SIGNALING PROPENSITY IN THE MICROENVIRONMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA

Pubblicazioni

IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib

Autori: Veronika Sandova, Gabriela Mladonicka Pavlasova, Vaclav Seda, Katerina Amruz Cerna, Sonali Sharma, Veronika Palusova, Yvona Brychtova, Sarka Pospisilova, Stacey M. Fernandes, Anna Panovska, Michael Doubek, Matthew S. Davids, Jennifer R. Brown, Jiri Mayer, Marek Mraz
Pubblicato in: Haematologica, 2020, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2021.278644

Genetic and Non-Genetic Mechanisms of Resistance to BCR Signaling Inhibitors in B Cell Malignancies

Autori: Laura Ondrisova, Marek Mraz
Pubblicato in: Frontiers in Oncology, Numero 10, 2020, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.591577

FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia

Autori: Vaclav Seda, Eva Vojackova, Laura Ondrisova, Lenka Kostalova, Sonali Sharma, Tomas Loja, Gabriela Mladonicka Pavlasova, Daniel Zicha, Marie Kudlickova Peskova, Jan Krivanek, Kvetoslava Liskova, Leos Kren, Vladimir Benes, Katerina Musilova Litzmanova, Marek Borsky, Jan Oppelt, Jan Verner, Sarka Pospisilova, Yvona Brychtova, Anna Panovska, Zhi Tan, Shuxing Zhang, Michael Doubek, Katerina Amruz Cerna
Pubblicato in: Blood, Numero 138/9, 2021, Pagina/e 758–772, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020008101

In Vitro and In Vivo Models of CLL–T Cell Interactions: Implications for Drug Testing

Autori: Eva Hoferkova, Sona Kadakova, Marek Mraz
Pubblicato in: Cancers, Numero 14(13), 3087, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14133087

miR-29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4: an Axis Affected by BCR inhibitors.

Autori: Sonali Sharma, Gabriela Pavlasova, Vaclav Seda, Katerina Cerna, Eva Vojackova, Daniel Filip, Laura Ondrisova, Veronika Sandova, Lenka Kostalova, Pedro F. Zeni, Marek Borsky, Jan Oppelt, Kvetoslava Liskova, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic, Leos Kren, Andrea Janikova, Sarka Pospisilova, Stacey Marie Fernandes, Medhat Shehata, Laura Z. Rassen
Pubblicato in: Blood, 2020, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020005627

Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drug

Autori: Eva Hoferkova, Vaclav Seda, Sona Kadakova, Jan Verner, Tomas Loja, Kvetoslava Matulova, Hana Skuhrova Francova, Eva Ondrouskova, Daniel Filip, Nicolas Blavet, Miroslav Boudny, Gabriela Mladonicka Pavlasova, Josef Vecera, Laura Ondrisova, Petra Pavelkova, Krystof Hlavac, Lenka Kostalova, Androniki Michaelou, Sarka Pospisilova, Jana Dorazilova, Vaclav Chochola, Josef Jaros, Michael Doubek, Marie Jar
Pubblicato in: Leukemia, Numero 14 June 2024, 2024, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-024-02284-w

The regulation and function of CD20: an “enigma” of B-cell biology and targeted therapy

Autori: Gabriela Pavlasova, Marek Mraz
Pubblicato in: Haematologica, Numero 105/6, 2020, Pagina/e 1494-1506, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.243543

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