Transgenic dissection of the neural circuitry of memory and dementia

Informazioni relative al progetto

MECEDGE

ID dell’accordo di sovvenzione: 796535

DOI

10.3030/796535

Progetto concluso il 21 Novembre 2018

Data della firma CE 6 Marzo 2018

Data di avvio 1 Maggio 2018

Data di completamento 29 Novembre 2020

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 196 400,40

Contributo UE

€ 196 400,40

Coordinato da

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway

Periodic Reporting for period 1 - MECEDGE (Transgenic dissection of the neural circuitry of memory and dementia)

Periodo di rendicontazione: 2018-05-01 al 2020-04-30

Sintesi del contesto e degli obiettivi generali del progetto

As the most common form of age-related dementia, Alzheimer's disease (AD) is an enormous and growing problem for an aging society. AD is a neurodegenerative disorder like Parkinson's disease (PD), but the former presents as a cognitive disorder, and the latter as a motor disorder (at least in early stages). The reason for this is not so much what happens (ultimately cell death in both cases), but *where* it happens (respectively, the entorhinal cortex, or EC, or the substantia nigra). This project attempts to explore what is it about the EC that makes it particularly susceptible to the pathological processes underlying AD, with particular emphasis on the role of activity. To do this, we combine transgenic lines we have created which allow us to manipulate the activity of neurons in this region with transgenic models of AD, and record the effects on both activity and AD-like phenotypes.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

Unfortunately, after the first four months of the project, the researcher had to return to the United States due to family reasons. Therefore, the project did not get past the initial stage of characterization of the transgenic models.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

While the project unfortunately had to be terminated due to the reason stated above, the success of the initial characterization of the lines will enable others in the lab to continue the research program. This could lead to a greater understanding of the role of activity in the progression of AD, and thereby new potential therapeutic avenues.

Anatomical characterization of EC LIII-specific Transgenic DREADD Expression