bagdonaite, Andrew J. Thompson, Xiaoning Wang, Max Søgaard, Cyrielle Fougeroux, Martin Frank, Jolene K. Diedrich, John R. Yates, Ali Salanti, Sergey Y. Vakhrushev, James C. Paulson, Hans H. Wandall
Pubblicato in: Viruses, Numero 13/4, 2021, Pagina/e 551, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13040551

Genetic glycoengineering in mammalian cells

Autori: Yoshiki Narimatsu, Christian Büll, Yen-Hsi Chen, Hans H. Wandall, Zhang Yang, Henrik Clausen
Pubblicato in: Journal of Biological Chemistry, Numero 296, 2021, Pagina/e 100448, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100448

Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context

Autori: Mathias Ingemann Nielsen, John Stegmayr, Oliver C. Grant, Zhang Yang, Ulf J. Nilsson, Irene Boos, Michael C. Carlsson, Robert J. Woods, Carlo Unverzagt, Hakon Leffler, Hans H. Wandall
Pubblicato in: Journal of Biological Chemistry, Numero 293/52, 2018, Pagina/e 20249-20262, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.004636

Quantitative characterization of O-GalNAc glycosylation

Autori: Tomislav Čaval, Noortje de Haan, Andriana Konstantinidi, Sergey Y Vakhrushev
Pubblicato in: Current Opinion in Structural Biology, Numero 68, 2023, Pagina/e 135-141, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2020.12.010

Twin Prime Editing Mediated Exon Skipping/Reinsertion for Restored Collagen VII Expression in Recessive Dystrophic Epidermolysis Bullosa

Autori: Benjamin J. Steinbeck, Xin D. Gao, Amber N. McElroy, Smriti Pandey, Jordan L. Doman, Megan J. Riddle, Lily Xia, Weili Chen, Cindy R. Eide, Andre H. Lengert, Sang Won Han, Bruce R. Blazar, Hans H. Wandall, Sally Dabelsteen, David R. Liu, Jakub Tolar, Mark J. Osborn
Pubblicato in: Journal of Investigative Dermatology, Numero 144, 2024, Pagina/e 2764-2777.e9, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.04.013

Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

Autori: Sally Dabelsteen, Emil M.H. Pallesen, Irina N. Marinova, Mathias I. Nielsen, Maria Adamopoulou, Troels B. Rømer, Asha Levann, Mikkel M. Andersen, Zilu Ye, David Thein, Eric P. Bennett, Christian Büll, Sam J. Moons, Thomas Boltje, Henrik Clausen, Sergey Y. Vakhrushev, Ieva Bagdonaite, Hans H. Wandall
Pubblicato in: Developmental Cell, Numero 54/5, 2020, Pagina/e 669-684.e7, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2020.06.039

In-Depth Profiling of <i>O</i>-Glycan Isomers in Human Cells Using C18 Nanoliquid Chromatography–Mass Spectrometry and Glycogenomics

Autori: Noortje de Haan; Yoshiki Narimatsu; Mikkel Koed Møller Aasted; Ida S. B. Larsen; Irina N. Marinova; Sally Dabelsteen; Sergey Y. Vakhrushev; Hans H. Wandall
Pubblicato in: Analytical Chemistry, Numero 2, 2022, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.1c05068

Golgi fragmentation – One of the earliest organelle phenotypes in Alzheimer’s disease neurons

Autori: Henriette Haukedal, Giulia I. Corsi, Veerendra P. Gadekar, Nadezhda T. Doncheva, Shekhar Kedia, Noortje de Haan, Abinaya Chandrasekaran, Pia Jensen, Pernille Schiønning, Sarah Vallin, Frederik Ravnkilde Marlet, Anna Poon, Carlota Pires, Fawzi Khoder Agha, Hans H. Wandall, Susanna Cirera, Anja Hviid Simonsen, Troels Tolstrup Nielsen, Jørgen Erik Nielsen, Poul Hyttel, Ravi Muddashetty, Blanca I. A
Pubblicato in: Frontiers in Neuroscience, Numero 17, 2024, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fnins.2023.1120086