Bacteriophage inhibition of antibiotic-resistant pathogenic microbes and founding for novel therapeutic strategies

Project Information

PHARMS

Grant agreement ID: 803077

DOI 10.3030/803077

Project closed

EC signature date 12 November 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 650,00

EU contribution € 1 499 650,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients

Author(s): Alina Bauer, Elisabeth Pachl, Johannes C. Hellmuth, Nikolaus Kneidinger, Motaharehsadat Heydarian, Marion Frankenberger, Hans C. Stubbe, Bernhard Ryffel, Agnese Petrera, Stefanie M. Hauck, Jürgen Behr, Rainer Kaiser, Clemens Scherer, Li Deng, Daniel Teupser, Narges Ahmidi, Maximilian Muenchhoff, Benjamin Schubert, Anne Hilgendorff
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1869, 2024, Page(s) 166592, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2022.166592

The role of virome in the gastrointestinal tract and beyond

Author(s): Kawtar Tiamani; Shiqi Luo; Sarah Schulz; Jinling Xue; Rita Costa; Mohammadali Khan Mirzaei; Li Deng
Published in: FEMS Microbiol. Rev. 46:fuac027 (2022), Issue 46:6, 2022, Page(s) 1-12, ISSN 0168-6445
Publisher: Blackwell
DOI: 10.1093/femsre/fuac027

Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

Author(s): Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius C. Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, J
Published in: Nature Cancer, Issue 5, 2024, Page(s) 187-208, ISSN 2662-1347
Publisher: Nature
DOI: 10.1038/s43018-023-00669-x

Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection

Author(s): Luo S, Ru J, Mirzaei MK, Xue J, Peng X, Ralser A, Mejías-Luque R, Gerhard M, Deng L
Published in: Gut Microbes, Issue 15:2, 2023, Page(s) 2257291, ISSN 1949-0976
Publisher: Landes Bioscience
DOI: 10.1080/19490976.2023.2257291

Gut Phage Database: phage mining in the cave of wonders

Author(s): Unterer M, Khan Mirzaei M, Li Deng
Published in: Signal Transduction and Targeted Therapy, Issue 6/1, 2021, Page(s) 193, ISSN 2059-3635
Publisher: Springer Nature
DOI: 10.1038/s41392-021-00615-2

Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.

Author(s): Bauer A, Pachl E, Hellmuth JC, Kneidinger N, Heydarian M, Frankenberger M, Stubbe HC, Ryffel B, Petrera A, Hauck SM, Behr J, Kaiser R, Scherer C, Deng L, Teupser D, Ahmidi N, Muenchhoff M, Schubert B, Hilgendorff A.
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1869:2, 2023, Page(s) 166592, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2022.166592

New technologies for developing phage-based tools to manipulate the human microbiome

Author(s): Khan Mirzaei M, Li Deng
Published in: Trends Microbiol, Issue 30/2, 2022, Page(s) 131-142, ISSN 0966-842x
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2021.04.007

Challenges of Studying the Human Virome - Relevant Emerging Technologies

Author(s): Khan Mirzaei M, Xue J, Costa R, Ru J, Schulz S, Taranu ZE, Li Deng
Published in: Trends Microbiol, Issue 29/2, 2021, Page(s) 171-181, ISSN 0966-842x
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2020.05.021

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning

Author(s): Jianfeng Sun, Jinlong Ru, Lorenzo Ramos-Mucci, Fei Qi, Zihao Chen, Suyuan Chen, Adam P. Cribbs, Li Deng, Xia Wang
Published in: International Journal of Molecular Sciences, Issue 24, 2025, Page(s) 1878, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24031878

Emerging technologies in the study of the virome

Author(s): Sophie E Smith; Wanqi Huang; Kawtar Tiamani; Magdalena Unterer; Mohammadali Khan Mirzaei; Li Deng
Published in: Crossref, Issue 54, 2022, Page(s) 101231, ISSN 1879-6257
Publisher: Elsevier BV
DOI: 10.1016/j.coviro.2022.101231

Bacteriophages Isolated from Stunted Children Can Regulate Gut Bacterial Communities in an Age-Specific Manner.

Author(s): Mohammadali Khan Mirzaei; Md. Anik Ashfaq Khan; Prakash Ghosh; Zofia E. Taranu; Mariia Taguer; Jinlong Ru; Rajashree Chowdhury; Md. Mamun Kabir; Li Deng; Dinesh Mondal; Corinne F. Maurice
Published in: Cell Host & Microbe, Issue 27/2, 2020, Page(s) 199-212.e5, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.01.004

ITN—VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics

Author(s): Goettsch, Winfried Beerenwinkel, Niko Deng, Li Dölken, Lars Dutilh, Bas E. Erhard, Florian Kaderali, Lars von Kleist, Max Marquet, Roland Matthijnssens, Jelle McCallin, Shawna McMahon, Dino Rattei, Thomas Van Rij, Ronald P. Robertson, David L. Schwemmle, Martin Stern-Ginossar, Noam Marz, Manja
Published in: Viruses, Issue 13/5, 2021, Page(s) 766, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13050766

Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature

Author(s): Ralser A, Dietl A, Jarosch S, Engelsberger V, Wanisch A, Janssen KP, Middelhoff M, Vieth M, Quante M, Haller D, Busch DH, Deng L, Mejías-Luque R, Gerhard M.
Published in: Gut, Issue 72:7, 2023, Page(s) 1258-1270, ISSN 1468-3288
Publisher: BMJ Publishing Group Ltd & British Society of Gastroenterology
DOI: 10.1136/gutjnl-2022-328075

Sustainable Microbiome: a symphony orchestrated by synthetic phages

Author(s): Mohammadali Khan Mirzaei, Li Deng
Published in: Microbial Biotechnology, 2020, ISSN 1751-7915
Publisher: Society for Applied Microbiology and John Wiley & Sons Ltd
DOI: 10.1111/1751-7915.13697

Targeted Single-Phage Isolation Reveals Phage-Dependent Heterogeneous Infection Dynamics

Author(s): Magdalena Unterer; Mohammadali Khan Mirzaei; Li Deng
Published in: Crossref, Issue 11:3, 2023, Page(s) e05149-22, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.05149-22

Helicobacter pylori infection alters gut virome by expanding temperate phages linked to increased risk of colorectal cancer

Author(s): Luo S, Ru J, Khan Mirzaei M, Xue J, Peng X, Ralser A, Hadi JL, Mejías-Luque R, Gerhard M, Deng L*
Published in: Gut, 2023, ISSN 1468-3288
Publisher: BMJ Publishing Group Ltd & British Society of Gastroenterology
DOI: 10.1136/gutjnl-2023-330362

ViroProfiler: a containerized bioinformatics pipeline for viral metagenomic data analysis

Author(s): Jinlong Ru; Mohammadali Khan Mirzaei; Jinling Xue; Xue Peng; Li Deng
Published in: Crossref, Issue 15, 2023, Page(s) 2192522, ISSN 1949-0984
Publisher: Taylor & Francis
DOI: 10.1080/19490976.2023.2192522

Differences in Gut Virome Related to Barrett Esophagus and Esophageal Adenocarcinoma

Author(s): Ma T, Ru J, Xue J, Schulz S, Khan Mirzaei M, Janssen K-P, Quante M, Li Deng
Published in: Microorganisms, Issue 9/8, 2021, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9081701

Phage Therapy in Germany—Update 2023

Author(s): Willy C, Bugert JJ, Classen AY, Deng L, Düchting A, Gross J, Hammerl JA, Korf IHE, Kühn C, Lieberknecht-Jouy S, Rohde C, Rupp M, Vehreschild MJGT, Vogele K, Wienecke S, Witzenrath M, Würstle S, Ziehr H, Moelling K, Broecker F.
Published in: Viruses, Issue 15:2, 2023, Page(s) 588, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15020588

A rigorous assessment and comparison of enumeration methods for environmental viruses

Author(s): Judith Kaletta, Carolin Pickl, Christian Griebler, Andreas Klingl, Rainer Kurmayer, Li Deng
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-75490-y

Defining the human gut host–phage network through single-cell viral tagging

Author(s): Mária Džunková, Soo Jen Low, Joshua N. Daly, Li Deng, Christian Rinke, Philip Hugenholtz
Published in: Nature Microbiology, Issue 4/12, 2019, Page(s) 2192-2203, ISSN 2058-5276
Publisher: Springer Nature
DOI: 10.1038/s41564-019-0526-2