Transgenerational epigenetic inheritance of chromatin states : the role of Polycomb and 3D chromosome architecture

Project Information

3DEpi

Grant agreement ID: 788972

DOI

10.3030/788972

Project closed

EC signature date 5 June 2018

Start date 1 November 2018

End date 31 October 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Higher-Order Chromosomal Structures Mediate Genome Function

Author(s): Ivana Jerković, Quentin Szabo, Frédéric Bantignies, Giacomo Cavalli
Published in: Journal of Molecular Biology, Issue 432/3, 2020, Page(s) 676-681, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.10.014

Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors

Author(s): Chetan C. Rawal, Vincent Loubiere, Nadejda L. Butova, Juliette Gracia, Victoria Parreno, Chiara Merigliano, Anne-Marie Martinez, Giacomo Cavalli, Irene Chiolo
Published in: Histochemistry and Cell Biology, Issue 162, 2024, Page(s) 133-147, ISSN 0948-6143
Publisher: Springer Verlag
DOI: 10.1007/s00418-024-02302-z

Principles of genome folding into topologically associating domains

Author(s): Quentin Szabo, Frédéric Bantignies, Giacomo Cavalli
Published in: Science Advances, Issue 5/4, 2019, Page(s) eaaw1668, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaw1668

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes

Author(s): Alessa R. Ringel, Quentin Szabo, Andrea M. Chiariello, Konrad Chudzik, Robert Schöpflin, Patricia Rothe, Alexandra L. Mattei, Tobias Zehnder, Dermot Harnett, Verena Laupert, Simona Bianco, Sara Hetzel, Juliane Glaser, Mai H.Q. Phan, Magdalena Schindler, Daniel M. Ibrahim, Christina Paliou, Andrea Esposito, Cesar A. Prada-Medina, Stefan A. Haas, Peter Giere, Martin Vingron, Lars Wittler, Alexander
Published in: Cell, Issue 185, 2022, Page(s) 3689-3704.e21, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.09.006

Transient loss of Polycomb components induces an epigenetic cancer fate

Author(s): V. Parreno, V. Loubiere, B. Schuettengruber, L. Fritsch, C. C. Rawal, M. Erokhin, B. Győrffy, D. Normanno, M. Di Stefano, J. Moreaux, N. L. Butova, I. Chiolo, D. Chetverina, A.-M. Martinez, G. Cavalli
Published in: Nature, Issue 629, 2024, Page(s) 688-696, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07328-w

HiCmapTools: a tool to access HiC contact maps

Author(s): Jia-Ming Chang, Yi-Fu Weng, Wei-Ting Chang, Fu-An Lin, Giacomo Cavalli
Published in: BMC Bioinformatics, Issue 23, 2022, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-022-04589-y

Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila

Author(s): Maximilian H. Fitz-James, Gonzalo Sabarís, Peter Sarkies, Frédéric Bantignies, Giacomo Cavalli
Published in: Molecular Cell, Issue 85, 2025, Page(s) 677-691.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.11.021

A mechanistic basis for genetic assimilation in natural fly populations

Author(s): Gonzalo Sabarís, Bernd Schuettengruber, Giorgio L. Papadopoulos, Marta Coronado-Zamora, Maximilian H. Fitz-James, Josefa González, Giacomo Cavalli
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2415982122

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping

Author(s): V. Loubiere, G. L. Papadopoulos, Q. Szabo, A-M. Martinez, G. Cavalli
Published in: Science Advances, Issue 6/2, 2020, Page(s) eaax4001, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax4001

Advances in epigenetics link genetics to the environment and disease

Author(s): Giacomo Cavalli, Edith Heard
Published in: Nature, Issue 571/7766, 2019, Page(s) 489-499, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1411-0

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

Author(s): Satish Sati, Boyan Bonev, Quentin Szabo, Daniel Jost, Paul Bensadoun, Francois Serra, Vincent Loubiere, Giorgio Lucio Papadopoulos, Juan-Carlos Rivera-Mulia, Lauriane Fritsch, Pauline Bouret, David Castillo, Josep Ll. Gelpi, Modesto Orozco, Cedric Vaillant, Franck Pellestor, Frederic Bantignies, Marc A. Marti-Renom, David M. Gilbert, Jean-Marc Lemaitre, Giacomo Cavalli
Published in: Molecular Cell, Issue 78/3, 2020, Page(s) 522-538.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.03.007

Regulation of single-cell genome organization into TADs and chromatin nanodomains

Author(s): Quentin Szabo, Axelle Donjon, Ivana Jerković, Giorgio L. Papadopoulos, Thierry Cheutin, Boyan Bonev, Elphège P. Nora, Benoit G. Bruneau, Frédéric Bantignies, Giacomo Cavalli
Published in: Nature Genetics, Issue 52/11, 2020, Page(s) 1151-1157, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-00716-8

Understanding 3D genome organization by multidisciplinary methods

Author(s): Ivana Jerkovic´, Giacomo Cavalli
Published in: Nature Reviews Molecular Cell Biology, 2021, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-021-00362-w

Mechanisms of Polycomb group protein function in cancer

Author(s): Victoria Parreno, Anne-Marie Martinez, Giacomo Cavalli
Published in: Cell Research, Issue 32, 2022, Page(s) 231-253, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-021-00606-6