Liver Investigation: Testing Marker Utility in Steatohepatitis

Risultati finali

Procedure for assessing risks and monitoring mitigation actions

Mid-term update of D2.2.

Final version of DMP.

Plans will be drawn up to regularly highlight the project developments at relevant conferences, in peer-reviewed journals and at dedicated workshops organised by the consortium. All journal publications will be open access. The dissemination plans, which will be continuously reviewed and updated, will identify key project related publications, which will be earmarked for “gold” open access. Dissemination will also be assured through the establishment and maintenance of a project website from the start of the project, with links to the participating researchers, clinicians and institutions.

Imaging manual to standardise image acquisition across all participating sites

LITMUS Imaging Manuals will be produced in parallel to the scanning protocol. One covering the MRI technical aspects and a second covering the ultrasound-based elastography technologies (using manufacturer protocols for VCTE, SSI, ARFI). These will be distributed to the participating sites to ensure standardised operating practices are followed across all participating sites.

Project Handbook

Quick reference guide for all LITMUS project participants

Mid-term report summarising recruitment into the LITMUS Registry and catalogue of available samples
SOPs for collection, processing and storage of whole blood, EDTA plasma, SST serum, urine, stool, frozen liver biopsies

Pre-analytical SOPs will be written covering, e.g. sample collection and analysis of the stability/quality of the metabolomics profile of serum/plasma samples.

Report describing minimally acceptable performance criteria for diagnostic testing

We will use Web-based surveys (SurveyMonkey) with all LITMUS participants to identify minimally acceptable performance criteria, using a modified Delphi approach over at least two rounds of surveys.

An optimised histological staging system for NAFLD-associated fibrosis

Development and validation of an optimised histological staging system for NAFLD-associated fibrosis with correlation to fibrosis severity measured by CPA.

Detailed plan for submission of biomarkers to the regulatory authorities (EMA and FDA) for qualification

Agreed project plan for LITMUS to secure an official description of the validation process from the agencies that studies engaging in biomarkers will need to follow and fulfil for biomarker qualification.

LITMUS Data Management Plan

This initial version of the DMP will describe the organisational and technical details about data collection, storage, retention, destruction, privacy and confidentiality. The Plan will also include details of the procedures for the transfer of data and will be accompanied by confirmation of compliance with national and EU law on the protection of individuals with regard to the processing of personal data.

Pubblicazioni

Diagnostic accuracy of acoustic radiation force impulse elastography for the staging of hepatic fibrosis in non-alcoholic fatty liver disease: a systematic review and meta-analysis

Autori: E. Selvaraj, M. Zafarmand, F. Mozes, A. Jayaswal, C. Levick, N. Palaniyappan, C. Liu, S. Neubauer, S. Harrison, P. Bossuyt, Q. Anstee, M. Pavlides
Pubblicato in: Journal of Hepatology, Numero 73(S1), 2020, Pagina/e S401-S652
Editore: Elsevier B.V.

High-throughput detection of novel circulating miRNA biomarkers of non-alcoholic fatty liver disease

Autori: Katherine Johnson, Peter J Leary, Matthew J Barter, Sarah H Charlton, Olivier Govaere, Simon J Cockell, Mattias Ekstedt, Karine Clément, Jörn M Schattenberg, Vlad Ratziu, Elisabetta Bugianesi, Ann K Daly, Quentin M Anstee
Pubblicato in: Hepatology, Numero 70(S1), 2019
Editore: John Wiley & Sons, Inc.

Histological and biopsychosocial predictors of quality of life in Spanish and UK cohorts of patients with Non-Alcoholic Fatty Liver Disease

Autori: Jesús Funuyet-Salas, Agustín Martín-Rodríguez, María Angeles Pérez-San-Gregorio, Luke Vale, Tomos Robinson, Quentin M. Anstee, Manuel Romero Gomez, on behalf of the LITMUS consortium Investigators
Pubblicato in: Journal of Hepatology, Numero 78(S1), 2023
Editore: Elsevier Inc.
DOI: 10.1016/s0168-8278(23)01969-4

Interplay between metabolic derangement, biomarkers of collagen remodeling and macrophage activation in non-diabetic patients with non-alcoholic fatty liver disease

Autori: C. Rosso, R. Younes, D. Leeming, R. Surabattula, G.P. Caviglia, M. Gaggini, A. Armandi, A. Olivero, M.L. Abate, A. Gastaldelli, D. Schuppan, E. Bugianesi
Pubblicato in: Journal of Hepatology, Numero 73(S1), 2020, Pagina/e S401-S652
Editore: Elsevier B.V.

Diagnostic accuracy of non-invasive tests for cirrhotic NASH – An individual participant data meta-analysis

Autori: F. E. Mózes, J. A. Lee, Y. Vali, E. A. Selvaraj, A. N. A.Jayaswal, J. Boursier, E. Bugianesi, R. Younes, M. Lupșor-Platon, S. Petta, T. Shima, T. Okanoue, S. Mahadeva, W-K. Chan, G. M. Hirschfield, P. J. Eddowes, P. N. Newsome, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, Y. Sumida, A. Okajima, J. M. Schattenberg, C. Labenz, W. Kim, M. S. Lee, G. P. Aithal, N. Palaniyappan, C. Cassinotto, S.
Pubblicato in: Journal of Hepatology, Numero 77(S1), 2022
Editore: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01231-4

Determinants of liver stiffness measurements in patients with NAFLD – an individual patient data meta-analysis

Autori: F. E. Mózes, E. A. Selvaraj, A. N. A. Jayaswal, J. Boursier, C. Fournier, E. Bugianesi, R. Younes, S. Petta, S. Mahadeva, W.-K. Chan, P. J. Eddowes, P. N. Newsome, G. Hirschfield, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, W. Kim, M. S. Lee, C. Cassinotto, G. Ooi, A. Nakajima, M. Yoneda, M.-H. Zheng, A. Geier, T. Tuthill, M. J. Brosnan, Q. M. Anstee, S. A. Harrison, P. M. Bossuyt, Michael Pa
Pubblicato in: Journal of Hepatology, Numero 77(S1), 2022
Editore: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01187-4

Diagnostic accuracy of magnetic resonance elastography for the staging of fibrosis and diagnosis of steatohepatitis in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis

Autori: F. Mozes, M. Zafarmand, A. Jayaswal, E. Selvaraj, C. Levick, N. Palaniyappan, C. Liu, S. Neubauer, Q. Anstee, S. Harrison, P. Bossuyt, M. Pavlides
Pubblicato in: Journal of Hepatology, Numero 73(S1), 2020, Pagina/e S401-S652
Editore: Elsevier B.V.

Evaluating the patient-perceived impact of non-alcoholic steatohepatitis with compensated cirrhosis

Autori: M. Breckons, L.C. Doward, L. McSweeney, M-M. Balp, J. Twiss, Y. Oluboyede, L. Vale, L. Ternent, C.A. Brass, A.J. Sanyal, Q.M. Anstee
Pubblicato in: Journal of Hepatology, Numero 73(S1), 2020, Pagina/e S401-S652
Editore: Elsevier B.V.

Patient-Reported Symptoms and Impact in Nonalcoholic Steatohepatitis: An Evaluation of the NASH-CHECK, a Novel PROM in NASH

Autori: D. Whalley, J. Twiss, L.C. Doward, M-M. Balp, C.A. Brass, J. Loeffler, P. Lopez, J. Cai, D. Cryer, Q.M. Anstee, A.J. Sanyal
Pubblicato in: Journal of Hepatology, Numero 73(S1), 2020, Pagina/e S401-S652
Editore: Elsevier B.V.

In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease

Autori: F. Carli, M. Gaggini, C. Rosso, C. Saponaro, C. Barbieri, V.D. Latta, E. Buzzigoli, D. Ciociaro, M.L. Abate, M. Marietti, R. Younes, E. Bugianesi, A. Gastaldelli
Pubblicato in: Journal of Hepatology, Numero 68, 2018, Pagina/e S566, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/s0168-8278(18)31389-8

Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients

Autori: G. Svegliati-Baroni, I. Pierantonelli, R. Younes, C. Rosso, C. Rychlicki, E. Bugianesi, A. Gastaldelli
Pubblicato in: Journal of Hepatology, Numero 68, 2018, Pagina/e S835, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/s0168-8278(18)31945-7

Selenoprotein P levels discriminate the degree of hepatic steatosis and are related to the NAS score in patients with non-alcoholic fatty liver disease

Autori: C. Rosso, R. Younes, E. Morello, M. Gaggini, G.P. Caviglia, C. Marinoni, M.J. Garcia Blanco, A. Olivero, G.M. Saracco, A. Gastaldelli, A. Smedile, E. Bugianesi
Pubblicato in: Digestive and Liver Disease, Numero 51, 2019, Pagina/e e26, ISSN 1590-8658
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.dld.2018.11.082

Accuracy of cytokeratin-18 (M30 and M65) in detecting NASH and fibrosis: a systematic review and meta-analysis

Autori: J. Lee, Y. Vali, Q. Anstee, K. Duffin, P. Bossuyt, M. Zafarmand
Pubblicato in: Journal of Hepatology, Numero 73(S1), 2020, Pagina/e S401-S652
Editore: Elsevier B.V.

Insulin secretion is an independent predictor of hepatic ballooning in non-diabetic subjects with non-alcoholic fatty liver disease

Autori: R. YOUNES, C. ROSSO, G.P. CAVIGLIA, A. ARMANDI, A. OLIVERO, M.L. ABATE, E. BUGIANESI
Pubblicato in: Journal of Hepatology, Numero 73(S1), 2020, Pagina/e S401-S652
Editore: Elsevier B.V.

Establishing the Cut-offs and Confounding factors of Magnetic Resonance Elastography for staging NAFLD-fibrosis: an IPD meta-analysis

Autori: J. Liang, J. Ampuero, K. Imajo, M. Noureddin, J. Behari, D. H. Lee, R. L. Ehman, F. Rorsman, J. Vessby, J. R. Lacalle, F. Mozes, M. Pavlides, Q. M. Anstee, S. A. Harrison, J. Castell, R. Loomba, M. Romero Gómez
Pubblicato in: journal of Hepatology, Numero 77(S1), 2022
Editore: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01224-7

Diagnostic accuracy of non-invasive tests for fibrotic NASH – An individual participant data meta-analysis

Autori: F. E. Mózes, J. A. Lee, Y. Vali, E. A. Selvaraj, A. N. A. Jayaswal, J. Boursier, E. Bugianesi, R. Younes, M. Lupșor-Platon, S. Petta, T. Shima, T. Okanoue, S. Mahadeva, W-K. Chan, G. M. Hirschfield, P. J. Eddowes, P. N. Newsome, V. W.-S. Wong, V. de Lédinghen, J. F. Cobbold, Y. Sumida, A. Okajima, J. M. Schattenberg, C. Labenz, W. Kim, M. S. Lee, G. P. Aithal, N. Palaniyappan, C. Cassinotto, S.
Pubblicato in: Journal of Hepatology, Numero 77(S1), 2022
Editore: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01237-5

Signature of circulating hepatic proteins detects fibrosing steatohepatitis in progressive Non-alcoholic Fatty Liver Disease

Autori: Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Jerome Boursier, Elisabetta Bugianesi, Vlad Ratziu, Ann Daly, Quentin M. Anstee
Pubblicato in: Journal of Hepatology, Numero 77(S1), 2022
Editore: Elsevier Inc.
DOI: 10.1016/s0168-8278(22)01210-7

Clinicians’ Perspectives on Barriers and Facilitators for the Adoption of Non-Invasive Liver Tests for NAFLD: A Mixed-Method Study

Autori: Yasaman Vali, Roel Eijk, Timothy Hicks, William S. Jones Jana Suklan, Adriaan G. Holleboom, Vlad Ratziu, Miranda W. Langendam, Quentin M. Anstee, and Patrick M. M. Bossuyt, on behalf of the LITMUS Investigators
Pubblicato in: Journal of Clinical Medicine, Numero 11(10), 2022, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11102707

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis

Autori: Ferenc E Mózes, Jenny A Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E Stauber, Adriaan G Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jérôme Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, Shalimar, Monica Lupșor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbo
Pubblicato in: Lancet Gastroenterology & Hepatology, Numero 8(8), 2023, ISSN 2468-1253
Editore: Elsevier Ltd
DOI: 10.1016/s2468-1253(23)00141-3

Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes

Autori: Pennisi, Grazia; Enea, Marco; Falco, Vincenzo; Aithal, Guruprasad P.; Palaniyappan, Naaventhan; Yilmaz, Yusuf; Boursier, Jerome; Cassinotto, Christophe; de Lédinghen, Victor; Chan, Wah Kheong; Mahadeva, Sanjiv; Eddowes, Peter; Newsome, Philip; Karlas, Thomas; Wiegand, Johannes; Wong, Vincent Wai-Sun; Schattenberg, Jörn M.; Labenz, Christian; Kim, Won; Lee, Myoung Seok; Lupsor-Platon, Monica; Cob
Pubblicato in: Hepatology, Numero 78(1), 2023, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000351

Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease

Autori: Angelo Armandi; Chiara Rosso; Gian Paolo Caviglia; Elisabetta Bugianesi
Pubblicato in: Metabolites, Numero 3, 2021, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo11030155

FibroTest for Evaluating Fibrosis in Non-Alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-Analysis

Autori: Vali, Y., Lee, J., Boursier, J., Spijker, R., Verheij, J., Brosnan, M. J., Anstee, Q. M., Bossuyt, P. M., Zafarmand, M. H. and On Behalf Of The Litmus Systematic Review, Team
Pubblicato in: J Clin Med, Numero 10(11), 2021, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10112415

Pathology and natural history of organ fibrosis

Autori: Joaquim Majo, Barbara Mara Klinkhammer, Peter Boor, Dina Tiniakos
Pubblicato in: Current Opinion in Pharmacology, Numero 49, 2019, Pagina/e 82-89, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2019.09.009

From the origin of NASH to the future of metabolic fatty liver disease

Autori: Andreas Geier, Dina Tiniakos, Helmut Denk, Michael Trauner
Pubblicato in: Gut, Numero 70(8), 2021, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323202

Metabolic signatures across the full spectrum of non-alcoholicfatty liver disease

Autori: Aidan J. McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Boursier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M. Schattenberg, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Oresic
Pubblicato in: JHEP Reports, Numero 4(5), 2022, ISSN 2589-5559
Editore: Elsevier B.V.
DOI: 10.1016/j.jhepr.2022.100477

Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients

Autori: Antonio Gil-Gómez; Ángela Rojas; María R. García-Lozano; Rocío Muñoz-Hernández; Rocío Gallego-Durán; Douglas Maya-Miles; Rocío Montero-Vallejo; Sheila Gato; Javier Gallego; Rubén Francés; Germán Soriano; Javier Ampuero; Manuel Romero-Gómez
Pubblicato in: International Journal of Molecular Sciences, Numero 23(19), 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911840

Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis

Autori: Jenny Lee, Yasaman Vali, Jérôme Boursier, Kevin Duffin, Joanne Verheij, M. Julia Brosnan, Koos Zwinderman, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad Hadi Zafarmand
Pubblicato in: PLOS ONE, Numero 15/9, 2020, Pagina/e e0238717, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0238717

Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?

Autori: Judith Aron-Wisnewsky, Moritz V. Warmbrunn, Max Nieuwdorp, Karine Clément
Pubblicato in: Gastroenterology, Numero 158/7, 2020, Pagina/e 1881-1898, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.01.049

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Autori: Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly
Pubblicato in: JHEP Reports, Numero 4(2), 2022, ISSN 2589-5559
Editore: Elsevier B.V.
DOI: 10.1016/j.jhepr.2021.100409

Transcriptomic profiling across the Non-Alcoholic Fatty Liver Disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Autori: Olivier Govaere, Simon Cockell, Dina Tiniakos, Rachel Queen, Ramy Younes, Michele Vacca, Leigh Alexander, Federico Ravaioli, Jeremy Palmer, Salvatore Petta, Jerome Boursier, Chiara Rosso, Katherine Johnson, Kristy Wonders, Christopher P. Day, Mattias Ekstedt, Matej Orešič, Rebecca Darlay, Heather J. Cordell, Fabio Marra, Antonio Vidal-Puig, Pierre Bedossa, Jörn M. Schattenberg, Karine Clément,
Pubblicato in: Science Translational Medicine, Numero 12(572), 2020, ISSN 1946-6242
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aba4448

Prognostic accuracy of FIB‐4, NAFLD fibrosis score, and APRI for NAFLD‐related events: A systematic review

Autori: Jenny Lee, Yasaman Vali, Jerome Boursier, Rene Spijker, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad H. Zafarmand
Pubblicato in: Liver International, Numero 41(2), 2020, ISSN 1478-3231
Editore: John Wiley & Sons, Inc.
DOI: 10.1111/liv.14669

Systematic Review with Meta-Analysis: Diagnostic Accuracy of Pro-C3 for Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

Autori: Mak AL, Lee J, van Dijk A-M, Vali Y, Aithal GP, Schattenberg JM, Anstee QM, Brosnan MJ, Zafarmand MH, Ramsoekh D, Harrison SA, Nieuwdorp M, Bossuyt PM, Holleboom AG
Pubblicato in: Biomedicines, Numero 9(12), 2021, Pagina/e 1920, ISSN 2227-9059
Editore: MBPI
DOI: 10.3390/biomedicines9121920

Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD

Autori: Elizabeth M. Brunt, Andrew D. Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Carolin Lackner, Dina G. Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Elaine Chng, Yayun Ren, George Goh Boon Bee, Elizabeth E. Powell, Mary Rinella, Arun J. Sanyal, Brent Neuschwander-Tetri, Zobair Younossi, Michael Charlton, Vlad Ratziu, Stephen A. Harrison, Dean Tai, Quentin M. Anstee
Pubblicato in: Journal of Hepatology, Numero 76(5), 2022, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2022.01.011

Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease

Autori: Partho Sen Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jörn M. Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič
Pubblicato in: iScience, Numero 25(9), 2022, ISSN 2589-0042
Editore: Elsevier B.V.
DOI: 10.1016/j.isci.2022.104949

Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study

Autori: Lee, Jenny; Westphal, Max; Vali, Yasaman; Boursier, Jerome; Petta, Salvatorre; Ostroff, Rachel; Alexander, Leigh; Chen, Yu; Fournier, Celine; Geier, Andreas; Francque, Sven; Wonders, Kristy; Tiniakos, Dina; Bedossa, Pierre; Allison, Mike; Papatheodoridis, Georgios; Cortez-Pinto, Helena; Pais, Raluca; Dufour, Jean-Francois; Leeming, Diana Julie; Harrison, Stephen; Cobbold, Jeremy; Holleboom, Adriaa
Pubblicato in: Hepatology, Numero 78(1), 2023, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000364

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue

Autori: Sami Qadri, Susanna Lallukka-Brück, Panu K. Luukkonen, You Zhou, Amalia Gastaldelli, Marju Orho-Melander, Henna Sammalkorpi, Anne Juuti, Anne K. Penttilä, Julia Perttilä, Antti Hakkarainen, Tiina E. Lehtimäki, Matej Orešič, Tuulia Hyötyläinen, Leanne Hodson, Vesa M. Olkkonen, Hannele Yki-Järvinen
Pubblicato in: Liver international, Numero 40(9), 2020, ISSN 1478-3231
Editore: John Wiley & Sons, Inc
DOI: 10.1111/liv.14507

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

Autori: Masoodi, M., Gastaldelli, A., Hyotylainen, T., Arretxe, E., Alonso, C., Gaggini, M., Brosnan, J., Anstee, Q. M., Millet, O., Ortiz, P., Mato, J. M., Dufour, J. F. and Oresic, M.
Pubblicato in: Nat Rev Gastroenterol Hepatol, 2021, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/s41575-021-00502-9

A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures

Autori: Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Mattias Ekstedt, Jörn M. Schattenberg, Jerome Boursier, Elisabetta Bugianesi, Vlad Ratziu, LITMUS Investigators, Ann K. Daly and Quentin M. Anstee
Pubblicato in: Nature Metabolism, Numero 5, 2023, ISSN 2522-5812
Editore: Springer Nature Ltd
DOI: 10.1038/s42255-023-00775-1

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

Autori: Govaere O, Petersen SK, Martinez-Lopez N, Wouters J, VanHaele M, Mancina RM, Jamialahmadi O, Bilkei-Gorzo O, Lassen PB, Darlay R, Peltier J, Palmer JM, Younes R, Tiniakos D, Aithal GP, Allison M, Vacca M, Göransson M, Berlinguer-Palmini R, Clark J, Drinnan MJ, Yki-Järvinen H, Dufour JF, Ekstedt M, Francque S, Petta S, Bugianesi E, Schattenberg JM, Day CP, Cordell HJ, Topal B, Clément K, Romeo S
Pubblicato in: Journal of Hepatology, 2021, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.012

Validation of NASH-CHECK: a novel patient-reported outcome measure for nonalcoholic steatohepatitis

Autori: James Twiss, Diane Whalley, Lynda Doward, Maria-Magdalena Balp, Clifford A. Brass, Donna Cryer, Arun Sanyal & Quentin M. Anstee
Pubblicato in: Journal of Patient-Reported Outcomes, Numero 7, 2023, ISSN 2509-8020
Editore: Springer Nature
DOI: 10.1186/s41687-023-00589-5

Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study

Autori: Yasaman Vali, Jenny Lee, Jerome Boursier, Salvatore Petta, Kristy Wonders, Dina Tiniakos, Pierre Bedossa, Andreas Geier, Sven Francque, Mike Allison, Georgios Papatheodoridis, Helena Cortez-Pinto, Raluca Pais, Jean-Francois Dufour, Diana Julie Leeming, Stephen A Harrison, Yu Chen, Jeremy F Cobbold, Michael Pavlides, Adriaan G Holleboom, Hannele Yki-Jarvinen, Javier Crespo, Morten Karsdal, Rachel O
Pubblicato in: Lancet Gastroenterology & Hepatology, Numero 8(8), 2023, ISSN 2468-1253
Editore: Elsevier Ltd
DOI: 10.1016/s2468-1253(23)00017-1

Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms

Autori: Christian A. Hudert, Leon A. Adams, Anna Alisi, Quentin M. Anstee, Annalisa Crudele, Laura G. Draijer, EU-PNAFLD investigators, Samuel Furse, Jan G. Hengstler, Benjamin Jenkins, Kylie Karnebeek, Deirdre A. Kelly, Bart G. Koot, Albert Koulman, David Meierhofer, Phillip E. Melton, Trevor A. Mori, Stuart G. Snowden, Indra van Mourik, Anita Vreugdenhil, Susanna Wiegand, Jake P. Mann
Pubblicato in: Hepatology Communications, Numero 6(8), 2022, ISSN 2471-254X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep4.1955

Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients

Autori: Mette Juul Nielsen, Ida Falk Villesen, Natasja Stæhr Gudmann, Diana Julie Leeming, Aleksander Krag, Morten Asser Karsdal, Tim Zimmermann, Detlef Schuppan
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-51394-4

Reporting of test comparisons in diagnostic accuracy studies: A literature review

Autori: Yasaman Vali, Bada Yang, Maria Olsen, Mariska M. G. Leeflang, Patrick M. Bossuyt
Pubblicato in: Research Synthesis Methods, Numero 12(3), 2021, ISSN 1759-2887
Editore: John Wiley & Sons Ltd
DOI: 10.1002/jrsm.1469

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

Autori: Judith Aron-Wisnewsky, Chloé Vigliotti, Julia Witjes, Phuong Le, Adriaan G. Holleboom, Joanne Verheij, Max Nieuwdorp, Karine Clément
Pubblicato in: Nature Reviews Gastroenterology & Hepatology, Numero 17/5, 2020, Pagina/e 279-297, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/s41575-020-0269-9

Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?

Autori: Morten A. Karsdal, Sönke Detlefsen, Samuel J. Daniels, Mette J. Nielsen, Aleksander Krag, Detlef Schuppan
Pubblicato in: Hepatology, Numero 71/1, 2020, Pagina/e 346-351, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30969

Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

Autori: Panu K. Luukkonen, Taru Tukiainen, Anne Juuti, Henna Sammalkorpi, P.A. Nidhina Haridas, Onni Niemelä, Johanna Arola, Marju Orho-Melander, Antti Hakkarainen, Petri T. Kovanen, Om Dwivedi, Leif Groop, Leanne Hodson, Amalia Gastaldelli, Tuulia Hyötyläinen, Matej Orešič, Hannele Yki-Järvinen
Pubblicato in: JCI Insight, Numero 5/5, 2020, ISSN 2379-3708
Editore: American Society for Clinical Investigation
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NASH in Lean Individuals

Autori: Ramy Younes, Elisabetta Bugianesi
Pubblicato in: Seminars in Liver Disease, Numero 39/01, 2019, Pagina/e 086-095, ISSN 0272-8087
Editore: Thieme Medical Publishers
DOI: 10.1055/s-0038-1677517

Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis

Autori: Geoff Farrell, Jörn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan
Pubblicato in: Hepatology, Numero 69/5, 2019, Pagina/e 2241-2257, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.30333

Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids

Autori: Panu K. Luukkonen, Auli Nick, Maarit Hölttä-Vuori, Christoph Thiele, Elina Isokuortti, Susanna Lallukka-Brück, You Zhou, Antti Hakkarainen, Nina Lundbom, Markku Peltonen, Marju Orho-Melander, Matej Orešič, Tuulia Hyötyläinen, Leanne Hodson, Elina Ikonen, Hannele Yki-Järvinen
Pubblicato in: JCI Insight, Numero 4/16, 2019, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.127902

Autori: Lorraine McSweeney, Matthew Breckons, Gulnar Fattakhova, Yemi Oluboyede, Luke Vale, Laura Ternent, Maria-Magdalena Balp, Lynda Doward, Clifford A. Brass, Fiona Beyer, Arun Sanyal, Quentin M. Anstee
Pubblicato in: JHEP Reports, 2020, Pagina/e 100099, ISSN 2589-5559
Editore: Elsevier Inc.
DOI: 10.1016/j.jhepr.2020.100099

Systematic Review with Meta-Analyses: Diagnostic Accuracy of FibroMeter Tests in Patients with Non-Alcoholic Fatty Liver Disease

Autori: Van Dijk, A. M., Vali, Y., Mak, A. L., Lee, J., Tushuizen, M. E., Zafarmand, M. H., Anstee, Q. M., Brosnan, M. J., Nieuwdorp, M., Bossuyt, P. M. and Holleboom, A. G.
Pubblicato in: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10132910

The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease

Autori: Timothy Hardy; Kristy Wonders; Ramy Younes; Guruprasad P. Aithal; Rocío Aller; Michael Allison; P. Bedossa; Fay Betsou; Jérôme Boursier; M. Julia Brosnan; Alastair Burt; Jeremy F.L. Cobbold; Helena Cortez-Pinto; Christopher Day; Jean-François Dufour; Mattias Ekstedt; Sven Francque; Seamus Conor Harrison; Luca Miele; Patrik Nasr; George V. Papatheodoridis; Salvatore Petta; Dina Tiniakos; Richar
Pubblicato in: Contemporary clinical trials, 98:106175, Numero 9, 2020, ISSN 1551-7144
Editore: Elsevier BV
DOI: 10.1016/j.cct.2020.106175

An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography

Autori: Jia-xu Liang, Javier Ampuero, Hao Niu, Kento Imajo, Mazen Noureddin, Jaideep Behari, Dae Ho Lee, Richard L. Ehman, Fredrik Rorsman, Johan Vessby, Juan R. Lacalle, Ferenc E. Mózes, Michael Pavlides, Quentin M. Anstee, Stephen A. Harrison, Javier Castell, Rohit Loomba, Manuel Romero-Gómez on behalf of the LITMUS Consortium Investigators
Pubblicato in: Journal of Hepatology, Numero 79(3), 2023, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2023.04.025

Protoporphyrin IX Binds to Iron(II)-Loaded and to Zinc-Loaded Human Frataxin

Autori: Ganeko Bernardo-Seisdedos, Andreas Schedlbauer, Tania Pereira-Ortuzar, José M. Mato and Oscar Millet
Pubblicato in: Life, Numero 13(1), 2023, ISSN 2075-1729
Editore: MDPI
DOI: 10.3390/life13010222

Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic target

Autori: Cristiana Bianco, Elia Casirati, Francesco Malvestiti, Luca Valenti
Pubblicato in: JHEP Reports, Numero 3(3), 2021, ISSN 2589-5559
Editore: Elsevier Inc.
DOI: 10.1016/j.jhepr.2021.100284

Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease

Autori: Nobuharu Tamaki, Noora Ahlholm, Panu K. Luukkonen, Kimmo Porthan, Suzanne R. Sharpton, Veeral Ajmera, Yuko Kono, Shravan Dave, Aijaz Ahmed, Vinay Sundaram, Michael J. Wilkinson, Heather Patton, Hersh Gupta, Vanessa Cervantes, Christie Hernandez, Scarlett J. Lopez, Ria Loomba, Amanda Baumgartner, Lisa Richards, Perttu E.T. Arkkila, Katriina Nemes, Helena Isoniemi, Hannele Yki-Järvinen and Rohit Lo
Pubblicato in: Journal of Clinical Investigation, Numero 132(21), 2022, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci162513

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk score

Autori: Cristiana Bianco, Oveis Jamialahmadi, Serena Pelusi, Guido Baselli,Paola Dongiovanni, Irene Zanoni, Luigi Santoro, Silvia Maier, Antonio Liguori, Marica Meroni, Vittorio Borroni, Roberta D’Ambrosio, Rocco Spagnuolo, Anna Alisi, Alessandro Federico, Elisabetta Bugianesi, Salvatore Petta, Luca Miele, Umberto Vespasiani-Gentilucci, Quentin M. Anstee, Felix Stickel, Jochen Hampe, Janett Fischer, Tho
Pubblicato in: Journal of Hepatology, Numero 74(4), 2021, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.11.024

Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS): Assessment & validation of imaging modality performance across the NAFLD spectrum in a prospectively recruited cohort study (the LITMUS imaging study): Study protocol

Autori: Michael Pavlides, Ferenc E. Mozes, Salma Akhtar, Kristy Wonders, Jeremy Cobbold, Elizabeth M. Tunnicliffe, Michael Allison, Edmund M. Godfrey, Guruprasad P. Aithal, Susan Francis, Manuel Romero-Gomez, Javier Castell, Isabel Fernandez-Lizaranzu, Rocio Aller, Rebeca Sigüenza Gonzalez, Salvador Agustin, Juan M. Peric, Jerome Boursier, Christophe Aube, Vlad Ratziu, Mathilde Wagner, Salvatore Petta, M
Pubblicato in: Contemporary Clinical Trials, Numero 134, 2023, ISSN 1551-7144
Editore: Elsevier BV
DOI: 10.1016/j.cct.2023.107352

Lack of genetic evidence that fatty liver disease predisposes to COVID-19

Autori: Luca Valenti, Oveis Jamialahmadi, Stefano Romeo
Pubblicato in: Journal of Hepatology, Numero 73/3, 2020, Pagina/e 709-711, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.05.015

Derivation and validation of the nonalcoholic fatty liver disease cirrhosis score (NCS) to distinguish bridging fibrosis from cirrhosis

Autori: Christian Labenz, Gerrit Toenges, Ming-Hua Zheng, Dora Ding, Robert P. Myers, Peter R. Galle, Angelo Armandi, Javier Ampuero, Manuel Romero Gómez, Elisabetta Bugianesi, Quentin M. Anstee, Jörn M. Schattenberg
Pubblicato in: European Journal of Internal Medicine, Numero 98, 2022, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/j.ejim.2021.12.011

Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles

Autori: Ibon Martínez‐Arranz; Chiara Bruzzone; Mazen Noureddin; Ruben Gil‐Redondo; Itziar Mincholé; Maider Bizkarguenaga; Enara Arretxe; Marta Iruarrizaga‐Lejarreta; David Fernández‐Ramos; Fernando Lopitz‐Otsoa; Rebeca Mayo; Nieves Embade; Elizabeth Newberry; Bettina Mittendorf; Laura Izquierdo‐Sánchez; Vaclav Smid; Jorge Arnold; Paula Iruzubieta; Ylenia Pérez Castaño; Marcin Krawczyk; U
Pubblicato in: Hepatology, Numero 76(4), 2022, ISSN 1527-3350
Editore: John Wiley & Sons, Inc.
DOI: 10.1002/hep.32427

Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis

Autori: Yasaman Vali, Jenny Lee, Jérôme Boursier, René Spijker, Jürgen Löffler, Joanne Verheij, M. Julia Brosnan, Zsolt Böcskei, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad Hadi Zafarmand, Michael Pavlides, Christina Levick, Kevin Duffin, Craig Hyde, Tim Bauer, Pierre Bedossa, Diana Leeming, Ann Daly, Remy Hanf, Pablo Ortiz, Matej Oresic, Detlef Schuppan, Guido Hanauer, Yu Chen, Elizabeth Shumba
Pubblicato in: Journal of Hepatology, Numero 73/2, 2020, Pagina/e 252-262, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.03.036

Reply to: “Ceruloplasmin variants might have different effects in different iron overload disorders”

Autori: Elena Corradini; Luca Valenti
Pubblicato in: Crossref, Numero 7, 2021, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.007

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Autori: Mozes, F. E.; Lee, J. A.; Selvaraj, E. A.; Jayaswal, A. N. A.; Trauner, M.; Boursier, J.; Fournier, C.; Staufer, K.; Stauber, R. E.; Bugianesi, E.; Younes, R.; Gaia, S.; Lupsor-Platon, M.; Petta, S.; Shima, T.; Okanoue, T.; Mahadeva, S.; Chan, W. -K.; Eddowes, P. J.; Newsome, P. N.; Wong, V. W. -S.; de Ledinghen, V.; Fan, J.; Shen, F.; Cobbold, J. F.; Sumida, Y.; Okajima, A.; Schattenberg, J. M.;
Pubblicato in: "Gut, BMJ Publishing Group, 2021, pp.gutjnl-2021-324243. ⟨10.1136/gutjnl-2021-324243⟩", Numero 2, 2021, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.48350/160159

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

Autori: Selvaraj, E. A., Mozes, F. E., Jayaswal, A. N. A., Zafarmand, M. H., Vali, Y., Lee, J. A., Levick, C. K., Young, L. A. J., Palaniyappan, N., Liu, C. H., Aithal, G. P., Romero-Gomez, M., Brosnan, M. J., Tuthill, T. A., Anstee, Q. M., Neubauer, S., Harrison, S. A., Bossuyt, P. M., Pavlides, M. and Investigators, Litmus
Pubblicato in: J Hepatol, Numero 75(4), 2021, Pagina/e 770-785, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.04.044

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes

Autori: Marica Meroni, Paola Dongiovanni, Miriam Longo, Fabrizia Carli, Guido Baselli, Raffaela Rametta, Serena Pelusi, Sara Badiali, Marco Maggioni, Melania Gaggini, Anna Ludovica Fracanzani, Stefano Romeo, Stefano Gatti, Nicholas O. Davidson, Amalia Gastaldelli, Luca Valenti
Pubblicato in: EBioMedicine, Numero 52, 2020, Pagina/e 102658, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102658

MAFLD vs NAFLD: Let the contest begin!

Autori: Cristiana Bianco, Stefano Romeo, Salvatore Petta, Michelle T. Long, Luca Valenti
Pubblicato in: Liver International, Numero 40/9, 2020, Pagina/e 2079-2081, ISSN 1478-3223
Editore: Blackwell Publishing Inc.
DOI: 10.1111/liv.14620

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