Addressing the dual emerging threats of African Swine Fever and Lumpy Skin Disease in Europe (DEFEND)

Projektinformationen

DEFEND

ID Finanzhilfevereinbarung: 773701

DOI

10.3030/773701

Projekt abgeschlossen

EK-Unterschriftsdatum 8 Mai 2018

Startdatum 1 Juni 2018

Enddatum 30 November 2023

Finanziert unter

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Gesamtkosten

€ 5 992 500,00

EU-Beitrag

€ 5 599 999,50

Koordiniert durch

THE PIRBRIGHT INSTITUTE LBG
United Kingdom

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (25)

Report on the identification and characterisation of subclinical LSDV infection
Publication on literature review and risk factor analysis
Report on the phylodynamic analysis of ASFV and LSDV in Europe
Report on proposed LSDV and ASFV molecular diagnostic and genotyping protocols.
Guidelines to implement compartmentalization for ASF in the European context
Measuring the persistence of antibodies post-LSD in the Balkans
Report of fieldwork experiences, including maps, routes, types of transboundary movements, risk factors

Report of fieldwork experiences including maps routes types of transboundary movements risk factors

Report of the indirect LSDV transmission and LSDV transmission via artificial insemination
ASF vaccination and post vaccination monitoring to assess the efficiency of ASF vaccination
Risk analysis framework
Candidate genes for LSD resistance
Report on LSDV transmission using in vitro and in vivo infected vectors
Report on LSDV in meat and hides before and after treatment
Methodological report on the implementation techniques of fieldwork activities in a comparative perspective
Optimal Selection Strategy
Standards for post-LSD-vaccination monitoring
Dissemination and communications tools (poster, webpage, factsheet)
Practice abstracts

"The resulting innovative knowledge and easy accessible end-user material from this project will feed into the EIP-AGRI (The agricultural European Innovation Partnership) website for broad dissemination. The end-user material to be produced contains a substantial number of summaries for practitioners in the EIP common format (""practice abstracts""), including the characteristics of the project (e.g. contact details of partners, etc). A full package of practice abstracts will be produced by the project, containing all the outcomes/recommendations which are ready for practice.A ""practice abstract"" is a short summary of around 1000-1500 characters (word count – no spaces; see below) which describes the main information/recommendation/practice that can serve the end-users in their daily practice. A total target number of 15 practice abstracts is foreseen for the project. A third of them are expected to be delivered in the first batch."

Influence of co-incident vaccination on immune parameters associated with LSD vaccination
Methodology to estimate ASF prevalence in wild boar in endemic and epidemic areas
Candidate genes for ASF resistance
Policy brief on implications, impacts, recommendations on conflict, migration and virus spread
Report on the ASFV and LSDV complete genome sequences generated in the project
GWAS results
Report on the PCR and virus isolation analysis of field captured biting insects during LSD outbreaks

Open Research Data Pilot (1)

Data Management Plan (DMP)

Veröffentlichungen

Peer reviewed articles (23)

Madin-Darby bovine kidney (MDBK) cells are a suitable cell line for the propagation and study of the bovine poxvirus lumpy skin disease virus

Autoren: Petra C. Fay, Charlotte G. Cook, Najith Wijesiriwardana, Gessica Tore, Loic Comtet, Alix Carpentier, Barbara Shih, Graham Freimanis, Ismar R. Haga, Philippa M. Beard
Veröffentlicht in: Journal of Virological Methods, Ausgabe 285, 2020, Seite(n) 113943, ISSN 0166-0934
Herausgeber: Elsevier BV
DOI: 10.1016/j.jviromet.2020.113943

Semi-quantitative risk assessment of African swine fever virus introduction in pig farms

Autoren: Annalisa Scollo; Francesco Valentini; Giorgio Franceschini; Alessia Rusinà; Stefania Calò; Veronica Cappa; Alessandro Bellato; Alessandro Mannelli; Giovanni Loris Alborali; Silvia Bellini
Veröffentlicht in: Front. Vet. Sci., 27 January 2023, Sec. Veterinary Epidemiology and Economics, Ausgabe 2, 2023, ISSN 2297-1769
Herausgeber: Frontiers in Veterinary Science
DOI: 10.3389/fvets.2023.1017001

Complete genome reconstruction of the global and European regional dispersal history of the lumpy skin disease virus

Autoren: Steven Van Borm; Simon Dellicour; Darren P. Martin; Philippe Lemey; Eirini I. Agianniotaki; Eleni D. Chondrokouki; Dejan Vidanovic; Nikola Vaskovic; Tamaš Petroviċ; Sava Laziċ; Xhelil Koleci; Ani Vodica; Igor Djadjovski; Kiril Krstevski; Frank Vandenbussche; Andy Haegeman; Kris De Clercq; Elisabeth Mathijs
Veröffentlicht in: Journal of Virology, Ausgabe 8, 2023, ISSN 1098-5514
Herausgeber: ASM
DOI: 10.1128/jvi.01394-23

Mathematical Approach to Estimating the Main Epidemiological Parameters of African Swine Fever in Wild Boar

Autoren: Federica Loi, Stefano Cappai, Alberto Laddomada, Francesco Feliziani, Annalisa Oggiano, Giulia Franzoni, Sandro Rolesu, Vittorio Guberti
Veröffentlicht in: Vaccines, Ausgabe 8/3, 2020, Seite(n) 521, ISSN 2076-393X
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030521

Potential link of single nucleotide polymorphisms to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa

Autoren: Antoinette Schalkwyk, Pravesh Kara, Karen Ebersohn, Arshad Mather, Cornelius Henry Annandale, Estelle Hildegard Venter, David Brian Wallace
Veröffentlicht in: Transboundary and Emerging Diseases, Ausgabe 67/6, 2020, Seite(n) 2946-2960, ISSN 1865-1674
Herausgeber: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.13670

A Review of Environmental Risk Factors for African Swine Fever in European Wild Boar.

Autoren: Hannes Bergmann; Katja Schulz; Franz Josef Conraths; Carola Sauter-Louis
Veröffentlicht in: Animals : an Open Access Journal from MDPI, Ausgabe 9, 2021, Seite(n) 2692, ISSN 2076-2615
Herausgeber: MDPI
DOI: 10.3390/ani11092692

A Review of Risk Factors of African Swine Fever Incursion in Pig Farming within the European Union Scenario

Autoren: Silvia Bellini, Gabriele Casadei, Giorgia De Lorenzi, Marco Tamba
Veröffentlicht in: Pathogens, Ausgabe 10/1, 2021, Seite(n) 84, ISSN 2076-0817
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10010084

Identification of Risk Factors for African Swine Fever: A Systematic Review

Autoren: Hannes Bergmann; Johanna Dups-Bergmann; Katja Schulz; Carolina Probst; Laura Zani; Melina Fischer; Jörn Gethmann; Nicolai Denzin; Sandra Blome; Franz J. Conraths; Carola Sauter-Louis
Veröffentlicht in: Viruses; Volume 14; Ausgabe 10; Pages: 2107, Ausgabe 2, 2022, Seite(n) 2107, ISSN 1999-4915
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14102107

Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs

Autoren: Lynnette C. Goatley †,Rachel H. Nash †,Catherine Andrews,Zoe Hargreaves,Priscilla TngORCID,Ana Luisa ReisORCID,Simon P. GrahamORCID andChristopher L. Netherton *ORCID
Veröffentlicht in: "Special Ausgabe ""African Swine Fever Virus 2.0""", 2022, ISSN 1999-4915
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14071487

Remote Sensing Provides a Rapid Epidemiological Context for the Control of African Swine Fever in Germany

Autoren: Hannes Bergmann, Eva-Maria Czaja, Annett Frick, Ulf Klaaß, Ronny Marquart, Annett Rudovsky, Diana Holland, Patrick Wysocki, Daike Lehnau, Ronald Schröder, Lisa Rogoll, Carola Sauter-Louis, Timo Homeier-Bachmann
Veröffentlicht in: Sensors, 2023, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23198202

R0 Estimation for the African Swine Fever Epidemics in Wild Boar of Czech Republic and Belgium

Autoren: Andrea Marcon, Annick Linden, Petr Satran, Vincenzo Gervasi, Alain Licoppe, Vittorio Guberti
Veröffentlicht in: Veterinary Sciences, Ausgabe 7/1, 2020, Seite(n) 2, ISSN 2306-7381
Herausgeber: Veterinary Sciences
DOI: 10.3390/vetsci7010002

Estimating the Directional Spread of Epidemics in Their Early Stages Using a Simple Regression Approach: A Study on African Swine Fever in Northern Italy

Autoren: Vincenzo Gervasi; Marco Sordilli; Federica Loi; Vittorio Guberti
Veröffentlicht in: Pathogens; Volume 12; Ausgabe 6; Pages: 812, Ausgabe 3, 2023, ISSN 2076-0817
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12060812

The diffusion metrics of African swine fever in wild boar

Autoren: Hartmut H. K. Lentz; Hannes Bergmann; Franz J. Conraths; Jana Schulz; Carola Sauter-Louis
Veröffentlicht in: Scientific Reports, Ausgabe 1, 2023, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-023-42300-0

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

Autoren: Petra C. Fay, Najith Wijesiriwardana, Henry Munyanduki, Beatriz Sanz-Bernardo, Isabel Lewis, Ismar R. Haga, Katy Moffat, Arnoud H. M. van Vliet, Jayne Hope, Simon P. Graham and Philippa M. Beard
Veröffentlicht in: Frontiers in Immunology, Ausgabe 2022 Volume 13, 2022, Seite(n) 1051008, ISSN 1664-3224
Herausgeber: Frontiers
DOI: 10.3389/fimmu.2022.1051008

A robust, cost-effective and widely applicable whole-genome sequencing protocol for capripoxviruses

Autoren: Elisabeth Mathijs; Andy Haegeman; Kris De Clercq; Steven Van Borm; Frank Vandenbussche
Veröffentlicht in: Journal of Virological Methods, Ausgabe 1, 2022, Seite(n) 114464, ISSN 0166-0934
Herausgeber: Elsevier BV
DOI: 10.1016/j.jviromet.2022.114464

Evaluation of the Efficiency of Active and Passive Surveillance in the Detection of African Swine Fever in Wild Boar

Autoren: Vincenzo Gervasi, Andrea Marcon, Silvia Bellini, Vittorio Guberti
Veröffentlicht in: Veterinary Sciences, Ausgabe 7/1, 2020, Seite(n) 5, ISSN 2306-7381
Herausgeber: Veterinary Sciences
DOI: 10.3390/vetsci7010005

Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by Stomoxys calcitrans

Autoren: Andy Haegeman; Charlotte Sohier; Laurent Mostin; Ilse De Leeuw; Willem Van Campe; Wannes Philips; Nick De Regge; Kris De Clercq
Veröffentlicht in: Viruses; Volume 15; Ausgabe 6; Pages: 1285, Ausgabe 7, 2023, ISSN 1999-4915
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15061285

Combining hunting and intensive carcass removal to eradicate African swine fever from wild boar populations

Autoren: Vincenzo Gervasi; Vittorio Guberti
Veröffentlicht in: Crossref, Ausgabe 10, 2022, Seite(n) 105633, ISSN 0167-5877
Herausgeber: Elsevier BV
DOI: 10.1016/j.prevetmed.2022.105633

African swine fever endemic persistence in wild boar populations: Key mechanisms explored through modelling

Autoren: Gervasi V., Guberti V.
Veröffentlicht in: Transboundary and Emerging Diseases, Ausgabe 2021; Volume 68, Ausgabe 5 p. 2812-2825, 2021, ISSN 1865-1682
Herausgeber: Wiley
DOI: 10.1111/tbed.14194

Estimating the risk of environmental contamination by forest users in African Swine Fever endemic areas

Autoren: Gervasi V., Marcon A., Guberti V.
Veröffentlicht in: Acta Veterinaria Scandinava, Ausgabe 64, Article number: 16 (2022) , 2022, ISSN 1751-0147
Herausgeber: Pubmed
DOI: 10.1186/s13028-022-00636-z

Semi-Quantitative Risk Assessment of African Swine Fever Virus Introduction in Outdoor Pig Farms

Autoren: Alessia Rusinà; Francesco Valentini; Annalisa Scollo; Giorgio Franceschini; Sara Salvato; Veronica Cappa; Alessandro Bellato; Alessandro Mannelli; Silvia Bellini
Veröffentlicht in: Pathogens; Volume 12; Ausgabe 5; Pages: 709, Ausgabe 5, 2023, ISSN 2076-0817
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12050709

Review: Vaccines and Vaccination against Lumpy Skin Disease

Autoren: Eeva Tuppurainen, Klaas Dietze, Janika Wolff, Hannes Bergmann, Daniel Beltran-Alcrudo, Anna Fahrion, Charles Euloge Lamien, Frank Busch, Carola Sauter-Louis, Franz J. Conraths, Kris De Clercq, Bernd Hoffmann and Sascha Knauf
Veröffentlicht in: Vaccines, Ausgabe 2021, 9(10), 1136, 2021, Seite(n) 1136, ISSN 2076-393X
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9101136

A field study evaluating the humoral immune response in Mongolian sheep vaccinated against sheeppox virus

Autoren: Petra Fay, Georgina Limon, Gerelmaa Ulziibat, Buyantogtokh Khanui, Odonchimeg Myagmarsuren, Gessica Tore, Bodisaikhan Khishgee, John Flannery, Batkhuyag Sandag, Batchuluun Damdinjav, Philippa M. Beard
Veröffentlicht in: Transboundary and Emerging Diseases, 2021, ISSN 1865-1674
Herausgeber: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.14163

Book chapters (1)

African swine fever vaccines

Autoren: Netherton, Christopher L.
Veröffentlicht in: Viruses, 2021, Seite(n) Pages: 161–182, ISBN 9789086869107
Herausgeber: Wageningen Academic
DOI: 10.3920/978-90-8686-910-7_6

Conference proceedings (1)

Host variation in susceptibility to lumpy skin disease: gene expression analyses of experimentally infected cows.

Autoren: Van Borm, S., Klingström, T., Niazi, A., De Clercq, K., Mostin, L., Haegeman, A., De Koning, D.J.
Veröffentlicht in: Proceeding of the World Conference of Genetics Applied to Livestock Production, 2023, Seite(n) 668 - 671, ISBN 978-90-8686-940-4
Herausgeber: Wageningen Academic
DOI: 10.3920/978-90-8686-940-4_154