Hypoglycaemia - REdefining SOLutions for better liVEs | Hypo-RESOLVE | Project | Results | H2020 | CORDIS

Risultati finali

Paper on the correlation of short duration CGM on observed rates of severe and non-severe hypoglycaemia in clinical trials (related to Task 5.1.1)

It will be investigated whether rates of CGM-detected low values from short duration CGM correlate with severe and non-severe hypoglycaemia reported during clinical trials.

Publication of consensus report and new guidelines

The ultimate goal is that the overall results of the project, including the consensus on classifications/ definitions, will be translated into guidelines for clinical investigations with glucose lowering medications and associated medical technologies. Classification of hypoglycaemia, methods of data collection and uniform standards of clinical and PROs will guide clinical research in the field.

Final Statistical Analysis plan

Using the classifications and research priorities developed in other tasks: development and implementation of a Statistical Analysis Plan (SAP) to 1) examine risk factors for severe hypoglycaemia, and 2) establish the clinical consequences of hypoglycaemic events at different glucose levels. Consequences will include biomedical (e.g. acute and chronic cognitive impairment, cardiac arrhythmias and mortality), psychological (fear of hypoglycaemia, quality of life), social (limitation of employment, loss of driving license), economic (costs to the individual and society).

Improvement and validation of the in-silico model of T1D patient (related to Task 5.3.2)

We will improve the description of hypoglycaemia in the model-based framework developed at UNIPD . The new in-silico model-based framework will be validated by comparing the incidence, frequency and duration of hypoglycaemia seen in the model with data from the validation datasets.

Identification of behavioural parameters affecting hypoglycaemia occurrence and effect of their optimization (related to Task 5.3.3)

Identification of behavioural risk factors for hypoglycaemia and modelling of the potential benefit of addressing each of those risk factors.

Paper on the minimum duration of CGM that is representative of an individual's hypoglycaemia risk (related to Task 5.1.2)

The minimum duration of CGM that accurately represents the hypoglycaemia risk (% time < 3.0 mmol/l) of the individual as assessed by CGM over 3 months will be determined.

Updated review of the evidence surrounding our proposed classification

A systematic review will be undertaken of the literature to establish the strength of the existing evidence base for the cut-off level, in terms of associated and predicted clinical consequences, and define what questions need to be answered in analysing the database sets. Definitions of hypoglycaemia will be extended to include continuous glucose monitoring data where these have been collected robustly with input from WP5.

Hypo-RESOLVE Position Paper

A position paper will be authored by the coordinator (RUMC) to inform about the project. It is aimed to be published in a high-ranked journal.

Report on the health care system costs of hypoglycaemia in five European countries

We will submit a publication detailing the health care system costs of hypoglycaemia in five European countries This will be submitted to a peerreviewed journal for open access publication

First study subject approvals package (WP5)

We will register the study on clinicaltrials.net with inclusion and exclusion criteria.

Systematic review and report on guidelines

A validated search strategy will be applied to collect the existing guidelines and documents. Completeness of the guidelines will be cross-checked with the agencies and organisations, and relevant literature will be added to the document. A consensus process of the group will be applied, and a report as deliverable will be available to all consortium members.

Develop Network of Clinical Investigators in IAH

Establishment of a network of clinical investigators to build bio resources focused on hypoglycaemia-prone patients and to collaborate in future intervention trials using shared protocols and approaches.

Summary of expert group meetings I

A multi-disciplinary expert group will be established to guide, comment and inform the analysis of clinical trial data as it is generated by the statistics groups.

External Project Website

An external project website will be developed and launched online.

Pubblicazioni

Einfluss der Jahreszeiten auf die glykämischen Kontrolle gemessen mit CGM-Metriken bei Personen mit Typ 1 Diabetes

Autori: Andrea Groselj-Strele, Hesham Elsayed, Monika Cigler, Haris Ziko, Daniel A Hochfellner, Julia Kopanz, Tina Pöttler, Katharina Secco, Amra Simic, Slave Trajanoski, Julia K Mader
Pubblicato in: Wiener Klinische Wochenschrift, Numero WKW 133. Jahrgang 2021 Supplement, 2021
Editore: Austrian Society of Internal Medicine, the Austrian Society of Cardiology, the Austrian Society of Pneumology

Kürzere Diabetesdauer und Betazellrestfunktion sind assoziiert mit einer besseren glykämischen Kontrolle gemessen mittels kontinuierlicher Glukosemessung bei Personen mit Typ 1 Diabetes

Autori: Monika Cigler, Hesham Elsayed, Haris Ziko, Daniel A Hochfellner, Julia Kopanz, Tina Pöttler, Katharina Secco, Amra Simic, Slave Trajanoski, Andrea Groselj-Strele, Julia K Mader
Pubblicato in: Wiener Klinische Wochenschrift, Numero WKW 133. Jahrgang 2021 Supplement, 2021
Editore: Austrian Society of Internal Medicine, the Austrian Society of Cardiology, the Austrian Society of Pneumology

A Mathematical Formula to Determine the Minimum Continuous Glucose Monitoring Duration to Assess Time-in-ranges: Sensitivity Analysis Over the Parameters

Autori: N. Camerlingo; M. Vettoretti; G. Sparacino; A. Facchinetti; J.K. Mader; P. Choudhary; S. Del Favero
Pubblicato in: IEEExplore, Numero 24, 2021, Pagina/e 1435-1438, ISBN 978-1-7281-1179-7
Editore: IEEE Engineering in Medicine and Biology Society
DOI: 10.1109/embc46164.2021.9630689

Glucokinase in AGRP Neurons Is Required for Normal Insulin Secretion and Action in Female Mice

Autori: MASA JOSIPOVIC; EMILY O. STARICOFF; CHRISTINE H. RICHES; LAURA SHEPPARD; MARK EVANS
Pubblicato in: Diabetes 2022, Numero Volume 71, Numero Supplement_1, 2022, Pagina/e 1311-P, ISSN 1939-327X
Editore: American Diabetes Society
DOI: 10.2337/db22-1311-p

Quality of Life in Adults with Type 2 Diabetes: A Mixed-Methods Exploration of the Psychosocial Impacts of Hypoglycaemia

Autori: Kevin Alan Matlock
Pubblicato in: Dissertation, 2022
Editore: SDU Library
DOI: 10.21996/b3ce-8244

The Impact of Hypoglycaemia on the Quality of Life of Family Members of Persons with Type 1 or Type 2 Diabetes

Autori: Mette Valdersdorf Jensen
Pubblicato in: SDU Library, 2022
Editore: University of Southern Denmark
DOI: 10.21996/5v07-3t82

The personal daily impact of hypoglycaemia among adults with diabetes: Development and first use of the Hypo-METRICS app

Autori: Uffe Søholm
Pubblicato in: SDU Library, 2022
Editore: University of Southern Denmark
DOI: 10.21996/q100-yf09

The Impact of Hypoglycaemia on Quality of Life Among Adults with Type 1 Diabetes

Autori: Hannah Chatwin
Pubblicato in: SDU Library, 2022
Editore: University of Southern Denmark
DOI: 10.21996/xcqk-ps10

Effects of hypoglycaemia on cognition and inflammation

Autori: Verhulst, C.E.M.
Pubblicato in: Radboud University, 20 juni 2023, Numero 20, 2023, ISBN 9789493315709
Editore: Radboud University

The impact of hypoglycaemia on quality of life in children and adolescents with type 1 diabetes

Autori: Manon Coolen
Pubblicato in: SDU Library, 2022
Editore: University of Southern Denmark
DOI: 10.21996/jb1p-ed62

Comparision between type 1 and type 2 diabetes and people without diabetes in hormonal, symptomatic and cardiac response to experimental hypoglycaemia

Autori: Therese Wilbek Fabricius
Pubblicato in: 2023
Editore: Faculty of Health and Medical Sciences, University of Copenhagen

Mathematical Models of Meal Amount and Timing Variability With Implementation in the Type-1 Diabetes Patient Decision Simulator

Autori: Nunzio Camerlingo, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino
Pubblicato in: Journal of Diabetes Science and Technology, Numero 15/2, 2021, Pagina/e 346-359, ISSN 1932-2968
Editore: Diabetes Technology Society
DOI: 10.1177/1932296820952123

Hypoglycaemia detection and prediction techniques: A systematic review on the latest developments

Autori: Omar Diouri, Monika Cigler, Martina Vettoretti, Julia K. Mader, Pratik Choudhary, Eric Renard
Pubblicato in: Diabetes/Metabolism Research and Reviews, Numero e3449, ahead of print, 2021, ISSN 1520-7552
Editore: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3449

Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion

Autori: AlexandrePicard1XavierBerney1JuditCastillo-Armengol12DavidTarussio1MaximeJan1Ana RodriguezSanchez-Archidona1SophieCroizier1BernardThorens1
Pubblicato in: Molecular Metabolism, Numero Volume 61, July 2022, 2022, Pagina/e 101479, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101479

Design of clinical trials to assess diabetes treatment: Minimum duration of continuous glucose monitoring data to estimate time-in-ranges with the desired precision

Autori: Nunzio Camerlingo MSc, Martina Vettoretti PhD, Giovanni Sparacino PhD, Andrea Facchinetti PhD, Julia K. Mader MD, Pratik Choudhary MD, Simone Del Favero PhD, on behalf of the Hypo-RESOLVE Consortium
Pubblicato in: Diabetes, Obesity and Metabolism, Numero vol. 23, issue 11, 2021, Pagina/e 2446-2454, ISSN 1463-1326
Editore: John Wiley & Sons Ltd
DOI: 10.1111/dom.14483

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis

Autori: Alexandre Picard; Salima Metref; David Tarussio; Wanda Dolci; Xavier Berney; Sophie Croizier; Gwenaël Labouebe; Bernard Thorens
Pubblicato in: Diabetes, Numero vol. 70, Numero 7, 2021, Pagina/e 1443-1457, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db20-1121

Sustained Proinflammatory Effects of Hypoglycemia in People With Type 2 Diabetes and in People Without Diabetes

Autori: Clementine E.M. Verhulst; Julia I.P. van Heck; Therese W. Fabricius; Rinke Stienstra; Steven Teerenstra; Rory J. McCrimmon; Cees J. Tack; Ulrik Pedersen-Bjergaard; Bastiaan E. de Galan, on behalf of the Hypo-RESOLVE consortium
Pubblicato in: Diabetes, Numero 2022; 71 (12), 2022, Pagina/e 2716–2727, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db22-0241

Changes in quality of life following hypoglycaemia in adults with type 2 diabetes: A systematic review of longitudinal studies

Autori: Kevin A. Matlock, Melanie Broadley, Christel Hendrieckx, Mark Clowes, Anthea Sutton, Simon R. Heller, Bastiaan E. de Galan, Frans Pouwer, Jane Speight, for the Hypo- RESOLVE consortium
Pubblicato in: Diabetic Medicine, Numero 2022;39:e14706, 2021, ISSN 1464-5491
Editore: Wiley Online Library
DOI: 10.1111/dme.14706

People with type 1 diabetes and impaired awareness of hypoglycaemia have a delayed reaction to perform a glucose scan during hypoglycaemia – a prospective observational study

Autori: Othmar Moser, Haris Ziko, Hesham Elsayed, Daniel Hochfellner, Tina Pöttler, Alexander Mueller, Max L Eckstein, Harald Sourij, Julia K Mader, on behalf of the Hypo-RESOLVE Consortium
Pubblicato in: Diabetic Medicine, Numero Volume37, Numero12, 2020, Pagina/e 2153-2159, ISSN 1464-5491
Editore: John Wiley & Sons Ltd
DOI: 10.1111/dme.14362

Hypo-METRICS: Hypoglycaemia—MEasurement, ThResholds and ImpaCtS—A multi-country clinical study to define the optimal threshold and duration of sensor-detected hypoglycaemia that impact the experience of hypoglycaemia, quality of life and health economic outcomes: The study protocol

Autori: Patrick Divilly, Natalie Zaremba, Zeinab Mahmoudi, Uffe Søholm, Daniel J. Pollard, Melanie Broadley, Evertine J. Abbink, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Eric Renard, Mark Evans, Jane Speight, Alan Brennan, Rory J. McCrimmon, Matthias Müllenborn, Simon Heller, Alexander Seibold, Julia K. Mader, Stephanie A. Amiel, Frans Pouwer, Pratik Choudhary, Hypo-RESOLVE Consortium
Pubblicato in: Diabetic Medicine, Numero Online Version of Record before inclusion in an issue, 2022, Pagina/e e14892, ISSN 1464-5491
Editore: John Wiley & Sons Ltd
DOI: 10.1111/dme.14892

The impact of hypoglycaemia on the quality of life of family members of adults with type 1 or type 2 diabetes: A qualitative systematic review

Autori: Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Alison Scope, Louise Preston, Simon Heller, Bastiaan E. de Galan, Frans Pouwer, Christel Hendrieckx, the Hypo-RESOLVE Consortium
Pubblicato in: Diabetic Medicine, Numero vol. 38, issue 10, 2021, ISSN 1464-5491
Editore: John Wiley & Sons Ltd
DOI: 10.1111/dme.14666

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia

Autori: Sevasti Gaspari, Gwenaël Labouèbe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens
Pubblicato in: EMBO Reports, Numero (2023)24:e57344, 2023, ISSN 1469-3178
Editore: EMBO Press
DOI: 10.15252/embr.202357344

Choosing the duration of continuous glucose monitoring for reliable assessment of time in range: A new analytical approach to overcome the limitations of correlation-based methods

Autori: Nunzio Camerlingo, Martina Vettoretti, Giovanni Sparacino, Andrea Facchinetti, Julia K. Mader, Pratik Choudhary, Simone Del Favero, the Hypo-RESOLVE Consortium
Pubblicato in: Diabetic Medicine, Numero May 2022, 2021, Pagina/e e14758, ISSN 1464-5491
Editore: John Wiley & Sons Ltd
DOI: 10.1111/dme.14758

The 12-Item Hypoglycemia Impact Profile (HIP12): psychometric validation of a brief measure of the impact of hypoglycemia on quality of life among adults with type 1 or type 2 diabetes

Autori: Melanie Broadley, Hannah Chatwin, Uffe Søholm, Stephanie A Amiel, Jill Carlton, Bastiaan E De Galan, Christel Hendrieckx, Rory J McCrimmon, Søren E Skovlund, Frans Pouwer, Jane Speight, on behalf of the Hypo-RESOLVE Consortium
Pubblicato in: BMJ Open Diab Res Care, Numero 2022;10:e002890, 2022, ISSN 2052-4897
Editore: BMJ
DOI: 10.1136/bmjdrc-2022-002890

Risk of Hypoglycemia in Type 1 Diabetes Management: an In-Silico Sensitivity Analysis to Assess and Rank the Quantitative Impact of Different Behavioral Factors

Autori: Roversi, Chiara; Camerlingo, Nunzio; Vettoretti, Martina; Facchinetti, Andrea; Choudary, Pratik; Sparacino, Giovanni; Del Favero, Simone
Pubblicato in: Computer Methods and Programs in Biomedicine, Numero 3, 2023, Pagina/e 107943, ISSN 1872-7565
Editore: Elsevier B.V.
DOI: 10.1016/j.cmpb.2023.107943

The impact of hypoglycaemia in children and adolescents with type 1 diabetes on parental quality of life and related outcomes: A systematic review

Autori: Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Hannah Chatwin, Alison Scope, Anna Cantrell, Simon Heller, Bastiaan E. de Galan, Christel Hendrieckx, Frans Pouwer, on behalf of the Hypo-RESOLVE consortium
Pubblicato in: Pediatrics Diabetes, Numero Volume23, Numero3, 2022, Pagina/e 390-405, ISSN 1464-5491
Editore: John Wiley & Sons Ltd
DOI: 10.1111/pedi.13308

Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia

Autori: Emily O.Staricoff, Mark L.Evans
Pubblicato in: Current Opinion in Endocrine and Metabolic Research, Numero Volume 24, 2022, 2021, Pagina/e 100353, ISSN 2451-9650
Editore: Elsevier
DOI: 10.1016/j.coemr.2022.100353

The impact of hypoglycemia on quality of life and related outcomes in children and adolescents with type 1 diabetes: A systematic review

Autori: Manon Coolen, Melanie Broadley, Christel Hendrieckx, Hannah Chatwin, Mark Clowes, Simon Heller, Bastiaan E. de Galan, Jane Speight, Frans Pouwer, for the Hypo-RESOLVE Consortium
Pubblicato in: Plos One, Numero 6(12): e0260896, 2021, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0260896

Baseline Glucose Variability and Interweek Variability Affects the Time to Stability of Continuous Glucose Monitoring-Derived Glycemic Indices

Autori: Suresh Rama Chandran, Peter Jacob, Pratik Choudhary, and on behalf of the Hypo-RESOLVE Consortium
Pubblicato in: Diabetes Technology & Therapeutics, Numero Vol. 22, No.12, 2020, Pagina/e 937-942, ISSN 1520-9156
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/dia.2020.0011

Hypoglycaemia symptom frequency, severity, burden, and utility among adults with type 1 diabetes and impaired awareness of hypoglycaemia: Baseline and 24-week findings from the HypoCOMPaSS study

Autori: Uffe Søholm, Elizabeth Holmes-Truscott, Melanie Broadley, Stephanie A Amiel, Christel Hendrieckx, Pratik Choudhary, Frans Pouwer, James A M Shaw, Jane Speight
Pubblicato in: Diabetic Medicine, Numero 2023 Sep 25:e15231, 2023, ISSN 1464-5491
Editore: John Wiley & Sons, Inc.
DOI: 10.1111/dme.15231

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Autori: Anastasiya Strembitska, Gwenaël Labouèbe, Alexandre Picard, Xavier P. Berney, David Tarussio, Maxime Jan & Bernard Thorens
Pubblicato in: Nature Communications, Numero 13:5761 (2022), 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-33484-6

Hypoglycaemia induces a sustained pro-inflammatory response in people with type 1 diabetes and healthy controls

Autori: Clementine E. M. Verhulst MD, Julia I. P. van Heck MSc, Therese W. Fabricius MD, Rinke Stienstra PhD, Steven Teerenstra PhD, Rory J. McCrimmon PhD, Cees J. Tack PhD, Ulrik Pedersen-Bjergaard PhD, Bastiaan E. de Galan PhD, on behalf of the Hypo-RESOLVE consortium
Pubblicato in: Diabetes, Obesity and Metabolism, Numero Volume 25, Numero11 (eprint ahead of print), 2023, Pagina/e 3114-3124, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.15205

An analytical approach to determine the optimal duration of continuous glucose monitoring data required to reliably estimate time in hypoglycemia

Autori: Nunzio Camerlingo, Martina Vettoretti, Andrea Facchinetti, Giovanni Sparacino, Julia K. Mader, Pratik Choudhary, Simone Del Favero
Pubblicato in: Scientific Reports, Numero 10/1, 2020, Pagina/e Article number: 18180, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-75079-5

Hypoglycaemia: Still the main drawback of insulin 100 years on: “From man to mouse”

Autori: Heather J. Merchant, Alison D. McNeilly
Pubblicato in: Diabetic Medicine, Numero 2021 Dec;38(12), 2020, Pagina/e e14721, ISSN 1464-5491
Editore: Wiley Online Library
DOI: 10.1111/dme.14721

Psychometric properties of an innovative smartphone application to investigate the daily impact of hypoglycemia in people with type 1 or type 2 diabetes: The Hypo-METRICS app

Autori: Uffe Søholm , Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Jill Carlton, Julia K. Mader, Petra Martina Baumann, Mikel Gomes, Gilberte Martine-Edith, Daniel J. Pollard, Dajana Rath, Simon Heller, Ulrik Pedersen-Bjergaard, Rory J. McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Thomas Forkmann, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans
Pubblicato in: PLoS ONE, Numero 18(3): e0283148, 2023, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0283148

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation

Autori: Simon Quenneville; Gwenaël Labouèbe; Davide Basco; Salima Metref; Benoit Viollet; Marc Foretz; Bernard Thorens
Pubblicato in: Diabetes/ Metabolism, Numero Vol. 69, issue 11, 2020, Pagina/e 2253-2266, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db20-0577

Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia

Autori: Keeran Vickneson, Jessica Blackburn, Jennifer R. Gallagher, Mark L. Evans, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Bernard Thorens, Alison D. McNeilly, Rory J. McCrimmon
Pubblicato in: Diabetologia, Numero 64/6, 2021, Pagina/e 1436-1441, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-021-05425-3

Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review

Autori: Clementine E M Verhulst, Therese W Fabricius, Steven Teerenstra, Peter L Kristensen, Cees J Tack, Rory J McCrimmon, Simon Heller, Mark L Evans, Stephanie A Amiel, Ulrik Pedersen-Bjergaard, Bastiaan E de Galan; Hypo-RESOLVE consortium
Pubblicato in: Diabetologia, Numero 2022 Oct;65(10):1601-1612, 2022, ISSN 1432-0428
Editore: Springer
DOI: 10.1007/s00125-022-05749-8

Reducing the burden of hypoglycaemia in people with diabetes through increased understanding: design of the Hypoglycaemia REdefining SOLutions for better liVEs (Hypo‐RESOLVE) project

Autori: B. E. Galan, R. J. McCrimmon, M. Ibberson, S. R. Heller, P. Choudhary, F. Pouwer, J. Speight, J. Carlton, T. R. Pieber, M. Rosilio, C. J. Tack, M. Müllenborn
Pubblicato in: Diabetic Medicine, Numero 37/6, 2020, Pagina/e 1066-1073, ISSN 0742-3071
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dme.14240

Modeling carbohydrate counting error in type 1 diabetes management

Autori: Chiara Roversi, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino
Pubblicato in: Diabetes Technology & Therapeutics, 2020, ISSN 1520-9156
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/dia.2019.0502

Impact of Carbohydrate Counting Error on Glycemic Control in Open-Loop Management of Type 1 Diabetes: Quantitative Assessment Through an in silico Trial

Autori: Chiara Roversi, MS, Martina Vettoretti, PhD, Simone Del Favero, PhD, Andrea Facchinetti, PhD, Pratik Choudhary, MD, Giovanni Sparacino, PhDon behalf of the Hypo-RESOLVE Consortium
Pubblicato in: Journal of Diabetes Science and Technology, Numero I-9, 2021, ISSN 1932-2968
Editore: Diabetes Technology Society
DOI: 10.1177/19322968211012392

The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods

Autori: Jill Carlton, Joanna Leaviss, Frans Pouwer, Christel Hendrieckx, Melanie M. Broadley, Mark Clowes, Rory J. McCrimmon, Simon R. Heller, Jane Speight
Pubblicato in: Diabetologia, Numero 64/6, 2021, Pagina/e 1213-1225, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-021-05382-x

Unmet support needs relating to hypoglycaemia among adults with type 1 diabetes: Results of a multi-country web-based qualitative study

Autori: Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan E. de Galan, Norbert Hermanns, Katharina Finke-Groene, Jane Speight, Frans Pouwer, the Hypo-RESOLVE Consortium
Pubblicato in: Diabetic Medicine, Numero Vol. 39, Numero 1, 2021, Pagina/e e14727, ISSN 1464-5491
Editore: John Wiley & Sons Ltd
DOI: 10.1111/dme.14727

Investigating the day-to-day impact of hypoglycaemia in adults with type 1 or type 2 diabetes: design and validation protocol of the Hypo-METRICS application

Autori: Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Zeinab Mahmoudi, Bastiaan de Galan,Ulrik Pedersen-Bjergaard, Alan Brennan, Daniel John Pollard, Rory J McCrimmon, Stephanie A. Amiel ,Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer, for the Hypo-RESOLVE Consortium
Pubblicato in: BMJ Open, Numero Volume 12, Numero 2, 2022, Pagina/e e051651, ISSN 1756-1833
Editore: BMJ
DOI: 10.1136/bmjopen-2021-051651

The impact of hypoglycaemia on quality of life among adults with type 1 diabetes: Results from “YourSAY: Hypoglycaemia”

Autori: Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan de Galan, Rory J. McCrimmon, Ulrik Pedersen-Bjergaard, FransP ouwer, Jane Speight, On behalf of the Hypo-RESOLVE Consortium
Pubblicato in: Journal of Diabetes and its Complications, Numero Volume 36, Numero 7, 2022, Pagina/e available online 21 June 2022, 108232, ISSN 1056-8727
Editore: Elsevier BV
DOI: 10.1016/j.jdiacomp.2022.108232

Producing a preference-based quality of LIFE measure to quantify the impact of HYPOGLYCAEMIA on people living with diabetes: A mixed-methods research protocol

Autori: Jill Carlton, Philip Powell, Donna Rowen, Melanie Broadley, Frans Pouwer, Jane Speight, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Christopher J. Child, Jonathan Comins, Rory J. McCrimmon, Bastiaan de Galan, John Brazier, Hypo-RESOLVE CONSORTIUM
Pubblicato in: Diabetic Medicine, Numero 2023;40:e15007, 2023, ISSN 1464-5491
Editore: Wiley Online Library
DOI: 10.1111/dme.15007

Generation of post-meal insulin correction boluses in type 1 diabetes simulation models for in-silico clinical trials: more realistic scenarios obtained using a decision tree approach

Autori: Nunzio Camerlingo, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Pratik Choudhary, Giovanni Sparacino, on behalf of the Hypo-RESOLVE Consortium
Pubblicato in: Computer Methods and Programs in Biomedicine, Numero Vol. 221(2022), 2022, Pagina/e 106862, ISSN 0169-2607
Editore: Elsevier BV
DOI: 10.1016/j.cmpb.2022.106862

‘Never again will I be carefree’: a qualitative study of the impact of hypoglycemia on quality of life among adults with type 1 diabetes

Autori: Hannah Chatwin, Dr Melanie Broadley, Mette Valdersdorf Jensen, Dr Christel Hendrieckx, Dr Jill Carlton, Prof Simon Heller, Prof Stephanie Amiel, MD, Prof Bastiaan de Galan, MD, Prof Norbert Hermanns, Katharina Finke-Grone, Prof Jane Speight, Prof Frans Pouwer
Pubblicato in: BMJ Open Diabetes Research & Care, Numero 9:e002322, 2021, ISSN 1756-1833
Editore: BMJ
DOI: 10.1136/bmjdrc-2021-002322

Toward an Optimal Definition of Hypoglycemia with Continuous Glucose Monitoring

Autori: Zeinab Mahmoudia, Simone Del Favero, PeterJacob, Pratik Choudhary, on behalf of the Hypo-RESOLVE Consortium
Pubblicato in: Computer Methods and Programs in Biomedicine, Numero Volume 209, September 2021, 106303, 2021, Pagina/e e106303, ISSN 0169-2607
Editore: Elsevier BV
DOI: 10.1016/j.cmpb.2021.106303

Hyperinsulinaemic–hypoglycaemic glucose clamps in human research: a systematic review of the literature

Autori: Therese W. Fabricius, Clementine E. M. Verhulst, Peter L. Kristensen, Cees J. Tack, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Stephanie A. Amiel, Thomas R. Pieber, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard
Pubblicato in: Diabetologia, Numero 64/4, 2021, Pagina/e 727-736, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05361-8

Assessing the Content Validity, Acceptability, and Feasibility of the Hypo-METRICS App: Survey and Interview Study

Autori: Uffe Søholm; Natalie Zaremba; Melanie Broadley; Johanne Lundager Axelsen; Patrick Divilly; Gilberte Martine-Edith; Stephanie A Amiel; Julia K Mader; Ulrik Pedersen-Bjergaard; Rory J McCrimmon; Eric Renard; Mark Evans; Bastiaan de Galan; Simon Heller; Christel Hendrieckx; Pratik Choudhary; Jane Speight; Frans Pouwer; Hypo-RESOLVE consortium Hypo-RESOLVE consortium
Pubblicato in: JMIR Diabetes, Numero 2023;8:e42100, 2023, ISSN 2371-4379
Editore: JMIR Publications Inc.
DOI: 10.2196/42100

The Impact of Hypoglycaemia on Quality of Life Outcomes Among Adults with Type 1 Diabetes: A Systematic Review

Autori: Hannah Chatwin, Melanie Broadley, Jane Speight, Anna Cantrell, Anthea Sutton, Simon Heller, Bastiaan de Galan, Christel Hendrieckx, Frans Pouwer; For the Hypo-RESOLVE Consortium
Pubblicato in: Diabetes Research and Clinical Practice, Numero Volume 174, 108752, April 2021, 2021, ISSN 1872-8227
Editore: international diabetes federation
DOI: 10.1016/j.diabres.2021.108752

Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes

Autori: Alison D. McNeilly, Jennifer R. Gallagher, Mark L. Evans, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Bernard Thorens, Albena T. Dinkova-Kostova, Jeffrey-T Huang, Michael LJ Ashford and Rory J. McCrimmon
Pubblicato in: Diabetologia, Numero 66, 1340–1352 (2023), 2023, ISSN 1432-0428
Editore: Springer Nature
DOI: 10.1007/s00125-023-05907-6

Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes

Autori: Clementine E.M. Verhulst; Therese W. Fabricius; Giesje Nefs; Roy P.C. Kessels; Frans Pouwer; Steven Teerenstra; Cees J. Tack; Melanie M. Broadley; Peter L. Kristensen; Rory J. McCrimmon; Simon Heller; Mark L. Evans; Ulrik Pedersen-Bjergaard; Bastiaan E. de Galan
Pubblicato in: Diabetes Care: The Journal of Clinical and Applied Research and Education, Numero 45(9), 2022, Pagina/e 2103 - 2110, ISSN 1935-5548
Editore: American Diabetes Society
DOI: 10.2337/dc21-2502

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