Transgenic dissection of the neural circuitry of memory and dementia

Informacje na temat projektu

MECEDGE

Identyfikator umowy o grant: 796535

DOI

10.3030/796535

Realizacja projektu zakończyła się 21 Listopada 2018

Data podpisania przez KE 6 Marca 2018

Data rozpoczęcia 1 Maja 2018

Data zakończenia 29 Listopada 2020

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 196 400,40

Wkład UE

€ 196 400,40

Koordynowany przez

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway

Periodic Reporting for period 1 - MECEDGE (Transgenic dissection of the neural circuitry of memory and dementia)

Okres sprawozdawczy: 2018-05-01 do 2020-04-30

Podsumowanie kontekstu i ogólnych celów projektu

As the most common form of age-related dementia, Alzheimer's disease (AD) is an enormous and growing problem for an aging society. AD is a neurodegenerative disorder like Parkinson's disease (PD), but the former presents as a cognitive disorder, and the latter as a motor disorder (at least in early stages). The reason for this is not so much what happens (ultimately cell death in both cases), but *where* it happens (respectively, the entorhinal cortex, or EC, or the substantia nigra). This project attempts to explore what is it about the EC that makes it particularly susceptible to the pathological processes underlying AD, with particular emphasis on the role of activity. To do this, we combine transgenic lines we have created which allow us to manipulate the activity of neurons in this region with transgenic models of AD, and record the effects on both activity and AD-like phenotypes.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

Unfortunately, after the first four months of the project, the researcher had to return to the United States due to family reasons. Therefore, the project did not get past the initial stage of characterization of the transgenic models.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

While the project unfortunately had to be terminated due to the reason stated above, the success of the initial characterization of the lines will enable others in the lab to continue the research program. This could lead to a greater understanding of the role of activity in the progression of AD, and thereby new potential therapeutic avenues.

Anatomical characterization of EC LIII-specific Transgenic DREADD Expression