Rezultaty
It will be investigated whether rates of CGM-detected low values from short duration CGM correlate with severe and non-severe hypoglycaemia reported during clinical trials.
Publication of consensus report and new guidelinesThe ultimate goal is that the overall results of the project, including the consensus on classifications/ definitions, will be translated into guidelines for clinical investigations with glucose lowering medications and associated medical technologies. Classification of hypoglycaemia, methods of data collection and uniform standards of clinical and PROs will guide clinical research in the field.
Final Statistical Analysis planUsing the classifications and research priorities developed in other tasks: development and implementation of a Statistical Analysis Plan (SAP) to 1) examine risk factors for severe hypoglycaemia, and 2) establish the clinical consequences of hypoglycaemic events at different glucose levels. Consequences will include biomedical (e.g. acute and chronic cognitive impairment, cardiac arrhythmias and mortality), psychological (fear of hypoglycaemia, quality of life), social (limitation of employment, loss of driving license), economic (costs to the individual and society).
Improvement and validation of the in-silico model of T1D patient (related to Task 5.3.2)We will improve the description of hypoglycaemia in the model-based framework developed at UNIPD . The new in-silico model-based framework will be validated by comparing the incidence, frequency and duration of hypoglycaemia seen in the model with data from the validation datasets.
Identification of behavioural parameters affecting hypoglycaemia occurrence and effect of their optimization (related to Task 5.3.3)Identification of behavioural risk factors for hypoglycaemia and modelling of the potential benefit of addressing each of those risk factors.
Paper on the minimum duration of CGM that is representative of an individual's hypoglycaemia risk (related to Task 5.1.2)The minimum duration of CGM that accurately represents the hypoglycaemia risk (% time < 3.0 mmol/l) of the individual as assessed by CGM over 3 months will be determined.
Updated review of the evidence surrounding our proposed classificationA systematic review will be undertaken of the literature to establish the strength of the existing evidence base for the cut-off level, in terms of associated and predicted clinical consequences, and define what questions need to be answered in analysing the database sets. Definitions of hypoglycaemia will be extended to include continuous glucose monitoring data where these have been collected robustly with input from WP5.
Hypo-RESOLVE Position PaperA position paper will be authored by the coordinator (RUMC) to inform about the project. It is aimed to be published in a high-ranked journal.
Report on the health care system costs of hypoglycaemia in five European countriesWe will submit a publication detailing the health care system costs of hypoglycaemia in five European countries This will be submitted to a peerreviewed journal for open access publication
First study subject approvals package (WP5)We will register the study on clinicaltrials.net with inclusion and exclusion criteria.
Systematic review and report on guidelinesA validated search strategy will be applied to collect the existing guidelines and documents. Completeness of the guidelines will be cross-checked with the agencies and organisations, and relevant literature will be added to the document. A consensus process of the group will be applied, and a report as deliverable will be available to all consortium members.
Develop Network of Clinical Investigators in IAHEstablishment of a network of clinical investigators to build bio resources focused on hypoglycaemia-prone patients and to collaborate in future intervention trials using shared protocols and approaches.
Summary of expert group meetings IA multi-disciplinary expert group will be established to guide, comment and inform the analysis of clinical trial data as it is generated by the statistics groups.
An external project website will be developed and launched online.
Publikacje
Autorzy:
Andrea Groselj-Strele, Hesham Elsayed, Monika Cigler, Haris Ziko, Daniel A Hochfellner, Julia Kopanz, Tina Pöttler, Katharina Secco, Amra Simic, Slave Trajanoski, Julia K Mader
Opublikowane w:
Wiener Klinische Wochenschrift, Numer WKW 133. Jahrgang 2021 Supplement, 2021
Wydawca:
Austrian Society of Internal Medicine, the Austrian Society of Cardiology, the Austrian Society of Pneumology
Autorzy:
Monika Cigler, Hesham Elsayed, Haris Ziko, Daniel A Hochfellner, Julia Kopanz, Tina Pöttler, Katharina Secco, Amra Simic, Slave Trajanoski, Andrea Groselj-Strele, Julia K Mader
Opublikowane w:
Wiener Klinische Wochenschrift, Numer WKW 133. Jahrgang 2021 Supplement, 2021
Wydawca:
Austrian Society of Internal Medicine, the Austrian Society of Cardiology, the Austrian Society of Pneumology
Autorzy:
N. Camerlingo; M. Vettoretti; G. Sparacino; A. Facchinetti; J.K. Mader; P. Choudhary; S. Del Favero
Opublikowane w:
IEEExplore, Numer 24, 2021, Strona(/y) 1435-1438, ISBN 978-1-7281-1179-7
Wydawca:
IEEE Engineering in Medicine and Biology Society
DOI:
10.1109/embc46164.2021.9630689
Autorzy:
MASA JOSIPOVIC;
EMILY O. STARICOFF;
CHRISTINE H. RICHES;
LAURA SHEPPARD;
MARK EVANS
Opublikowane w:
Diabetes 2022, Numer Volume 71, Numer Supplement_1, 2022, Strona(/y) 1311-P, ISSN 1939-327X
Wydawca:
American Diabetes Society
DOI:
10.2337/db22-1311-p
Autorzy:
Kevin Alan Matlock
Opublikowane w:
Dissertation, 2022
Wydawca:
SDU Library
DOI:
10.21996/b3ce-8244
Autorzy:
Mette Valdersdorf Jensen
Opublikowane w:
SDU Library, 2022
Wydawca:
University of Southern Denmark
DOI:
10.21996/5v07-3t82
Autorzy:
Uffe Søholm
Opublikowane w:
SDU Library, 2022
Wydawca:
University of Southern Denmark
DOI:
10.21996/q100-yf09
Autorzy:
Hannah Chatwin
Opublikowane w:
SDU Library, 2022
Wydawca:
University of Southern Denmark
DOI:
10.21996/xcqk-ps10
Autorzy:
Verhulst, C.E.M.
Opublikowane w:
Radboud University, 20 juni 2023, Numer 20, 2023, ISBN 9789493315709
Wydawca:
Radboud University
Autorzy:
Manon Coolen
Opublikowane w:
SDU Library, 2022
Wydawca:
University of Southern Denmark
DOI:
10.21996/jb1p-ed62
Autorzy:
Therese Wilbek Fabricius
Opublikowane w:
2023
Wydawca:
Faculty of Health and Medical Sciences, University of Copenhagen
Autorzy:
Nunzio Camerlingo, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino
Opublikowane w:
Journal of Diabetes Science and Technology, Numer 15/2, 2021, Strona(/y) 346-359, ISSN 1932-2968
Wydawca:
Diabetes Technology Society
DOI:
10.1177/1932296820952123
Autorzy:
Omar Diouri, Monika Cigler, Martina Vettoretti, Julia K. Mader, Pratik Choudhary, Eric Renard
Opublikowane w:
Diabetes/Metabolism Research and Reviews, Numer e3449, ahead of print, 2021, ISSN 1520-7552
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/dmrr.3449
Autorzy:
AlexandrePicard1XavierBerney1JuditCastillo-Armengol12DavidTarussio1MaximeJan1Ana RodriguezSanchez-Archidona1SophieCroizier1BernardThorens1
Opublikowane w:
Molecular Metabolism, Numer Volume 61, July 2022, 2022, Strona(/y) 101479, ISSN 2212-8778
Wydawca:
Elsevier GmbH
DOI:
10.1016/j.molmet.2022.101479
Autorzy:
Nunzio Camerlingo MSc, Martina Vettoretti PhD, Giovanni Sparacino PhD, Andrea Facchinetti PhD, Julia K. Mader MD, Pratik Choudhary MD, Simone Del Favero PhD, on behalf of the Hypo-RESOLVE Consortium
Opublikowane w:
Diabetes, Obesity and Metabolism, Numer vol. 23, issue 11, 2021, Strona(/y) 2446-2454, ISSN 1463-1326
Wydawca:
John Wiley & Sons Ltd
DOI:
10.1111/dom.14483
Autorzy:
Alexandre Picard; Salima Metref; David Tarussio; Wanda Dolci; Xavier Berney; Sophie Croizier; Gwenaël Labouebe; Bernard Thorens
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Diabetes, Numer vol. 70, Numer 7, 2021, Strona(/y) 1443-1457, ISSN 0012-1797
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American Diabetes Association
DOI:
10.2337/db20-1121
Autorzy:
Clementine E.M. Verhulst; Julia I.P. van Heck; Therese W. Fabricius; Rinke Stienstra; Steven Teerenstra; Rory J. McCrimmon; Cees J. Tack; Ulrik Pedersen-Bjergaard; Bastiaan E. de Galan, on behalf of the Hypo-RESOLVE consortium
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Diabetes, Numer 2022; 71 (12), 2022, Strona(/y) 2716–2727, ISSN 0012-1797
Wydawca:
American Diabetes Association
DOI:
10.2337/db22-0241
Autorzy:
Kevin A. Matlock, Melanie Broadley, Christel Hendrieckx, Mark Clowes, Anthea Sutton, Simon R. Heller, Bastiaan E. de Galan, Frans Pouwer, Jane Speight, for the Hypo- RESOLVE consortium
Opublikowane w:
Diabetic Medicine, Numer 2022;39:e14706, 2021, ISSN 1464-5491
Wydawca:
Wiley Online Library
DOI:
10.1111/dme.14706
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Othmar Moser, Haris Ziko, Hesham Elsayed, Daniel Hochfellner, Tina Pöttler, Alexander Mueller, Max L Eckstein, Harald Sourij, Julia K Mader, on behalf of the Hypo-RESOLVE Consortium
Opublikowane w:
Diabetic Medicine, Numer Volume37, Numer12, 2020, Strona(/y) 2153-2159, ISSN 1464-5491
Wydawca:
John Wiley & Sons Ltd
DOI:
10.1111/dme.14362
Autorzy:
Patrick Divilly, Natalie Zaremba, Zeinab Mahmoudi, Uffe Søholm, Daniel J. Pollard, Melanie Broadley, Evertine J. Abbink, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Eric Renard, Mark Evans, Jane Speight, Alan Brennan, Rory J. McCrimmon, Matthias Müllenborn, Simon Heller, Alexander Seibold, Julia K. Mader, Stephanie A. Amiel, Frans Pouwer, Pratik Choudhary, Hypo-RESOLVE Consortium
Opublikowane w:
Diabetic Medicine, Numer Online Version of Record before inclusion in an issue, 2022, Strona(/y) e14892, ISSN 1464-5491
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John Wiley & Sons Ltd
DOI:
10.1111/dme.14892
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Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Alison Scope, Louise Preston, Simon Heller, Bastiaan E. de Galan, Frans Pouwer, Christel Hendrieckx, the Hypo-RESOLVE Consortium
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Diabetic Medicine, Numer vol. 38, issue 10, 2021, ISSN 1464-5491
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John Wiley & Sons Ltd
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10.1111/dme.14666
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Sevasti Gaspari, Gwenaël Labouèbe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens
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EMBO Reports, Numer (2023)24:e57344, 2023, ISSN 1469-3178
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10.15252/embr.202357344
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Nunzio Camerlingo, Martina Vettoretti, Giovanni Sparacino, Andrea Facchinetti, Julia K. Mader, Pratik Choudhary, Simone Del Favero, the Hypo-RESOLVE Consortium
Opublikowane w:
Diabetic Medicine, Numer May 2022, 2021, Strona(/y) e14758, ISSN 1464-5491
Wydawca:
John Wiley & Sons Ltd
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10.1111/dme.14758
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Melanie Broadley, Hannah Chatwin, Uffe Søholm, Stephanie A Amiel, Jill Carlton, Bastiaan E De Galan, Christel Hendrieckx, Rory J McCrimmon, Søren E Skovlund, Frans Pouwer, Jane Speight, on behalf of the Hypo-RESOLVE Consortium
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BMJ Open Diab Res Care, Numer 2022;10:e002890, 2022, ISSN 2052-4897
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BMJ
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10.1136/bmjdrc-2022-002890
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Roversi, Chiara; Camerlingo, Nunzio; Vettoretti, Martina; Facchinetti, Andrea; Choudary, Pratik; Sparacino, Giovanni; Del Favero, Simone
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Computer Methods and Programs in Biomedicine, Numer 3, 2023, Strona(/y) 107943, ISSN 1872-7565
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10.1016/j.cmpb.2023.107943
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Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Hannah Chatwin, Alison Scope, Anna Cantrell, Simon Heller, Bastiaan E. de Galan, Christel Hendrieckx, Frans Pouwer, on behalf of the Hypo-RESOLVE consortium
Opublikowane w:
Pediatrics Diabetes, Numer Volume23, Numer3, 2022, Strona(/y) 390-405, ISSN 1464-5491
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John Wiley & Sons Ltd
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10.1111/pedi.13308
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Emily O.Staricoff, Mark L.Evans
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Current Opinion in Endocrine and Metabolic Research, Numer Volume 24, 2022, 2021, Strona(/y) 100353, ISSN 2451-9650
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10.1016/j.coemr.2022.100353
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Manon Coolen, Melanie Broadley, Christel Hendrieckx, Hannah Chatwin, Mark Clowes, Simon Heller, Bastiaan E. de Galan, Jane Speight, Frans Pouwer, for the Hypo-RESOLVE Consortium
Opublikowane w:
Plos One, Numer 6(12): e0260896, 2021, ISSN 1932-6203
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Public Library of Science
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10.1371/journal.pone.0260896
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Suresh Rama Chandran, Peter Jacob, Pratik Choudhary, and on behalf of the Hypo-RESOLVE Consortium
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Diabetes Technology & Therapeutics, Numer Vol. 22, No.12, 2020, Strona(/y) 937-942, ISSN 1520-9156
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Uffe Søholm, Elizabeth Holmes-Truscott, Melanie Broadley, Stephanie A Amiel, Christel Hendrieckx, Pratik Choudhary, Frans Pouwer, James A M Shaw, Jane Speight
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Diabetic Medicine, Numer 2023 Sep 25:e15231, 2023, ISSN 1464-5491
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Anastasiya Strembitska, Gwenaël Labouèbe, Alexandre Picard, Xavier P. Berney, David Tarussio, Maxime Jan & Bernard Thorens
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Nature Communications, Numer 13:5761 (2022), 2022, ISSN 2041-1723
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Nature Publishing Group
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10.1038/s41467-022-33484-6
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Clementine E. M. Verhulst MD, Julia I. P. van Heck MSc, Therese W. Fabricius MD, Rinke Stienstra PhD, Steven Teerenstra PhD, Rory J. McCrimmon PhD, Cees J. Tack PhD, Ulrik Pedersen-Bjergaard PhD, Bastiaan E. de Galan PhD, on behalf of the Hypo-RESOLVE consortium
Opublikowane w:
Diabetes, Obesity and Metabolism, Numer Volume 25, Numer11 (eprint ahead of print), 2023, Strona(/y) 3114-3124, ISSN 1462-8902
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Blackwell Publishing Inc.
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Nunzio Camerlingo, Martina Vettoretti, Andrea Facchinetti, Giovanni Sparacino, Julia K. Mader, Pratik Choudhary, Simone Del Favero
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Scientific Reports, Numer 10/1, 2020, Strona(/y) Article number: 18180, ISSN 2045-2322
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Nature Publishing Group
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10.1038/s41598-020-75079-5
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Heather J. Merchant, Alison D. McNeilly
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Diabetic Medicine, Numer 2021 Dec;38(12), 2020, Strona(/y) e14721, ISSN 1464-5491
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Wiley Online Library
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10.1111/dme.14721
Autorzy:
Uffe Søholm , Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Jill Carlton, Julia K. Mader, Petra Martina Baumann, Mikel Gomes, Gilberte Martine-Edith, Daniel J. Pollard, Dajana Rath, Simon Heller, Ulrik Pedersen-Bjergaard, Rory J. McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Thomas Forkmann, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans
Opublikowane w:
PLoS ONE, Numer 18(3): e0283148, 2023, ISSN 1932-6203
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Public Library of Science
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Diabetes/ Metabolism, Numer Vol. 69, issue 11, 2020, Strona(/y) 2253-2266, ISSN 0012-1797
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Keeran Vickneson, Jessica Blackburn, Jennifer R. Gallagher, Mark L. Evans, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Bernard Thorens, Alison D. McNeilly, Rory J. McCrimmon
Opublikowane w:
Diabetologia, Numer 64/6, 2021, Strona(/y) 1436-1441, ISSN 0012-186X
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Clementine E M Verhulst, Therese W Fabricius, Steven Teerenstra, Peter L Kristensen, Cees J Tack, Rory J McCrimmon, Simon Heller, Mark L Evans, Stephanie A Amiel, Ulrik Pedersen-Bjergaard, Bastiaan E de Galan; Hypo-RESOLVE consortium
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Diabetologia, Numer 2022 Oct;65(10):1601-1612, 2022, ISSN 1432-0428
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Diabetic Medicine, Numer 37/6, 2020, Strona(/y) 1066-1073, ISSN 0742-3071
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Diabetes Technology & Therapeutics, 2020, ISSN 1520-9156
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Chiara Roversi, MS, Martina Vettoretti, PhD, Simone Del Favero, PhD, Andrea Facchinetti, PhD, Pratik Choudhary, MD, Giovanni Sparacino, PhDon behalf of the Hypo-RESOLVE Consortium
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Journal of Diabetes Science and Technology, Numer I-9, 2021, ISSN 1932-2968
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Diabetes Technology Society
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Autorzy:
Jill Carlton, Joanna Leaviss, Frans Pouwer, Christel Hendrieckx, Melanie M. Broadley, Mark Clowes, Rory J. McCrimmon, Simon R. Heller, Jane Speight
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Diabetologia, Numer 64/6, 2021, Strona(/y) 1213-1225, ISSN 0012-186X
Wydawca:
Springer Verlag
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10.1007/s00125-021-05382-x
Autorzy:
Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan E. de Galan, Norbert Hermanns, Katharina Finke-Groene, Jane Speight, Frans Pouwer, the Hypo-RESOLVE Consortium
Opublikowane w:
Diabetic Medicine, Numer Vol. 39, Numer 1, 2021, Strona(/y) e14727, ISSN 1464-5491
Wydawca:
John Wiley & Sons Ltd
DOI:
10.1111/dme.14727
Autorzy:
Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Zeinab Mahmoudi, Bastiaan de Galan,Ulrik Pedersen-Bjergaard, Alan Brennan, Daniel John Pollard, Rory J McCrimmon, Stephanie A. Amiel ,Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer, for the Hypo-RESOLVE Consortium
Opublikowane w:
BMJ Open, Numer Volume 12, Numer 2, 2022, Strona(/y) e051651, ISSN 1756-1833
Wydawca:
BMJ
DOI:
10.1136/bmjopen-2021-051651
Autorzy:
Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan de Galan, Rory J. McCrimmon, Ulrik Pedersen-Bjergaard, FransP ouwer, Jane Speight, On behalf of the Hypo-RESOLVE Consortium
Opublikowane w:
Journal of Diabetes and its Complications, Numer Volume 36, Numer 7, 2022, Strona(/y) available online 21 June 2022, 108232, ISSN 1056-8727
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Elsevier BV
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10.1016/j.jdiacomp.2022.108232
Autorzy:
Jill Carlton, Philip Powell, Donna Rowen, Melanie Broadley, Frans Pouwer, Jane Speight, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Christopher J. Child, Jonathan Comins, Rory J. McCrimmon, Bastiaan de Galan, John Brazier, Hypo-RESOLVE CONSORTIUM
Opublikowane w:
Diabetic Medicine, Numer 2023;40:e15007, 2023, ISSN 1464-5491
Wydawca:
Wiley Online Library
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10.1111/dme.15007
Autorzy:
Nunzio Camerlingo, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Pratik Choudhary, Giovanni Sparacino, on behalf of the Hypo-RESOLVE Consortium
Opublikowane w:
Computer Methods and Programs in Biomedicine, Numer Vol. 221(2022), 2022, Strona(/y) 106862, ISSN 0169-2607
Wydawca:
Elsevier BV
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10.1016/j.cmpb.2022.106862
Autorzy:
Hannah Chatwin, Dr Melanie Broadley, Mette Valdersdorf Jensen, Dr Christel Hendrieckx, Dr Jill Carlton, Prof Simon Heller, Prof Stephanie Amiel, MD, Prof Bastiaan de Galan, MD, Prof Norbert Hermanns, Katharina Finke-Grone, Prof Jane Speight, Prof Frans Pouwer
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BMJ Open Diabetes Research & Care, Numer 9:e002322, 2021, ISSN 1756-1833
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BMJ
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10.1136/bmjdrc-2021-002322
Autorzy:
Zeinab Mahmoudia, Simone Del Favero, PeterJacob, Pratik Choudhary, on behalf of the Hypo-RESOLVE Consortium
Opublikowane w:
Computer Methods and Programs in Biomedicine, Numer Volume 209, September 2021, 106303, 2021, Strona(/y) e106303, ISSN 0169-2607
Wydawca:
Elsevier BV
DOI:
10.1016/j.cmpb.2021.106303
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Therese W. Fabricius, Clementine E. M. Verhulst, Peter L. Kristensen, Cees J. Tack, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Stephanie A. Amiel, Thomas R. Pieber, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard
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Diabetologia, Numer 64/4, 2021, Strona(/y) 727-736, ISSN 0012-186X
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Springer Verlag
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10.1007/s00125-020-05361-8
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Uffe Søholm; Natalie Zaremba; Melanie Broadley; Johanne Lundager Axelsen; Patrick Divilly; Gilberte Martine-Edith; Stephanie A Amiel; Julia K Mader; Ulrik Pedersen-Bjergaard; Rory J McCrimmon; Eric Renard; Mark Evans; Bastiaan de Galan; Simon Heller; Christel Hendrieckx; Pratik Choudhary; Jane Speight; Frans Pouwer; Hypo-RESOLVE consortium Hypo-RESOLVE consortium
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JMIR Diabetes, Numer 2023;8:e42100, 2023, ISSN 2371-4379
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JMIR Publications Inc.
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10.2196/42100
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Hannah Chatwin, Melanie Broadley, Jane Speight, Anna Cantrell, Anthea Sutton, Simon Heller, Bastiaan de Galan, Christel Hendrieckx, Frans Pouwer; For the Hypo-RESOLVE Consortium
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Diabetes Research and Clinical Practice, Numer Volume 174, 108752, April 2021, 2021, ISSN 1872-8227
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international diabetes federation
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10.1016/j.diabres.2021.108752
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Clementine E.M. Verhulst; Therese W. Fabricius; Giesje Nefs; Roy P.C. Kessels; Frans Pouwer; Steven Teerenstra; Cees J. Tack; Melanie M. Broadley; Peter L. Kristensen; Rory J. McCrimmon; Simon Heller; Mark L. Evans; Ulrik Pedersen-Bjergaard; Bastiaan E. de Galan
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