Nuclear magnetic resonance spectroscopy of liquid-liquid phase separation

Pubblicazioni

A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity

Autori: Senthil T. Kumar; Anne-Laure Mahul-Mellier; Ramanath Narayana Hegde; Gwladys Rivière; Rani Moons; Alain Ibáñez de Opakua; Pedro Magalhães; Iman Rostami; Sonia Donzelli; Frank Sobott; Markus Zweckstetter; Hilal A. Lashuel
Pubblicato in: Science Advances, Numero 1, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abn0044

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

Autori: T. Ukmar-Godec, P. Fang, A. Ibáñez de Opakua, F. Henneberg, A. Godec, K.-T. Pan, M.-S. Cima-Omori, A. Chari, E. Mandelkow, H. Urlaub, M. Zweckstetter
Pubblicato in: Science Advances, Numero 6/30, 2020, Pagina/e eaba3916, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aba3916

Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction

Autori: Yue Wu, Wing-Sze Tam, Ho-Fai Chau, Simranjeet Kaur, Waygen Thor, Wei Shen Aik, Wai-Lun Chan, Markus Zweckstetter, Ka-Leung Wong
Pubblicato in: Chemical Science, Numero 11/41, 2020, Pagina/e 11266-11273, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc04849f

Contributions of the N‐terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA‐induced phase separation

Autori: Milan Zachrdla; Adriana Savastano; Alain Ibáñez de Opakua; Maria‐Sol Cima‐Omori; Markus Zweckstetter
Pubblicato in: Protein Science, Numero 1, 2022, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4409

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates

Autori: Adriana Savastano, David Flores, Harindranath Kadavath, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstetter
Pubblicato in: Angewandte Chemie International Edition, Numero 60/2, 2021, Pagina/e 726-730, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202011157

Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding

Autori: Dajun Sang; Tong Shu; Christian F. Pantoja; Alain Ibáñez de Opakua; Markus Zweckstetter; Liam J. Holt
Pubblicato in: Molecular Cell, Numero 1, 2022, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2022.08.016

Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure

Autori: Lukas S. Stelzl; Lisa M. Pietrek; A. Holla; J. S. Oroz; M. Sikora; J. Köfinger; Benjamin Schuler; Markus Zweckstetter; Gerhard Hummer
Pubblicato in: JACS Au, Numero 1, 2022, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1101/2021.11.23.469691

Phase Separation in Biology and Disease; Current Perspectives and Open Questions

Autori: Steven Boeynaems, Shasha Chong, Jörg Gsponer, Liam Holt, Dragomir Milovanovic, Diana M Mitrea, Oliver Mueller-Cajar, Bede Portz, John F Reilly, Christopher D Reinkemeier, Benjamin R Sabari, Serena Sanulli, James Shorter, Emily Sontag, Lucia Strader, Jeanne Stachowiak, Stephanie C Weber, Michael White, Huaiying Zhang, Markus Zweckstetter, Shana Elbaum-Garfinkle, Richard Kriwacki
Pubblicato in: Journal of Molecular Biology, 2023, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2023.167971

Dynamic Aha1 co‐chaperone binding to human Hsp90

Autori: Javier Oroz, Laura J. Blair, Markus Zweckstetter
Pubblicato in: Protein Science, Numero 28/9, 2019, Pagina/e 1545-1551, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.3678

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Autori: Javier Oroz, Bliss J. Chang, Piotr Wysoczanski, Chung-Tien Lee, Ángel Pérez-Lara, Pijush Chakraborty, Romina V. Hofele, Jeremy D. Baker, Laura J. Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A. Dickey, Markus Zweckstetter
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-06880-0

Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease

Autori: Sandeep K. Rai, Adriana Savastano, Priyanka Singh, Samrat Mukhopadhyay, Markus Zweckstetter
Pubblicato in: Protein Science, 2021, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4093

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

Autori: Pijush Chakraborty, Gwladys Rivière, Shu Liu, Alain Ibáñez de Opakua, Rıza Dervişoğlu, Alina Hebestreit, Loren B. Andreas, Ina M. Vorberg, Markus Zweckstetter
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24362-8

Lysine/RNA-interactions drive and regulate biomolecular condensation

Autori: Tina Ukmar-Godec, Saskia Hutten, Matthew P. Grieshop, Nasrollah Rezaei-Ghaleh, Maria-Sol Cima-Omori, Jacek Biernat, Eckhard Mandelkow, Johannes Söding, Dorothee Dormann, Markus Zweckstetter
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-10792-y

Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations

Autori: Fiamma A. Buratti; Nicola Boeffinger; Hugo A. Garro; Jesica S. Flores; Francisco J. Hita; Phelippe do Carmo Gonçalves; Federico dos Reis Copello; Leonardo Lizarraga; Giulia Rossetti; Paolo Carloni; Markus Zweckstetter; Tiago F. Outeiro; Stefan Eimer; Christian Griesinger; Claudio O. Fernández
Pubblicato in: Protein science 31(7), e4360 (2022). doi:10.1002/pro.4360, Numero 1, 2022, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4360

Potent Tau aggregation inhibitor D-peptides selected against Tau-repeat 2 using mirror image phage display

Autori: Marwa Nidal Malhis; Senthilvelrajan Kaniyappan; Isabelle Aillaud; Ram Reddy Chandupatla; Lisa Marie Ramirez; Markus Zweckstetter; Anselm H. C. Horn; Anselm H. C. Horn; Eckhard Mandelkow; Heinrich Sticht; Susanne Aileen Funke
Pubblicato in: ChemBioChem, Numero 1, 2021, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100287

NMR hawk-eyed view of AlphaFold2 structures.

Autori: Markus Zweckstetter; Markus Zweckstetter
Pubblicato in: Protein Science : A Publication of the Protein Society, Numero 1, 2021, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4175

Peptidyl Prolyl Isomerase A Modulates the Liquid–Liquid Phase Separation of Proline-Rich IDPs

Autori: Maria Babu; Filippo Favretto; Marija Rankovic; Markus Zweckstetter
Pubblicato in: Journal of the American Chemical Society, Numero 1, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c07149

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

Autori: Adriana Savastano, Alain Ibáñez de Opakua, Marija Rankovic, Markus Zweckstetter
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19843-1

Interplay between tau and α-synuclein liquid-liquid phase separation.

Autori: Anna Siegert; Marija Rankovic; Filippo Favretto; Tina Ukmar-Godec; Timo Strohäker; Stefan Becker; Markus Zweckstetter; Markus Zweckstetter
Pubblicato in: Protein Science : A Publication of the Protein Society, Numero 1, 2021, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4025

Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils

Autori: Savastano, Adriana; Jaipuria, Garima; Andreas, Loren; Mandelkow, Eckhard; Zweckstetter, Markus
Pubblicato in: Crossref, Numero 1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-78161-0

The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure

Autori: Alisa Cario, Adriana Savastano, Neil B. Wood, Zhu Liu,Michael J. Previs, Adam G. Hendricks, Markus Zweckstetter, Christopher L. Berger
Pubblicato in: Proceedings of the National Academy of Sciences, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2114215119

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein

Autori: Benedikt Frieg; James A. Geraets; Timo Strohäker; Christian Dienemann; Panagiota Mavroeidi; Byung Chul Jung; Woojin S. Kim; Seung-Jae Lee; Maria Xilouri; Markus Zweckstetter; Gunnar F. Schröder
Pubblicato in: Communications biology 5(1), 1040 (2022). doi:10.1038/s42003-022-03948-y, Numero 1, 2022, ISSN 2399-3642
Editore: Springer
DOI: 10.1038/s42003-022-03948-y

Molecular interactions of FG nucleoporin repeats at high resolution

Autori: Alain Ibáñez de Opakua, James A Geraets, Benedikt Frieg, Christian Dienemann, Adriana Savastano, Marija Rankovic, Maria-Sol Cima-Omori, Gunnar F Schröder, Markus Zweckstetter
Pubblicato in: Nature Chemistry, 2022, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-022-01035-7

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Autori: Susmitha Ambadipudi, Jithender G. Reddy, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstetter
Pubblicato in: Chemical Science, Numero 10/26, 2019, Pagina/e 6503-6507, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc00531e

Biomolecular condensation of the microtubule-associated protein tau

Autori: Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstetter
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 99, 2020, Pagina/e 202-214, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2019.06.007

RNA polymerase II clustering through carboxy-terminal domain phase separation

Autori: Marc Boehning, Claire Dugast-Darzacq, Marija Rankovic, Anders S. Hansen, Taekyung Yu, Herve Marie-Nelly, David T. McSwiggen, Goran Kokic, Gina M. Dailey, Patrick Cramer, Xavier Darzacq, Markus Zweckstetter
Pubblicato in: Nature Structural & Molecular Biology, Numero 25/9, 2018, Pagina/e 833-840, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-018-0112-y

Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry.

Autori: Anton Abyzov; Martin Blackledge; Markus Zweckstetter
Pubblicato in: Crossref, Numero 1, 2022, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00774

Reorientational Dynamics of Amyloid-β from NMR Spin Relaxation and Molecular Simulation

Autori: Nasrollah Rezaei-Ghaleh, Giacomo Parigi, Markus Zweckstetter
Pubblicato in: The Journal of Physical Chemistry Letters, Numero 10/12, 2019, Pagina/e 3369-3375, ISSN 1948-7185
Editore: American Chemical Society
DOI: 10.1021/acs.jpclett.9b01050

Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress

Autori: Lulu Jiang, Pijush Chakraborty , Lushuang Zhang , Melissa Wong, Shannon E Hill, Chelsea Joy Webber , Jenna Libera, Laura J Blair, Benjamin Wolozin , Markus Zweckstetter
Pubblicato in: Science Advances, 2023, ISSN 2375-2548
Editore: American Association for the Advancement of Science’s
DOI: 10.1126/sciadv.add9789

Hsp multichaperone complex buffers pathologically modified Tau.

Autori: Antonia Moll; Lisa Marie Ramirez; Momchil Ninov; Juliane Schwarz; Henning Urlaub; Markus Zweckstetter
Pubblicato in: Nature Communications, Numero 1, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-31396-z

Molecular Basis of Small-Molecule Binding to α-Synuclein

Autori: Paul Robustelli; Alain Ibanez-de-Opakua; Cecily Campbell-Bezat; Fabrizio Giordanetto; Stefan Becker; Markus Zweckstetter; Albert C. Pan; David E. Shaw
Pubblicato in: Crossref, Numero 1, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c07591

Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR

Autori: Christian F Pantoja, Alain Ibáñez de Opakua, Maria-Sol Cima-Omori, Markus Zweckstetter
Pubblicato in: Angewandte Chemie International Edition, 2023, ISSN 0044-8249
Editore: Wiley-VCH
DOI: 10.1002/anie.202218078

Die krankheitsassoziierte Tau‐Phosphorylierung behindert die Tubulinpolymerisation in Tau‐Kondensaten

Autori: Adriana Savastano, David Flores, Harindranath Kadavath, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstetter
Pubblicato in: Angewandte Chemie, Numero 133/2, 2021, Pagina/e 737-741, ISSN 0044-8249
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202011157

Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop

Autori: Antonia Lott, Javier Oroz, Markus Zweckstetter
Pubblicato in: Protein Science, Numero 29/12, 2020, Pagina/e 2422-2432, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.3969

Local and Global Dynamics in Intrinsically Disordered Synuclein

Autori: Nasrollah Rezaei‐Ghaleh, Giacomo Parigi, Andrea Soranno, Andrea Holla, Stefan Becker, Benjamin Schuler, Claudio Luchinat, Markus Zweckstetter
Pubblicato in: Angewandte Chemie International Edition, Numero 57/46, 2018, Pagina/e 15262-15266, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201808172

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