Resultado final Documents, reports (11) Risk assessment procedure Procedure for assessing risks and monitoring mitigation actions Revised LITMUS Data Management Plan Mid-term update of D2.2. Detailed dissemination plan Plans will be drawn up to regularly highlight the project developments at relevant conferences, in peer-reviewed journals and at dedicated workshops organised by the consortium. All journal publications will be open access. The dissemination plans, which will be continuously reviewed and updated, will identify key project related publications, which will be earmarked for “gold” open access. Dissemination will also be assured through the establishment and maintenance of a project website from the start of the project, with links to the participating researchers, clinicians and institutions. Imaging manual to standardise image acquisition across all participating sites LITMUS Imaging Manuals will be produced in parallel to the scanning protocol. One covering the MRI technical aspects and a second covering the ultrasound-based elastography technologies (using manufacturer protocols for VCTE, SSI, ARFI). These will be distributed to the participating sites to ensure standardised operating practices are followed across all participating sites. Project Handbook Quick reference guide for all LITMUS project participants Mid-term report summarising recruitment into the LITMUS Registry and catalogue of available samples SOPs for collection, processing and storage of whole blood, EDTA plasma, SST serum, urine, stool, frozen liver biopsies Pre-analytical SOPs will be written covering, e.g. sample collection and analysis of the stability/quality of the metabolomics profile of serum/plasma samples. Report describing minimally acceptable performance criteria for diagnostic testing We will use Web-based surveys (SurveyMonkey) with all LITMUS participants to identify minimally acceptable performance criteria, using a modified Delphi approach over at least two rounds of surveys. An optimised histological staging system for NAFLD-associated fibrosis Development and validation of an optimised histological staging system for NAFLD-associated fibrosis with correlation to fibrosis severity measured by CPA. Detailed plan for submission of biomarkers to the regulatory authorities (EMA and FDA) for qualification Agreed project plan for LITMUS to secure an official description of the validation process from the agencies that studies engaging in biomarkers will need to follow and fulfil for biomarker qualification. LITMUS Data Management Plan This initial version of the DMP will describe the organisational and technical details about data collection, storage, retention, destruction, privacy and confidentiality. The Plan will also include details of the procedures for the transfer of data and will be accompanied by confirmation of compliance with national and EU law on the protection of individuals with regard to the processing of personal data. Publicaciones Conference proceedings (17) Diagnostic accuracy of acoustic radiation force impulse elastography for the staging of hepatic fibrosis in non-alcoholic fatty liver disease: a systematic review and meta-analysis Autores: E. Selvaraj, M. Zafarmand, F. Mozes, A. Jayaswal, C. Levick, N. Palaniyappan, C. Liu, S. Neubauer, S. Harrison, P. Bossuyt, Q. Anstee, M. Pavlides Publicado en: Journal of Hepatology, Issue 73(S1), 2020, Page(s) S401-S652 Editor: Elsevier B.V. High-throughput detection of novel circulating miRNA biomarkers of non-alcoholic fatty liver disease Autores: Katherine Johnson, Peter J Leary, Matthew J Barter, Sarah H Charlton, Olivier Govaere, Simon J Cockell, Mattias Ekstedt, Karine Clément, Jörn M Schattenberg, Vlad Ratziu, Elisabetta Bugianesi, Ann K Daly, Quentin M Anstee Publicado en: Hepatology, Issue 70(S1), 2019 Editor: John Wiley & Sons, Inc. Histological and biopsychosocial predictors of quality of life in Spanish and UK cohorts of patients with Non-Alcoholic Fatty Liver Disease Autores: Jesús Funuyet-Salas, Agustín Martín-Rodríguez, María Angeles Pérez-San-Gregorio, Luke Vale, Tomos Robinson, Quentin M. Anstee, Manuel Romero Gomez, on behalf of the LITMUS consortium Investigators Publicado en: Journal of Hepatology, Issue 78(S1), 2023 Editor: Elsevier Inc. DOI: 10.1016/s0168-8278(23)01969-4 Interplay between metabolic derangement, biomarkers of collagen remodeling and macrophage activation in non-diabetic patients with non-alcoholic fatty liver disease Autores: C. Rosso, R. Younes, D. Leeming, R. Surabattula, G.P. Caviglia, M. Gaggini, A. Armandi, A. Olivero, M.L. Abate, A. Gastaldelli, D. Schuppan, E. Bugianesi Publicado en: Journal of Hepatology, Issue 73(S1), 2020, Page(s) S401-S652 Editor: Elsevier B.V. Diagnostic accuracy of non-invasive tests for cirrhotic NASH – An individual participant data meta-analysis Autores: F. E. Mózes, J. A. Lee, Y. Vali, E. A. Selvaraj, A. N. A.Jayaswal, J. Boursier, E. Bugianesi, R. Younes, M. Lupșor-Platon, S. Petta, T. Shima, T. Okanoue, S. Mahadeva, W-K. Chan, G. M. Hirschfield, P. J. Eddowes, P. N. Newsome, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, Y. Sumida, A. Okajima, J. M. Schattenberg, C. Labenz, W. Kim, M. S. Lee, G. P. Aithal, N. Palaniyappan, C. Cassinotto, S. Publicado en: Journal of Hepatology, Issue 77(S1), 2022 Editor: Elsevier Inc. DOI: 10.1016/s0168-8278(22)01231-4 Determinants of liver stiffness measurements in patients with NAFLD – an individual patient data meta-analysis Autores: F. E. Mózes, E. A. Selvaraj, A. N. A. Jayaswal, J. Boursier, C. Fournier, E. Bugianesi, R. Younes, S. Petta, S. Mahadeva, W.-K. Chan, P. J. Eddowes, P. N. Newsome, G. Hirschfield, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, W. Kim, M. S. Lee, C. Cassinotto, G. Ooi, A. Nakajima, M. Yoneda, M.-H. Zheng, A. Geier, T. Tuthill, M. J. Brosnan, Q. M. Anstee, S. A. Harrison, P. M. Bossuyt, Michael Pa Publicado en: Journal of Hepatology, Issue 77(S1), 2022 Editor: Elsevier Inc. DOI: 10.1016/s0168-8278(22)01187-4 Diagnostic accuracy of magnetic resonance elastography for the staging of fibrosis and diagnosis of steatohepatitis in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis Autores: F. Mozes, M. Zafarmand, A. Jayaswal, E. Selvaraj, C. Levick, N. Palaniyappan, C. Liu, S. Neubauer, Q. Anstee, S. Harrison, P. Bossuyt, M. Pavlides Publicado en: Journal of Hepatology, Issue 73(S1), 2020, Page(s) S401-S652 Editor: Elsevier B.V. Evaluating the patient-perceived impact of non-alcoholic steatohepatitis with compensated cirrhosis Autores: M. Breckons, L.C. Doward, L. McSweeney, M-M. Balp, J. Twiss, Y. Oluboyede, L. Vale, L. Ternent, C.A. Brass, A.J. Sanyal, Q.M. Anstee Publicado en: Journal of Hepatology, Issue 73(S1), 2020, Page(s) S401-S652 Editor: Elsevier B.V. Patient-Reported Symptoms and Impact in Nonalcoholic Steatohepatitis: An Evaluation of the NASH-CHECK, a Novel PROM in NASH Autores: D. Whalley, J. Twiss, L.C. Doward, M-M. Balp, C.A. Brass, J. Loeffler, P. Lopez, J. Cai, D. Cryer, Q.M. Anstee, A.J. Sanyal Publicado en: Journal of Hepatology, Issue 73(S1), 2020, Page(s) S401-S652 Editor: Elsevier B.V. In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease Autores: F. Carli, M. Gaggini, C. Rosso, C. Saponaro, C. Barbieri, V.D. Latta, E. Buzzigoli, D. Ciociaro, M.L. Abate, M. Marietti, R. Younes, E. Bugianesi, A. Gastaldelli Publicado en: Journal of Hepatology, Issue 68, 2018, Page(s) S566, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/s0168-8278(18)31389-8 Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients Autores: G. Svegliati-Baroni, I. Pierantonelli, R. Younes, C. Rosso, C. Rychlicki, E. Bugianesi, A. Gastaldelli Publicado en: Journal of Hepatology, Issue 68, 2018, Page(s) S835, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/s0168-8278(18)31945-7 Selenoprotein P levels discriminate the degree of hepatic steatosis and are related to the NAS score in patients with non-alcoholic fatty liver disease Autores: C. Rosso, R. Younes, E. Morello, M. Gaggini, G.P. Caviglia, C. Marinoni, M.J. Garcia Blanco, A. Olivero, G.M. Saracco, A. Gastaldelli, A. Smedile, E. Bugianesi Publicado en: Digestive and Liver Disease, Issue 51, 2019, Page(s) e26, ISSN 1590-8658 Editor: W. B. Saunders Co., Ltd. DOI: 10.1016/j.dld.2018.11.082 Accuracy of cytokeratin-18 (M30 and M65) in detecting NASH and fibrosis: a systematic review and meta-analysis Autores: J. Lee, Y. Vali, Q. Anstee, K. Duffin, P. Bossuyt, M. Zafarmand Publicado en: Journal of Hepatology, Issue 73(S1), 2020, Page(s) S401-S652 Editor: Elsevier B.V. Insulin secretion is an independent predictor of hepatic ballooning in non-diabetic subjects with non-alcoholic fatty liver disease Autores: R. YOUNES, C. ROSSO, G.P. CAVIGLIA, A. ARMANDI, A. OLIVERO, M.L. ABATE, E. BUGIANESI Publicado en: Journal of Hepatology, Issue 73(S1), 2020, Page(s) S401-S652 Editor: Elsevier B.V. Establishing the Cut-offs and Confounding factors of Magnetic Resonance Elastography for staging NAFLD-fibrosis: an IPD meta-analysis Autores: J. Liang, J. Ampuero, K. Imajo, M. Noureddin, J. Behari, D. H. Lee, R. L. Ehman, F. Rorsman, J. Vessby, J. R. Lacalle, F. Mozes, M. Pavlides, Q. M. Anstee, S. A. Harrison, J. Castell, R. Loomba, M. Romero Gómez Publicado en: journal of Hepatology, Issue 77(S1), 2022 Editor: Elsevier Inc. DOI: 10.1016/s0168-8278(22)01224-7 Diagnostic accuracy of non-invasive tests for fibrotic NASH – An individual participant data meta-analysis Autores: F. E. Mózes, J. A. Lee, Y. Vali, E. A. Selvaraj, A. N. A. Jayaswal, J. Boursier, E. Bugianesi, R. Younes, M. Lupșor-Platon, S. Petta, T. Shima, T. Okanoue, S. Mahadeva, W-K. Chan, G. M. Hirschfield, P. J. Eddowes, P. N. Newsome, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, Y. Sumida, A. Okajima, J. M. Schattenberg, C. Labenz, W. Kim, M. S. Lee, G. P. Aithal, N. Palaniyappan, C. Cassinotto, S. Publicado en: Journal of Hepatology, Issue 77(S1), 2022 Editor: Elsevier Inc. DOI: 10.1016/s0168-8278(22)01237-5 Signature of circulating hepatic proteins detects fibrosing steatohepatitis in progressive Non-alcoholic Fatty Liver Disease Autores: Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Jerome Boursier, Elisabetta Bugianesi, Vlad Ratziu, Ann Daly, Quentin M. Anstee Publicado en: Journal of Hepatology, Issue 77(S1), 2022 Editor: Elsevier Inc. DOI: 10.1016/s0168-8278(22)01210-7 Peer reviewed articles (50) Clinicians’ Perspectives on Barriers and Facilitators for the Adoption of Non-Invasive Liver Tests for NAFLD: A Mixed-Method Study Autores: Yasaman Vali, Roel Eijk, Timothy Hicks, William S. Jones Jana Suklan, Adriaan G. Holleboom, Vlad Ratziu, Miranda W. Langendam, Quentin M. Anstee, and Patrick M. M. Bossuyt, on behalf of the LITMUS Investigators Publicado en: Journal of Clinical Medicine, Issue 11(10), 2022, ISSN 2077-0383 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/jcm11102707 Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis Autores: Ferenc E Mózes, Jenny A Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E Stauber, Adriaan G Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jérôme Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, Shalimar, Monica Lupșor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbo Publicado en: Lancet Gastroenterology & Hepatology, Issue 8(8), 2023, ISSN 2468-1253 Editor: Elsevier Ltd DOI: 10.1016/s2468-1253(23)00141-3 Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes Autores: Pennisi, Grazia; Enea, Marco; Falco, Vincenzo; Aithal, Guruprasad P.; Palaniyappan, Naaventhan; Yilmaz, Yusuf; Boursier, Jerome; Cassinotto, Christophe; de Lédinghen, Victor; Chan, Wah Kheong; Mahadeva, Sanjiv; Eddowes, Peter; Newsome, Philip; Karlas, Thomas; Wiegand, Johannes; Wong, Vincent Wai-Sun; Schattenberg, Jörn M.; Labenz, Christian; Kim, Won; Lee, Myoung Seok; Lupsor-Platon, Monica; Cob Publicado en: Hepatology, Issue 78(1), 2023, ISSN 0270-9139 Editor: John Wiley & Sons Inc. DOI: 10.1097/hep.0000000000000351 Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease Autores: Angelo Armandi; Chiara Rosso; Gian Paolo Caviglia; Elisabetta Bugianesi Publicado en: Metabolites, Issue 3, 2021, ISSN 2218-1989 Editor: MDPI DOI: 10.3390/metabo11030155 FibroTest for Evaluating Fibrosis in Non-Alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-Analysis Autores: Vali, Y., Lee, J., Boursier, J., Spijker, R., Verheij, J., Brosnan, M. J., Anstee, Q. M., Bossuyt, P. M., Zafarmand, M. H. and On Behalf Of The Litmus Systematic Review, Team Publicado en: J Clin Med, Issue 10(11), 2021, ISSN 2077-0383 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/jcm10112415 Pathology and natural history of organ fibrosis Autores: Joaquim Majo, Barbara Mara Klinkhammer, Peter Boor, Dina Tiniakos Publicado en: Current Opinion in Pharmacology, Issue 49, 2019, Page(s) 82-89, ISSN 1471-4892 Editor: Elsevier BV DOI: 10.1016/j.coph.2019.09.009 From the origin of NASH to the future of metabolic fatty liver disease Autores: Andreas Geier, Dina Tiniakos, Helmut Denk, Michael Trauner Publicado en: Gut, Issue 70(8), 2021, ISSN 0017-5749 Editor: BMJ Publishing Group DOI: 10.1136/gutjnl-2020-323202 Metabolic signatures across the full spectrum of non-alcoholicfatty liver disease Autores: Aidan J. McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Boursier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M. Schattenberg, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Oresic Publicado en: JHEP Reports, Issue 4(5), 2022, ISSN 2589-5559 Editor: Elsevier B.V. DOI: 10.1016/j.jhepr.2022.100477 Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients Autores: Antonio Gil-Gómez; Ángela Rojas; María R. García-Lozano; Rocío Muñoz-Hernández; Rocío Gallego-Durán; Douglas Maya-Miles; Rocío Montero-Vallejo; Sheila Gato; Javier Gallego; Rubén Francés; Germán Soriano; Javier Ampuero; Manuel Romero-Gómez Publicado en: International Journal of Molecular Sciences, Issue 23(19), 2022, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms231911840 Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis Autores: Jenny Lee, Yasaman Vali, Jérôme Boursier, Kevin Duffin, Joanne Verheij, M. Julia Brosnan, Koos Zwinderman, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad Hadi Zafarmand Publicado en: PLOS ONE, Issue 15/9, 2020, Page(s) e0238717, ISSN 1932-6203 Editor: Public Library of Science DOI: 10.1371/journal.pone.0238717 Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity? Autores: Judith Aron-Wisnewsky, Moritz V. Warmbrunn, Max Nieuwdorp, Karine Clément Publicado en: Gastroenterology, Issue 158/7, 2020, Page(s) 1881-1898, ISSN 0016-5085 Editor: W. B. Saunders Co., Ltd. DOI: 10.1053/j.gastro.2020.01.049 Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance Autores: Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly Publicado en: JHEP Reports, Issue 4(2), 2022, ISSN 2589-5559 Editor: Elsevier B.V. DOI: 10.1016/j.jhepr.2021.100409 Transcriptomic profiling across the Non-Alcoholic Fatty Liver Disease spectrum reveals gene signatures for steatohepatitis and fibrosis Autores: Olivier Govaere, Simon Cockell, Dina Tiniakos, Rachel Queen, Ramy Younes, Michele Vacca, Leigh Alexander, Federico Ravaioli, Jeremy Palmer, Salvatore Petta, Jerome Boursier, Chiara Rosso, Katherine Johnson, Kristy Wonders, Christopher P. Day, Mattias Ekstedt, Matej Orešič, Rebecca Darlay, Heather J. Cordell, Fabio Marra, Antonio Vidal-Puig, Pierre Bedossa, Jörn M. Schattenberg, Karine Clément, Publicado en: Science Translational Medicine, Issue 12(572), 2020, ISSN 1946-6242 Editor: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aba4448 Prognostic accuracy of FIB‐4, NAFLD fibrosis score, and APRI for NAFLD‐related events: A systematic review Autores: Jenny Lee, Yasaman Vali, Jerome Boursier, Rene Spijker, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad H. Zafarmand Publicado en: Liver International, Issue 41(2), 2020, ISSN 1478-3231 Editor: John Wiley & Sons, Inc. DOI: 10.1111/liv.14669 Systematic Review with Meta-Analysis: Diagnostic Accuracy of Pro-C3 for Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease Autores: Mak AL, Lee J, van Dijk A-M, Vali Y, Aithal GP, Schattenberg JM, Anstee QM, Brosnan MJ, Zafarmand MH, Ramsoekh D, Harrison SA, Nieuwdorp M, Bossuyt PM, Holleboom AG Publicado en: Biomedicines, Issue 9(12), 2021, Page(s) 1920, ISSN 2227-9059 Editor: MBPI DOI: 10.3390/biomedicines9121920 Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD Autores: Elizabeth M. Brunt, Andrew D. Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Carolin Lackner, Dina G. Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Elaine Chng, Yayun Ren, George Goh Boon Bee, Elizabeth E. Powell, Mary Rinella, Arun J. Sanyal, Brent Neuschwander-Tetri, Zobair Younossi, Michael Charlton, Vlad Ratziu, Stephen A. Harrison, Dean Tai, Quentin M. Anstee Publicado en: Journal of Hepatology, Issue 76(5), 2022, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/j.jhep.2022.01.011 Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease Autores: Partho Sen Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jörn M. Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič Publicado en: iScience, Issue 25(9), 2022, ISSN 2589-0042 Editor: Elsevier B.V. DOI: 10.1016/j.isci.2022.104949 Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study Autores: Lee, Jenny; Westphal, Max; Vali, Yasaman; Boursier, Jerome; Petta, Salvatorre; Ostroff, Rachel; Alexander, Leigh; Chen, Yu; Fournier, Celine; Geier, Andreas; Francque, Sven; Wonders, Kristy; Tiniakos, Dina; Bedossa, Pierre; Allison, Mike; Papatheodoridis, Georgios; Cortez-Pinto, Helena; Pais, Raluca; Dufour, Jean-Francois; Leeming, Diana Julie; Harrison, Stephen; Cobbold, Jeremy; Holleboom, Adriaa Publicado en: Hepatology, Issue 78(1), 2023, ISSN 0270-9139 Editor: John Wiley & Sons Inc. DOI: 10.1097/hep.0000000000000364 The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue Autores: Sami Qadri, Susanna Lallukka-Brück, Panu K. Luukkonen, You Zhou, Amalia Gastaldelli, Marju Orho-Melander, Henna Sammalkorpi, Anne Juuti, Anne K. Penttilä, Julia Perttilä, Antti Hakkarainen, Tiina E. Lehtimäki, Matej Orešič, Tuulia Hyötyläinen, Leanne Hodson, Vesa M. Olkkonen, Hannele Yki-Järvinen Publicado en: Liver international, Issue 40(9), 2020, ISSN 1478-3231 Editor: John Wiley & Sons, Inc DOI: 10.1111/liv.14507 Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests Autores: Masoodi, M., Gastaldelli, A., Hyotylainen, T., Arretxe, E., Alonso, C., Gaggini, M., Brosnan, J., Anstee, Q. M., Millet, O., Ortiz, P., Mato, J. M., Dufour, J. F. and Oresic, M. Publicado en: Nat Rev Gastroenterol Hepatol, 2021, ISSN 1759-5045 Editor: Nature Publishing Group DOI: 10.1038/s41575-021-00502-9 A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures Autores: Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Mattias Ekstedt, Jörn M. Schattenberg, Jerome Boursier, Elisabetta Bugianesi, Vlad Ratziu, LITMUS Investigators, Ann K. Daly and Quentin M. Anstee Publicado en: Nature Metabolism, Issue 5, 2023, ISSN 2522-5812 Editor: Springer Nature Ltd DOI: 10.1038/s42255-023-00775-1 Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease Autores: Govaere O, Petersen SK, Martinez-Lopez N, Wouters J, VanHaele M, Mancina RM, Jamialahmadi O, Bilkei-Gorzo O, Lassen PB, Darlay R, Peltier J, Palmer JM, Younes R, Tiniakos D, Aithal GP, Allison M, Vacca M, Göransson M, Berlinguer-Palmini R, Clark J, Drinnan MJ, Yki-Järvinen H, Dufour JF, Ekstedt M, Francque S, Petta S, Bugianesi E, Schattenberg JM, Day CP, Cordell HJ, Topal B, Clément K, Romeo S Publicado en: Journal of Hepatology, 2021, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/j.jhep.2021.12.012 Validation of NASH-CHECK: a novel patient-reported outcome measure for nonalcoholic steatohepatitis Autores: James Twiss, Diane Whalley, Lynda Doward, Maria-Magdalena Balp, Clifford A. Brass, Donna Cryer, Arun Sanyal & Quentin M. Anstee Publicado en: Journal of Patient-Reported Outcomes, Issue 7, 2023, ISSN 2509-8020 Editor: Springer Nature DOI: 10.1186/s41687-023-00589-5 Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study Autores: Yasaman Vali, Jenny Lee, Jerome Boursier, Salvatore Petta, Kristy Wonders, Dina Tiniakos, Pierre Bedossa, Andreas Geier, Sven Francque, Mike Allison, Georgios Papatheodoridis, Helena Cortez-Pinto, Raluca Pais, Jean-Francois Dufour, Diana Julie Leeming, Stephen A Harrison, Yu Chen, Jeremy F Cobbold, Michael Pavlides, Adriaan G Holleboom, Hannele Yki-Jarvinen, Javier Crespo, Morten Karsdal, Rachel O Publicado en: Lancet Gastroenterology & Hepatology, Issue 8(8), 2023, ISSN 2468-1253 Editor: Elsevier Ltd DOI: 10.1016/s2468-1253(23)00017-1 Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms Autores: Christian A. Hudert, Leon A. Adams, Anna Alisi, Quentin M. Anstee, Annalisa Crudele, Laura G. Draijer, EU-PNAFLD investigators, Samuel Furse, Jan G. Hengstler, Benjamin Jenkins, Kylie Karnebeek, Deirdre A. Kelly, Bart G. Koot, Albert Koulman, David Meierhofer, Phillip E. Melton, Trevor A. Mori, Stuart G. Snowden, Indra van Mourik, Anita Vreugdenhil, Susanna Wiegand, Jake P. Mann Publicado en: Hepatology Communications, Issue 6(8), 2022, ISSN 2471-254X Editor: John Wiley & Sons Inc. DOI: 10.1002/hep4.1955 Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients Autores: Mette Juul Nielsen, Ida Falk Villesen, Natasja Stæhr Gudmann, Diana Julie Leeming, Aleksander Krag, Morten Asser Karsdal, Tim Zimmermann, Detlef Schuppan Publicado en: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Editor: Nature Publishing Group DOI: 10.1038/s41598-019-51394-4 Reporting of test comparisons in diagnostic accuracy studies: A literature review Autores: Yasaman Vali, Bada Yang, Maria Olsen, Mariska M. G. Leeflang, Patrick M. Bossuyt Publicado en: Research Synthesis Methods, Issue 12(3), 2021, ISSN 1759-2887 Editor: John Wiley & Sons Ltd DOI: 10.1002/jrsm.1469 Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders Autores: Judith Aron-Wisnewsky, Chloé Vigliotti, Julia Witjes, Phuong Le, Adriaan G. Holleboom, Joanne Verheij, Max Nieuwdorp, Karine Clément Publicado en: Nature Reviews Gastroenterology & Hepatology, Issue 17/5, 2020, Page(s) 279-297, ISSN 1759-5045 Editor: Nature Publishing Group DOI: 10.1038/s41575-020-0269-9 Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis? Autores: Morten A. Karsdal, Sönke Detlefsen, Samuel J. Daniels, Mette J. Nielsen, Aleksander Krag, Detlef Schuppan Publicado en: Hepatology, Issue 71/1, 2020, Page(s) 346-351, ISSN 0270-9139 Editor: John Wiley & Sons Inc. DOI: 10.1002/hep.30969 Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease Autores: Panu K. Luukkonen, Taru Tukiainen, Anne Juuti, Henna Sammalkorpi, P.A. Nidhina Haridas, Onni Niemelä, Johanna Arola, Marju Orho-Melander, Antti Hakkarainen, Petri T. 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Mato and Oscar Millet Publicado en: Life, Issue 13(1), 2023, ISSN 2075-1729 Editor: MDPI DOI: 10.3390/life13010222 Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic target Autores: Cristiana Bianco, Elia Casirati, Francesco Malvestiti, Luca Valenti Publicado en: JHEP Reports, Issue 3(3), 2021, ISSN 2589-5559 Editor: Elsevier Inc. DOI: 10.1016/j.jhepr.2021.100284 Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease Autores: Nobuharu Tamaki, Noora Ahlholm, Panu K. Luukkonen, Kimmo Porthan, Suzanne R. Sharpton, Veeral Ajmera, Yuko Kono, Shravan Dave, Aijaz Ahmed, Vinay Sundaram, Michael J. Wilkinson, Heather Patton, Hersh Gupta, Vanessa Cervantes, Christie Hernandez, Scarlett J. Lopez, Ria Loomba, Amanda Baumgartner, Lisa Richards, Perttu E.T. Arkkila, Katriina Nemes, Helena Isoniemi, Hannele Yki-Järvinen and Rohit Lo Publicado en: Journal of Clinical Investigation, Issue 132(21), 2022, ISSN 0021-9738 Editor: American Society for Clinical Investigation DOI: 10.1172/jci162513 Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk score Autores: Cristiana Bianco, Oveis Jamialahmadi, Serena Pelusi, Guido Baselli,Paola Dongiovanni, Irene Zanoni, Luigi Santoro, Silvia Maier, Antonio Liguori, Marica Meroni, Vittorio Borroni, Roberta D’Ambrosio, Rocco Spagnuolo, Anna Alisi, Alessandro Federico, Elisabetta Bugianesi, Salvatore Petta, Luca Miele, Umberto Vespasiani-Gentilucci, Quentin M. Anstee, Felix Stickel, Jochen Hampe, Janett Fischer, Tho Publicado en: Journal of Hepatology, Issue 74(4), 2021, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/j.jhep.2020.11.024 Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS): Assessment & validation of imaging modality performance across the NAFLD spectrum in a prospectively recruited cohort study (the LITMUS imaging study): Study protocol Autores: Michael Pavlides, Ferenc E. Mozes, Salma Akhtar, Kristy Wonders, Jeremy Cobbold, Elizabeth M. Tunnicliffe, Michael Allison, Edmund M. Godfrey, Guruprasad P. Aithal, Susan Francis, Manuel Romero-Gomez, Javier Castell, Isabel Fernandez-Lizaranzu, Rocio Aller, Rebeca Sigüenza Gonzalez, Salvador Agustin, Juan M. Peric, Jerome Boursier, Christophe Aube, Vlad Ratziu, Mathilde Wagner, Salvatore Petta, M Publicado en: Contemporary Clinical Trials, Issue 134, 2023, ISSN 1551-7144 Editor: Elsevier BV DOI: 10.1016/j.cct.2023.107352 Lack of genetic evidence that fatty liver disease predisposes to COVID-19 Autores: Luca Valenti, Oveis Jamialahmadi, Stefano Romeo Publicado en: Journal of Hepatology, Issue 73/3, 2020, Page(s) 709-711, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/j.jhep.2020.05.015 Derivation and validation of the nonalcoholic fatty liver disease cirrhosis score (NCS) to distinguish bridging fibrosis from cirrhosis Autores: Christian Labenz, Gerrit Toenges, Ming-Hua Zheng, Dora Ding, Robert P. Myers, Peter R. Galle, Angelo Armandi, Javier Ampuero, Manuel Romero Gómez, Elisabetta Bugianesi, Quentin M. Anstee, Jörn M. Schattenberg Publicado en: European Journal of Internal Medicine, Issue 98, 2022, ISSN 0953-6205 Editor: Elsevier BV DOI: 10.1016/j.ejim.2021.12.011 Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles Autores: Ibon Martínez‐Arranz; Chiara Bruzzone; Mazen Noureddin; Ruben Gil‐Redondo; Itziar Mincholé; Maider Bizkarguenaga; Enara Arretxe; Marta Iruarrizaga‐Lejarreta; David Fernández‐Ramos; Fernando Lopitz‐Otsoa; Rebeca Mayo; Nieves Embade; Elizabeth Newberry; Bettina Mittendorf; Laura Izquierdo‐Sánchez; Vaclav Smid; Jorge Arnold; Paula Iruzubieta; Ylenia Pérez Castaño; Marcin Krawczyk; U Publicado en: Hepatology, Issue 76(4), 2022, ISSN 1527-3350 Editor: John Wiley & Sons, Inc. DOI: 10.1002/hep.32427 Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis Autores: Yasaman Vali, Jenny Lee, Jérôme Boursier, René Spijker, Jürgen Löffler, Joanne Verheij, M. Julia Brosnan, Zsolt Böcskei, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad Hadi Zafarmand, Michael Pavlides, Christina Levick, Kevin Duffin, Craig Hyde, Tim Bauer, Pierre Bedossa, Diana Leeming, Ann Daly, Remy Hanf, Pablo Ortiz, Matej Oresic, Detlef Schuppan, Guido Hanauer, Yu Chen, Elizabeth Shumba Publicado en: Journal of Hepatology, Issue 73/2, 2020, Page(s) 252-262, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/j.jhep.2020.03.036 Reply to: “Ceruloplasmin variants might have different effects in different iron overload disorders” Autores: Elena Corradini; Luca Valenti Publicado en: Crossref, Issue 7, 2021, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/j.jhep.2021.07.007 Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis Autores: Mozes, F. E.; Lee, J. A.; Selvaraj, E. A.; Jayaswal, A. N. A.; Trauner, M.; Boursier, J.; Fournier, C.; Staufer, K.; Stauber, R. E.; Bugianesi, E.; Younes, R.; Gaia, S.; Lupsor-Platon, M.; Petta, S.; Shima, T.; Okanoue, T.; Mahadeva, S.; Chan, W. -K.; Eddowes, P. J.; Newsome, P. N.; Wong, V. W. -S.; de Ledinghen, V.; Fan, J.; Shen, F.; Cobbold, J. F.; Sumida, Y.; Okajima, A.; Schattenberg, J. M.; Publicado en: "Gut, BMJ Publishing Group, 2021, pp.gutjnl-2021-324243. ⟨10.1136/gutjnl-2021-324243⟩", Issue 2, 2021, ISSN 0017-5749 Editor: BMJ Publishing Group DOI: 10.48350/160159 Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis Autores: Selvaraj, E. A., Mozes, F. E., Jayaswal, A. N. A., Zafarmand, M. H., Vali, Y., Lee, J. A., Levick, C. K., Young, L. A. J., Palaniyappan, N., Liu, C. H., Aithal, G. P., Romero-Gomez, M., Brosnan, M. J., Tuthill, T. A., Anstee, Q. M., Neubauer, S., Harrison, S. A., Bossuyt, P. M., Pavlides, M. and Investigators, Litmus Publicado en: J Hepatol, Issue 75(4), 2021, Page(s) 770-785, ISSN 0168-8278 Editor: Elsevier BV DOI: 10.1016/j.jhep.2021.04.044 Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes Autores: Marica Meroni, Paola Dongiovanni, Miriam Longo, Fabrizia Carli, Guido Baselli, Raffaela Rametta, Serena Pelusi, Sara Badiali, Marco Maggioni, Melania Gaggini, Anna Ludovica Fracanzani, Stefano Romeo, Stefano Gatti, Nicholas O. Davidson, Amalia Gastaldelli, Luca Valenti Publicado en: EBioMedicine, Issue 52, 2020, Page(s) 102658, ISSN 2352-3964 Editor: Elsevier BV DOI: 10.1016/j.ebiom.2020.102658 Non-peer reviewed articles (1) MAFLD vs NAFLD: Let the contest begin! Autores: Cristiana Bianco, Stefano Romeo, Salvatore Petta, Michelle T. Long, Luca Valenti Publicado en: Liver International, Issue 40/9, 2020, Page(s) 2079-2081, ISSN 1478-3223 Editor: Blackwell Publishing Inc. DOI: 10.1111/liv.14620 Buscando datos de OpenAIRE... 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