Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine

Informazioni relative al progetto

CISTEM

ID dell’accordo di sovvenzione: 778354

DOI

10.3030/778354

Progetto chiuso

Data della firma CE 4 Ottobre 2017

Data di avvio 1 Gennaio 2018

Data di completamento 30 Giugno 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 364 500,00

Contributo UE

€ 364 500,00

Coordinato da

BIOSENSE INSTITUTE - RESEARCH AND DEVELOPMENT INSTITUTE FOR INFORMATION TECHNOLOGIES IN BIOSYSTEMS
Serbia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Communication and public engagement plan No. 1
Report on workshops/Networking activities

Report on Workshop List of attendees work programme workshop results summary audiovisual material and slides Networking activities Events future potential collaborative project

Communication and public engagement plan No. 2

Demonstrators, pilots, prototypes (2)

Microfluidic chip modelling the Duchenne Muscular

A microfluidic chip will be designed for modelling the Duchenne Muscular Dystrophy (DMD) cardiomyopathy

Microfluidic device for iPSC differentiation into Cardiomyocyte

Fabrication of microfluidic device dedicated to the iPSC differentiation into cardiomyocyte. The microfluidic chip will exploit a biochemical procedure for iPSC differentiation. This first prototype will be fabricated in PDMS.

Websites, patent fillings, videos etc. (1)

Project website

project website

Pubblicazioni

Peer reviewed articles (7)

Surface modifications of COP-based microfluidic devices for improved immobilisation of hydrogel proteins: long-term 3D culture with contractile cell types and ischaemia model

Autori: Sandra González-Lana; Teodora Randelovic; Jesús Ciriza; María López-Valdeolivas; Rosa Monge; Carlos Sánchez-Somolinos; Ignacio Ochoa
Pubblicato in: Lab on a chip, Numero 8, 2023, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/d3lc00075c

Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling

Autori: María Virumbrales-Muñoz, Jose M. Ayuso, Alodia Lacueva, Teodora Randelovic, Megan K. Livingston, David J. Beebe, Sara Oliván, Desirée Pereboom, Manuel Doblare, Luis Fernández, Ignacio Ochoa
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-42529-8

Towards novel biomimetic in vitro models of the blood-brain barrier for drug permeability evaluation

Autori: Mármol, Inés; Abizanda-Campo, Sara; Ayuso, José M.; Ochoa, Ignacio; Oliván, Sara
Pubblicato in: Bioengineering, Numero 10, 2023, ISSN 2306-5354
Editore: mdpi
DOI: 10.3390/bioengineering10050572

Current approaches for the recreation of cardiac ischaemic environment in vitro

Autori: Laura Paz-Artigas, Pilar Montero-Calle, Olalla Iglesias-García, Manuel M. Mazo, Ignacio Ochoa , Jesús Ciriza
Pubblicato in: International Journal of Pharmaceutics, 2023, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.122589

Gene therapy. The legacy of Wacław Szybalski.

Autori: Jozef Dulak
Pubblicato in: Acta Biochimica Polonica, Numero 5, 2020, ISSN 1734-154X
Editore: Polskie Towarzystwo Biochemiczne
DOI: 10.18388/abp.2020_5805

Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells

Autori: Alicja Martyniak, Mateusz Jeż, Józef Dulak, Jacek Stępniewski
Pubblicato in: IUBMB Life, 2023, ISSN 1521-6551
Editore: John Wiley & Sons
DOI: 10.1002/iub.2685

Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

Autori: Kalina Andrysiak; Jacek Stępniewski; Jozef Dulak
Pubblicato in: Pflugers Archiv - European Journal of Physiology, Numero 3, 2021, ISSN 0031-6768
Editore: Springer Verlag
DOI: 10.1007/s00424-021-02536-z

Book chapters (1)

Heart-on-a-chip

Autori: Pierre Gaudriault, Dario Fassini, Antoni Homs-Corbera
Pubblicato in: Organ-on-a-chip, 2020, Pagina/e 255-293, ISBN 9780128172025
Editore: Elsevier
DOI: 10.1016/b978-0-12-817202-5.00008-5

Thesis and dissertations (1)

Application of human induced pluripotent stem cells and CRISPR/Cas9 gene editing technology for investigation of molecular background of Duchenne muscular dystrophy-related cardiomyopathy

Autori: Kalina Andrysiak
Pubblicato in: 2022
Editore: Repozytorium Uniwersytetu Jagiellońskiego