Bacteriophage inhibition of antibiotic-resistant pathogenic microbes and founding for novel therapeutic strategies

Informazioni relative al progetto

PHARMS

ID dell’accordo di sovvenzione: 803077

DOI

10.3030/803077

Progetto chiuso

Data della firma CE 12 Novembre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 650,00

Contributo UE

€ 1 499 650,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients

Autori: Alina Bauer, Elisabeth Pachl, Johannes C. Hellmuth, Nikolaus Kneidinger, Motaharehsadat Heydarian, Marion Frankenberger, Hans C. Stubbe, Bernhard Ryffel, Agnese Petrera, Stefanie M. Hauck, Jürgen Behr, Rainer Kaiser, Clemens Scherer, Li Deng, Daniel Teupser, Narges Ahmidi, Maximilian Muenchhoff, Benjamin Schubert, Anne Hilgendorff
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numero 1869, 2024, Pagina/e 166592, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2022.166592

The role of virome in the gastrointestinal tract and beyond

Autori: Kawtar Tiamani; Shiqi Luo; Sarah Schulz; Jinling Xue; Rita Costa; Mohammadali Khan Mirzaei; Li Deng
Pubblicato in: FEMS Microbiol. Rev. 46:fuac027 (2022), Numero 46:6, 2022, Pagina/e 1-12, ISSN 0168-6445
Editore: Blackwell
DOI: 10.1093/femsre/fuac027

Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

Autori: Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius C. Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, J
Pubblicato in: Nature Cancer, Numero 5, 2024, Pagina/e 187-208, ISSN 2662-1347
Editore: Nature
DOI: 10.1038/s43018-023-00669-x

Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection

Autori: Luo S, Ru J, Mirzaei MK, Xue J, Peng X, Ralser A, Mejías-Luque R, Gerhard M, Deng L
Pubblicato in: Gut Microbes, Numero 15:2, 2023, Pagina/e 2257291, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2023.2257291

Gut Phage Database: phage mining in the cave of wonders

Autori: Unterer M, Khan Mirzaei M, Li Deng
Pubblicato in: Signal Transduction and Targeted Therapy, Numero 6/1, 2021, Pagina/e 193, ISSN 2059-3635
Editore: Springer Nature
DOI: 10.1038/s41392-021-00615-2

Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients.

Autori: Bauer A, Pachl E, Hellmuth JC, Kneidinger N, Heydarian M, Frankenberger M, Stubbe HC, Ryffel B, Petrera A, Hauck SM, Behr J, Kaiser R, Scherer C, Deng L, Teupser D, Ahmidi N, Muenchhoff M, Schubert B, Hilgendorff A.
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numero 1869:2, 2023, Pagina/e 166592, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2022.166592

New technologies for developing phage-based tools to manipulate the human microbiome

Autori: Khan Mirzaei M, Li Deng
Pubblicato in: Trends Microbiol, Numero 30/2, 2022, Pagina/e 131-142, ISSN 0966-842x
Editore: Elsevier BV
DOI: 10.1016/j.tim.2021.04.007

Challenges of Studying the Human Virome - Relevant Emerging Technologies

Autori: Khan Mirzaei M, Xue J, Costa R, Ru J, Schulz S, Taranu ZE, Li Deng
Pubblicato in: Trends Microbiol, Numero 29/2, 2021, Pagina/e 171-181, ISSN 0966-842x
Editore: Elsevier BV
DOI: 10.1016/j.tim.2020.05.021

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning

Autori: Jianfeng Sun, Jinlong Ru, Lorenzo Ramos-Mucci, Fei Qi, Zihao Chen, Suyuan Chen, Adam P. Cribbs, Li Deng, Xia Wang
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2025, Pagina/e 1878, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24031878

Emerging technologies in the study of the virome

Autori: Sophie E Smith; Wanqi Huang; Kawtar Tiamani; Magdalena Unterer; Mohammadali Khan Mirzaei; Li Deng
Pubblicato in: Crossref, Numero 54, 2022, Pagina/e 101231, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/j.coviro.2022.101231

Bacteriophages Isolated from Stunted Children Can Regulate Gut Bacterial Communities in an Age-Specific Manner.

Autori: Mohammadali Khan Mirzaei; Md. Anik Ashfaq Khan; Prakash Ghosh; Zofia E. Taranu; Mariia Taguer; Jinlong Ru; Rajashree Chowdhury; Md. Mamun Kabir; Li Deng; Dinesh Mondal; Corinne F. Maurice
Pubblicato in: Cell Host & Microbe, Numero 27/2, 2020, Pagina/e 199-212.e5, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2020.01.004

ITN—VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics

Autori: Goettsch, Winfried Beerenwinkel, Niko Deng, Li Dölken, Lars Dutilh, Bas E. Erhard, Florian Kaderali, Lars von Kleist, Max Marquet, Roland Matthijnssens, Jelle McCallin, Shawna McMahon, Dino Rattei, Thomas Van Rij, Ronald P. Robertson, David L. Schwemmle, Martin Stern-Ginossar, Noam Marz, Manja
Pubblicato in: Viruses, Numero 13/5, 2021, Pagina/e 766, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13050766

Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature

Autori: Ralser A, Dietl A, Jarosch S, Engelsberger V, Wanisch A, Janssen KP, Middelhoff M, Vieth M, Quante M, Haller D, Busch DH, Deng L, Mejías-Luque R, Gerhard M.
Pubblicato in: Gut, Numero 72:7, 2023, Pagina/e 1258-1270, ISSN 1468-3288
Editore: BMJ Publishing Group Ltd & British Society of Gastroenterology
DOI: 10.1136/gutjnl-2022-328075

Sustainable Microbiome: a symphony orchestrated by synthetic phages

Autori: Mohammadali Khan Mirzaei, Li Deng
Pubblicato in: Microbial Biotechnology, 2020, ISSN 1751-7915
Editore: Society for Applied Microbiology and John Wiley & Sons Ltd
DOI: 10.1111/1751-7915.13697

Targeted Single-Phage Isolation Reveals Phage-Dependent Heterogeneous Infection Dynamics

Autori: Magdalena Unterer; Mohammadali Khan Mirzaei; Li Deng
Pubblicato in: Crossref, Numero 11:3, 2023, Pagina/e e05149-22, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/spectrum.05149-22

Helicobacter pylori infection alters gut virome by expanding temperate phages linked to increased risk of colorectal cancer

Autori: Luo S, Ru J, Khan Mirzaei M, Xue J, Peng X, Ralser A, Hadi JL, Mejías-Luque R, Gerhard M, Deng L*
Pubblicato in: Gut, 2023, ISSN 1468-3288
Editore: BMJ Publishing Group Ltd & British Society of Gastroenterology
DOI: 10.1136/gutjnl-2023-330362

ViroProfiler: a containerized bioinformatics pipeline for viral metagenomic data analysis

Autori: Jinlong Ru; Mohammadali Khan Mirzaei; Jinling Xue; Xue Peng; Li Deng
Pubblicato in: Crossref, Numero 15, 2023, Pagina/e 2192522, ISSN 1949-0984
Editore: Taylor & Francis
DOI: 10.1080/19490976.2023.2192522

Differences in Gut Virome Related to Barrett Esophagus and Esophageal Adenocarcinoma

Autori: Ma T, Ru J, Xue J, Schulz S, Khan Mirzaei M, Janssen K-P, Quante M, Li Deng
Pubblicato in: Microorganisms, Numero 9/8, 2021, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms9081701

Phage Therapy in Germany—Update 2023

Autori: Willy C, Bugert JJ, Classen AY, Deng L, Düchting A, Gross J, Hammerl JA, Korf IHE, Kühn C, Lieberknecht-Jouy S, Rohde C, Rupp M, Vehreschild MJGT, Vogele K, Wienecke S, Witzenrath M, Würstle S, Ziehr H, Moelling K, Broecker F.
Pubblicato in: Viruses, Numero 15:2, 2023, Pagina/e 588, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v15020588

A rigorous assessment and comparison of enumeration methods for environmental viruses

Autori: Judith Kaletta, Carolin Pickl, Christian Griebler, Andreas Klingl, Rainer Kurmayer, Li Deng
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-75490-y

Defining the human gut host–phage network through single-cell viral tagging

Autori: Mária Džunková, Soo Jen Low, Joshua N. Daly, Li Deng, Christian Rinke, Philip Hugenholtz
Pubblicato in: Nature Microbiology, Numero 4/12, 2019, Pagina/e 2192-2203, ISSN 2058-5276
Editore: Springer Nature
DOI: 10.1038/s41564-019-0526-2