Liver Investigation: Testing Marker Utility in Steatohepatitis

Rezultaty

Procedure for assessing risks and monitoring mitigation actions

Mid-term update of D2.2.

Final version of DMP.

Plans will be drawn up to regularly highlight the project developments at relevant conferences, in peer-reviewed journals and at dedicated workshops organised by the consortium. All journal publications will be open access. The dissemination plans, which will be continuously reviewed and updated, will identify key project related publications, which will be earmarked for “gold” open access. Dissemination will also be assured through the establishment and maintenance of a project website from the start of the project, with links to the participating researchers, clinicians and institutions.

Imaging manual to standardise image acquisition across all participating sites

LITMUS Imaging Manuals will be produced in parallel to the scanning protocol. One covering the MRI technical aspects and a second covering the ultrasound-based elastography technologies (using manufacturer protocols for VCTE, SSI, ARFI). These will be distributed to the participating sites to ensure standardised operating practices are followed across all participating sites.

Project Handbook

Quick reference guide for all LITMUS project participants

Mid-term report summarising recruitment into the LITMUS Registry and catalogue of available samples
SOPs for collection, processing and storage of whole blood, EDTA plasma, SST serum, urine, stool, frozen liver biopsies

Pre-analytical SOPs will be written covering, e.g. sample collection and analysis of the stability/quality of the metabolomics profile of serum/plasma samples.

Report describing minimally acceptable performance criteria for diagnostic testing

We will use Web-based surveys (SurveyMonkey) with all LITMUS participants to identify minimally acceptable performance criteria, using a modified Delphi approach over at least two rounds of surveys.

An optimised histological staging system for NAFLD-associated fibrosis

Development and validation of an optimised histological staging system for NAFLD-associated fibrosis with correlation to fibrosis severity measured by CPA.

Detailed plan for submission of biomarkers to the regulatory authorities (EMA and FDA) for qualification

Agreed project plan for LITMUS to secure an official description of the validation process from the agencies that studies engaging in biomarkers will need to follow and fulfil for biomarker qualification.

LITMUS Data Management Plan

This initial version of the DMP will describe the organisational and technical details about data collection, storage, retention, destruction, privacy and confidentiality. The Plan will also include details of the procedures for the transfer of data and will be accompanied by confirmation of compliance with national and EU law on the protection of individuals with regard to the processing of personal data.

Publikacje

Diagnostic accuracy of acoustic radiation force impulse elastography for the staging of hepatic fibrosis in non-alcoholic fatty liver disease: a systematic review and meta-analysis

Autorzy: E. Selvaraj, M. Zafarmand, F. Mozes, A. Jayaswal, C. Levick, N. Palaniyappan, C. Liu, S. Neubauer, S. Harrison, P. Bossuyt, Q. Anstee, M. Pavlides
Opublikowane w: Journal of Hepatology, Numer 73(S1), 2020, Strona(/y) S401-S652
Wydawca: Elsevier B.V.

High-throughput detection of novel circulating miRNA biomarkers of non-alcoholic fatty liver disease

Autorzy: Katherine Johnson, Peter J Leary, Matthew J Barter, Sarah H Charlton, Olivier Govaere, Simon J Cockell, Mattias Ekstedt, Karine Clément, Jörn M Schattenberg, Vlad Ratziu, Elisabetta Bugianesi, Ann K Daly, Quentin M Anstee
Opublikowane w: Hepatology, Numer 70(S1), 2019
Wydawca: John Wiley & Sons, Inc.

Histological and biopsychosocial predictors of quality of life in Spanish and UK cohorts of patients with Non-Alcoholic Fatty Liver Disease

Autorzy: Jesús Funuyet-Salas, Agustín Martín-Rodríguez, María Angeles Pérez-San-Gregorio, Luke Vale, Tomos Robinson, Quentin M. Anstee, Manuel Romero Gomez, on behalf of the LITMUS consortium Investigators
Opublikowane w: Journal of Hepatology, Numer 78(S1), 2023
Wydawca: Elsevier Inc.
DOI: 10.1016/s0168-8278(23)01969-4

Interplay between metabolic derangement, biomarkers of collagen remodeling and macrophage activation in non-diabetic patients with non-alcoholic fatty liver disease

Autorzy: C. Rosso, R. Younes, D. Leeming, R. Surabattula, G.P. Caviglia, M. Gaggini, A. Armandi, A. Olivero, M.L. Abate, A. Gastaldelli, D. Schuppan, E. Bugianesi
Opublikowane w: Journal of Hepatology, Numer 73(S1), 2020, Strona(/y) S401-S652
Wydawca: Elsevier B.V.

Diagnostic accuracy of non-invasive tests for cirrhotic NASH – An individual participant data meta-analysis

Autorzy: F. E. Mózes, J. A. Lee, Y. Vali, E. A. Selvaraj, A. N. A.Jayaswal, J. Boursier, E. Bugianesi, R. Younes, M. Lupșor-Platon, S. Petta, T. Shima, T. Okanoue, S. Mahadeva, W-K. Chan, G. M. Hirschfield, P. J. Eddowes, P. N. Newsome, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, Y. Sumida, A. Okajima, J. M. Schattenberg, C. Labenz, W. Kim, M. S. Lee, G. P. Aithal, N. Palaniyappan, C. Cassinotto, S.
Opublikowane w: Journal of Hepatology, Numer 77(S1), 2022
Wydawca: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01231-4

Determinants of liver stiffness measurements in patients with NAFLD – an individual patient data meta-analysis

Autorzy: F. E. Mózes, E. A. Selvaraj, A. N. A. Jayaswal, J. Boursier, C. Fournier, E. Bugianesi, R. Younes, S. Petta, S. Mahadeva, W.-K. Chan, P. J. Eddowes, P. N. Newsome, G. Hirschfield, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, W. Kim, M. S. Lee, C. Cassinotto, G. Ooi, A. Nakajima, M. Yoneda, M.-H. Zheng, A. Geier, T. Tuthill, M. J. Brosnan, Q. M. Anstee, S. A. Harrison, P. M. Bossuyt, Michael Pa
Opublikowane w: Journal of Hepatology, Numer 77(S1), 2022
Wydawca: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01187-4

Diagnostic accuracy of magnetic resonance elastography for the staging of fibrosis and diagnosis of steatohepatitis in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis

Autorzy: F. Mozes, M. Zafarmand, A. Jayaswal, E. Selvaraj, C. Levick, N. Palaniyappan, C. Liu, S. Neubauer, Q. Anstee, S. Harrison, P. Bossuyt, M. Pavlides
Opublikowane w: Journal of Hepatology, Numer 73(S1), 2020, Strona(/y) S401-S652
Wydawca: Elsevier B.V.

Evaluating the patient-perceived impact of non-alcoholic steatohepatitis with compensated cirrhosis

Autorzy: M. Breckons, L.C. Doward, L. McSweeney, M-M. Balp, J. Twiss, Y. Oluboyede, L. Vale, L. Ternent, C.A. Brass, A.J. Sanyal, Q.M. Anstee
Opublikowane w: Journal of Hepatology, Numer 73(S1), 2020, Strona(/y) S401-S652
Wydawca: Elsevier B.V.

Patient-Reported Symptoms and Impact in Nonalcoholic Steatohepatitis: An Evaluation of the NASH-CHECK, a Novel PROM in NASH

Autorzy: D. Whalley, J. Twiss, L.C. Doward, M-M. Balp, C.A. Brass, J. Loeffler, P. Lopez, J. Cai, D. Cryer, Q.M. Anstee, A.J. Sanyal
Opublikowane w: Journal of Hepatology, Numer 73(S1), 2020, Strona(/y) S401-S652
Wydawca: Elsevier B.V.

In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease

Autorzy: F. Carli, M. Gaggini, C. Rosso, C. Saponaro, C. Barbieri, V.D. Latta, E. Buzzigoli, D. Ciociaro, M.L. Abate, M. Marietti, R. Younes, E. Bugianesi, A. Gastaldelli
Opublikowane w: Journal of Hepatology, Numer 68, 2018, Strona(/y) S566, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/s0168-8278(18)31389-8

Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients

Autorzy: G. Svegliati-Baroni, I. Pierantonelli, R. Younes, C. Rosso, C. Rychlicki, E. Bugianesi, A. Gastaldelli
Opublikowane w: Journal of Hepatology, Numer 68, 2018, Strona(/y) S835, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/s0168-8278(18)31945-7

Selenoprotein P levels discriminate the degree of hepatic steatosis and are related to the NAS score in patients with non-alcoholic fatty liver disease

Autorzy: C. Rosso, R. Younes, E. Morello, M. Gaggini, G.P. Caviglia, C. Marinoni, M.J. Garcia Blanco, A. Olivero, G.M. Saracco, A. Gastaldelli, A. Smedile, E. Bugianesi
Opublikowane w: Digestive and Liver Disease, Numer 51, 2019, Strona(/y) e26, ISSN 1590-8658
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.dld.2018.11.082

Accuracy of cytokeratin-18 (M30 and M65) in detecting NASH and fibrosis: a systematic review and meta-analysis

Autorzy: J. Lee, Y. Vali, Q. Anstee, K. Duffin, P. Bossuyt, M. Zafarmand
Opublikowane w: Journal of Hepatology, Numer 73(S1), 2020, Strona(/y) S401-S652
Wydawca: Elsevier B.V.

Insulin secretion is an independent predictor of hepatic ballooning in non-diabetic subjects with non-alcoholic fatty liver disease

Autorzy: R. YOUNES, C. ROSSO, G.P. CAVIGLIA, A. ARMANDI, A. OLIVERO, M.L. ABATE, E. BUGIANESI
Opublikowane w: Journal of Hepatology, Numer 73(S1), 2020, Strona(/y) S401-S652
Wydawca: Elsevier B.V.

Establishing the Cut-offs and Confounding factors of Magnetic Resonance Elastography for staging NAFLD-fibrosis: an IPD meta-analysis

Autorzy: J. Liang, J. Ampuero, K. Imajo, M. Noureddin, J. Behari, D. H. Lee, R. L. Ehman, F. Rorsman, J. Vessby, J. R. Lacalle, F. Mozes, M. Pavlides, Q. M. Anstee, S. A. Harrison, J. Castell, R. Loomba, M. Romero Gómez
Opublikowane w: journal of Hepatology, Numer 77(S1), 2022
Wydawca: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01224-7

Diagnostic accuracy of non-invasive tests for fibrotic NASH – An individual participant data meta-analysis

Autorzy: F. E. Mózes, J. A. Lee, Y. Vali, E. A. Selvaraj, A. N. A. Jayaswal, J. Boursier, E. Bugianesi, R. Younes, M. Lupșor-Platon, S. Petta, T. Shima, T. Okanoue, S. Mahadeva, W-K. Chan, G. M. Hirschfield, P. J. Eddowes, P. N. Newsome, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, Y. Sumida, A. Okajima, J. M. Schattenberg, C. Labenz, W. Kim, M. S. Lee, G. P. Aithal, N. Palaniyappan, C. Cassinotto, S.
Opublikowane w: Journal of Hepatology, Numer 77(S1), 2022
Wydawca: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01237-5

Signature of circulating hepatic proteins detects fibrosing steatohepatitis in progressive Non-alcoholic Fatty Liver Disease

Autorzy: Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Jerome Boursier, Elisabetta Bugianesi, Vlad Ratziu, Ann Daly, Quentin M. Anstee
Opublikowane w: Journal of Hepatology, Numer 77(S1), 2022
Wydawca: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01210-7

Clinicians’ Perspectives on Barriers and Facilitators for the Adoption of Non-Invasive Liver Tests for NAFLD: A Mixed-Method Study

Autorzy: Yasaman Vali, Roel Eijk, Timothy Hicks, William S. Jones Jana Suklan, Adriaan G. Holleboom, Vlad Ratziu, Miranda W. Langendam, Quentin M. Anstee, and Patrick M. M. Bossuyt, on behalf of the LITMUS Investigators
Opublikowane w: Journal of Clinical Medicine, Numer 11(10), 2022, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11102707

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Autorzy: Ferenc E Mózes, Jenny A Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E Stauber, Adriaan G Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jérôme Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, Shalimar, Monica Lupșor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbo
Opublikowane w: Lancet Gastroenterology & Hepatology, Numer 8(8), 2023, ISSN 2468-1253
Wydawca: Elsevier Ltd
DOI: 10.1016/s2468-1253(23)00141-3

Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes

Autorzy: Pennisi, Grazia; Enea, Marco; Falco, Vincenzo; Aithal, Guruprasad P.; Palaniyappan, Naaventhan; Yilmaz, Yusuf; Boursier, Jerome; Cassinotto, Christophe; de Lédinghen, Victor; Chan, Wah Kheong; Mahadeva, Sanjiv; Eddowes, Peter; Newsome, Philip; Karlas, Thomas; Wiegand, Johannes; Wong, Vincent Wai-Sun; Schattenberg, Jörn M.; Labenz, Christian; Kim, Won; Lee, Myoung Seok; Lupsor-Platon, Monica; Cob
Opublikowane w: Hepatology, Numer 78(1), 2023, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000351

Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease

Autorzy: Angelo Armandi; Chiara Rosso; Gian Paolo Caviglia; Elisabetta Bugianesi
Opublikowane w: Metabolites, Numer 3, 2021, ISSN 2218-1989
Wydawca: MDPI
DOI: 10.3390/metabo11030155

FibroTest for Evaluating Fibrosis in Non-Alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-Analysis

Autorzy: Vali, Y., Lee, J., Boursier, J., Spijker, R., Verheij, J., Brosnan, M. J., Anstee, Q. M., Bossuyt, P. M., Zafarmand, M. H. and On Behalf Of The Litmus Systematic Review, Team
Opublikowane w: J Clin Med, Numer 10(11), 2021, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10112415

Pathology and natural history of organ fibrosis

Autorzy: Joaquim Majo, Barbara Mara Klinkhammer, Peter Boor, Dina Tiniakos
Opublikowane w: Current Opinion in Pharmacology, Numer 49, 2019, Strona(/y) 82-89, ISSN 1471-4892
Wydawca: Elsevier BV
DOI: 10.1016/j.coph.2019.09.009

From the origin of NASH to the future of metabolic fatty liver disease

Autorzy: Andreas Geier, Dina Tiniakos, Helmut Denk, Michael Trauner
Opublikowane w: Gut, Numer 70(8), 2021, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323202

Metabolic signatures across the full spectrum of non-alcoholicfatty liver disease

Autorzy: Aidan J. McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Boursier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M. Schattenberg, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Oresic
Opublikowane w: JHEP Reports, Numer 4(5), 2022, ISSN 2589-5559
Wydawca: Elsevier B.V.
DOI: 10.1016/j.jhepr.2022.100477

Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients

Autorzy: Antonio Gil-Gómez; Ángela Rojas; María R. García-Lozano; Rocío Muñoz-Hernández; Rocío Gallego-Durán; Douglas Maya-Miles; Rocío Montero-Vallejo; Sheila Gato; Javier Gallego; Rubén Francés; Germán Soriano; Javier Ampuero; Manuel Romero-Gómez
Opublikowane w: International Journal of Molecular Sciences, Numer 23(19), 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911840

Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis

Autorzy: Jenny Lee, Yasaman Vali, Jérôme Boursier, Kevin Duffin, Joanne Verheij, M. Julia Brosnan, Koos Zwinderman, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad Hadi Zafarmand
Opublikowane w: PLOS ONE, Numer 15/9, 2020, Strona(/y) e0238717, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0238717

Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?

Autorzy: Judith Aron-Wisnewsky, Moritz V. Warmbrunn, Max Nieuwdorp, Karine Clément
Opublikowane w: Gastroenterology, Numer 158/7, 2020, Strona(/y) 1881-1898, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.01.049

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Autorzy: Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly
Opublikowane w: JHEP Reports, Numer 4(2), 2022, ISSN 2589-5559
Wydawca: Elsevier B.V.
DOI: 10.1016/j.jhepr.2021.100409

Transcriptomic profiling across the Non-Alcoholic Fatty Liver Disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Autorzy: Olivier Govaere, Simon Cockell, Dina Tiniakos, Rachel Queen, Ramy Younes, Michele Vacca, Leigh Alexander, Federico Ravaioli, Jeremy Palmer, Salvatore Petta, Jerome Boursier, Chiara Rosso, Katherine Johnson, Kristy Wonders, Christopher P. Day, Mattias Ekstedt, Matej Orešič, Rebecca Darlay, Heather J. Cordell, Fabio Marra, Antonio Vidal-Puig, Pierre Bedossa, Jörn M. Schattenberg, Karine Clément,
Opublikowane w: Science Translational Medicine, Numer 12(572), 2020, ISSN 1946-6242
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aba4448

Prognostic accuracy of FIB‐4, NAFLD fibrosis score, and APRI for NAFLD‐related events: A systematic review

Autorzy: Jenny Lee, Yasaman Vali, Jerome Boursier, Rene Spijker, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad H. Zafarmand
Opublikowane w: Liver International, Numer 41(2), 2020, ISSN 1478-3231
Wydawca: John Wiley & Sons, Inc.
DOI: 10.1111/liv.14669

Systematic Review with Meta-Analysis: Diagnostic Accuracy of Pro-C3 for Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

Autorzy: Mak AL, Lee J, van Dijk A-M, Vali Y, Aithal GP, Schattenberg JM, Anstee QM, Brosnan MJ, Zafarmand MH, Ramsoekh D, Harrison SA, Nieuwdorp M, Bossuyt PM, Holleboom AG
Opublikowane w: Biomedicines, Numer 9(12), 2021, Strona(/y) 1920, ISSN 2227-9059
Wydawca: MBPI
DOI: 10.3390/biomedicines9121920

Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD

Autorzy: Elizabeth M. Brunt, Andrew D. Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Carolin Lackner, Dina G. Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Elaine Chng, Yayun Ren, George Goh Boon Bee, Elizabeth E. Powell, Mary Rinella, Arun J. Sanyal, Brent Neuschwander-Tetri, Zobair Younossi, Michael Charlton, Vlad Ratziu, Stephen A. Harrison, Dean Tai, Quentin M. Anstee
Opublikowane w: Journal of Hepatology, Numer 76(5), 2022, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2022.01.011

Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease

Autorzy: Partho Sen Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jörn M. Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič
Opublikowane w: iScience, Numer 25(9), 2022, ISSN 2589-0042
Wydawca: Elsevier B.V.
DOI: 10.1016/j.isci.2022.104949

Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study

Autorzy: Lee, Jenny; Westphal, Max; Vali, Yasaman; Boursier, Jerome; Petta, Salvatorre; Ostroff, Rachel; Alexander, Leigh; Chen, Yu; Fournier, Celine; Geier, Andreas; Francque, Sven; Wonders, Kristy; Tiniakos, Dina; Bedossa, Pierre; Allison, Mike; Papatheodoridis, Georgios; Cortez-Pinto, Helena; Pais, Raluca; Dufour, Jean-Francois; Leeming, Diana Julie; Harrison, Stephen; Cobbold, Jeremy; Holleboom, Adriaa
Opublikowane w: Hepatology, Numer 78(1), 2023, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000364

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue

Autorzy: Sami Qadri, Susanna Lallukka-Brück, Panu K. Luukkonen, You Zhou, Amalia Gastaldelli, Marju Orho-Melander, Henna Sammalkorpi, Anne Juuti, Anne K. Penttilä, Julia Perttilä, Antti Hakkarainen, Tiina E. Lehtimäki, Matej Orešič, Tuulia Hyötyläinen, Leanne Hodson, Vesa M. Olkkonen, Hannele Yki-Järvinen
Opublikowane w: Liver international, Numer 40(9), 2020, ISSN 1478-3231
Wydawca: John Wiley & Sons, Inc
DOI: 10.1111/liv.14507

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

Autorzy: Masoodi, M., Gastaldelli, A., Hyotylainen, T., Arretxe, E., Alonso, C., Gaggini, M., Brosnan, J., Anstee, Q. M., Millet, O., Ortiz, P., Mato, J. M., Dufour, J. F. and Oresic, M.
Opublikowane w: Nat Rev Gastroenterol Hepatol, 2021, ISSN 1759-5045
Wydawca: Nature Publishing Group
DOI: 10.1038/s41575-021-00502-9

A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures

Autorzy: Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Mattias Ekstedt, Jörn M. Schattenberg, Jerome Boursier, Elisabetta Bugianesi, Vlad Ratziu, LITMUS Investigators, Ann K. Daly and Quentin M. Anstee
Opublikowane w: Nature Metabolism, Numer 5, 2023, ISSN 2522-5812
Wydawca: Springer Nature Ltd
DOI: 10.1038/s42255-023-00775-1

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

Autorzy: Govaere O, Petersen SK, Martinez-Lopez N, Wouters J, VanHaele M, Mancina RM, Jamialahmadi O, Bilkei-Gorzo O, Lassen PB, Darlay R, Peltier J, Palmer JM, Younes R, Tiniakos D, Aithal GP, Allison M, Vacca M, Göransson M, Berlinguer-Palmini R, Clark J, Drinnan MJ, Yki-Järvinen H, Dufour JF, Ekstedt M, Francque S, Petta S, Bugianesi E, Schattenberg JM, Day CP, Cordell HJ, Topal B, Clément K, Romeo S
Opublikowane w: Journal of Hepatology, 2021, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.012

Validation of NASH-CHECK: a novel patient-reported outcome measure for nonalcoholic steatohepatitis

Autorzy: James Twiss, Diane Whalley, Lynda Doward, Maria-Magdalena Balp, Clifford A. Brass, Donna Cryer, Arun Sanyal & Quentin M. Anstee
Opublikowane w: Journal of Patient-Reported Outcomes, Numer 7, 2023, ISSN 2509-8020
Wydawca: Springer Nature
DOI: 10.1186/s41687-023-00589-5

Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study

Autorzy: Yasaman Vali, Jenny Lee, Jerome Boursier, Salvatore Petta, Kristy Wonders, Dina Tiniakos, Pierre Bedossa, Andreas Geier, Sven Francque, Mike Allison, Georgios Papatheodoridis, Helena Cortez-Pinto, Raluca Pais, Jean-Francois Dufour, Diana Julie Leeming, Stephen A Harrison, Yu Chen, Jeremy F Cobbold, Michael Pavlides, Adriaan G Holleboom, Hannele Yki-Jarvinen, Javier Crespo, Morten Karsdal, Rachel O
Opublikowane w: Lancet Gastroenterology & Hepatology, Numer 8(8), 2023, ISSN 2468-1253
Wydawca: Elsevier Ltd
DOI: 10.1016/s2468-1253(23)00017-1

Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms

Autorzy: Christian A. Hudert, Leon A. Adams, Anna Alisi, Quentin M. Anstee, Annalisa Crudele, Laura G. Draijer, EU-PNAFLD investigators, Samuel Furse, Jan G. Hengstler, Benjamin Jenkins, Kylie Karnebeek, Deirdre A. Kelly, Bart G. Koot, Albert Koulman, David Meierhofer, Phillip E. Melton, Trevor A. Mori, Stuart G. Snowden, Indra van Mourik, Anita Vreugdenhil, Susanna Wiegand, Jake P. Mann
Opublikowane w: Hepatology Communications, Numer 6(8), 2022, ISSN 2471-254X
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes

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MAFLD vs NAFLD: Let the contest begin!

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