CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.
I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .
Risultati finali
Final press release with summary on the general project progress and main findings will be published
First quarterly electronic bulletins online (si apre in una nuova finestra)Publication of the first quarterly electronic bulletin with information on the project progress and first results
Release of project website public and internal part, communication package (logo, flyer, social media announcement (si apre in una nuova finestra)Corporate design eg logo PPT layout flyer and public and internal part of EQIPD website set up to disseminate results to the public
First press release (si apre in una nuova finestra)The first EQIPD press release with general information focusing on the aims of the project as well as the outcomes from the first project meeting will be published
All sites involved in the animal experiments will obtain ethical approval for their experiments
Report factors identified by historical data of published data (si apre in una nuova finestra)A report will be generated that describes the experimental design factors identified from the systematic review of published academic data that affect outcomes
Report on factors that underlie the robustness and generalisability of commonly used assays (si apre in una nuova finestra)A report of the prevalence and impact of factors related to the robustness and generalisability of commonly used assays derived from the analyses of data from members of the consortium of published academic studies
Report on validated guiding principles for robustness and data quality in preclinical Neuroscience and Safety research (si apre in una nuova finestra)Based on the outcome of the harmonisation experiments a report will be generated to provide guiding principles for optimal study design and experimentation
Outcome report from cross site validation (si apre in una nuova finestra)An outcome report on stage 1 of the crosssite validation study localization stage will be generated by the sites involved in the experiments on the basis of the generated data This will involve data summaries statistical analyses and conclusions
Outcome report from harmonized testing (si apre in una nuova finestra)An outcome report on stage 2 of the crosssite validation study harmonisation stage will be generated by the sites involved in the experiments on the basis of the generated data This will involve data summaries statistical analyses and conclusions
Evaluation of existing training modules (si apre in una nuova finestra)Generation of a list of existing training modules on keyprinciples for preclinical robustness and quality including an evaluation of each module against 1 the scope of EQIPD as determined by WPs 2 3 4 5 and 6 and 2 our predefined set of User Specification Requirements USR
With input from WPs 2 and 3 develop harmonized protocols for cross validation testing (si apre in una nuova finestra)Based on input from WPs 2 and 3 the local experimental protocols will be updated in order to perform stage 2 of the crosssite validation studies eg harmonisation
Data sharing procedures beyond EQIPD (si apre in una nuova finestra)A legally valid Data Deposition agreement will be developed to ensure that data depositors have control over whether or not their data can be made public before or after the end of this consortium
Final version of the framework of key principles and criteria for guiding the design, conduct and analysis of preclinical efficacy and safety research (si apre in una nuova finestra)The framework will be reevaluated and refined with the conclusions of the prospective crosssite validation studies performed by WP23 at a second consensus meeting A final guidance will be agreed and then published A process for continuous improvement of the guidance will be agreed
Final version of quality assurance system ready for implementation in industry and academia in non-regulated research (si apre in una nuova finestra)Readytouse set of recommendations addressing the needs of research organizations of different types with the integrated risk assessment and tiered implementation tools
Outcome report from Ring testing (si apre in una nuova finestra)An outcome report on stage 3 of the crosssite validation study Ring testing stage will be generated by the sites involved in the experiments on the basis of the generated data This will involve data summaries statistical analyses and conclusions
A diagram of the EQIPDDWH solution to house all different database structures required for WPs 2 and 4 with appropriate capacity and user rights
Comprehensive, engaging, selection of training materials on scientific quality, hosted on a web-based platform (si apre in una nuova finestra)A Learning Environment has been selected and installed and existing training modules or those newly developed have been collated in the Education section of this Learning Environment utilizing a collection of links to various training modules and have undergone alpha and beta testing
Structure and first incentives for electronic community enabling social learning, hosted on a web-based platform (si apre in una nuova finestra)The social learning Exposure section of the learning environment is populated and live for use including eg electronic bulletins links to existing discussion groups Facebook Twitter LinkedIn
Specifications and a working example of an information exchange protocol will be established to enable errorless and fully transparent communication between office study design assistants electronic lab journals and labbased research software
A transparent protocol for unbiased inclusion of experimental paradigms and data sets required for WPs 2 and 4An ontology for the description of in vivo experiments such as these including quality aspects and working alongside other groups sharing the same ambition and develop a template for the depositing of such work in open access fora such as figshare Our data will be deposited using the template devised
Pubblicazioni
Autori:
Anton Bespalov, René Bernard, Anja Gilis, Björn Gerlach, Javier Guillén, Vincent Castagné, Isabel A Lefevre, Fiona Ducrey, Lee Monk, Sandrine Bongiovanni, Bruce Altevogt, María Arroyo-Araujo, Lior Bikovski, Natasja de Bruin, Esmeralda Castaños-Vélez, Alexander Dityatev, Christoph H Emmerich, Raafat Fares, Chantelle Ferland-Beckham, Christelle Froger-Colléaux, Valerie Gailus-Durner, Sabine
Pubblicato in:
eLife, Numero 10, 2021, ISSN 2050-084X
Editore:
eLife Sciences Publications
DOI:
10.7554/elife.63294
Autori:
Bernhard Voelkl, Naomi S. Altman, Anders Forsman, Wolfgang Forstmeier, Jessica Gurevitch, Ivana Jaric, Natasha A. Karp, Martien J. Kas, Holger Schielzeth, Tom Van de Casteele, Hanno Würbel
Pubblicato in:
Nature Reviews Neuroscience, Numero 21/7, 2020, Pagina/e 384-393, ISSN 1471-003X
Editore:
Nature Publishing Group
DOI:
10.1038/s41583-020-0313-3
Autori:
Betül R. Erdogan, Jan Vollert, Martin C. Michel
Pubblicato in:
Naunyn-Schmiedeberg's Arch Pharmacol, Numero 393, 2020, Pagina/e 1769-1772, ISSN 1432-1912
Editore:
Springer
DOI:
10.1007/s00210-020-01926-x
Autori:
Jan Vollert, Esther Schenker, Malcolm Macleod, Anton Bespalov, Hanno Wuerbel, Martin Christian Michel, Ulrich Dirnagl, Heidrun Potschka, Kimberley E Wever, Thomas Steckler, Bruce Altevogt, Andrew S C Rice
Pubblicato in:
BMJ Open Science, Numero 2/1, 2018, Pagina/e e000004, ISSN 2398-8703
Editore:
BMJ
DOI:
10.1136/bmjos-2018-000004
Autori:
Steckler, T., Macleod, M., Kas, M. J. H., Gilis, A., & Wever, K. E.
Pubblicato in:
Biotechniek, Numero 57 (2), 2018, Pagina/e 18-23, ISSN 0166-6207
Editore:
Stichting Proefdierkundige Informatie
Autori:
Harvey J Motulsky, Martin C Michel
Pubblicato in:
British Journal of Pharmacology, Numero 175/18, 2018, Pagina/e 3636-3637, ISSN 0007-1188
Editore:
Wiley-Blackwell
DOI:
10.1111/bph.14441
Autori:
Betul R. Erdogan, Irem Karaomerlioglu, Zeynep E. Yesilyurt, Nihal Ozturk, A. Elif Muderrisoglu, Martin C. Michel, Ebru Arioglu-Inan
Pubblicato in:
Naunyn-Schmiedeberg's Archives of Pharmacology, Numero 393/2, 2020, Pagina/e 243-251, ISSN 0028-1298
Editore:
Springer Verlag
DOI:
10.1007/s00210-019-01727-x
Autori:
Marjan Amiri, Sandra Murgas, Andreas Stang, Martin C. Michel
Pubblicato in:
Neurourology and Urodynamics, Numero 39/2, 2019, Pagina/e 754-761, ISSN 0733-2467
Editore:
John Wiley & Sons Inc.
DOI:
10.1002/nau.24275
Autori:
Anton Bespalov, Thomas Steckler, Phil Skolnick
Pubblicato in:
European Neuropsychopharmacology, Numero 29/12, 2019, Pagina/e 1312-1320, ISSN 0924-977X
Editore:
Elsevier BV
DOI:
10.1016/j.euroneuro.2019.10.007
Autori:
Martin C. Michel, T.J. Murphy, Harvey J. Motulsky
Pubblicato in:
Molecular Pharmacology, Numero 97/1, 2019, Pagina/e 49-60, ISSN 0026-895X
Editore:
American Society for Pharmacology and Experimental Therapeutics
DOI:
10.1124/mol.119.118927
Autori:
Martin C. Michel, T.J. Murphy, Harvey J. Motulsky
Pubblicato in:
Journal of Pharmacology and Experimental Therapeutics, Numero 372/1, 2019, Pagina/e 136-147, ISSN 0022-3565
Editore:
American Society for Pharmacology and Experimental Therapeutics
DOI:
10.1124/jpet.119.264143
Autori:
Martin C. Michel, T.J. Murphy, Harvey J. Motulsky
Pubblicato in:
Drug Metabolism and Disposition, Numero 48/1, 2019, Pagina/e 64-74, ISSN 0090-9556
Editore:
American Society for Pharmacology and Experimental Therapeutics
DOI:
10.1124/dmd.119.090027
Autori:
Jan Vollert, Esther Schenker, Malcolm Macleod, Anton Bespalov, Hanno Wuerbel, Martin Michel, Ulrich Dirnagl, Heidrun Potschka, Ann-Marie Waldron, Kimberley Wever, Thomas Steckler, Tom van de Casteele, Bruce Altevogt, Annesha Sil, Andrew S C Rice
Pubblicato in:
BMJ Open Science, Numero 4/1, 2020, Pagina/e e100046, ISSN 2398-8703
Editore:
BMJ
DOI:
10.1136/bmjos-2019-100046
Autori:
Annesha Sil, Arina Erfani, Nicola Lamb, Rachel Copland, Gernot Riedel, Bettina Platt
Pubblicato in:
Journal of Alzheimer's Disease (in press currently- preprint online on BioRxiv), 2021
Editore:
BioRxiv
DOI:
10.1101/2021.04.29.440396
Autori:
Kaitlyn Hair, Juan Pita Almenar, and Emily Sena, on behalf of the EQIPD WP2 study group
Pubblicato in:
Open Science Framework, Numero N/A, 2019, Pagina/e N/A
Editore:
Open Science Framework
Autori:
Kaitlyn Hair and Emily Sena, on behalf of the EQIPD WP2 study group
Pubblicato in:
Open Science Framework, Numero N/A, 2019, Pagina/e N/A
Editore:
Open Science Framework
Autori:
Isabel A. Lefevre
Pubblicato in:
Invited speaker, 11th World Congress on Alternatives and Animal Use in the Life Science (WC11), Numero Congress postponed to August 2021, abstract published on July 6, 2020, 2020, Pagina/e p 204
Editore:
World Congress on Alternatives and Animal Use in the Life Sciences
Autori:
Isabel A. Lefevre, Rita J. Balice-Gordon
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 35-54, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_276
Autori:
Betül R. Erdogan, Martin C. Michel
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 163-175, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_283
Autori:
Anton Bespalov, Karsten Wicke, Vincent Castagné
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 81-100, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_279
Autori:
Javier Guillén, Thomas Steckler
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 367-382, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_292
Autori:
Anja Gilis
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 349-365, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_291
Autori:
Patrizia Voehringer, Janet R. Nicholson
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 197-222, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_285
Autori:
Sandrine Bongiovanni, Robert Purdue, Oleg Kornienko, René Bernard
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 1-17, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_274
Autori:
Patricia Kabitzke, Kristin M. Cheng, Bruce Altevogt
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 19-34, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_275
Autori:
Wenlong Huang, Nathalie Percie du Sert, Jan Vollert, Andrew S. C. Rice
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 55-69, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_277
Autori:
Ulrich Dirnagl
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 71-79, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_278
Autori:
Björn Gerlach, Christopher Untucht, Alfred Stefan
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 257-275, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_287
Autori:
Malcolm R. Macleod, Ezgi Tanriver-Ayder, Kaitlyn Hair, Emily Sena
Pubblicato in:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 299-317, ISBN 978-3-030-33655-4
Editore:
Springer International Publishing
DOI:
10.1007/164_2019_289
Autori:
Malcolm Macleod, Thomas Steckler
Pubblicato in:
Nature, Numero 568/7753, 2019, Pagina/e 458-458, ISSN 0028-0836
Editore:
Nature Publishing Group
DOI:
10.1038/d41586-019-01293-5
Autori:
Bespalov A, Michel M, Steckler T (eds.)
Pubblicato in:
Handbook of Experimental Pharmacology, Good Research Practice in Non-Clinical Pharmacology and Biomedicine, Numero 257, 2020, Pagina/e 1-424, ISBN 978-3-030-33656-1
Editore:
Springer
DOI:
10.1007/978-3-030-33656-1
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