Descrizione del progetto DEENESFRITPL Svelare i misteri della domesticazione dei cavalli La domesticazione del cavallo ha segnato il corso della storia umana, rivoluzionando i trasporti, il commercio, la guerra e l'agricoltura. Tuttavia, i meccanismi alla base di questo sviluppo rimangono avvolti nell'incertezza. Il recente sequenziamento del genoma ha rivelato che le prime testimonianze archeologiche di cavalli domestici non coincidono con gli antenati degli equini attuali. Invece, una misteriosa ondata di domesticazione durante la prima età del bronzo sembra aver dato origine al cavallo moderno. Con il sostegno del programma azioni Marie Skłodowska-Curie, il progetto EARLYRIDERS individuerà le origini geografiche e temporali della domesticazione del cavallo moderno. Sequenziando oltre 300 campioni provenienti da potenziali centri di domesticazione e utilizzando l'innovativo metodo hyRAD, EARLYRIDERS esplorerà la domesticazione e l'aumento della carica patogena nelle antiche popolazioni di cavalli. Mostra l’obiettivo del progetto Nascondi l’obiettivo del progetto Obiettivo The goal of the EARLYRIDERS project is to identify the geographic and temporal locus of modern horse domestication. It also focuses on the interplay between domestication and the increase of pathogen load in horses, and the role of epizootic transfer of human pathogens, especially plague. Horse domestication represents a turning point in human history, revolutionizing transport, trade, warfare, agriculture, and allowing humans to form larger, interconnected societies. Despite its importance for human history, this process remains poorly understood. Recent genome sequencing shows that the earliest archaeological remains of domestic horses are not the ancestors of modern domestic horses and that another, still unknown, wave of domestication forged the modern horse during the Early Bronze Age. Horse riding also allowed a rapid spread of diseases. For instance, the plague, that regularly haunted human populations in history, has been already commonly found in human remains dating to the Early Bronze Age. As the gene essential for the transmission through fleas was absent in these ancient strains, the plague might have been transmitted through other, still unknown vectors. This represents a serious gap in understanding of the early epidemiology of this important disease. As the spread of plague appears to be concurrent to horse domestication, the question remains whether the horse accounted for its spread, either as a vector or passively, by contagious riders. We aim at identifying the source of the second domestication wave and pathogen load in ancient horse populations by sequencing 300+ samples originating from all potential centers of domestication. Full genome sequencing is not possible due to low endogenous DNA content, therefore the samples will be subjected to sequence enrichment techniques, including the novel hyRAD method developed by the experienced researcher, scalable to thousands of loci in hundreds of samples at moderate cost. Campo scientifico humanitieshistory and archaeologyhistorynatural sciencesbiological sciencesgeneticsDNAmedical and health scienceshealth sciencespublic healthepidemiologyagricultural sciencesagriculture, forestry, and fisheriesagriculturenatural sciencesbiological sciencesgeneticsgenomes Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2017 - Individual Fellowships Invito a presentare proposte H2020-MSCA-IF-2017 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore UNIVERSITE PAUL SABATIER TOULOUSE III Contribution nette de l'UE € 173 076,00 Indirizzo ROUTE DE NARBONNE 118 31062 Toulouse Cedex 9 Francia Mostra sulla mappa Regione Occitanie Midi-Pyrénées Haute-Garonne Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 173 076,00
