Descripción del proyecto
Combinación de metabolómica con imagenología por resonancia magnética para estudiar la biología humana en todo el cuerpo
El proyecto NICI, financiado con fondos europeos, presentará un método innovador para estudiar la biología humana mediante el uso de imagenología química no invasiva (NICI, por sus siglas en inglés). El desarrollo de la tomografía por resonancia magnética nuclear (RMN) para detectar biomarcadores metabólicos recién descubiertos facilitará el mapeado dinámico de los procesos bioquímicos de todo el cuerpo. En el proyecto se establecerá una nueva metodología que utiliza organoides tridimensionales (3D) cultivados conjuntamente como modelos de órganos humanos. Se creará una plataforma que integre escáneres de resonancia magnética nuclear de 7 Teslas y métodos de adquisición de datos relacionados a fin de crear un sistema de imagenología bioquímica 3D. El método de obtención de imágenes químicas 3D y su valor predictivo y pronóstico se validarán en la estrategia de estratificación de los pacientes con metástasis hepática de cáncer gastrointestinal.
Objetivo
The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body.
Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.
Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging.
Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding.
Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.
High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging.
Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.
The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.)
Ámbito científico
- medical and health sciencesclinical medicineinternal medicine
- medical and health sciencesclinical medicineoncology
- medical and health sciencesclinical medicinepaediatrics
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
- engineering and technologyother engineering and technologiesmicrotechnologymolecular engineering
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETOPEN-1-2016-2017
Régimen de financiación
RIA - Research and Innovation actionCoordinador
3584 CX Utrecht
Países Bajos