Descripción del proyecto
Visión holística de la artrosis
La artrosis (OA, por sus siglas en inglés) es una enfermedad articular degenerativa frecuente que afecta principalmente a las personas mayores, pero que también puede afectar a personas más jóvenes y a deportistas. La artrosis causa dolor articular, limita la movilidad y reduce la independencia y la calidad de vida en general. Aunque se han implicado diversos factores de riesgo en el desarrollo de la artrosis, es necesario integrar la información específica del paciente a nivel celular, tisular, orgánico y corporal. El equipo del proyecto OACTIVE, financiado con fondos europeos, pretende colmar esta laguna adoptando un enfoque holístico que combine datos específicos de cada paciente con información procedente de biomarcadores, modelos de comportamiento y factores ambientales. Los investigadores pretenden desarrollar intervenciones personalizadas para retrasar la aparición y ralentizar la progresión de la artrosis, utilizando también la realidad aumentada para aumentar la motivación y el compromiso de los pacientes.
Objetivo
Osteoarthritis (OA) is a degenerative disease of the articular cartilage and the most common form of arthritis that causes joint pain, mobility limitation and, thus, reduces independence and overall quality of life. Although the usual population associated with the condition is the elderly (65 years old ranges from 12- 30%), who are mostly inactive, athletes and younger individuals are also susceptible. Whilst the available data have implicated the role of the various modifiable or non-modifiable risk factors in the development and progression of OA, no study has conclusively explored the interaction and integration of other information sets in a patient-specific manner. The current OACTIVE project intents to make a significant leap forward adopting a multi-scale holistic approach where patient-specific information from various levels, including cell, tissue, organ and whole body will be integrated and combined with information from other sources such as biochemical/inflammatory biomarkers, behaviour modeling and social/environmental risk factors to generate robust predictors for new personalised interventions for delaying onset and slowing down progression of OA. OACTIVE targets to patient-specific OA prediction and interventions by using a combination of mechanistic, phenomenological computational models, simulations and big data analytics. Once constructed, these models will be used to simulate and predict optimal treatments, better diagnostics, and improved patient outcomes. Overcoming the limitation of the current treatment interventions, Augmented Reality empowered interventions will be developed in a personalised framework allowing patients experience the treatment as more enjoyable, resulting in greater motivation, engagement, and training adherence. OACTIVE’s mission is to improve healthcare by transforming and accelerating the OA diagnosis and prediction based on a more comprehensive understanding of disease pathophysiology, dynamics, and patient outcomes.
Ámbito científico
- medical and health sciencesclinical medicinerheumatology
- medical and health sciencesbasic medicinephysiologypathophysiology
- natural sciencescomputer and information sciencesdata sciencebig data
- natural sciencescomputer and information sciencesartificial intelligencemachine learningdeep learning
- natural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SC1-2017-CNECT-2
Régimen de financiación
RIA - Research and Innovation actionCoordinador
1700 Nicosia
Chipre